메뉴 건너뛰기




Volumn 57, Issue 8, 2010, Pages 948-957

Biochemical and behavioral effects of long-term citalopram administration and discontinuation in rats: Role of serotonin synthesis

Author keywords

Discontinuation; Efficacy; Reactivity; Serotonin; SSRI; Synthesis; Turnover

Indexed keywords

BIOCHEMICAL MARKER; CITALOPRAM; SEROTONIN;

EID: 78649635889     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.10.001     Document Type: Article
Times cited : (27)

References (84)
  • 2
    • 0024412155 scopus 로고
    • Chronic administration of clomipramine prevents the increase in serotonin and noradrenaline induced by chronic stress
    • A. Adell, C. García-Marquez, A. Armario, and E. Gelpí Chronic administration of clomipramine prevents the increase in serotonin and noradrenaline induced by chronic stress Psychopharmacology (Berl.) 99 1989 22 26
    • (1989) Psychopharmacology (Berl.) , vol.99 , pp. 22-26
    • Adell, A.1    García-Marquez, C.2    Armario, A.3    Gelpí, E.4
  • 3
    • 0031960136 scopus 로고    scopus 로고
    • SSRIS versus tricyclic antidepressants in depressed inpatients: A meta-analysis of efficacy and tolerability
    • I.M. Anderson SSRIS versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability Depress. Anxiety 7 1 1998 11 17
    • (1998) Depress. Anxiety , vol.7 , Issue.1 , pp. 11-17
    • Anderson, I.M.1
  • 4
    • 0027163303 scopus 로고
    • 5-HT and antidepressants: New views from microdialysis studies
    • F. Artigas 5-HT and antidepressants: new views from microdialysis studies Trends Pharmacol. Sci. 14 1993 262
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 262
    • Artigas, F.1
  • 6
    • 0026881731 scopus 로고
    • Clinical pharmacokinetics of citalopram and other selective serotonergic reuptake inhibitors (SSRI)
    • P. Baumann Clinical pharmacokinetics of citalopram and other selective serotonergic reuptake inhibitors (SSRI) Int. Clin. Psychopharmacol. 6 5 1992 13 20
    • (1992) Int. Clin. Psychopharmacol. , vol.6 , Issue.5 , pp. 13-20
    • Baumann, P.1
  • 7
    • 0030038570 scopus 로고    scopus 로고
    • Reduction of serotonergic function in rat brain by tryptophan depletion: Effects in control and fluvoxamine-treated rats
    • N. Bel, and F. Artigas Reduction of serotonergic function in rat brain by tryptophan depletion: effects in control and fluvoxamine-treated rats J. Neurochem. 67 1996 669 676
    • (1996) J. Neurochem. , vol.67 , pp. 669-676
    • Bel, N.1    Artigas, F.2
  • 8
    • 33646797031 scopus 로고    scopus 로고
    • Physiologic mechanisms underlying the antidepressant discontinuation syndrome
    • P. Blier, and P. Tremblay Physiologic mechanisms underlying the antidepressant discontinuation syndrome J. Clin. Psychiatry 67 4 2006 8 13
    • (2006) J. Clin. Psychiatry , vol.67 , Issue.4 , pp. 8-13
    • Blier, P.1    Tremblay, P.2
  • 9
    • 0023606602 scopus 로고
    • Modifications of the serotonin system by antidepressant treatments: Implications for the therapeutic response in major depression
    • P. Blier, C. de Montigny, and Y. Chaput Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression J. Clin. Psychopharmacol. 7 1987 24S 35S
    • (1987) J. Clin. Psychopharmacol. , vol.7
    • Blier, P.1    De Montigny, C.2    Chaput, Y.3
  • 10
    • 0028872564 scopus 로고
    • Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats
    • F.J. Bosker, K.E. van Esseveldt, A.A. Klompmakers, and H.G. Westenberg Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats Psychopharmacology (Berl.) 117 1995 358 363
    • (1995) Psychopharmacology (Berl.) , vol.117 , pp. 358-363
