Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1243-1253

  Mallei, Alessandra ^a   Giambelli, Roberto ^a,e   Gass, Peter ^b   Racagni, Giorgio ^a,c   Mathé, Aleksander A ^d   Vollmayr, Barbara ^b   Popoli, Maurizio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^d KAROLINSKA INSTITUTE   (Sweden)

^e Rotta Research Laboratorium   (Italy)

Author keywords

Antidepressant; Learned helplessness; Proteomics; Synaptosome

Indexed keywords

ACONITATE HYDRATASE; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; MEMBRANE PROTEIN; NORTRIPTYLINE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE E1; STATHMIN; SYNAPTIC PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL METABOLISM; CELL REMODELING; CENTRIFUGATION; CONTROLLED STUDY; DEPRESSION; DISEASE PREDISPOSITION; DRUG TARGETING; ENERGY METABOLISM; FRONTAL CORTEX; HIPPOCAMPUS; LEARNED HELPLESSNESS; MALE; MASS SPECTROMETRY; MOUSE; NERVE ENDING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; SYNAPSE; SYNAPTOSOME; TWO DIMENSIONAL GEL ELECTROPHORESIS; AMINO ACID SEQUENCE; ANIMAL BEHAVIOR; CELLULAR PARAMETERS; CELLULAR REMODELLING; COMPARATIVE STUDY; DRUG MECHANISM; MENTAL DISEASE; MOLECULAR PATHOLOGY; PROTEIN FUNCTION; PURIFICATION; RAT; STRESS;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CEREBRAL CORTEX; COMPUTER SIMULATION; DEPRESSION; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENERGY METABOLISM; HELPLESSNESS, LEARNED; HIPPOCAMPUS; MALE; PREFRONTAL CORTEX; PROTEINS; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SOFTWARE; SYNAPSES; TREATMENT OUTCOME; UP-REGULATION;

EID: 79954570431     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.12.012     Document Type: Article

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