메뉴 건너뛰기




Volumn 4, Issue 8, 2009, Pages

Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; CARBOXYLYASE; CITALOPRAM; SEROTONIN; ANTIDEPRESSANT AGENT;

EID: 69849101826     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006797     Document Type: Article
Times cited : (28)

References (131)
  • 1
    • 69849083353 scopus 로고    scopus 로고
    • World Health Organization (2008) Mental Health Disorders: Depression. http://www.who.int/mental_health/management/depression/definition/en.
    • (2008) Mental Health Disorders: Depression
  • 2
    • 0035819481 scopus 로고    scopus 로고
    • Burden of Disease-Implications for Future Research
    • Michaud CM, Murray CJL, Bloom BR (2001) Burden of Disease-Implications for Future Research. JAMA 285: 535-539.
    • (2001) JAMA , vol.285 , pp. 535-539
    • Michaud, C.M.1    Murray, C.J.L.2    Bloom, B.R.3
  • 5
    • 58149377976 scopus 로고    scopus 로고
    • Antidepressants on trial: How valid is the evidence?
    • Parker G (2009) Antidepressants on trial: how valid is the evidence? Br J Psychiatry 194: 1-3.
    • (2009) Br J Psychiatry , vol.194 , pp. 1-3
    • Parker, G.1
  • 6
    • 31444441701 scopus 로고    scopus 로고
    • New approaches to antidepressant drug discovery: Beyond monoamines
    • Berton O, Nestler EJ (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7: 137-151.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 137-151
    • Berton, O.1    Nestler, E.J.2
  • 7
    • 14844298782 scopus 로고    scopus 로고
    • Is mood chemistry?
    • Castren E (2005) Is mood chemistry? Nat Rev Neurosci 6: 241-246.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 241-246
    • Castren, E.1
  • 8
    • 0037354040 scopus 로고    scopus 로고
    • Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex
    • Felton TM, Kang TB, Hjorth S, Auerbach SB (2003) Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn-Schmiedeberg's Archives of Pharmacology 367: 297-305.
    • (2003) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.367 , pp. 297-305
    • Felton, T.M.1    Kang, T.B.2    Hjorth, S.3    Auerbach, S.B.4
  • 9
    • 0033943655 scopus 로고    scopus 로고
    • Differential Effect of Local Infusion of Serotonin Reuptake Inhibitors in the Raphe versus Forebrain and the Role of Depolarization-Induced Release in Increased Extracellular Serotonin
    • Tao R, Ma Z, Auerbach SB (2000) Differential Effect of Local Infusion of Serotonin Reuptake Inhibitors in the Raphe versus Forebrain and the Role of Depolarization-Induced Release in Increased Extracellular Serotonin. J Pharmacol Exp Ther 294: 571-579.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 571-579
    • Tao, R.1    Ma, Z.2    Auerbach, S.B.3
  • 10
    • 0026654169 scopus 로고
    • Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex
    • Invernizzi R, Belli S, Samanin R (1992) Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res 584: 322-324.
    • (1992) Brain Res , vol.584 , pp. 322-324
    • Invernizzi, R.1    Belli, S.2    Samanin, R.3
  • 11
    • 0026569201 scopus 로고
    • Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum
    • Perry KW, Fuller RW (1992) Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum. Life Sci 50: 1683-1690.
    • (1992) Life Sci , vol.50 , pp. 1683-1690
    • Perry, K.W.1    Fuller, R.W.2
  • 12
    • 0027442597 scopus 로고
    • Acute uptake inhibition increases extracellular serotonin in the rat forebrain
    • Rutter JJ, Auerbach SB (1993) Acute uptake inhibition increases extracellular serotonin in the rat forebrain. J Pharmacol Exp Ther 265: 1319-1324.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 1319-1324
    • Rutter, J.J.1    Auerbach, S.B.2
  • 13
    • 0037971245 scopus 로고    scopus 로고
    • Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice
    • Gardier AM, David DJ, Jego G, Przybylski C, Jacquot C, et al. (2003) Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of Neurochemistry 86: 13-24.
    • (2003) Journal of Neurochemistry , vol.86 , pp. 13-24
    • Gardier, A.M.1    David, D.J.2    Jego, G.3    Przybylski, C.4    Jacquot, C.5
  • 14
    • 0035205403 scopus 로고    scopus 로고
    • Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635
    • Hervas I, Vilaro MT, Romero L, Scorza MC, Mengod G, et al. (2001) Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635. Neuropsychopharmacology 24: 11-20.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 11-20
    • Hervas, I.1    Vilaro, M.T.2    Romero, L.3    Scorza, M.C.4    Mengod, G.5
  • 15
    • 0028183684 scopus 로고
    • Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis
    • Hjorth S, Auerbach SB (1994) Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis. Neuropharmacology 33: 331-334.
    • (1994) Neuropharmacology , vol.33 , pp. 331-334
    • Hjorth, S.1    Auerbach, S.B.2
  • 16
    • 35848945707 scopus 로고    scopus 로고
    • Glucocorticoid receptor antagonists hasten and augment neurochemical responses to a selective serotonin reuptake inhibitor antidepressant
    • Johnson DA, Grant EJ, Ingram CD, Gartside SE (2007) Glucocorticoid receptor antagonists hasten and augment neurochemical responses to a selective serotonin reuptake inhibitor antidepressant. Biol Psychiatry 62: 1228-1235.
    • (2007) Biol Psychiatry , vol.62 , pp. 1228-1235
    • Johnson, D.A.1    Grant, E.J.2    Ingram, C.D.3    Gartside, S.E.4
  • 17
  • 18
    • 0034130350 scopus 로고    scopus 로고
    • Effects of chronic fluoxetine treatment in the presence and absence of (+/-)pindolol: A microdialysis study
    • Dawson LA, Nguyen HQ, Smith DI, Schechter LE (2000) Effects of chronic fluoxetine treatment in the presence and absence of (+/-)pindolol: a microdialysis study. Br J Pharmacol 130: 797-804.