    • Bosker, F.J.1    Van Esseveldt, K.E.2    Klompmakers, A.A.3    Westenberg, H.G.4
  • 11
    • 0029896156 scopus 로고    scopus 로고
    • Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine (5-HT) in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors
    • F.J. Bosker, T.Y. de Winter, A.A. Klompmakers, and H.G. Westenberg Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine (5-HT) in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors J. Neurochem. 66 1996 2546 2555
    • (1996) J. Neurochem. , vol.66 , pp. 2546-2555
    • Bosker, F.J.1    De Winter, T.Y.2    Klompmakers, A.A.3    Westenberg, H.G.4
  • 12
    • 0032053109 scopus 로고    scopus 로고
    • Behavioral tolerance to and withdrawal from multiple fluoxetine administration
    • J.M. Bjork, O. Gaytan, N. Patt, A.C. Swann, and N. Dafny Behavioral tolerance to and withdrawal from multiple fluoxetine administration Int. J. Neurosci. 93 1998 163 179
    • (1998) Int. J. Neurosci. , vol.93 , pp. 163-179
    • Bjork, J.M.1    Gaytan, O.2    Patt, N.3    Swann, A.C.4    Dafny, N.5
  • 13
    • 0027313688 scopus 로고
    • The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain
    • S. Caccia, M. Anelli, A.M. Codegoni, C. Fracasso, and S. Garattini The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain Br. J. Pharmacol. 110 1993 355 359
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 355-359
    • Caccia, S.1    Anelli, M.2    Codegoni, A.M.3    Fracasso, C.4    Garattini, S.5
  • 15
    • 3042823920 scopus 로고    scopus 로고
    • Effects of chronic treatment with escitalopram or citalopram on extracellular 5-HT in the prefrontal cortex of rats: Role of 5-HT1A receptors
    • I. Ceglia, S. Acconcia, C. Fracasso, M. Colovic, S. Caccia, and R.W. Invernizzi Effects of chronic treatment with escitalopram or citalopram on extracellular 5-HT in the prefrontal cortex of rats: role of 5-HT1A receptors Br. J. Pharmacol. 142 2004 469 478
    • (2004) Br. J. Pharmacol. , vol.142 , pp. 469-478
    • Ceglia, I.1    Acconcia, S.2    Fracasso, C.3    Colovic, M.4    Caccia, S.5    Invernizzi, R.W.6
  • 16
    • 0026348807 scopus 로고
    • Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat
    • Y. Chaput, C. de Montigny, and P. Blier Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat Neuropsychopharmacology 5 1991 219 229
    • (1991) Neuropsychopharmacology , vol.5 , pp. 219-229
    • Chaput, Y.1    De Montigny, C.2    Blier, P.3
  • 17
    • 37749008643 scopus 로고    scopus 로고
    • Functional characterization of the human TPH2 5' regulatory region: Untranslated region and polymorphisms modulate gene expression in vitro
    • G.L. Chen, E.J. Vallender, and G.M. Miller Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro Hum. Genet. 122 2008 645 657
    • (2008) Hum. Genet. , vol.122 , pp. 645-657
    • Chen, G.L.1    Vallender, E.J.2    Miller, G.M.3
  • 21
    • 0016169114 scopus 로고
    • Habituation and sensitization of the rat startle response: Effects of raphe lesions
    • M. Davis, and M.H. Sheard Habituation and sensitization of the rat startle response: effects of raphe lesions Physiol. Behav. 12 1974 425 431
    • (1974) Physiol. Behav. , vol.12 , pp. 425-431
    • Davis, M.1    Sheard, M.H.2
  • 22
    • 0019305880 scopus 로고
    • Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle
    • M. Davis, D.I. Strachan, and E. Kass Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle Science 209 1980 521 523
    • (1980) Science , vol.209 , pp. 521-523
    • Davis, M.1    Strachan, D.I.2    Kass, E.3
  • 23
    • 0025318311 scopus 로고
    • Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan
    • P.L. Delgado, D.S. Charney, L.H. Price, G.K. Aghajanian, H. Landis, and G.R. Heninger Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan Arch. Gen. Psychiatry 47 1990 411 418
    • (1990) Arch. Gen. Psychiatry , vol.47 , pp. 411-418
    • Delgado, P.L.1    Charney, D.S.2    Price, L.H.3    Aghajanian, G.K.4    Landis, H.5    Heninger, G.R.6
  • 24
    • 0034566066 scopus 로고    scopus 로고
    • Compliance with antidepressant therapy and antidepressant discontinuation symptoms
    • K. Demyttenaere, and P. Haddad Compliance with antidepressant therapy and antidepressant discontinuation symptoms Acta Psychiatr. Scand. Suppl. 403 2000 50 56
    • (2000) Acta Psychiatr. Scand. Suppl. , vol.403 , pp. 50-56
    • Demyttenaere, K.1    Haddad, P.2
  • 26
    • 27544503357 scopus 로고    scopus 로고
    • Relationship of total health care charges to selective serotonin reuptake inhibitor utilization patterns including the length of antidepressant therapy - Results from a managed care administrative claims database
    • M.T. Eaddy, B.G. Druss, M.W. Sarnes, T.S. Regan, and L.E. Frankum Relationship of total health care charges to selective serotonin reuptake inhibitor utilization patterns including the length of antidepressant therapy - results from a managed care administrative claims database J. Manag. Care Pharm. 11 2005 145 150
    • (2005) J. Manag. Care Pharm. , vol.11 , pp. 145-150
    • Eaddy, M.T.1    Druss, B.G.2    Sarnes, M.W.3    Regan, T.S.4    Frankum, L.E.5
  • 27
    • 0032874856 scopus 로고    scopus 로고
    • Activation and desensitization by cyclic antidepressant drugs of alpha(2)-autoreceptors, alpha(2)-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo
    • S. Esteban, J. Llado, A. Sastre-Coll, and J.A. Garsia-Sevilla Activation and desensitization by cyclic antidepressant drugs of alpha(2)-autoreceptors, alpha(2)-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo Naunyn-Schmiedebergs Arch. Pharmacol. 360 1999 135 143
    • (1999) Naunyn-Schmiedebergs Arch. Pharmacol. , vol.360 , pp. 135-143
    • Esteban, S.1    Llado, J.2    Sastre-Coll, A.3    Garsia-Sevilla, J.A.4
  • 29
    • 0020431887 scopus 로고
    • Kinetics of citalopram in test animals; Drug exposure in safety studies
    • O.K. Fredricson Kinetics of citalopram in test animals; drug exposure in safety studies Prog. Neuropsychopharmacol. Biol. Psychiatry 6 1982 297 309
    • (1982) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.6 , pp. 297-309
    • Fredricson, O.K.1
  • 30
    • 34250002859 scopus 로고    scopus 로고
    • Expanding the black box - Depression, antidepressants, and the risk of suicide
    • R.A. Friedman, and A.C. Leon Expanding the black box - depression, antidepressants, and the risk of suicide N. Engl. J. Med. 356 2007 2343 2346
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2343-2346
    • Friedman, R.A.1    Leon, A.C.2
  • 31
    • 0028283115 scopus 로고
    • Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis
    • R.W. Fuller Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis Life Sci. 55 1994 163 167
    • (1994) Life Sci. , vol.55 , pp. 163-167
    • Fuller, R.W.1
  • 32
    • 0024217751 scopus 로고
    • Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors
    • M.A. Geyer, and G.S. Tapson Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors Neuropsychopharmacology 1 1988 135 147
    • (1988) Neuropsychopharmacology , vol.1 , pp. 135-147
    • Geyer, M.A.1    Tapson, G.S.2
  • 33
    • 33845700619 scopus 로고    scopus 로고
