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Volumn 65, Issue 3, 2009, Pages 211-219

Gene × Environment Interactions at the Serotonin Transporter Locus

Author keywords

5 HTTLPR; Depression; Gene Environment interaction; meta analysis; stressful life events

Indexed keywords

SEROTONIN TRANSPORTER;

EID: 58149308050     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.06.009     Document Type: Article
Times cited : (452)

References (34)
  • 2
    • 38349150151 scopus 로고    scopus 로고
    • The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis
    • Uher R., and McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Mol Psychiatry 13 (2008) 131-146
    • (2008) Mol Psychiatry , vol.13 , pp. 131-146
    • Uher, R.1    McGuffin, P.2
  • 3
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3    Taylor, A.4    Craig, I.W.5    Harrington, H.6
  • 4
    • 0025959790 scopus 로고
    • Effect modification and the limits of biological inference from epidemiologic data
    • Thompson W.D. Effect modification and the limits of biological inference from epidemiologic data. J Clin Epidemiol 44 (1991) 221-232
    • (1991) J Clin Epidemiol , vol.44 , pp. 221-232
    • Thompson, W.D.1
  • 5
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch N.J. Searching for genetic determinants in the new millennium. Nature 405 (2000) 847-856
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 7
    • 58149305554 scopus 로고    scopus 로고
    • Araya R, et al. (under review): Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotion symptoms in pre-adolescent children.
    • Araya R, et al. (under review): Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotion symptoms in pre-adolescent children.
  • 8
    • 58149312714 scopus 로고    scopus 로고
    • Middeldorp CM, Boomsma DI (in press): Genetics and psychopathology. In: Berntson GG, Cacioppo JT, editors. Handbook of Neuroscience for Behavioral Sciences. New York: Wiley.
    • Middeldorp CM, Boomsma DI (in press): Genetics and psychopathology. In: Berntson GG, Cacioppo JT, editors. Handbook of Neuroscience for Behavioral Sciences. New York: Wiley.
  • 10
    • 6044228097 scopus 로고    scopus 로고
    • Gene-environment interaction analysis of serotonin system markers with adolescent depression
    • Eley T.C., Sugden K., Corsico A., Gregory A.M., Sham P., McGuffin P., et al. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 9 (2004) 908-915
    • (2004) Mol Psychiatry , vol.9 , pp. 908-915
    • Eley, T.C.1    Sugden, K.2    Corsico, A.3    Gregory, A.M.4    Sham, P.5    McGuffin, P.6
  • 12
    • 13444280555 scopus 로고    scopus 로고
    • The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression
    • Gillespie N.A., Whitfield J.B., Williams B., Heath A.C., and Martin N.G. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med 35 (2005) 101-111
    • (2005) Psychol Med , vol.35 , pp. 101-111
    • Gillespie, N.A.1    Whitfield, J.B.2    Williams, B.3    Heath, A.C.4    Martin, N.G.5
  • 13
    • 13244260769 scopus 로고    scopus 로고
    • Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden
    • Grabe H.J., Lange M., Wolff B., Völzke H., Lucht M., Freyberger H.J., et al. Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry 10 (2005) 220-224
    • (2005) Mol Psychiatry , vol.10 , pp. 220-224
    • Grabe, H.J.1    Lange, M.2    Wolff, B.3    Völzke, H.4    Lucht, M.5    Freyberger, H.J.6
  • 14
    • 33748324559 scopus 로고    scopus 로고
    • Stress-related negative affectivity and genetically altered serotonin transporter function: Evidence of synergism in shaping risk of depression
    • Jacobs N., Kenis G., Peeters F., Derom C., Vlietinck R., and van Os J. Stress-related negative affectivity and genetically altered serotonin transporter function: Evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 63 (2006) 989-996
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 989-996
    • Jacobs, N.1    Kenis, G.2    Peeters, F.3    Derom, C.4    Vlietinck, R.5    van Os, J.6
  • 15
    • 33645337891 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children
    • Kaufman J., Yang B.Z., Douglas-Palumberi H., Grasso D., Lipschitz D., Houshyar S., et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 59 (2006) 673-680
    • (2006) Biol Psychiatry , vol.59 , pp. 673-680
    • Kaufman, J.1    Yang, B.Z.2    Douglas-Palumberi, H.3    Grasso, D.4    Lipschitz, D.5    Houshyar, S.6
  • 16
    • 33745556951 scopus 로고    scopus 로고
    • Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene
    • Sjoberg R.L., Nilsson K.W., Nordquist N., Ohrvik J., Leppert J., Lindström L., and Oreland L. Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol 9 (2006) 443-449
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 443-449
    • Sjoberg, R.L.1    Nilsson, K.W.2    Nordquist, N.3    Ohrvik, J.4    Leppert, J.5    Lindström, L.6    Oreland, L.7
  • 17
    • 32144435933 scopus 로고    scopus 로고
    • Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder
    • Surtees P.G., Wainwright N.W., Willis-Owen S.A., Luben R., Day N.E., and Flint J. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry 59 (2006) 224-229
    • (2006) Biol Psychiatry , vol.59 , pp. 224-229
    • Surtees, P.G.1    Wainwright, N.W.2    Willis-Owen, S.A.3    Luben, R.4    Day, N.E.5    Flint, J.6
  • 18
    • 33748895036 scopus 로고    scopus 로고
    • Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology
    • Taylor S.E., Way B.M., Welch W.T., Hilmert C.J., Lehman B.J., and Eisenberger N.I. Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol Psychiatry 60 (2006) 671-676
    • (2006) Biol Psychiatry , vol.60 , pp. 671-676
    • Taylor, S.E.1    Way, B.M.2    Welch, W.T.3    Hilmert, C.J.4    Lehman, B.J.5    Eisenberger, N.I.6
  • 20
    • 34547478713 scopus 로고    scopus 로고
    • The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: Evidence from the Spanish PREDICT-Gene cohort
    • Cervilla J.A., Molina E., Rivera M., Torres-González F., Bellón J.A., Moreno B., et al. The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: Evidence from the Spanish PREDICT-Gene cohort. Mol Psychiatry 12 (2007) 748-755
    • (2007) Mol Psychiatry , vol.12 , pp. 748-755
    • Cervilla, J.A.1    Molina, E.2    Rivera, M.3    Torres-González, F.4    Bellón, J.A.5    Moreno, B.6
  • 21
    • 34548021027 scopus 로고    scopus 로고
    • Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders
    • Kim J.M., Stewart R., Kim S.W., Yang S.J., Shin I.S., Kim Y.H., and Yoon J.S. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry 62 (2007) 423-428
    • (2007) Biol Psychiatry , vol.62 , pp. 423-428
    • Kim, J.M.1    Stewart, R.2    Kim, S.W.3    Yang, S.J.4    Shin, I.S.5    Kim, Y.H.6    Yoon, J.S.7
  • 22
    • 18244389951 scopus 로고    scopus 로고
    • The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication
    • Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., and Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Arch Gen Psychiatry 62 (2005) 529-535
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 529-535
    • Kendler, K.S.1    Kuhn, J.W.2    Vittum, J.3    Prescott, C.A.4    Riley, B.5
  • 24
    • 30344484828 scopus 로고    scopus 로고
    • Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood
    • Fox N.A., Nichols K.E., Henderson H.A., Rubin K., Schmidt L., Hamer D., et al. Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. Psychol Sci 16 (2005) 921-926
    • (2005) Psychol Sci , vol.16 , pp. 921-926
    • Fox, N.A.1    Nichols, K.E.2    Henderson, H.A.3    Rubin, K.4    Schmidt, L.5    Hamer, D.6
  • 25
    • 33846523951 scopus 로고    scopus 로고
    • Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients
    • Gibb B.E., McGeary J.E., Beevers C.G., and Miller I.W. Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients. Suicide Life Threat Behav 36 (2006) 687-693
    • (2006) Suicide Life Threat Behav , vol.36 , pp. 687-693
    • Gibb, B.E.1    McGeary, J.E.2    Beevers, C.G.3    Miller, I.W.4
  • 26
    • 85047697355 scopus 로고    scopus 로고
    • Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression
    • Zalsman G., Huang Y.Y., Oquendo M.A., Burke A.K., Hu X.Z., Brent D.A., et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163 (2006) 1588-1593
    • (2006) Am J Psychiatry , vol.163 , pp. 1588-1593
    • Zalsman, G.1    Huang, Y.Y.2    Oquendo, M.A.3    Burke, A.K.4    Hu, X.Z.5    Brent, D.A.6
  • 27
    • 37349021685 scopus 로고    scopus 로고
    • Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to gene-environment interaction
    • Gunthert K.C., Conner T.S., Armeli S., Tennen H., Covault J., and Kranzler H.R. Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to gene-environment interaction. Psychosom Med 69 (2007) 762-768
    • (2007) Psychosom Med , vol.69 , pp. 762-768
    • Gunthert, K.C.1    Conner, T.S.2    Armeli, S.3    Tennen, H.4    Covault, J.5    Kranzler, H.R.6
  • 28
    • 36949041037 scopus 로고    scopus 로고
    • Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders
    • Stein M.B., Schork N.J., and Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology 33 (2008) 312-319
    • (2008) Neuropsychopharmacology , vol.33 , pp. 312-319
    • Stein, M.B.1    Schork, N.J.2    Gelernter, J.3
  • 29
    • 0035922669 scopus 로고    scopus 로고
    • Epidemiological methods for studying genes and environmental factors in complex diseases
    • Clayton D., and McKeigue P.M. Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 358 (2001) 1356-1360
    • (2001) Lancet , vol.358 , pp. 1356-1360
    • Clayton, D.1    McKeigue, P.M.2
  • 30
    • 33644930553 scopus 로고    scopus 로고
    • Genotype × Environment interaction in psychopathology: Fact or artifact?
    • Eaves L.J. Genotype × Environment interaction in psychopathology: Fact or artifact?. Twin Res Hum Genet 9 (2006) 1-8
    • (2006) Twin Res Hum Genet , vol.9 , pp. 1-8
    • Eaves, L.J.1
  • 31
    • 4644232945 scopus 로고    scopus 로고
    • Meta-analysis of serotonin transporter polymorphisms and affective disorders
    • Lotrich F.E., and Pollock B.G. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 14 (2004) 121-129
    • (2004) Psychiatr Genet , vol.14 , pp. 121-129
    • Lotrich, F.E.1    Pollock, B.G.2
  • 32
  • 33
    • 4143145303 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies
    • Munafo M.R., and Flint J. Meta-analysis of genetic association studies. Trends Genet 20 (2004) 439-444
    • (2004) Trends Genet , vol.20 , pp. 439-444
    • Munafo, M.R.1    Flint, J.2
  • 34
    • 0037426052 scopus 로고    scopus 로고
    • Problems of reporting genetic associations with complex outcomes
    • Colhoun H.M., McKeigue P.M., and Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 361 (2003) 865-872
    • (2003) Lancet , vol.361 , pp. 865-872
    • Colhoun, H.M.1    McKeigue, P.M.2    Davey Smith, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.