    • (2000) Br J Pharmacol , vol.130 , pp. 797-804
    • Dawson, L.A.1    Nguyen, H.Q.2    Smith, D.I.3    Schechter, L.E.4
  • 19
    • 0029664774 scopus 로고    scopus 로고
    • The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram
    • Arborelius L, Nomikos GG, Hertel P, Salmi P, Grillner P, et al. (1996) The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. Naunyn Schmiedebergs Arch Pharmacol 353: 630-640.
    • (1996) Naunyn Schmiedebergs Arch Pharmacol , vol.353 , pp. 630-640
    • Arborelius, L.1    Nomikos, G.G.2    Hertel, P.3    Salmi, P.4    Grillner, P.5
  • 20
    • 0029010971 scopus 로고
    • Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat
    • Bosker FJ, Klompmakers AA, Westenberg HG (1995) Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 34: 501-508.
    • (1995) Neuropharmacology , vol.34 , pp. 501-508
    • Bosker, F.J.1    Klompmakers, A.A.2    Westenberg, H.G.3
  • 21
    • 58449090678 scopus 로고    scopus 로고
    • Do antidepressants really work? A clinicians' guide to evaluating the evidence
    • Thase ME (2008) Do antidepressants really work? A clinicians' guide to evaluating the evidence. Curr Psychiatry Rep 10: 487-494.
    • (2008) Curr Psychiatry Rep , vol.10 , pp. 487-494
    • Thase, M.E.1
  • 22
    • 39849093340 scopus 로고    scopus 로고
    • Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration. PLoS
    • Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, et al. (2008) Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration. PLoS Medicine 5: e45.
    • (2008) Medicine , vol.5
    • Kirsch, I.1    Deacon, B.J.2    Huedo-Medina, T.B.3    Scoboria, A.4    Moore, T.J.5
  • 23
    • 33644854626 scopus 로고    scopus 로고
    • Pindolol augmentation of antidepressant response
    • Artigas F, Adell A, Celada P (2006) Pindolol augmentation of antidepressant response. Curr Drug Targets 7: 139-147.
    • (2006) Curr Drug Targets , vol.7 , pp. 139-147
    • Artigas, F.1    Adell, A.2    Celada, P.3
  • 25
    • 67649379066 scopus 로고    scopus 로고
    • Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity
    • Taylor TN, Caudle WM, Shepherd KR, Noorian A, Jackson CR, et al. (2009) Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity. J Neurosci 29: 8103-8113.
    • (2009) J Neurosci , vol.29 , pp. 8103-8113
    • Taylor, T.N.1    Caudle, W.M.2    Shepherd, K.R.3    Noorian, A.4    Jackson, C.R.5
  • 27
    • 0028032353 scopus 로고
    • Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients
    • Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, et al. (1994) Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psychiatry 51: 865-874.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 865-874
    • Delgado, P.L.1    Price, L.H.2    Miller, H.L.3    Salomon, R.M.4    Aghajanian, G.K.5
  • 28
    • 0022454164 scopus 로고
    • Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain
    • Chaput Y, de Montigny C, Blier P (1986) Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn Schmiedebergs Arch Pharmacol 333: 342-348.
    • (1986) Naunyn Schmiedebergs Arch Pharmacol , vol.333 , pp. 342-348
    • Chaput, Y.1    de Montigny, C.2    Blier, P.3
  • 29
    • 0023935722 scopus 로고
    • Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: An electrophysiological study in the rat brain
    • Blier P, Chaput Y, Montigny C (1988) Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology 337: 246-254.
    • (1988) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.337 , pp. 246-254
    • Blier, P.1    Chaput, Y.2    Montigny, C.3
  • 30
    • 0034307584 scopus 로고    scopus 로고
    • Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size
    • Pothos EN, Larsen KE, Krantz DE, Liu Y, Haycock JW, et al. (2000) Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size. J Neurosci 20: 7297-7306.
    • (2000) J Neurosci , vol.20 , pp. 7297-7306
    • Pothos, E.N.1    Larsen, K.E.2    Krantz, D.E.3    Liu, Y.4    Haycock, J.W.5
  • 31
    • 0014665350 scopus 로고    scopus 로고
    • Azmitia EC Jr, McEwen BS (1969) Corticosterone Regulation of Tryptophan Hydroxylase in Midbrain of the Rat. Science 166: 1274-1276.
    • Azmitia EC Jr, McEwen BS (1969) Corticosterone Regulation of Tryptophan Hydroxylase in Midbrain of the Rat. Science 166: 1274-1276.
  • 32
    • 63449114543 scopus 로고    scopus 로고
    • Acoustic stimulation in vivo and corticotropin-releasing factor in vitro increase tryptophan hydroxylase activity in the rat caudal dorsal raphe nucleus
    • Evans AK, Heerkens JL, Lowry CA (2009) Acoustic stimulation in vivo and corticotropin-releasing factor in vitro increase tryptophan hydroxylase activity in the rat caudal dorsal raphe nucleus. Neurosci Lett 455: 36-41.
    • (2009) Neurosci Lett , vol.455 , pp. 36-41
    • Evans, A.K.1    Heerkens, J.L.2    Lowry, C.A.3
  • 33
    • 0035960875 scopus 로고    scopus 로고
    • Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress
    • Daugherty WP, Corley KC, Phan TH, Boadle-Biber MC (2001) Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress. Brain Res 923: 103-111.
    • (2001) Brain Res , vol.923 , pp. 103-111
    • Daugherty, W.P.1    Corley, K.C.2    Phan, T.H.3    Boadle-Biber, M.C.4
  • 34
    • 0015216394 scopus 로고
    • Brain serotonin content: Physiological dependence on plasma tryptophan levels
    • Fernstrom JD, Wurtman RJ (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173: 149-152.
    • (1971) Science , vol.173 , pp. 149-152
    • Fernstrom, J.D.1    Wurtman, R.J.2
  • 35
    • 0018104243 scopus 로고
    • Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain
    • Carlsson A, Lindqvist M (1978) Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain. Naunyn Schmiedebergs Arch Pharmacol 303: 157-164.
    • (1978) Naunyn Schmiedebergs Arch Pharmacol , vol.303 , pp. 157-164
    • Carlsson, A.1    Lindqvist, M.2
  • 36
    • 51249094300 scopus 로고    scopus 로고
    • Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats
    • Olivier JD, Jans LA, Korte-Bouws GA, Korte SM, Deen PM, et al. (2008) Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats. Psychopharmacology (Berl) 200: 243-254.
