Antidepressant-placebo differences in 16 clinical trials over 10 years at a single site: Role of baseline severity

Psychopharmacology

Volumn 214, Issue 4, 2011, Pages 961-965

  Khan, Arif ^a   Bhat, Amritha ^a   Faucett, James ^a   Kolts, Russell ^b   Brown, Walter A ^c,d  

^a Northwest Clinical Research Center   (United States)

^b EASTERN WASHINGTON UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

Baseline severity; Depression; Obesity

Indexed keywords

ANTIDEPRESSANT AGENT; DULOXETINE; ESCITALOPRAM; FLUOXETINE; NEFAZODONE; PAROXETINE; PLACEBO; SERTRALINE; VENLAFAXINE; VILAZODONE;

ARTICLE; BODY MASS; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; EXPLORATORY RESEARCH; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TREATMENT OUTCOME; UNITED STATES;

ANTIDEPRESSIVE AGENTS; DEPRESSION; HUMANS; PLACEBOS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; WASHINGTON;

EID: 79953653507     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2107-1     Document Type: Article

References (15)

1. Elkin I, Shea MT, Watkins JT, Imber SD, Sotsky SM, Collins JF, Glass DR, Pilkonis PA, Leber WR, Docherty JP et al (1989) National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments. Arch Gen Psychiatry 46:971-982 (Pubitemid 19278225)
2. Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J (2010) Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 303:47-53
3. Khan A, Khan S, Brown WA (2002a) Are placebo controls necessary to test new antidepressants and anxiolytics? Int J Neuropsychopharmcol 5:193-197
4. Khan A, Leventhal RM, Khan SR, Brown WA (2002b) Severity of depression and response to antidepressants and placebo: an analysis of the Food and Drug Administration database. J Clin Psychopharmacol 22:40-45 (Pubitemid 34101291)
5. Khan A, Broadhead AE, Kolts RL, Brown WA (2005) Severity of depressive symptoms and response to antidepressants and placebo in antidepressant trials. J Psychiatr Res 39:145-150 (Pubitemid 39602638)
6. Khan A, Schwartz K, Kolts RL, Ridgeway D, Lineberry C (2007a) Relationship between depression severity entry criteria and antidepressant clinical trial outcomes. Biol Psychiatry 62:65-71 (Pubitemid 46898225)
7. Khan A, Schwartz KA, Kolts RL, Brown WA (2007b) BMI, sex, and antidepressant response. J Affect Disord 99:101-106 (Pubitemid 46275023)
8. Khan A, Bhat A, Kolts R, Thase M, Brown W (2010) Why has the antidepressant-placebo difference in antidepressant clinical trials diminished over the past three decades? CNS Neurosci Ther 16:217-226
9. Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT (2008) Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 5:e45
10. Klerman GL, Cole JO (1965) Clinical pharmacology of imipramine and related antidepressant compounds. Pharmacol Rev 17:101-141
11. Kloiber S, Ising M, Reppermund S, Hortsmann S, Dose T, Majer M, Zihl J, Pfister H, Unschuld PG, Holsboer F, Lucae S (2007) Overweight and obesity affect treatment response in major depression. Biol Psychiatry 62:321-326 (Pubitemid 47444280)
12. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuipers P, Penninx BWJH, Zitman FG (2010) Overweight, obesity, and depression: a systematic review and meta-analyses of longitudinal studies. Arch Gen Psychiatry 67:220-229
13. National Institute for Clinical Excellence (2004) Depression: management of depression in primary and secondary care. Clinical Practice Guideline No 23. National Institute for Clinical Excellence, London, p 670
14. Simon GE, Korff MV, Saunders K, Miglioretti DL, Crane PK, van Belle G, Kessler RC (2006) Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry 63:824-830
15. Walsh BT, Seidman SN, Sysko R, Gould M (2002) Placebo response in studies of major depression: variable, substantial, and growing. JAMA 287:1840-1847 (Pubitemid 34303629)