Depressed patients have higher body temperature: 5-HT transporter long promoter region effects

Neuropsychobiology

Volumn 47, Issue 3, 2003, Pages 120-127

  Rausch, Jeffrey L ^a   Johnson, M E ^a   Corley, K M ^a   Hobby, H M ^a   Shendarkar, N ^a   Fei, Y ^a   Ganapathy, V ^a   Leibach, F H ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

5 HT; 5 HT transporter long promoter region; Body temperature; Depression; Serotonin; Serotonin transporter

Indexed keywords

PSYCHOTROPIC AGENT; SEROTONIN TRANSPORTER;

ADULT; AGE; AGED; ALLELE; ARTICLE; BODY TEMPERATURE; CHROMOSOME; CIRCADIAN RHYTHM; CONTROLLED STUDY; FEMALE; GENE DELETION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL PATIENT; NUCLEOTIDE SEQUENCE; OUTCOMES RESEARCH; OUTPATIENT; PRIORITY JOURNAL; PROMOTER REGION; PSYCHIATRIC DIAGNOSIS; RANDOMIZATION; STATISTICAL SIGNIFICANCE; TEMPERATURE MEASUREMENT; TIME;

ADOLESCENT; ADULT; AGED; BODY TEMPERATURE; CARRIER PROTEINS; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER, MAJOR; DNA PRIMERS; FEMALE; GENE DELETION; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MODELS, GENETIC; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); ROC CURVE; SENSITIVITY AND SPECIFICITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SLEEP, REM;

EID: 0037641276     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070579     Document Type: Article

References (66)