    • A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: A fear-potentiated startle study
    • C. Grillon, J. Levenson, and D.S. Pine A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study Neuropsychopharmacology 32 2007 225 231
    • (2007) Neuropsychopharmacology , vol.32 , pp. 225-231
    • Grillon, C.1    Levenson, J.2    Pine, D.S.3
  • 34
    • 0035082671 scopus 로고    scopus 로고
    • Antidepressant discontinuation syndromes
    • P.M. Haddad Antidepressant discontinuation syndromes Drug Saf. 24 2001 183 197
    • (2001) Drug Saf. , vol.24 , pp. 183-197
    • Haddad, P.M.1
  • 35
    • 3042739104 scopus 로고    scopus 로고
    • Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition
    • C.J. Harmer, N.C. Shelley, P.J. Cowen, and G.M. Goodwin Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition Am. J. Psychiatry 161 2004 1256 1263
    • (2004) Am. J. Psychiatry , vol.161 , pp. 1256-1263
    • Harmer, C.J.1    Shelley, N.C.2    Cowen, P.J.3    Goodwin, G.M.4
  • 36
    • 20044392347 scopus 로고    scopus 로고
    • Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: An autoradiographic study
    • S. Hasegawa, A. Watanabe, K.Q. Nguyen, G. Debonnel, and M. Diksic Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study Psychopharmacology (Berl.) 179 2005 781 790
    • (2005) Psychopharmacology (Berl.) , vol.179 , pp. 781-790
    • Hasegawa, S.1    Watanabe, A.2    Nguyen, K.Q.3    Debonnel, G.4    Diksic, M.5
  • 37
    • 20444474608 scopus 로고    scopus 로고
    • Antidepressant drug use & the risk of suicide
    • D. Healy, and G. Aldred Antidepressant drug use & the risk of suicide Int. Rev. Psychiatry 17 2005 163 172
    • (2005) Int. Rev. Psychiatry , vol.17 , pp. 163-172
    • Healy, D.1    Aldred, G.2
  • 38
    • 33745915255 scopus 로고    scopus 로고
    • Did regulators fail over selective serotonin reuptake inhibitors?
    • D. Healy Did regulators fail over selective serotonin reuptake inhibitors? B.M.J. 333 2006 92 95
    • (2006) B.M.J. , vol.333 , pp. 92-95
    • Healy, D.1
  • 39
    • 34249080888 scopus 로고    scopus 로고
    • Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system
    • J.R. Homberg, J.D. Olivier, and B.M. Smits Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system Neuroscience 146 2007 1662 1676
    • (2007) Neuroscience , vol.146 , pp. 1662-1676
    • Homberg, J.R.1    Olivier, J.D.2    Smits, B.M.3
  • 40
    • 69849101826 scopus 로고    scopus 로고
    • Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain
    • 101371/journalpone0006797
    • G. Honig, M. Jongsma, M.C.G. van der Hart, and L.H. Tecott Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain PloS ONE 4 8 2009 e66797 10.1371/journal.pone.0006797
    • (2009) PloS ONE , vol.4 , Issue.8 , pp. 66797
    • Honig, G.1    Jongsma, M.2    Van Der Hart, M.C.G.3    Tecott, L.H.4
  • 41
    • 0028294525 scopus 로고
    • Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
    • J. Hyttel Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs) Int. Clin. Psychopharmacol. 9 1 1994 19 26
    • (1994) Int. Clin. Psychopharmacol. , vol.9 , Issue.1 , pp. 19-26
    • Hyttel, J.1
  • 42
    • 35848939596 scopus 로고    scopus 로고
    • Role of TPH-2 in brain function: News from behavioral and pharmacologic studies
    • R.W. Invernizzi Role of TPH-2 in brain function: news from behavioral and pharmacologic studies J. Neurosci. Res. 85 2007 3030 3035
    • (2007) J. Neurosci. Res. , vol.85 , pp. 3030-3035
    • Invernizzi, R.W.1
  • 43
    • 34548688720 scopus 로고    scopus 로고
    • The effects of increased central serotonergic activity on prepulse inhibition and habituation of the human startle response