    • (2008) Psychopharmacology (Berl) , vol.200 , pp. 243-254
    • Olivier, J.D.1    Jans, L.A.2    Korte-Bouws, G.A.3    Korte, S.M.4    Deen, P.M.5
  • 38
    • 0009637974 scopus 로고    scopus 로고
    • Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion
    • Smith KA, Morris JS, Friston KJ, Cowen PJ, Dolan RJ (1999) Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion. Br J Psychiatry 174: 525-529.
    • (1999) Br J Psychiatry , vol.174 , pp. 525-529
    • Smith, K.A.1    Morris, J.S.2    Friston, K.J.3    Cowen, P.J.4    Dolan, R.J.5
  • 39
    • 0025318311 scopus 로고
    • Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan
    • Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, et al. (1990) Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47: 411-418.
    • (1990) Arch Gen Psychiatry , vol.47 , pp. 411-418
    • Delgado, P.L.1    Charney, D.S.2    Price, L.H.3    Aghajanian, G.K.4    Landis, H.5
  • 40
    • 0026005750 scopus 로고
    • Rapid serotonin depletion as a provocative challenge test for patients with major depression: Relevance to antidepressant action and the neurobiology of depression
    • Delgado PL, Price LH, Miller HL, Salomon RM, Licinio J, et al. (1991) Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacol Bull 27: 321-330.
    • (1991) Psychopharmacol Bull , vol.27 , pp. 321-330
    • Delgado, P.L.1    Price, L.H.2    Miller, H.L.3    Salomon, R.M.4    Licinio, J.5
  • 41
    • 0028103989 scopus 로고
    • Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders
    • Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN (1994) Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry 51: 687-697.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 687-697
    • Benkelfat, C.1    Ellenbogen, M.A.2    Dean, P.3    Palmour, R.M.4    Young, S.N.5
  • 42
    • 0030975670 scopus 로고    scopus 로고
    • The effect of tryptophan depletion on mood in medication-free, former patients with major affective disorder
    • Leyton M, Young SN, Blier P, Ellenbogen MA, Palmour RM, et al. (1997) The effect of tryptophan depletion on mood in medication-free, former patients with major affective disorder. Neuropsychopharmacology 16: 294-297.
    • (1997) Neuropsychopharmacology , vol.16 , pp. 294-297
    • Leyton, M.1    Young, S.N.2    Blier, P.3    Ellenbogen, M.A.4    Palmour, R.M.5
  • 43
    • 0033739006 scopus 로고    scopus 로고
    • Depressive relapse following acute tryptophan depletion in patients with major depressive disorder
    • Leyton M, Ghadirian AM, Young SN, Palmour RM, Blier P, et al. (2000) Depressive relapse following acute tryptophan depletion in patients with major depressive disorder. J Psychopharmacol 14: 284-287.
    • (2000) J Psychopharmacol , vol.14 , pp. 284-287
    • Leyton, M.1    Ghadirian, A.M.2    Young, S.N.3    Palmour, R.M.4    Blier, P.5
  • 44
    • 2642607850 scopus 로고    scopus 로고
    • Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors
    • Moore P, Gillin C, Bhatti T, DeModena A, Seifritz E, et al. (1998) Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors. Arch Gen Psychiatry 55: 534-539.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 534-539
    • Moore, P.1    Gillin, C.2    Bhatti, T.3    DeModena, A.4    Seifritz, E.5
  • 45
    • 0016731963 scopus 로고
    • Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients
    • Shopsin B, Gershon S, Goldstein M, Friedman E, Wilk S (1975) Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients. Psychopharmacol Commun 1: 239-249.
    • (1975) Psychopharmacol Commun , vol.1 , pp. 239-249
    • Shopsin, B.1    Gershon, S.2    Goldstein, M.3    Friedman, E.4    Wilk, S.5
  • 46
    • 0017885571 scopus 로고
    • L-tryptophan and 5-hydroxytryptophan in the treatment of depression. A review
    • d'Elia G, Hanson L, Raotma H (1978) L-tryptophan and 5-hydroxytryptophan in the treatment of depression. A review. Acta Psychiatr Scand 57: 239-252.
    • (1978) Acta Psychiatr Scand , vol.57 , pp. 239-252
    • d'Elia, G.1    Hanson, L.2    Raotma, H.3
  • 47
    • 0016862287 scopus 로고
    • Letter: Potentiation of antidepressant action of clomipramine by tryptophan
    • Wålinder J, Skott A, Nagy A, Carlsson A, Roos BE (1975) Letter: Potentiation of antidepressant action of clomipramine by tryptophan. Lancet 1: 984.
    • (1975) Lancet , vol.1 , pp. 984
    • Wålinder, J.1    Skott, A.2    Nagy, A.3    Carlsson, A.4    Roos, B.E.5
  • 49
    • 0025509077 scopus 로고
    • 5-HT uptake inhibitors and tricyclic antidepressants: Relation between trytophan availability and clinical response in depressed patients
    • Møller SE (1990) 5-HT uptake inhibitors and tricyclic antidepressants: relation between trytophan availability and clinical response in depressed patients. European Neuropsychopharmacology 1: 41-44.
    • (1990) European Neuropsychopharmacology , vol.1 , pp. 41-44
    • Møller, S.E.1
  • 51
    • 0018128208 scopus 로고
    • Effects of antidepressant agents on the synthesis of brain monoamines
    • Carlsson A, Lindqvist M (1978) Effects of antidepressant agents on the synthesis of brain monoamines. Journal of Neural Transmission 43: 73-91.
    • (1978) Journal of Neural Transmission , vol.43 , pp. 73-91
    • Carlsson, A.1    Lindqvist, M.2
  • 52
    • 0029851995 scopus 로고    scopus 로고
    • Influence of fluoxetine on regional serotonin synthesis in the rat brain
    • Muck-Seler D, Jevric-Causevic A, Diksic M (1996) Influence of fluoxetine on regional serotonin synthesis in the rat brain. J Neurochem 67: 2434-2442.
