High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: Normalization by chronic antidepressant treatment

Journal of Neurochemistry

Volumn 69, Issue 6, 1997, Pages 2477-2483

  Zangen, Abraham ^a   Overstreet, David H ^b   Yadid, Gal ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Depression; Desipramine; Flinders sensitive line rats; Limbic system; Rat model; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ANTIDEPRESSANT AGENT; DESIPRAMINE; SEROTONIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN LEVEL; BRAIN METABOLISM; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; LIMBIC SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030667338     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69062477.x     Document Type: Article

References (45)

1. Adell A., Garcia-Marquez C., Armario A., and Gelpi E. (1988) Chronic stress increases serotonin and noradrenaline in rat brain and sensitizes their responses to further acute stress. J. Neurochem. 50, 1678-1681.
2. Akiskal H. S. (1995) Mood disorders: introduction and overview, in Comprehensive Textbook of Psychiatry, Vol. VI (Kaplan H. I. and Sadock B. J., eds), pp. 1067-1068. Williams and Wilkins, Baltimore.
3. Alpers H. S. and Himwich H. E. (1972) The effect of chronic imipramine administration on rat brain levels of serotonin, 5-hydroxyindoleacetic acid, norepinephrine and dopamine. J. Pharmacol Exp. Ther. 180, 531-538.
4. Asberg M., Bertilsson L., Martensson B., Scalia G. P., Thoren P., and Traskman-Bendz L. (1984) CSF monoamine metabolites in melancholia. Acta Psychiatr. Scand. 69, 201-219.
5. Banki C. M. (1978) 5-Hydroxytryptamine content of whole blood in psychiatric illness and alcoholism. Acta Psychiatr. Scand. 57, 232-238.
6. Baraban J. M. and Aghajanian G. K. (1980) Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology 19, 355-363.
7. Bel N. and Artigas F. (1996) In vivo effects of simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies. J. Pharmacol Exp. Ther. 287, 1064-1072.
8. Beskow J. (1990) Depression and suicide. Pharmacopsychiatry 23 (Suppl.), 3-8.
9. Blier P. and deMontigny C. (1994) Current advances and trends in the treatment of depression. Trends Pharmacol. Sci. 15, 220-226.
10. Borsini F. and Meli A. (1988) Is the forced swim test a suitable model for revealing antidepressant activity? Psychopharmacology 94, 147-160.
11. Buss Lassen J., Lund J., and Sondergaard I. (1980) Central and peripheral 5-HT uptake in rats treated chronically with femoxetine, paroxetine and chlomipramine. Psychopharmacology 68, 229-235.
12. Caccia S., Anelli M., Codegoni A. M., Fracasso C., and Garattini S. (1993) The effect of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain. Br. J. Pharmacol. 110, 355-359.
13. Cheetham S. C., Crompton M. R., Czudek C., Horton R. W., Katona C. L. E., and Reynolds G. P. (1989) Serotonin concentrations and turnover in brains of depressed suicides. Brain Res. 502, 332-340.
14. Commissiong J. W. (1985) Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity. Biochem. Pharmacol. 34, 1127-1131.
15. Coppen A., Turner P., and Roswell A. R. (1976) 5-Hydroxytryptamine (5-HT) in the whole blood patients with depressive illness. Postgrad. Med. J. 52, 156-158.
16. Corona G. L., Cucchi M. L., Santagostino G., Frattini P., Zerbi F., Fenoglio L., and Savoldi R. (1982) Blood noradrenaline and 5-HT levels in depressed women during amitriptyline and lithium treatment. Psychopharmacology 77, 236-241.
17. 3H]-Paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments. Eur. J. Pharmacol 235, 137-142.
18. Elewans C. S. and Azmitia E. (1984) Tryptophan hydroxylase in hippocampus and midbrain following unilateral injection of 5,7-dihydroxytryptamine. Brain Res. 307, 125-133.
19. Groenewegen H. J., Wright C. I., and Beijer A. V. (1996) The nucleus accumbens: gateway for limbic structures to reach the motor system? Prog. Brain Res. 107, 485-511.
20. 3H]-imipramine recognition sites in rat brain by chronic treatment with antidepressants. Eur. J. Pharmacol. 138, 159-165.
21. Jacobs B. L. and Azmitia E. C. (1992) Structure and function of the brain serotonin system. Physiol. Rev. 72, 165-229.