    • DOI 10.1038/sj.npp.1301350, PII 1301350
    • K.S. Jensen, B. Oranje, M. Wienberg, and B.Y. Glenthoj The effects of increased central serotonergic activity on prepulse inhibition and habituation of the human startle response Neuropsychopharmacology 32 2007 2117 2124 (Pubitemid 47417698)
    • (2007) Neuropsychopharmacology , vol.32 , Issue.10 , pp. 2117-2124
    • Jensen, K.S.1    Oranje, B.2    Wienberg, M.3    Glenthoj, B.Y.4
  • 44
  • 46
    • 61449173676 scopus 로고    scopus 로고
    • Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats
    • K. Kanemaru, K. Nishi, S. Hasegawa, and M. Diksic Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats Neurochem. Int. 54 2009 363 371
    • (2009) Neurochem. Int. , vol.54 , pp. 363-371
    • Kanemaru, K.1    Nishi, K.2    Hasegawa, S.3    Diksic, M.4
  • 47
    • 0034820990 scopus 로고    scopus 로고
    • Profiling of tryptophan-related plasma indoles in patients with carcinoid tumors by automated, on-line, solid-phase extraction and HPLC with fluorescence detection
    • I.P. Kema, W.G. Meijer, G. Meiborg, B. Ooms, P.H. Willemse, and E.G. de Vries Profiling of tryptophan-related plasma indoles in patients with carcinoid tumors by automated, on-line, solid-phase extraction and HPLC with fluorescence detection Clin. Chem. 47 2001 1811 1820
    • (2001) Clin. Chem. , vol.47 , pp. 1811-1820
    • Kema, I.P.1    Meijer, W.G.2    Meiborg, G.3    Ooms, B.4    Willemse, P.H.5    De Vries, E.G.6
  • 49
    • 39849093340 scopus 로고    scopus 로고
    • Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration
    • 101371/journalpmed0050045
    • I. Kirsch, B.J. Deacon, T.B. Huedo-Medina, A. Scoboria, T.J. Moore, and B.T. Johnson Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration PLoS Med. 5 2008 e45 10.1371/journal.pmed.0050045
    • (2008) PLoS Med. , vol.5 , pp. 45
    • Kirsch, I.1    Deacon, B.J.2    Huedo-Medina, T.B.3    Scoboria, A.4    Moore, T.J.5    Johnson, B.T.6
  • 51
    • 0023723009 scopus 로고
    • Pharmacological effects of serotonin reuptake inhibitors
    • B.E. Leonard Pharmacological effects of serotonin reuptake inhibitors J. Clin. Psychiatry 49 1988 12 17
    • (1988) J. Clin. Psychiatry , vol.49 , pp. 12-17
    • Leonard, B.E.1
  • 52
    • 0035130579 scopus 로고    scopus 로고
    • Effects of MDMA (ecstasy) on prepulse inhibition and habituation of startle in humans after pretreatment with citalopram, haloperidol, or ketanserin
    • M.E. Liechti, M.A. Geyer, D. Hell, and F.X. Vollenweider Effects of MDMA (ecstasy) on prepulse inhibition and habituation of startle in humans after pretreatment with citalopram, haloperidol, or ketanserin Neuropsychopharmacology 24 2001 240 252
    • (2001) Neuropsychopharmacology , vol.24 , pp. 240-252
    • Liechti, M.E.1    Geyer, M.A.2    Hell, D.3    Vollenweider, F.X.4
  • 53
    • 0031104882 scopus 로고    scopus 로고
    • Characterization of the disruptions of prepulse inhibition and habituation of startle induced by alpha-ethyltryptamine
    • D.L. Martinez, and M.A. Geyer Characterization of the disruptions of prepulse inhibition and habituation of startle induced by alpha-ethyltryptamine Neuropsychopharmacology 16 1997 246 255
    • (1997) Neuropsychopharmacology , vol.16 , pp. 246-255
    • Martinez, D.L.1    Geyer, M.A.2
  • 54
    • 0025340254 scopus 로고
    • Serotonin autoreceptor subsensitivity and antidepressant activity
    • C. Moret, and M. Briley Serotonin autoreceptor subsensitivity and antidepressant activity Eur. J. Pharmacol. 16 1990 351 356
