Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats

Journal of Psychiatry and Neuroscience

Volumn 37, Issue 4, 2012, Pages 224-230

  Nonkes, Lourens J P ^a   de Pooter, Maaike ^a   Homberg, Judith R ^a  

^a RADBOUD UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER; SUCROSE PALMITATE;

ANIMAL EXPERIMENT; ARTICLE; ATTENTION; BEHAVIOR THERAPY; CONTROLLED STUDY; FEAR; GENE SILENCING; IMPAIRED FEAR EXTINCTION; MALE; MENTAL DISEASE; NONHUMAN; RAT;

EID: 84862611550     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.110116     Document Type: Article

References (30)

1. Burmeister M, McInnis MG, Zollner S. Psychiatric genetics: progress amid controversy. Nat Rev Genet 2008;9:527-540.
2. Ellis BJ, Boyce WT, Belsky J, et al. Differential susceptibility to the environment: an evolutionary-neurodevelopmental theory. Dev Psychopathol 2011;23:7-28.
3. Homberg JR, Lesch KP. Looking on the bright side of serotonin transporter gene variation. Biol Psychiatry 2011;69:513-519.
4. Xie P, Kranzler HR, Poling J, et al. Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on post-traumatic stress disorder diagnosis in 2 independent populations. Arch Gen Psychiatry 2009;66:1201-1209.
5. Wang Z, Baker DG, Harrer J, et al. The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR /rs25531 polymorphism. Depress Anxiety 2011;28:1067-1073.
6. Bryant RA, Felmingham KL, Falconer EM, et al. Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in posttraumatic stress disorder. Biol Psychiatry 2010;67:1217-1219.
7. Schipper P, Kiliaan AJ, Homberg JR. A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats. Behav Pharmacol 2011; 22:324-334.
8. Wellman CL, Izquierdo A, Garrett JE, et al. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci 2007;27:684-691.
9. Brigman JL, Mathur P, Harvey-White J, et al. Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex 2010;20:1955-1963.
10. Nonkes LJ, Maes JH, Homberg JR. Improved cognitive flexibility in serotonin transporter knockout rats is unchanged following chronic cocaine self-administration. Addict Biol 2011 July 25. [Epub ahead of print]
11. Caspi A, Hariri AR, Holmes A, et al. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010;167:509-527.
12. Smits BM, Mudde J, Plasterk RH, et al. Target-selected mutagenesis of the rat. Genomics 2004;83:332-334.
13. Smits BM, Mudde JB, van de Belt J, et al. Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics 2006;16: 159-169.
14. Homberg JR, Olivier JD, Smits BM, et al. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience 2007;146: 1662-1676.
15. Anstey ML, Rogers SM, Ott SR, et al. Serotonin mediates behavioral gregarization underlying swarm formation in desert locusts. Science 2009;323:627-630.
16. Branchi I. The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology 2011; 36: 339-351.
17. Bagot RC, Meaney MJ. Epigenetics and the biological basis of gene × environment interactions. J Am Acad Child Adolesc Psychiatry 2010; 49:752-771.
18. Kilpatrick DG, Koenen KC, Ruggiero KJ, et al. The serotonin transporter genotype and social support and moderation of posttrau-matic stress disorder and depression in hurricane-exposed adults. Am J Psychiatry 2007;164:1693-1699.
19. Koenen KC, Aiello AE, Bakshis E, et al. Modification of the association between serotonin transporter genotype and risk of posttrau-matic stress disorder in adults by county-level social environment. Am J Epidemiol 2009;169:704-711.
20. Coppens CM, de Boer SF, Koolhaas JM. Coping styles and behavioural flexibility: towards underlying mechanisms. Philos Trans R Soc Lond B Biol Sci 2010;365:4021-4028.
21. Dolan RJ. The human amygdala and orbital prefrontal cortex in behavioural regulation. Philos Trans R Soc Lond B Biol Sci 2007;362: 787-799.
22. Quirk GJ, Beer JS. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Curr Opin Neurobiol 2006; 16:723-727.
23. Altamura C, Dell'Acqua ML, Moessner R, et al. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex 2007;17:1394-1401.
24. Nonkes LJ, Tomson K, Maertin A, et al. Orbitofrontal cortex and amygdalar over-activity is associated with an inability to use the value of expected outcomes to guide behaviour in serotonin transporter knockout rats. Neurobiol Learn Mem 2010;94:65-72.
25. Heinz A, Braus DF, Smolka MN, et al. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 2005;8:20-21.
26. Pezawas L, Meyer-Lindenberg A, Drabant EM, et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834.
27. Hariri AR, Mattay VS, Tessitore A, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002;297:400-403.
28. Murrough JW, Huang Y, Hu J, et al. Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biol Psychiatry 2011; 70:1033-1038.
29. Bouton M, Woods A, Moody E, et al. Counteracting the context-dependence of extinction: relapse and tests of some relapse prevention methods. In: Hermans D, Vansteenwegen D, editors. Fear and learning: from basic processes to clinical implications. Washington: American Psychological Association; 2006. p. 175-196.
30. Muller JM, Morelli E, Ansorge M, et al. Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks. Genes Brain Behav 2011;10:166-175.