    • (1996) J Neurochem , vol.67 , pp. 2434-2442
    • Muck-Seler, D.1    Jevric-Causevic, A.2    Diksic, M.3
  • 53
    • 0030907810 scopus 로고    scopus 로고
    • Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis
    • Moret C, Briley M (1997) Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis. Journal of Neural Transmission 104: 147-160.
    • (1997) Journal of Neural Transmission , vol.104 , pp. 147-160
    • Moret, C.1    Briley, M.2
  • 54
    • 0035091860 scopus 로고    scopus 로고
    • Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram
    • Stenfors C, Yu H, Ross SB (2001) Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn Schmiedebergs Arch Pharmacol 363: 222-232.
    • (2001) Naunyn Schmiedebergs Arch Pharmacol , vol.363 , pp. 222-232
    • Stenfors, C.1    Yu, H.2    Ross, S.B.3
  • 55
    • 0035578219 scopus 로고    scopus 로고
    • Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: An autoradiographic study with alpha-[14C]methyl-L-tryptophan(2)
    • Yamane F, Okazawa H, Blier P, Diksic M (2001) Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochem Pharmacol 62: 1481-1489.
    • (2001) Biochem Pharmacol , vol.62 , pp. 1481-1489
    • Yamane, F.1    Okazawa, H.2    Blier, P.3    Diksic, M.4
  • 56
    • 24744463656 scopus 로고    scopus 로고
    • Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
    • Cervo L, Canetta A, Calcagno E, Burbassi S, Sacchetti G, et al. (2005) Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. J Neurosci 25: 8165-8172.
    • (2005) J Neurosci , vol.25 , pp. 8165-8172
    • Cervo, L.1    Canetta, A.2    Calcagno, E.3    Burbassi, S.4    Sacchetti, G.5
  • 57
    • 0032908563 scopus 로고    scopus 로고
    • Barton CL HP (1999) Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: Evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse 31: 13-19.
    • Barton CL HP (1999) Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: Evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse 31: 13-19.
  • 58
    • 0025615031 scopus 로고
    • Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers
    • de Montigny C, Chaput Y, Blier P (1990) Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. J Clin Psychiatry 51 Suppl B: pp 4-8.
    • (1990) J Clin Psychiatry , vol.51 , Issue.SUPPL. B , pp. 4-8
    • de Montigny, C.1    Chaput, Y.2    Blier, P.3
  • 59
    • 0026659714 scopus 로고
    • Effect of antidepressant drugs on monoamine synthesis in brain in vivo
    • Moret C, Briley M (1992) Effect of antidepressant drugs on monoamine synthesis in brain in vivo. Neuropharmacology 31: 679-684.
    • (1992) Neuropharmacology , vol.31 , pp. 679-684
    • Moret, C.1    Briley, M.2
  • 60
    • 0036837312 scopus 로고    scopus 로고
    • Evidence for involvement of 5-hydroxytryptamine(1B) autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine
    • Stenfors C, Ross SB (2002) Evidence for involvement of 5-hydroxytryptamine(1B) autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine. Life Sci 71: 2867-2880.
    • (2002) Life Sci , vol.71 , pp. 2867-2880
    • Stenfors, C.1    Ross, S.B.2
  • 61
    • 0032874856 scopus 로고    scopus 로고
    • Activation and desensitization by cyclic antidepressant drugs of a2-autoreceptors, a2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo
    • Esteban S, Lladó J, Sastre-Coll A, García-Sevilla JA (1999) Activation and desensitization by cyclic antidepressant drugs of a2-autoreceptors, a2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology 360: 135-143.
    • (1999) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.360 , pp. 135-143
    • Esteban, S.1    Lladó, J.2    Sastre-Coll, A.3    García-Sevilla, J.A.4
  • 62
    • 61449173676 scopus 로고    scopus 로고
    • Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats
    • Kanemaru K, Nishi K, Hasegawa S, Diksic M (2009) Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats. Neurochemistry International 54: 363-371.
    • (2009) Neurochemistry International , vol.54 , pp. 363-371
    • Kanemaru, K.1    Nishi, K.2    Hasegawa, S.3    Diksic, M.4
  • 63
    • 0034716977 scopus 로고    scopus 로고
    • Augmentation with a 5-HT1A, but not a 5-HT1B receptor antagonist critically depends on the dose of citalopram
    • Cremers TIFH, de Boer P, Liao Y, Bosker FJ, den Boer JA, et al. (2000) Augmentation with a 5-HT1A, but not a 5-HT1B receptor antagonist critically depends on the dose of citalopram. European Journal of Pharmacology 397: 63-74.
    • (2000) European Journal of Pharmacology , vol.397 , pp. 63-74
    • Cremers, T.I.F.H.1    de Boer, P.2    Liao, Y.3    Bosker, F.J.4    den Boer, J.A.5
  • 64
    • 0027464747 scopus 로고
    • Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat
    • Trouvin JH, Gardier AM, Chanut E, Pages N, Jacquot C (1993) Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat. Life Sciences 52: PL187-PL192.
    • (1993) Life Sciences , vol.52
    • Trouvin, J.H.1    Gardier, A.M.2    Chanut, E.3    Pages, N.4    Jacquot, C.5
  • 65
    • 0034235212 scopus 로고    scopus 로고
    • Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation
    • Anthony JP, Sexton TJ, Neumaier JF (2000) Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation. J Neurosci Res 61: 82-87.
    • (2000) J Neurosci Res , vol.61 , pp. 82-87
    • Anthony, J.P.1    Sexton, T.J.2    Neumaier, J.F.3
  • 66
    • 0033622128 scopus 로고    scopus 로고
    • The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: Studies with dual administration of [11C] and [14C] labeled tracer
    • Shoaf SE, Carson RE, Hommer D, Williams WA, Higley JD, et al. (2000) The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: studies with dual administration of [11C] and [14C] labeled tracer. J Cereb Blood Flow Metab 20: 244-252.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 244-252
    • Shoaf, S.E.1    Carson, R.E.2    Hommer, D.3    Williams, W.A.4    Higley, J.D.5
  • 67
    • 17444438320 scopus 로고    scopus 로고
    • Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations
    • Shoaf SE, Carson R, Hommer D, Williams W, Higley JD, et al. (1998) Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations. Neuropsychopharmacology 19: 345-353.
