Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: An autoradiographic study

Neurochemical Research

Volumn 24, Issue 12, 1999, Pages 1611-1620

  Yamane, Fumitaka ^a,b   Tohyama, Yoshihiro ^a,c   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Autoradiography; D fenfluramine; Dorsal raphe; Serotonin synthesis rate; Tryptophan hydroxylase; 14C methyl L tryptophan

Indexed keywords

DEXFENFLURAMINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN STEM; CAUDATE NUCLEUS; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; THALAMUS NUCLEUS;

ANIMALIA;

EID: 0032743566     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021120603457     Document Type: Article

References (37)

1. Goldstein, D., and Potvin, J. 1994. Long-term weight loss; the effect of pharmacological agents. Am. J. Clin. Nutr. 60:647-657.
2. Samanin, R., and Garattini, S. 1990. The pharmacology of serotonergic drugs affecting appetite. Pages 163-192, in Wurtman R. J., and Wurtman J. J., (ed.), Nutrition and the Brain, Vol. 8 Raven Press, New York.
3. Molliver, D., and Molliver, M. 1990. Anatomic evidence for a neurotoxic effect of D-fenfluramine upon serotonergic projections in the rat. Brain Res. 511:165-168.
4. Davis, R., and Faulds, D. 1996. Dexfenfluramine. An update review of its therapeutic use in the management of obesity. Drug 52:696-724.
5. Garanttini, S., Mennini, T., Bendotti, C., Invernizzi, R., and Samanin, R. 1986. Neurochemical mechanism of action of drugs which modify feeding via the serotonergic system. Appetite. 7 (Suppl.):15-18.
6. Mennini, T., Garattini, S., and Cocia, S. 1985. Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms. Psychopharmacology 85:111-114.
7. Knapp, S., and Mandel, A. J. 1976. Coincidence of blockade of synaptosomal 5-hydroxytryptamine uptake and decrease in tryptophan hydroxylase activity; effects of fenfluramine J. Pharmacol. Exp. Therap. 198:123-132.
8. Schuster, C. R., Lewis, M., and Seiden, L. S. 1986. Fenfluramine; neurotoxicity,. Psychopharmacol. Bull. 22:148-151.
9. Steranka, L. R., and Sanders-Bush, B. 1979. Long-term effect of fenfluramine on centralserotonergic mechanisms. Neuropharmacology 18:895-903.
10. Appel, N. M., Contrera, J. F., and De Souza, E. B. 1989. Fenfluramine selectively and differentially decreases the density of serotonergic nerve terminals in rat brain; evidence from immunocytochemical studies. J. Pharmacol. Exp. Ther. 249:928-943.
11. Kleven, M. S., and Seiden, L. S. 1989. D-,L-,DL-fenfluramine cause long term lasting depletions of serotonin in rat brain. Brain Res. 505:351-353.
12. Ricaurte, G. A., Molliver, M. E., Martello, M. B., Katz, J. L., Wilson, M. A., and Martello, A. L. 1991. Dexfenfluramine neurotoxicity in brains of non-human primates. Lancet 338:1487-1488.
13. Sotelo, C. 1991. Immunohistochemical study of short- and longterm effects of DL-fenfluramine on the serotonergic innervation of the rat hippocampal formation. Brain Res. 541:309-326.
14. Harvey, J., and McMaster, S. 1975. Fenfluramine; evidence for a neurotoxic action after chronic treatment with low dosages in the rat. Psychopharmacol. Commun. 1:217-228.
15. McCann, U., Hatzidimitriou, G., Ridenour, A., Ficsher, C., Yuan, J., Katz, J., and Ricaurte, G. 1994. Dexfenfluramine and serotonin neurotoxicity: further preclinical evidences that clinical caution is indicated. J. Pharmacol. Exp. Ther. 269:792-798.
16. Diksic, M., Nagahiro, S., Chaly, T, Sourkes, T. L., Yamamoto, Y. L., and Feindel, W. 1991. Serotonin synthesis rate measured in living dog brain by positron emission tomography. J Neurochem 56:153-162.