    • (1990) Eur. J. Pharmacol. , vol.16 , pp. 351-356
    • Moret, C.1    Briley, M.2
  • 55
    • 0026659714 scopus 로고
    • Effect of antidepressant drugs on monoamine synthesis in brain in vivo
    • C. Moret, and M. Briley Effect of antidepressant drugs on monoamine synthesis in brain in vivo Neuropharmacology 31 1992 679 684
    • (1992) Neuropharmacology , vol.31 , pp. 679-684
    • Moret, C.1    Briley, M.2
  • 56
    • 0028329427 scopus 로고
    • Effects of storage on binding and stability of tryptophan in human serum
    • C.J. Morgan, and A.A. Badawy Effects of storage on binding and stability of tryptophan in human serum Ann. Clin. Biochem. 31 1994 190 192
    • (1994) Ann. Clin. Biochem. , vol.31 , pp. 190-192
    • Morgan, C.J.1    Badawy, A.A.2
  • 57
    • 0030296734 scopus 로고    scopus 로고
    • Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus
    • J. Neumaier, D. Root, and M. Hamblin Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus Neuropsychopharmacology 15 1996 515 522
    • (1996) Neuropsychopharmacology , vol.15 , pp. 515-522
    • Neumaier, J.1    Root, D.2    Hamblin, M.3
  • 58
    • 0028215631 scopus 로고
    • Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro
    • J.J. O'Connor, and Z.L. Kruk Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro Brain Res. 21 1994 328 335
    • (1994) Brain Res. , vol.21 , pp. 328-335
    • O'Connor, J.J.1    Kruk, Z.L.2
  • 59
    • 65249156122 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
    • J.C. O'Connor, C. André, Y. Wang, M.A. Lawson, S.S. Szegedi, J. Lestage, N. Castanon, K.W. Kelley, and R. Dantzer Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin J. Neurosci. 29 2009 4200 4209
    • (2009) J. Neurosci. , vol.29 , pp. 4200-4209
    • O'Connor, J.C.1    André, C.2    Wang, Y.3    Lawson, M.A.4    Szegedi, S.S.5    Lestage, J.6    Castanon, N.7    Kelley, K.W.8    Dantzer, R.9
  • 60
    • 0020051547 scopus 로고
    • Determination of the antidepressant agent citalopram and metabolites in plasma by liquid chromatography with fluorescence detection
    • E. Oyehaug, E.T. Ostensen, and B. Salvesen Determination of the antidepressant agent citalopram and metabolites in plasma by liquid chromatography with fluorescence detection J. Chromatogr. 227 1982 129 135
    • (1982) J. Chromatogr. , vol.227 , pp. 129-135
    • Oyehaug, E.1    Ostensen, E.T.2    Salvesen, B.3
  • 61
    • 14544290102 scopus 로고    scopus 로고
    • Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats
    • B. Pouzet, M.P. Andersen, and S. Hogg Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats Psychopharmacology (Berl.) 178 2005 9 16
    • (2005) Psychopharmacology (Berl.) , vol.178 , pp. 9-16
    • Pouzet, B.1    Andersen, M.P.2    Hogg, S.3
  • 62
    • 0019450985 scopus 로고
    • Effects of zimelidine on serotoninergic and noradrenergic neurons after repeated administration in the rat
    • S.B. Ross, H. Hall, A.L. Renyi, and D. Westerlund Effects of zimelidine on serotoninergic and noradrenergic neurons after repeated administration in the rat Psychopharmacology (Berl.) 72 1981 219 225
    • (1981) Psychopharmacology (Berl.) , vol.72 , pp. 219-225
    • Ross, S.B.1    Hall, H.2    Renyi, A.L.3    Westerlund, D.4
  • 65
    • 70449890181 scopus 로고    scopus 로고
    • Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular evidence and psychiatric implications
    • S. Russo, I.P. Kema, F.J. Bosker, J. Haavik, and J. Korf Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular evidence and psychiatric implications World J. Biol. Psychiatry 10 2009 258 268