    • (1998) Neuropsychopharmacology , vol.19 , pp. 345-353
    • Shoaf, S.E.1    Carson, R.2    Hommer, D.3    Williams, W.4    Higley, J.D.5
  • 68
    • 0033053136 scopus 로고    scopus 로고
    • The validity of the PET/alpha-[11C]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain
    • Benkelfat C, Young SN, Okazawa H, Leyton M, Diksic M (1999) The validity of the PET/alpha-[11C]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain. Neuropsychopharmacology 21: 153-157.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 153-157
    • Benkelfat, C.1    Young, S.N.2    Okazawa, H.3    Leyton, M.4    Diksic, M.5
  • 69
    • 0027313688 scopus 로고
    • The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain
    • Caccia S, Anelli M, Codegoni AM, Fracasso C, Garattini S (1993) The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain. Br J Pharmacol 110: 355-359.
    • (1993) Br J Pharmacol , vol.110 , pp. 355-359
    • Caccia, S.1    Anelli, M.2    Codegoni, A.M.3    Fracasso, C.4    Garattini, S.5
  • 70
    • 0026534129 scopus 로고
    • Anorectic activity of fluoxetine and norfluoxetine in rats: Relationship between brain concentrations and in-vitro potencies on monoaminergic mechanisms
    • Caccia S, Bizzi A, Coltro G, Fracasso C, Frittoli E, et al. (1992) Anorectic activity of fluoxetine and norfluoxetine in rats: relationship between brain concentrations and in-vitro potencies on monoaminergic mechanisms. J Pharm Pharmacol 44: 250-254.
    • (1992) J Pharm Pharmacol , vol.44 , pp. 250-254
    • Caccia, S.1    Bizzi, A.2    Coltro, G.3    Fracasso, C.4    Frittoli, E.5
  • 71
  • 73
    • 34648820003 scopus 로고    scopus 로고
    • Brain metabolic changes following 4-week citalopram infusion: Increased 18FDG uptake and gamma-amino butyric acid levels
    • Marsteller DA, Barbarich-Marsteller NC, Patel VD, Dewey SL (2007) Brain metabolic changes following 4-week citalopram infusion: increased 18FDG uptake and gamma-amino butyric acid levels. Synapse 61: 877-881.
    • (2007) Synapse , vol.61 , pp. 877-881
    • Marsteller, D.A.1    Barbarich-Marsteller, N.C.2    Patel, V.D.3    Dewey, S.L.4
  • 74
    • 69849112701 scopus 로고
    • Effect of long-term administration of fluoxetine on brain serotonin metabolism in rat
    • Trouvin JH, Chanut E, Jacquot C, Gardier AM (1992) Effect of long-term administration of fluoxetine on brain serotonin metabolism in rat. Appetite 19: 222-222.
    • (1992) Appetite , vol.19 , pp. 222-222
    • Trouvin, J.H.1    Chanut, E.2    Jacquot, C.3    Gardier, A.M.4
  • 75
    • 0029906449 scopus 로고    scopus 로고
    • Inhibition of rat brain monoamine oxidase enzymes by fluoxetine and norfluoxetine
    • Holt A, Baker GB (1996) Inhibition of rat brain monoamine oxidase enzymes by fluoxetine and norfluoxetine. Naunyn Schmiedebergs Arch Pharmacol 354: 17-24.
    • (1996) Naunyn Schmiedebergs Arch Pharmacol , vol.354 , pp. 17-24
    • Holt, A.1    Baker, G.B.2
  • 76
    • 0028702477 scopus 로고
    • Chronic administration of citalopram inhibited El mouse convulsions and decreased monoamine oxidase-A activity
    • Kabuto H, Yokoi I, Endo A, Takei M, Kurimoto T, et al. (1994) Chronic administration of citalopram inhibited El mouse convulsions and decreased monoamine oxidase-A activity. Acta Med Okayama 48: 311-316.
    • (1994) Acta Med Okayama , vol.48 , pp. 311-316
    • Kabuto, H.1    Yokoi, I.2    Endo, A.3    Takei, M.4    Kurimoto, T.5
  • 77
    • 0028030863 scopus 로고
    • The anticonvulsant effect of citalopram on El mice, and the levels of tryptophan and tyrosine and their metabolites in the brain
    • Kabuto H, Yokoi I, Takei M, Kurimoto T, Mori A (1994) The anticonvulsant effect of citalopram on El mice, and the levels of tryptophan and tyrosine and their metabolites in the brain. Neurochem Res 19: 463-467.
    • (1994) Neurochem Res , vol.19 , pp. 463-467
    • Kabuto, H.1    Yokoi, I.2    Takei, M.3    Kurimoto, T.4    Mori, A.5
  • 78
    • 33744504184 scopus 로고    scopus 로고
    • Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake
    • Pinna G, Costa E, Guidotti A (2006) Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology 186: 362-372.
    • (2006) Psychopharmacology , vol.186 , pp. 362-372
    • Pinna, G.1    Costa, E.2    Guidotti, A.3
  • 79
    • 33748111816 scopus 로고    scopus 로고
    • Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype
    • Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thummler S, et al. (2006) Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nat Neurosci 9: 1134-1141.
    • (2006) Nat Neurosci , vol.9 , pp. 1134-1141
    • Heurteaux, C.1    Lucas, G.2    Guy, N.3    El Yacoubi, M.4    Thummler, S.5
  • 80
    • 34247872922 scopus 로고    scopus 로고
    • Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test
    • O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, et al. (2007) Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berl) 192: 357-371.
    • (2007) Psychopharmacology (Berl) , vol.192 , pp. 357-371
    • O'Leary, O.F.1    Bechtholt, A.J.2    Crowley, J.J.3    Hill, T.E.4    Page, M.E.5
  • 81
    • 0034889181 scopus 로고    scopus 로고
    • Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram
    • Brøsen K, Naranjo CA (2001) Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. European Neuropsychopharmacology 11: 275-283.
    • (2001) European Neuropsychopharmacology , vol.11 , pp. 275-283
    • Brøsen, K.1    Naranjo, C.A.2
  • 82
    • 0034075099 scopus 로고    scopus 로고
    • Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?
