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Volumn 100, Issue , 2015, Pages 208-220

A review of biotransformation and pharmacology of ginsenoside compound K

Author keywords

Biotransformation; Ginseng; Ginsenoside compound K; Pharmacological activities

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIALLERGIC AGENT; ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; BETA GLUCOSIDASE; COMPOUND K; DRUG METABOLITE; GINSENOSIDE; UNCLASSIFIED DRUG; GINSENOSIDE M1;

EID: 84921027428     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.11.019     Document Type: Review
Times cited : (217)

References (101)
  • 1
    • 0035240033 scopus 로고    scopus 로고
    • Panax ginseng - A non-organ-specific cancer preventive?
    • TK Yun Panax ginseng - a non-organ-specific cancer preventive? Lancet Oncol 2 1 2001 49 55
    • (2001) Lancet Oncol , vol.2 , Issue.1 , pp. 49-55
    • Yun, T.K.1
  • 2
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • LP Christensen Ginsenosides chemistry, biosynthesis, analysis, and potential health effects Adv Food Nutr Res 55 2009 1 99
    • (2009) Adv Food Nutr Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 3
    • 84873549615 scopus 로고    scopus 로고
    • Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats
    • J Shi, W Xue, WJ Zhao, and KX Li Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats Acta Pharmacol Sin 34 2 2013 214 220
    • (2013) Acta Pharmacol Sin , vol.34 , Issue.2 , pp. 214-220
    • Shi, J.1    Xue, W.2    Zhao, W.J.3    Li, K.X.4
  • 4
    • 40449126802 scopus 로고    scopus 로고
    • Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice
    • J Sun, X Song, and S Hu Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice Clin Vaccine Immunol 15 2 2008 303 307
    • (2008) Clin Vaccine Immunol , vol.15 , Issue.2 , pp. 303-307
    • Sun, J.1    Song, X.2    Hu, S.3
  • 5
    • 0029098678 scopus 로고
    • Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng
    • M Mochizuki, YC Yoo, K Matsuzawa, K Sato, I Saiki, and S Tono-Oka Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng Biol Pharm Bull 18 9 1995 1197 1202
    • (1995) Biol Pharm Bull , vol.18 , Issue.9 , pp. 1197-1202
    • Mochizuki, M.1    Yoo, Y.C.2    Matsuzawa, K.3    Sato, K.4    Saiki, I.5    Tono-Oka, S.6
  • 7
    • 25444483090 scopus 로고    scopus 로고
    • Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models
    • Y.W. Shin, and D.H. Kim Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models J Pharmacol Sci 99 1 2005 83 88
    • (2005) J Pharmacol Sci , vol.99 , Issue.1 , pp. 83-88
    • Shin, Y.W.1    Kim, D.H.2
  • 8
    • 84906938482 scopus 로고    scopus 로고
    • Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation
    • K. Kim, M. Park, Y.M. Lee, M.R. Rhyu, and H.Y. Kim Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation Arch Pharm Res 37 9 2014 1193 1200
    • (2014) Arch Pharm Res , vol.37 , Issue.9 , pp. 1193-1200
    • Kim, K.1    Park, M.2    Lee, Y.M.3    Rhyu, M.R.4    Kim, H.Y.5
  • 9
    • 33748639056 scopus 로고    scopus 로고
    • Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K
    • W Zhou, MQ Feng, JY Li, and P Zhou Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K J Asian Nat Prod Res 8 6 2006 519 527
    • (2006) J Asian Nat Prod Res , vol.8 , Issue.6 , pp. 519-527
    • Zhou, W.1    Feng, M.Q.2    Li, J.Y.3    Zhou, P.4
  • 10
    • 84875108087 scopus 로고    scopus 로고
    • Compound K, a ginsenoside metabolite, inhibits colon cancer growth via multiple pathways including p53-p21 interactions
    • Z Zhang, GJ Du, CZ Wang, XD Wen, T Calway, and Z Li Compound K, a ginsenoside metabolite, inhibits colon cancer growth via multiple pathways including p53-p21 interactions Int J Mol Sci 14 2 2013 2980 2995
    • (2013) Int J Mol Sci , vol.14 , Issue.2 , pp. 2980-2995