    • (2009) World J. Biol. Psychiatry , vol.10 , pp. 258-268
    • Russo, S.1    Kema, I.P.2    Bosker, F.J.3    Haavik, J.4    Korf, J.5
  • 67
    • 33646762803 scopus 로고    scopus 로고
    • Antidepressant discontinuation syndrome: Consensus panel recommendations for clinical management and additional research
    • A.F. Schatzberg, P. Blier, P.L. Delgado, M. Fava, P.M. Haddad, and R.C. Shelton Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research J. Clin. Psychiatry 67 4 2006 27 30
    • (2006) J. Clin. Psychiatry , vol.67 , Issue.4 , pp. 27-30
    • Schatzberg, A.F.1    Blier, P.2    Delgado, P.L.3    Fava, M.4    Haddad, P.M.5    Shelton, R.C.6
  • 68
    • 33744931105 scopus 로고    scopus 로고
    • Efficacy and safety of selective serotonin reuptake inhibitors in the treatment of depression in children and adolescents: Practitioner review
    • S.C. Sharp, and J.A. Hellings Efficacy and safety of selective serotonin reuptake inhibitors in the treatment of depression in children and adolescents: practitioner review Clin. Drug Investig. 26 2006 247 255
    • (2006) Clin. Drug Investig. , vol.26 , pp. 247-255
    • Sharp, S.C.1    Hellings, J.A.2
  • 69
    • 0036655971 scopus 로고    scopus 로고
    • Prevention of the serotonin reuptake inhibitor discontinuation syndrome
    • L. Sher Prevention of the serotonin reuptake inhibitor discontinuation syndrome Med. Hypotheses 59 2002 92 94
    • (2002) Med. Hypotheses , vol.59 , pp. 92-94
    • Sher, L.1
  • 70
    • 34547148852 scopus 로고    scopus 로고
    • Suicide attempts among patients starting depression treatment with medications or psychotherapy
    • G.E. Simon, and J. Savarino Suicide attempts among patients starting depression treatment with medications or psychotherapy Am. J. Psychiatry 164 2007 1029 1034
    • (2007) Am. J. Psychiatry , vol.164 , pp. 1029-1034
    • Simon, G.E.1    Savarino, J.2
  • 71
    • 0024591462 scopus 로고
    • The effects of chronic treatment with amitriptyline and MDL 72394 on the control of 5-HT release in vivo
    • A.J. Sleight, R.J. Smith, C.A. Marsden, and M.G. Palfreyman The effects of chronic treatment with amitriptyline and MDL 72394 on the control of 5-HT release in vivo Neuropharmacology 28 1989 477 480
    • (1989) Neuropharmacology , vol.28 , pp. 477-480
    • Sleight, A.J.1    Smith, R.J.2    Marsden, C.A.3    Palfreyman, M.G.4
  • 72
    • 0036837312 scopus 로고    scopus 로고
    • Evidence for involvement of hydroxytryptamine (1B)autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine
    • C. Stenfors, and S. Ross Evidence for involvement of hydroxytryptamine (1B)autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine Life Sci. 71 2002 2867 2880
    • (2002) Life Sci. , vol.71 , pp. 2867-2880
    • Stenfors, C.1    Ross, S.2
  • 73
    • 0023165062 scopus 로고
    • Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists
    • J.S. Sprouse, and G.K. Aghajanian Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists Synapse 1 1987 3 9
    • (1987) Synapse , vol.1 , pp. 3-9
    • Sprouse, J.S.1    Aghajanian, G.K.2
  • 75
    • 0027464747 scopus 로고
    • Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat
    • J.H. Trouvin, A.M. Gardier, E. Chanut, N. Pages, and C. Jacquot Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat Life Sci. 52 1993 PL187 192
    • (1993) Life Sci. , vol.52 , pp. 187-192
    • Trouvin, J.H.1    Gardier, A.M.2    Chanut, E.3    Pages, N.4    Jacquot, C.5
  • 76
    • 70349564376 scopus 로고    scopus 로고
    • Antidepressant discontinuation and risk of suicide attempt: A retrospective, nested case-control study