    • Rasmussen BB, Brosen K (2000) Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monit 22: 143-154.
    • (2000) Ther Drug Monit , vol.22 , pp. 143-154
    • Rasmussen, B.B.1    Brosen, K.2
  • 85
    • 0019989539 scopus 로고
    • Citalopram, a selective serotonin reuptake inhibitor: Clinical antidepressive and long-term effect-a phase II study
    • Pedersen OL, Kragh-Sorensen P, Bjerre M, Overo KF, Gram LF (1982) Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect-a phase II study. Psychopharmacology (Berl) 77: 199-204.
    • (1982) Psychopharmacology (Berl) , vol.77 , pp. 199-204
    • Pedersen, O.L.1    Kragh-Sorensen, P.2    Bjerre, M.3    Overo, K.F.4    Gram, L.F.5
  • 86
    • 0023376225 scopus 로고
    • Citalopram-a highly selective 5-HT uptake inhibitor-in the treatment of depressed patients
    • Dufour H, Bouchacourt M, Thermoz P, Viala A, Phak Rop P, et al. (1987) Citalopram-a highly selective 5-HT uptake inhibitor-in the treatment of depressed patients. Int Clin Psychopharmacol 2: 225-237.
    • (1987) Int Clin Psychopharmacol , vol.2 , pp. 225-237
    • Dufour, H.1    Bouchacourt, M.2    Thermoz, P.3    Viala, A.4    Phak Rop, P.5
  • 87
    • 0015793337 scopus 로고
    • In-vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain
    • Carlsson A, Lindqvist M (1973) In-vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain. J Neural Transm 34: 79-91.
    • (1973) J Neural Transm , vol.34 , pp. 79-91
    • Carlsson, A.1    Lindqvist, M.2
  • 88
    • 0015486970 scopus 로고
    • The influence of nerve-impulse flow on the synthesis and metabolism of 5-hydroxytryptamine in the central nervous system
    • Carlsson A, Bedard P, Lindqvist M, Magnusson T (1972) The influence of nerve-impulse flow on the synthesis and metabolism of 5-hydroxytryptamine in the central nervous system. Biochem Soc Symp. pp 17-32.
    • (1972) Biochem Soc Symp , pp. 17-32
    • Carlsson, A.1    Bedard, P.2    Lindqvist, M.3    Magnusson, T.4
  • 89
    • 0015449343 scopus 로고
    • The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo
    • Carlsson A, Lindqvist M (1972) The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo. J Neural Transm 33: 23-43.
    • (1972) J Neural Transm , vol.33 , pp. 23-43
    • Carlsson, A.1    Lindqvist, M.2
  • 90
    • 0014843495 scopus 로고
    • Accumulation of 5-hydroxytryptophan in mouse brain after decarboxylase inhibition
    • Carlsson A, Lindqvist M (1970) Accumulation of 5-hydroxytryptophan in mouse brain after decarboxylase inhibition. J Pharm Pharmacol 22: 726-727.
    • (1970) J Pharm Pharmacol , vol.22 , pp. 726-727
    • Carlsson, A.1    Lindqvist, M.2
  • 91
    • 0015266959 scopus 로고
    • Appraisal of current methods to estimate the turnover rate of serotonin and catecholamines in human brain
    • Costa E (1972) Appraisal of current methods to estimate the turnover rate of serotonin and catecholamines in human brain. Adv Biochem Psychopharmacol 4: 171-183.
    • (1972) Adv Biochem Psychopharmacol , vol.4 , pp. 171-183
    • Costa, E.1
  • 93
    • 0028998849 scopus 로고
    • The acute effects of reserpine and NSD-1015 on the brain serotonin synthesis rate measured by an autoradiographic method
    • Muck-Seler D, Diksic M (1995) The acute effects of reserpine and NSD-1015 on the brain serotonin synthesis rate measured by an autoradiographic method. Neuropsychopharmacology 12: 251-262.
    • (1995) Neuropsychopharmacology , vol.12 , pp. 251-262
    • Muck-Seler, D.1    Diksic, M.2
  • 94
    • 34548009344 scopus 로고    scopus 로고
    • Long-term administration of citalopram reduces basal and stress-induced extracellular noradrenaline levels in rat brain
    • Kawahara Y, Kawahara H, Kaneko F, Tanaka M (2007) Long-term administration of citalopram reduces basal and stress-induced extracellular noradrenaline levels in rat brain. Psychopharmacology 194: 73-81.
    • (2007) Psychopharmacology , vol.194 , pp. 73-81
    • Kawahara, Y.1    Kawahara, H.2    Kaneko, F.3    Tanaka, M.4
  • 96
    • 0017120186 scopus 로고
    • The role of intraneuronal amine levels in the feedback control of dopamine, noradrenaline and 5-hydroxytryptamine synthesis in rat brain
    • Carlsson A, Kehr W, Lindqvist M (1976) The role of intraneuronal amine levels in the feedback control of dopamine, noradrenaline and 5-hydroxytryptamine synthesis in rat brain. Journal of Neural Transmission 39: 1-19.
    • (1976) Journal of Neural Transmission , vol.39 , pp. 1-19
    • Carlsson, A.1    Kehr, W.2    Lindqvist, M.3
  • 97
    • 0026557512 scopus 로고
    • The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: Relationship to receptor reserve
    • Bohmaker K, Bordi F, Meller E (1992) The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. Neuropharmacology 31: 451-459.
    • (1992) Neuropharmacology , vol.31 , pp. 451-459
    • Bohmaker, K.1    Bordi, F.2    Meller, E.3
  • 98
    • 0026100906 scopus 로고
    • Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat
    • Badawy AA, Morgan CJ (1991) Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat. Br J Pharmacol 102: 429-433.
    • (1991) Br J Pharmacol , vol.102 , pp. 429-433
    • Badawy, A.A.1    Morgan, C.J.2
  • 99
    • 0019995480 scopus 로고
    • Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by acute administration of small doses of antidepressants
    • Badawy AA, Evans M (1982) Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by acute administration of small doses of antidepressants. Br J Pharmacol 77: 59-67.