1. Maes M, Song C, Lin AH, Bonaccorso S, Kenis G, De Jongh R, Bosmans E, Scharpe S: Negative immunoregulatory effects of antidepressants: Inhibition of interferon-gamma and stimulation of interleukin-10 secretion. Neuropsychopharmacology 1999;20:370-379.
2. Sluzewska A: Indicators of immune activation in depressed patients. Adv Exp Med Biol 1999;461:59-73.
3. Seidel A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H: Cytokine production and serum proteins in depression. Scand J Immunol 1995;41:534-538.
4. Nassberger L, Traskman-Bendz L: Increased soluble interleukin-2 receptor concentrations in suicide attempters. Acta Psychiatr Scand 1993;88:48-52.
5. Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E: Interleukin-1 beta: A putative mediator of HPA axis hyperactivity in major depression? Am J Psychiatry 1993;150:1189-1193.
6. Maes M, Scharpe S, Meltzer HY, Bosmans E, Suy E, Calabrese J, Cosyns P: Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res 1993;49:11-27.
7. Maes M, Scharpe S, Meltzer HY, Okayli G, Bosmans E, D'Hondt P, Vanden Bossche BV, Cosyns P: Increased neopterin and interferon-gamma secretion and lower availability ofL- tryptophan in major depression: Further evidence for an immune response. Psychiatry Res 1994;54:143-160.
8. Sluzewska A, Rybakowski JK, Laciak M, Mackiewicz A, Sobieska M, Wiktorowicz K: Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann NY Acad Sci 1995;762:474-476.
9. Seidel A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H: Increased CD56+ natural killer cells and related cytokines in major depression. Clin Immunol Immunopathol 1996; 78:83-85.
10. Frommberger UH, Bauer J, Haselbauer P, Fraulin A, Riemann D, Berger M: Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: Comparison between the acute state and after remission. Eur Arch Psychiatry Clin Neurosci 1997;247:228-233.
11. Ramamoorthy S, Ramamoorthy JD, Prasad PD, Bhat GK, Mahesh VB, Leibach FH, Ganapathy V: Regulation of the human serotonin transporter by interleukin-1 beta. Biochem Biophys Res Commun 1995;216:560-567.
12. Mossner R, Heils A, Stober G, Okladnova O, Daniel S, Lesch KP: Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6. Neurochem Int 1998;33:251-254.
13. Morikawa O, Sakai N, Obara H, Saito N: Effects of interferon-alpha, interferon-gamma and cAMP on the transcriptional regulation of the serotonin transporter. Eur J Pharmacol 1998;349:317-324.
14. Dunn AJ: Cytokine activation of the HPA axis. Ann NY Acad Sci 2000;917:608-617.
15. Myers RD: Serotonin and thermoregulation: Old and new views. J Physiol (Paris) 1981;77: 505-513.
16. von Zerssen D, Barthelmes H, Dirlich G, Doerr P, Emerich HM, von Lindern L, Lund R, Pirke KM: Circadian rhythms in endogenous depression. Psychiatry Res 1985;16:51-63.
17. Bicakova-Rocher A, Gorceix A, Reinberg A, Ashkenazi II, Ticher A: Temperature rhythm of patients with major affective disorders: Reduced circadian period length. Chronobiol Int 1996;13:47-57.
18. Barbini B, Benedetti F, Colombo C, Guglielmo E, Campori E, Smeraldi E: Perceived mood and skin body temperature rhythm in depression. Eur Arch Psychiatry Clin Neurosci 1998; 248:157-160.
19. Kramer BA, Katz JL: Circadian temperature variation and depressive illness. J Clin Psychiatry 1978;39:439-444.
20. Pflug B, Martin W: Analysis of circadian temperature rhythm in endogenous depressive illness. Arch Psychiatr Nervenkr 1980;229:127-143.
21. Dahl K, Avery DH, Lewy AJ, Savage MV, Brengelmann GL, Larsen LH, Vitiello MV, Prinz PN: Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression. Acta Psychiatr Scand 1993;88:60-66.
22. Avery DH, Wildschiodtz G, Rafaelsen OJ: Nocturnal temperature in affective disorder. J Affect Disord 1982;4:61-71.
23. Avery DH, Dahl K, Savage MV, Brengelmann GL, Larsen LH, Kenny MA, Eder DN, Vitiello MV, Prinz PN: Circadian temperature and cortisol rhythms during a constant routine are phase-delayed in hypersomnic winter depression. Biol Psychiatry 1997;41:1109-1123.
24. Gordijn MC, Beersma DG, Korte HJ, Van den Hoofdakker RH: Testing the hypothesis of a circadian phase disturbance underlying depressive mood in nonseasonal depression. J Biol Rhythms 1998;13:132-147.
25. Eastman CI, Gallo LC, Lahmeyer HW, Fogg LF: The circadian rhythm of temperature during light treatment for winter depression. Biol Psychiatry 1993;34:210-220.
26. Parry BL, Le Veau B, Mostofi N, Naham HC, Loving R, Clopton P, Gillin JC: Temperature circadian rhythms during the menstrual cycle and sleep deprivation in premenstrual dysphoric disorder and normal comparison subjects. J Biol Rhythms 1997;12:34-46.
27. Pflug B, Johnsson A, Ekse AT: Manic-depressive states and daily temperature. Some circadian studies. Acta Psychiatr Scand 1981;63: 277-289.
28. Szuba MP, Guze BH, Baxter LR Jr: Electroconvulsive therapy increases circadian amplitude and lowers core body temperature in depressed subjects. Biol Psychiatry 1997;42: 1130-1137.
29. Souetre E, Salvati E, Wehr TA, Sack DA, Krebs B, Darcourt G: Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects. Am J Psychiatry 1988;145:1133-1137.
30. Avery DH, Wildschiodtz G, Smallwood RG, Martin D, Rafaelsen OJ: REM latency and core temperature relationships in primary depression. Acta Psychiatr Scand 1986;74:269-280.
31. Monk TH, Buysse DJ, Frank E, Kupfer DJ, Dettling J, Ritenour AM: Nocturnal and circadian body temperatures of depressed outpatients during symptomatic and recovered states. Psychiatry Res 1994;51:297-311.
32. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin E, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
33. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES, Easton DF, Rubinsztein DC: Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 1998;81:58-63.
34. Poncz M, Solowiejezyk D, Harpel B, Mory Y, Schwantz E, Surrey S: Constitution of human gene libraries from small amounts of peripheral blood: Analysis of β-like globin genes. Hemoglobin 1982;6:27-36.