    • R.J. Valuck, H.D. Orton, and A.M. Libby Antidepressant discontinuation and risk of suicide attempt: a retrospective, nested case-control study J. Clin. Psychiatry 70 2009 1069 1077
    • (2009) J. Clin. Psychiatry , vol.70 , pp. 1069-1077
    • Valuck, R.J.1    Orton, H.D.2    Libby, A.M.3
  • 77
    • 0037966344 scopus 로고    scopus 로고
    • Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients
    • A.R. Van Gool, D. Fekkes, W.H. Kruit, P.G. Mulder, T.L. Ten Hagen, M. Bannink, M. Maes, and A.M. Eggermont Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients Psychiatry Res. 119 2003 125 132
    • (2003) Psychiatry Res. , vol.119 , pp. 125-132
    • Van Gool, A.R.1    Fekkes, D.2    Kruit, W.H.3    Mulder, P.G.4    Ten Hagen, T.L.5    Bannink, M.6    Maes, M.7    Eggermont, A.M.8
  • 78
    • 3142664534 scopus 로고    scopus 로고
    • Pegylated interferon-alpha2b treatment in melanoma patients: Influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations
    • A.R. Van Gool, H.H. van Ojik, W.H. Kruit, M. Bannink, P.G. Mulder, A.M. Eggermont, r.G. Stote, and D. Fekkes Pegylated interferon-alpha2b treatment in melanoma patients: influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations Anticancer Drugs 15 2004 587 591
    • (2004) Anticancer Drugs , vol.15 , pp. 587-591
    • Van Gool, A.R.1    Van Ojik, H.H.2    Kruit, W.H.3    Bannink, M.4    Mulder, P.G.5    Eggermont, A.M.6    Stote, R.G.7    Fekkes, D.8
  • 79
    • 1642410061 scopus 로고    scopus 로고
    • Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats
    • H.M. van der Stelt, L.M. Broersen, B. Olivier, and H.G. Westenberg Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats Psychopharmacology (Berl.) 172 2004 137 144
    • (2004) Psychopharmacology (Berl.) , vol.172 , pp. 137-144
    • Van Der Stelt, H.M.1    Broersen, L.M.2    Olivier, B.3    Westenberg, H.G.4
  • 80
    • 0019496673 scopus 로고
    • Tryptophan deprivation: Effects on mouse-killing and reactivity in the rat
    • M. Vergnes, and E. Kempf Tryptophan deprivation: effects on mouse-killing and reactivity in the rat Pharmacol. Biochem. Behav. 14 1 1981 19 23
    • (1981) Pharmacol. Biochem. Behav. , vol.14 , Issue.1 , pp. 19-23
    • Vergnes, M.1    Kempf, E.2
  • 81
    • 15044352896 scopus 로고    scopus 로고
    • Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice
    • A.H. Veenema, T.I. Cremers, M.E. Jongsma, P.J. Steenbergen, S.F. De Boer, and J.M. Koolhaas Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice Psychopharmacology (Berl.) 178 2005 151 160
    • (2005) Psychopharmacology (Berl.) , vol.178 , pp. 151-160
    • Veenema, A.H.1    Cremers, T.I.2    Jongsma, M.E.3    Steenbergen, P.J.4    De Boer, S.F.5    Koolhaas, J.M.6
  • 82
    • 0018420335 scopus 로고
    • Tryptophan-free diet: Effects on the acoustic startle reflex in rats
    • J.K. Walters, M. Davis, and M.H. Sheard Tryptophan-free diet: effects on the acoustic startle reflex in rats Psychopharmacology (Berl.) 62 1979 103 109
    • (1979) Psychopharmacology (Berl.) , vol.62 , pp. 103-109
    • Walters, J.K.1    Davis, M.2    Sheard, M.H.3
  • 83
    • 72649104599 scopus 로고    scopus 로고
    • LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microglia
    • Y. Wang, M.A. Lawson, R. Dantzer, and K.W. Kelley LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microglia Brain Behav. Immun. 24 2010 201 209
    • (2010) Brain Behav. Immun. , vol.24 , pp. 201-209
    • Wang, Y.1    Lawson, M.A.2    Dantzer, R.3    Kelley, K.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.