22. Maes M. and Meltzer H. Y. (1995) The serotonin hypothesis of major depression, in Psychopharmacology: The Fourth Generation of Progress (Bloom F. E. and Kupfer D. J., eds), pp. 933-944. Raven Press, New York.
23. Mann J. J., Arango V., Marzuk P. M., Theccanat S., and Reis D. J. (1989) Evidence for the 5-HT hypothesis of suicide: a review of post-mortem studies. Br. J. Psychiatry 155, 7-14.
24. Meltzer H. Y. and Arora R. C. (1986) Platelet markers of suicidality. Ann. NY Acad. Sci. 487, 271-280.
25. Mongeau R., Blier P., and DeMontigny C. (1993) In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of alpha-2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus. Naunyn Schmiedebergs Arch. Pharmacol. 347, 266-272.
26. Mongeau R., DeMontigny C. and Blier P. (1994) Electrophysiologic evidence for desensitization of alpha(2)-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration. Neuropharmacology 10, 41-51.
27. Muck-Seler D., Jakovljevic M., and Deanovic Z. (1991) Platelet serotonin in subtypes of schizophrenia and unipolar depression. Psychiatry Res. 38, 105-113.
28. Overstreet D. H. (1993) The Flinders sensitive line rats: a genetic animal model of depression. Neurosci. Biobehav. Rev. 17, 51-68.
29. Overstreet D. H., Pucilowski O., Rezvani A. H., and Janowski D. S. (1995) Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders sensitive line rats as an animal model of depression. Psychopharmacology 121, 27-37.
30. Palkovits M. and Brownstein M. J. (1988) Maps and Guide to Microdissection of the Rat Brain. Elsevier, New York.
31. Pucilowski O. and Overstreet D. H. (1993) Effect of chronic antidepressants on responses to apomorphine in selectively bred rat strains. Behav. Brain Res. 32, 471-475.
32. Quan-Bui K. H. L., Plaisant O., Leboyer M., Gay C., Kamal L., Devynck M. A., and Meyer P. (1984) Reduced platelet serotonin in depression. Psychiatry Res. 13, 129-139.
33. Quintana J. (1992) Platelet serotonin and plasma tryptophan decreases in endogenous depression. Clinical, therapeutic, and biological correlation. J. Affect. Disord. 24, 55-62.
34. Reddy P. L., Khanna S., Subhash M. N., Channabasavanna S. M., and Rao B. S. (1992) CSF amine metabolites in depression. Biol. Psychiatry 31, 112-118.
35. Roy A., Pickar D., Linnoila M., Doran A. R., Ninan P., and Paul S. M. (1985) Cerebrospinal fluid monoamine metabolite concentrations in melancholia. Psychiatry Res. 15, 281-292.
36. Sarrias M. J., Artigas F., Martinez E., Gelpi E., Alvarez E., Udina C., and Casas M. (1987) Decreased plasma serotonin in melancholic patients, a study with clomipramine. Biol. Psychiatry 22, 1429-1438.
37. Schiller G. D., Pucilowski O., Wienicke C., and Overstreet D. H. (1992) Immobility-reducing effects of antidepressants in a genetic model of depression. Brain Res. Bull. 28, 821-823.
38. Stachowiak M. K., Stricker E. M., Jacoby J. H., and Zigmond M. J. (1986) Increased tryptophan activity in serotonergic nerve terminals spared by 5,7-dihydroxytryptamine. Biochem. Pharmacol. 35, 1241-1248.
39. Stahl S. M., Woo D. J., Mefford I. N., Berger P. A., and Ciaranello R. D. (1983) Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders. Am. J. Psychiatry 140, 26-30.
40. 2 Adrenoceptor modulation of rat ventral hippocampal 5-hydroxytryptamine release in vivo. Naunyn Schmiedebergs Arch. Pharmacol. 345, 137-143.
41. Todrick A., Tait A. C., and Marshell E. F. (1960) Blood platelet 5-hydroxytryptamine levels in psychiatric patients. Br. J. Psychiatry 106, 884-890.
42. van Praag H. M. (1986) Biological suicide research: outcome and limitations. Biol. Psychiatry 21, 1305-1323.
43. 3H]-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder. J. Affect. Disord. 20, 101-113.
44. Yadid G., Pacak K., Kopin I. J., and Goldstein D. S. (1994) Endogenous serotonin stimulates striatal dopamine release in conscious rats. J. Pharmacol. Exp. Ther. 270, 1158-1165.
45. Yoshida T., Suzuki S., Sagitas S., Kobayashi A., and Nakazawa K. (1989) Effects of lithium on alterations of pharmacokinetics of imipramine and on related changes of monoamines in rat brain. Eur. J. Pharmacol. 173, 143-149.