35. Lesch KP, Balling U, Gross J, Strauss K, Wolozin B, Murphy DL, Riederer P: Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994;95:157-162.
36. Nelson W, Tong YL, Lee JK, Halberg F: Methods for cosinor-rhythmometry. Chronobiologia 1979;6:305-323.
37. Gowers DS, Carpenter AV, Nash D, Ellis HM: Oral temperatures in a group of healthy industrial workers. J Occup Environ Med 1995;37: 1259-1260.
38. Carroll BJ, Feinberg M, Greden JF, Tarika J, Albala AA, Haskett RF, James NM, Kronfol Z, Lohr N, Steiner M, de Vigne JP, Young E: A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility. Arch Gen Psychiatry 1981;38:15-22.
39. Schittecatte M, Garcia-Valentin J, Charles G, Machowski R, Pena-Othaitz MJ, Mendlewicz J, Wilmotte J: Efficacy of the 'clonidine REM suppression test (CHREST)' to separate patients with major depression from controls; a comparison with three currently proposed biological markers of depression. J Affect Disord 1995;33:151-157.
40. Arana GW, Baldessarini RJ, Ornsteen M: The dexamethasone suppression test for diagnosis and prognosis in psychiatry. Commentary and review. Arch Gen Psychiatry 1985;42:1193-1204.
41. Harold I, Kaplan MD, Benjamin J, Sadock MD: Mood disorders; in Sadock B, Sadock V (eds): Comprehensive Textbook of Psychiatry, ed 6. Baltimore, Williams and Wilkins, 1995, p 1095.
42. Rush AJ, Giles DE, Schlesser MA, Orsulak PJ, Parker CR Jr, Weissenburger JE, Crowley GT, Khatami M, Vasavada N: The dexamethasone suppression test in patients with mood disorders. J Clin Psychiatry 1996;57:470-484.
43. Aggernaes H, Kirkegaard C, Krog-Meyer I, Kijne B, Larsen JK, Laursen AL, Lykke-Olesen L, Mikkelsen PL, Rasmussen S, Bjorum N: Dexamethasone suppression test and TRH test in endogenous depression. Acta Psychiatr Scand 1983;67:258-264.
44. Steiner M, Goldman SE, Gupta RN, Boiago IM, Pellettier JR: Specificity of the combined dexamethasone suppression and TRH/TSH tests in melancholia. Prog Neuropsychopharmacol Biol Psychiatry 1985;9:655-659.
45. Lieber AL, Newbury N: Use of biologic markers in a general hospital affective disorders program. J Clin Psychiatry 1985;46:217-221.
46. Evans DL, McCartney CF, Nemeroff CB, Raft D, Quade D, Golden RN, Haggerty JJ Jr, Holmes V, Simon JS, Droba M: Depression in women treated for gynecological cancer: Clinical and neuroendocrine assessment. Am J Psychiatry 1986;143:447-452.
47. Rush AJ, Giles DE, Schlesser MA, Orsulak PJ, Weissenberger JE, Fulton CL, Fairchild CJ, Roffwarg HP: Dexamethasone response, thyrotropin-releasing hormone stimulation, rapid eye movement latency, and subtypes of depression. Biol Psychiatry 1997,41:915-928.
48. Dratcu L, Calil HM: The dexamethasone suppression test: Its relationship to diagnoses, severity of depression and response to treatment. Prog Neuropsychopharmacol Biol Psychiatry 1989;13:99-117.
49. Lu RB, Ho SL, Huang HC, Lin YT: The specificity of the dexamethasone suppression test in endogenous depressive patients. Neuropsychopharmacology 1988;1:157-162.
50. Nelson WH, Khan A, Orr WW Jr, Tamragouri RN: The dexamethasone suppression test: Interaction of diagnosis, sex, and age in psychiatric inpatients. Biol Psychiatry 1984;19:1293-1304.
51. Maes M, Meltzer HY, Cosyns P, Suy E, Schotte C: An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: Results of a large-scaled and controlled study. Psy-choneuroendocrinology 1993;18:607-620.
52. Exstein I, Pottash AL, Gold MS: The thyrotro-pin-releasing hormone test in the diagnosis of unipolar depression. Psychiatry Res 1981;5: 311-316.
53. Ansseau M, Kupfer DJ, Reynolds CF 3rd: In-ternight variability of REM latency in major depression: Implications for the use of REM latency as a biological correlate. Biol Psychiatry 1985;20:489-505.
54. Giles DE, Roffwarg HP, Rush AJ, Guzick DS: Age-adjusted threshold values for reduced REM latency in unipolar depression using ROC analysis. Biol Psychiatry 1990;27:841-853.
55. Burton R: The Anatomy of Melancholy; in Shilleto AR (ed): Distemperature of Particular Parts, Causes. London, Bell and Sons, 1926, vol 1, p 434.
56. Pflug B, Erikson R, Johnsson A: Depression and daily temperature. A long-term study. Acta Psychiatr Scand 1976;54:254-266.
57. Lund R, Kammerloher A, Dirlich G: Body temperature in endogenously depressed patients during depression and remission; in Wehr TA, Goodwin FK (eds): Circadian Rhythms in Psychiatry. Pacific Grove, The Boxwood Press, 1983, vol 2, pp 77-88.
58. Fleisher MR, Cambell DB: Fenfluramine over-dosage. Lancet 1969;ii:1306-1307.
59. Preston E, Ma S, Haas N: Ambient temperature modulation of fenfluramine-induced thermogenesis in the rat. Neuropharmacology 1990;29:277-283.
60. Clement HW, Schafer F, Ruwe C, Gemsa D, Wesemann W: Stress-induced changes of extra-cellular 5-hydroxyindoleacetic acid concentrations followed in the nucleus raphe dorsalis and the frontal cortex of the rat. Brain Res 1993; 614:117-124.
61. Oka T, Oka K, Hori T: Mechanisms and mediators of psychological stress-induced rise in core temperature. Psychosom Med 2001;63: 476-486.
62. Marazziti D, DiMuro A, Castrogiovanni P: Psychological stress and body temperature changes in humans. Physiol Behav 1992;52: 393-395.
63. Kronfol Z, Remick DG: Cytokines and the brain: Implications for clinical psychiatry. Am J Psychiatry 2000;157:683-694.
64. Maes M: Evidence for an immune response in major depression: A review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 1995;19:11-38.
65. Leonard BE: The immune system, depression and the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 2001;25: 767-780.
66. Ramamoorthy S, Ramamoorthy JD, Prasad PD, Bhat GK, Mahesh VB, Leibach FH, Ganapathy V: Regulation of the human serotonin transporter by interleukin-1 beta. Biochem Biophys Res Commun 1995;216:560-567.