Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats

Journal of Neuroscience

Volumn 17, Issue 23, 1997, Pages 9361-9366

  Lorrain, Daniel S ^a,b   Matuszewich, Leslie ^a,c   Friedman, Ross D ^a   Hull, Elaine M ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Copulation; Lateral hypothalamic area; Male rats; Medial preoptic area; Microdialysis; Postejaculatory interval; Serotonin

Indexed keywords

SEROTONIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COPULATION; EJACULATION; FEMALE; LATERAL HYPOTHALAMUS; MALE; MATING; MEDIAL PREOPTIC AREA; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL;

EID: 0030669989     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-23-09361.1997     Document Type: Article

References (26)

1. Aoyagi K, Oomura Y, Shimizu N (1992) Concurrent measurement of serotonin metabolism and single neuron activity changes in the lateral hypothalamus of freely behaving rat. Behav Brain Res 49:205-212.
2. Bitran D, Hull EM (1987) Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 11:365-389.
3. Cechetto DF, Chen SJ (1990) Subcortical sites mediating sympathetic responses from insular cortex in rats. Am J Physiol 258:R245-R255.
4. 1B receptors in brain regions and its effects on male rat sexual behaviour. Eur J Pharmacol 210:121-129.
5. 2 receptor in the regulation of sexual performance of male rats. Life Sci 45:1263-1270.
6. Fornal CA, Metzler CW, Marrosu F, Ribiero-do-Valle L, Jacobs BL (1996) A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements. Brain Res 716:123-133.
7. Fumero B, Fernandez-Vera JR, Gonzalez-Mora JL, Mas M (1994) Changes in monoamine turnover in forebrain areas associated with masculine sexual behavior: a microdialysis study. Brain Res 662:233-239.
8. Glickman SE, Schiff BB (1967) A biological theory of reinforcement. Psychol Rev 74:81-109.
9. Gorzalka BB, Mendelson SC, Watson NV (1990) Serotonin receptor subtypes and sexual behavior. Ann NY Acad Sci 600:435-446.
10. Herman JB, Brotman AW, Pollack MH, Falk WE, Biederman J, Rosenbaum JF (1990) Fluoxetine-induced sexual dysfunction. J Clin Psychiatry 51:25-27.
11. 2 agonists using the post-prandial satiety sequence in rats. Psychopharmacology 113:369-377.
12. Kline MD (1989) Fluoxetine and anorgasmia. Am J Psychiatry 146:804-805.
13. Mas M, Rodriguez del Castillo A, Guerra M, Davidson JM, Battaner E (1987) Neurochemical correlates of male sexual behavior. Physiol Behav 41:341-345.
14. Mas M, Fumero B, Fernandez-Vera JR, Gonzalez-Mora JL (1995) Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdialysis. Brain Res 675:13-19.
15. Masters W, Johnson V (1966) Human sexual response. Boston: Little Brown.
16. Meisel RL, Sachs BD (1994) The physiology of male sexual behavior. In: The physiology of reproduction (Knobil E, Neill J, eds), pp 3-106. New York: Raven.
17. Morley JE, Levine AS, Gosnell BA, Mitchell JE, Krahn DD, Nizielski SE (1985) Peptides and feeding. Peptides 6[Suppl 2]:181-192.
18. Schwartz DH, McClane S, Hernandez L, Hoebel BG (1989) Feeding increases extracellular serotonin in the lateral hypothalamus of the rat as measured by microdialysis. Brain Res 479:349-354.
19. Singh J, Desiraju T, Raju TR (1996) Comparison of intracranial self-stimulation evoked from lateral hypothalamus and ventral tegmentum: analysis based on stimulation parameters and behavioural response characteristics. Brain Res Bull 41:399-408.
20. Verma S, Chhina GS, Kumar VM, Singh B (1989) Inhibition of male sexual behavior by serotonin application in the medial preoptic area. Physiol Behav 46:327-330.
21. Wayner MJ (1970) Motor control functions of the lateral hypothalamus and adjunctive behavior. Physiol Behav 5:1319-1325.
22. Wayner MJ, Barone FC, Laoullis CC (1981) The lateral hypothalamus and adjunctive behavior. In: Handbook of the hypothalamus, Vol 3, Part B (Morgane PJ, Panksepp J, eds), pp 107-146. New York: Dekker.
23. Wilson CA (1994) Pharmacological targets for the control of male and female sexual behaviour. In: Sexual pharmacology (Riley AJ, Peet M, Wilson CA, eds), pp 1-58. Oxford: Oxford Medical Publications.
24. Yasui Y, Breder CD, Saper CB, Cechetto DF (1990) Autonomic responses and efferent pathways from the insular cortex in the rat. J Comp Neurol 303:355-374.
25. Yells D, Prendergast M, Hendricks S, Nakamura M (1994) Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis. Pharmacol Biochem Behav 49:121-127.
26. Zajecka J, Fawcett J, Schaff M, Jeffriess H, Guy C (1991) The role of serotonin in sexual dysfunction: fluoxetine-associated orgasm dysfunction. J Clin Psychiatry 52:66-68.