    • (1982) Br J Pharmacol , vol.77 , pp. 59-67
    • Badawy, A.A.1    Evans, M.2
  • 100
    • 0019423704 scopus 로고
    • Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of antidepressants
    • Badawy AA, Evans M (1981) Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of antidepressants. Biochem Pharmacol 30: 1211-1216.
    • (1981) Biochem Pharmacol , vol.30 , pp. 1211-1216
    • Badawy, A.A.1    Evans, M.2
  • 102
    • 34249080888 scopus 로고    scopus 로고
    • Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system
    • Homberg JR, Olivier JD, Smits BM, Mul JD, Mudde J, et al. (2007) Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience 146: 1662-1676.
    • (2007) Neuroscience , vol.146 , pp. 1662-1676
    • Homberg, J.R.1    Olivier, J.D.2    Smits, B.M.3    Mul, J.D.4    Mudde, J.5
  • 103
    • 26944447116 scopus 로고    scopus 로고
    • Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter
    • Kim D-K, Tolliver TJ, Huang S-J, Martin BJ, Andrews AM, et al. (2005) Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 49: 798-810.
    • (2005) Neuropharmacology , vol.49 , pp. 798-810
    • Kim, D.-K.1    Tolliver, T.J.2    Huang, S.-J.3    Martin, B.J.4    Andrews, A.M.5
  • 104
    • 0031978809 scopus 로고    scopus 로고
    • Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine ("Ecstasy") in Serotonin Transporter-Deficient Mice
    • Bengel D, Murphy DL, Andrews AM, Wichems CH, Feltner D, et al. (1998) Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine ("Ecstasy") in Serotonin Transporter-Deficient Mice. Mol Pharmacol 53: 649-655.
    • (1998) Mol Pharmacol , vol.53 , pp. 649-655
    • Bengel, D.1    Murphy, D.L.2    Andrews, A.M.3    Wichems, C.H.4    Feltner, D.5
  • 105
    • 0242456044 scopus 로고    scopus 로고
    • Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
    • Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, et al. (2003) Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry 54: 960-971.
    • (2003) Biol Psychiatry , vol.54 , pp. 960-971
    • Lira, A.1    Zhou, M.2    Castanon, N.3    Ansorge, M.S.4    Gordon, J.A.5
  • 106
    • 40949084721 scopus 로고    scopus 로고
    • A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders
    • Olivier JD, Van Der Hart MG, Van Swelm RP, Dederen PJ, Homberg JR, et al. (2008) A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience 152: 573-584.
    • (2008) Neuroscience , vol.152 , pp. 573-584
    • Olivier, J.D.1    Van Der Hart, M.G.2    Van Swelm, R.P.3    Dederen, P.J.4    Homberg, J.R.5
  • 107
    • 7444232259 scopus 로고    scopus 로고
    • Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    • Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA (2004) Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306: 879-881.
    • (2004) Science , vol.306 , pp. 879-881
    • Ansorge, M.S.1    Zhou, M.2    Lira, A.3    Hen, R.4    Gingrich, J.A.5
  • 108
    • 33644535782 scopus 로고    scopus 로고
    • Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment
    • Maciag D, Williams L, Coppinger D, Paul IA (2006) Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment. Eur J Pharmacol 532: 265-269.
    • (2006) Eur J Pharmacol , vol.532 , pp. 265-269
    • Maciag, D.1    Williams, L.2    Coppinger, D.3    Paul, I.A.4
  • 109
    • 0018140078 scopus 로고
    • Activation of tryptophan hydroxylase from central serotonergic neurons by calcium and depolarization
    • Boadle-Biber MC (1978) Activation of tryptophan hydroxylase from central serotonergic neurons by calcium and depolarization. Biochem Pharmacol 27: 1069-1079.
    • (1978) Biochem Pharmacol , vol.27 , pp. 1069-1079
    • Boadle-Biber, M.C.1
  • 110
    • 0031722347 scopus 로고    scopus 로고
    • Advances in the molecular characterization of tryptophan hydroxylase
    • Mockus SM, Vrana KE (1998) Advances in the molecular characterization of tryptophan hydroxylase. J Mol Neurosci 10: 163-179.
    • (1998) J Mol Neurosci , vol.10 , pp. 163-179
    • Mockus, S.M.1    Vrana, K.E.2
  • 111
    • 0026536243 scopus 로고
    • Effects of short-and long-term administration of fluoxetine on the monoamine content of rat brain
    • Caccia S, Fracasso C, Garattini S, Guiso G, Sarati S (1992) Effects of short-and long-term administration of fluoxetine on the monoamine content of rat brain. Neuropharmacology 31: 343-347.
    • (1992) Neuropharmacology , vol.31 , pp. 343-347
    • Caccia, S.1    Fracasso, C.2    Garattini, S.3    Guiso, G.4    Sarati, S.5
  • 112
    • 34548178798 scopus 로고    scopus 로고
    • Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle
    • Kam K, Nicoll R (2007) Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle. J Neurosci 27: 9192-9200.
    • (2007) J Neurosci , vol.27 , pp. 9192-9200
    • Kam, K.1    Nicoll, R.2
  • 113
    • 10344221595 scopus 로고    scopus 로고
    • Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression
    • Mathews TA, Fedele DE, Coppelli FM, Avila AM, Murphy DL, et al. (2004) Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of Neuroscience Methods 140: 169-181.
    • (2004) Journal of Neuroscience Methods , vol.140 , pp. 169-181
    • Mathews, T.A.1    Fedele, D.E.2    Coppelli, F.M.3    Avila, A.M.4    Murphy, D.L.5
  • 114
    • 60749121149 scopus 로고    scopus 로고
    • Cremers TI, de Vries MG, Huinink KD, Loon JP, Hart MV, et al. (2008) Quantitative microdialysis using modified ultraslow microdialysis: Direct rapid and reliable determination of free brain concentrations with the MetaQuant technique. J Neurosci Methods.
    • Cremers TI, de Vries MG, Huinink KD, Loon JP, Hart MV, et al. (2008) Quantitative microdialysis using modified ultraslow microdialysis: Direct rapid and reliable determination of free brain concentrations with the MetaQuant technique. J Neurosci Methods.