17. Mandell, A., and Knapp, S. 1977. Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. Fed. Proc. 36:2142-2148.
18. Costa, E., Garratt, J. C., and Revuelta, A. 1971. Action of fenfluramine on monoamine stores of rat tissues. Br. J. Pharmac. 41:57-64.
19. Invernizzi, R., Berettera, C., Garattini, S., and Samanin, R. 1986. D- and L-isomers of fenfluramine differ markedly in their interaction with brain serotonin and cathecolamines in the rat. Eur. J. Pharmacol. 120:9-15.
20. Mück-Šeler, D., and Diksic, M. 1995. The acute effects of reserpine and NSD-1015 on the brain serotonin synthesis rate measured by an autoradiographic method. Neuropsychopharmacology 12:251-262.
21. Diksic, M., Nagahiro, S., Sourkes, T. L., and Yamamoto, Y. L. 1990. A new method to measure brain serotonin synthesis in vivo I. Theory and basic data for a biological model. J. Cereb. Blood. Flow. Metab. 10:1-12.
22. Nagahiro, S., Takada, A., Diksic, M., Sourkes, T. L., Missala, K., and Yamamoto, Y. L. 1990. A autoradiographic method in normal and lithium-treated rats. J. Cereb. Blood. Flow. Metab. 10:13-21.
23. Mück-Šeler, D., and Diksic, M. 1996. DL-Fenfluramine increases the 5-HT synthesis rate in the terminals while decreasing it in the cell bodies of the rat brain. Brain Res. 737:45-50.
24. 14C]methyl-L-tryptophan. Appl. Radiat.Isot. 44:1167-1172.
25. Sourkes, T. L. 1974 Effect of α-methyl tryptophan on tryptophan, 5-hydroxytryptamine and protein metabolism in the brain. In: Ciba Foundation Symposium 22 New Series.:361-378
26. Takada, A., Gridiša, M., and Diksic, M. 1992. BlooD-brain barrier transfer of L-Trp and α-MTrp in Li-treated rats. Neurochem. Int. 21:513-519.
27. Paxinos, G., and Watson, C. 1986. The Rat Brain in Stereotaxic Coordinates, Academic Press, New York.
28. Diksic, M., Nagahiro, S., and Grdiša, M. 1995. The regional rate of serotonin synthesis estimated by the α-methyl-tryptophan method in rat brain from one-time method. J. Cereb.Blood. Flow.Metab. 15:806-813.
29. Vanier, M., Tsuiki, K., Grdiša, M., Worsly, K., and Diksic, M. 1995. Determination of the lumped constant for the α-methyl tryptophan method of estimating the rate of serotonin synthesis. J. Neurochem. 64:624-35.
30. Bevington, P. R. 1969. Data Reduction and Error Analysis for the Physical Sciences, pp. 92-118, McGraw-Hill, New York.
31. Mück-Šeler, D., Jevric-Causevic, A., and Diksic, M. 1996. Acute and short-term fluoxetine treatments have different effects on serotonin synthesis in the brain: an autoradiographic study in the rat. J. Neurochem. 67:2434-2442.
32. 1a agonist buspirone on serotonin synthesis in the rat brain. J. Neurochem. 72:2022-2031.
33. Kleven, M. S., Dwoskin, L. P., and Sparber, S. B. 1983. Pharmacological evidence for the existence of multiple functional pools of brain serotonin: Analysis of brain perfusate from conscious rats. J. Neurochem. 41:1143-1149.
34. Costa, E., Groppetti, A., and Revuelta, A. 1971. Action of fenfluramine on monoamine stores of rat tissues. Brit. J. Pharmacol 41:57-64.
35. Blundell, J. E., and Leshem, M. B. 1973. Dissociation of the anorexic effects of fenfluramine and amphetamine following intrahypothalamic injection. Br. J. Pharmacol. 47:183
36. Azmitia, E. C., and Segal, M. 1978. An autographic analysis of the different ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179:641-668.
37. Molliver, M. 1987. Serotonergic neuronal system: what their anatomic organization tells us about function. J. Clin. Psychopharmacol. 7:3S-23S.