  • 115
    • 0026515597 scopus 로고
    • Structure and function of the brain serotonin system
    • Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72: 165-229.
    • (1992) Physiol Rev , vol.72 , pp. 165-229
    • Jacobs, B.L.1    Azmitia, E.C.2
  • 116
    • 0017870968 scopus 로고
    • Potent and long-lasting potentiation of two 5-hydroxytryptophan-induced effects in mice by three selective 5-HT uptake inhibitors
    • Buus Lassen J (1978) Potent and long-lasting potentiation of two 5-hydroxytryptophan-induced effects in mice by three selective 5-HT uptake inhibitors. European Journal of Pharmacology 47: 351-358.
    • (1978) European Journal of Pharmacology , vol.47 , pp. 351-358
    • Buus Lassen, J.1
  • 117
    • 56349119282 scopus 로고    scopus 로고
    • Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice
    • Fox M, Jensen C, French H, Stein A, Huang S-J, et al. (2008) Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. Psychopharmacology 201: 203-218.
    • (2008) Psychopharmacology , vol.201 , pp. 203-218
    • Fox, M.1    Jensen, C.2    French, H.3    Stein, A.4    Huang, S.-J.5
  • 118
    • 0030038570 scopus 로고    scopus 로고
    • Reduction of Serotonergic Function in Rat Brain by Tryptophan Depletion: Effects in Control and Fluvoxamine-Treated Rats
    • Núria B (1996) Reduction of Serotonergic Function in Rat Brain by Tryptophan Depletion: Effects in Control and Fluvoxamine-Treated Rats. Journal of Neurochemistry 67: 669-676.
    • (1996) Journal of Neurochemistry , vol.67 , pp. 669-676
    • Núria, B.1
  • 119
    • 34249306939 scopus 로고    scopus 로고
    • Serotonergic vulnerability and depression: Assumptions, experimental evidence and implications
    • Jans LA, Riedel WJ, Markus CR, Blokland A (2007) Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry 12: 522-543.
    • (2007) Mol Psychiatry , vol.12 , pp. 522-543
    • Jans, L.A.1    Riedel, W.J.2    Markus, C.R.3    Blokland, A.4
  • 120
    • 2142651647 scopus 로고    scopus 로고
    • Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders
    • Agazzi A, De Ponti F, De Giorgio R, Candura SM, Anselmi L, et al. (2003) Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders. Dig Liver Dis 35: 590-595.
    • (2003) Dig Liver Dis , vol.35 , pp. 590-595
    • Agazzi, A.1    De Ponti, F.2    De Giorgio, R.3    Candura, S.M.4    Anselmi, L.5
  • 121
    • 39649095363 scopus 로고    scopus 로고
    • Nutritional therapies for mental disorders
    • Lakhan SE, Vieira KF (2008) Nutritional therapies for mental disorders. Nutr J 7: 2.
    • (2008) Nutr J , vol.7 , pp. 2
    • Lakhan, S.E.1    Vieira, K.F.2
  • 123
    • 69849114642 scopus 로고    scopus 로고
    • Osipova DV, Kulikov AV, Popova NK (2008) C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test. J Neurosci Res.
    • Osipova DV, Kulikov AV, Popova NK (2008) C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test. J Neurosci Res.
  • 124
    • 38049004434 scopus 로고    scopus 로고
    • The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains
    • Tenner K, Qadri F, Bert B, Voigt JP, Bader M (2008) The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neurosci Lett 431: 21-25.
    • (2008) Neurosci Lett , vol.431 , pp. 21-25
    • Tenner, K.1    Qadri, F.2    Bert, B.3    Voigt, J.P.4    Bader, M.5
  • 125
    • 35248874282 scopus 로고    scopus 로고
    • Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: Relation with tryptophan hydroxylase-2 activity
    • Calcagno E, Canetta A, Guzzetti S, Cervo L, Invernizzi RW (2007) Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem 103: 1111-1120.
    • (2007) J Neurochem , vol.103 , pp. 1111-1120
    • Calcagno, E.1    Canetta, A.2    Guzzetti, S.3    Cervo, L.4    Invernizzi, R.W.5
  • 126
    • 11344282078 scopus 로고    scopus 로고
    • Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression
    • Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, et al. (2005) Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16.
    • (2005) Neuron , vol.45 , pp. 11-16
    • Zhang, X.1    Gainetdinov, R.R.2    Beaulieu, J.M.3    Sotnikova, T.D.4    Burch, L.H.5
  • 127
    • 28744445782 scopus 로고    scopus 로고
    • Overview: A rare opportunity or just one less reason to be depressed
    • author reply 705-706
    • Blakely RD (2005) Overview: a rare opportunity or just one less reason to be depressed. Neuron 48: 701-702. author reply 705-706.
    • (2005) Neuron , vol.48 , pp. 701-702
    • Blakely, R.D.1
  • 128
    • 69849109054 scopus 로고    scopus 로고
    • Zhou Z, Peters EJ, Hamilton SP, McMahon F, Thomas C, et al. (2005) Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16. Neuron 48: 702-703; author reply 705-706.
    • Zhou Z, Peters EJ, Hamilton SP, McMahon F, Thomas C, et al. (2005) Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16. Neuron 48: 702-703; author reply 705-706.
  • 129
    • 33644811359 scopus 로고    scopus 로고
    • Glatt CE, Carlson E, Taylor TR, Risch N, Reus VI, et al. (2005) Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16. Neuron 48: 704-705; author reply 705-706.
    • Glatt CE, Carlson E, Taylor TR, Risch N, Reus VI, et al. (2005) Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16. Neuron 48: 704-705; author reply 705-706.
  • 130
    • 33644811359 scopus 로고    scopus 로고
    • Van Den Bogaert A, De Zutter S, Heyrman L, Mendlewicz J, Adolfsson R, et al. (2005) Response to Zhang et al (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major Depression. Neuron 45: 11-16. Neuron 48: 704; author reply 705-706.
    • Van Den Bogaert A, De Zutter S, Heyrman L, Mendlewicz J, Adolfsson R, et al. (2005) Response to Zhang et al (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major Depression. Neuron 45: 11-16. Neuron 48: 704; author reply 705-706.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.