    • Zhang, Z.1    Du, G.J.2    Wang, C.Z.3    Wen, X.D.4    Calway, T.5    Li, Z.6
  • 11
    • 79959563146 scopus 로고    scopus 로고
    • Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-the key step of inflammation
    • EH Joh, IA Lee, IH Jung, and DH Kim Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-the key step of inflammation Biochem Pharmacol 82 3 2011 278 286
    • (2011) Biochem Pharmacol , vol.82 , Issue.3 , pp. 278-286
    • Joh, E.H.1    Lee, I.A.2    Jung, I.H.3    Kim, D.H.4
  • 12
    • 84918829210 scopus 로고    scopus 로고
    • Ginsenoside metabolite compound K alleviates adjuvant-induced arthritis by suppressing T cell activation
    • J Chen, H Wu, Q Wang, Y Chang, K Liu, and S Song Ginsenoside metabolite compound K alleviates adjuvant-induced arthritis by suppressing T cell activation Inflammation 37 5 2014 1608 1615
    • (2014) Inflammation , vol.37 , Issue.5 , pp. 1608-1615
    • Chen, J.1    Wu, H.2    Wang, Q.3    Chang, Y.4    Liu, K.5    Song, S.6
  • 13
    • 1542407770 scopus 로고    scopus 로고
    • Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin
    • S Kim, BY Kang, SY Cho, DS Sung, HK Chang, and MH Yeom Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin Biochem Biophys Res Commun 316 2 2004 348 355
    • (2004) Biochem Biophys Res Commun , vol.316 , Issue.2 , pp. 348-355
    • Kim, S.1    Kang, B.Y.2    Cho, S.Y.3    Sung, D.S.4    Chang, H.K.5    Yeom, M.H.6
  • 14
    • 26044454091 scopus 로고    scopus 로고
    • Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury
    • HU Lee, EA Bae, MJ Han, NJ Kim, and DH Kim Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury Liver Int 25 5 2005 1069 1073
    • (2005) Liver Int , vol.25 , Issue.5 , pp. 1069-1073
    • Lee, H.U.1    Bae, E.A.2    Han, M.J.3    Kim, N.J.4    Kim, D.H.5
  • 15
    • 85008072417 scopus 로고
    • Soil bacterial hydrolysis leading to genuine aglycone. V. on ginsenosides Rbl, Rb2 and Rc of theginseng root saponins
    • I Yosioka, T Sugawara, K Imai, and I Kitagawa Soil bacterial hydrolysis leading to genuine aglycone. V. On ginsenosides Rbl, Rb2 and Rc of theginseng root saponins Chem Pharm Bull (Tokyo) 20 11 1972 2418 2421
    • (1972) Chem Pharm Bull (Tokyo) , vol.20 , Issue.11 , pp. 2418-2421
    • Yosioka, I.1    Sugawara, T.2    Imai, K.3    Kitagawa, I.4
  • 16
    • 0025946582 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats
    • M Karikura, T Miyase, H Tanizawa, T Taniyama, and Y Takino Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats Chem Pharm Bull (Tokyo) 39 9 1991 2357 2361
    • (1991) Chem Pharm Bull (Tokyo) , vol.39 , Issue.9 , pp. 2357-2361
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Taniyama, T.4    Takino, Y.5
  • 17
    • 0025077096 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats
    • M Karikura, T Miyase, H Tanizawa, Y Takino, T Taniyama, and T Hayashi Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats Chem Pharm Bull (Tokyo) 38 10 1990 2859 2861
    • (1990) Chem Pharm Bull (Tokyo) , vol.38 , Issue.10 , pp. 2859-2861
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Takino, Y.4    Taniyama, T.5    Hayashi, T.6
  • 18
    • 0029840531 scopus 로고    scopus 로고
    • Main ginseng saponin metabolites formed by intestinal bacteria
    • H Hasegawa, JH Sung, S Matsumiya, and M Uchiyama Main ginseng saponin metabolites formed by intestinal bacteria Planta Med 62 5 1996 453 457
    • (1996) Planta Med , vol.62 , Issue.5 , pp. 453-457
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4
  • 19
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins
    • H. Hasegawa, J.H. Sung, and Y. Benno Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins Planta Med 63 5 1997 436 440
    • (1997) Planta Med , vol.63 , Issue.5 , pp. 436-440
    • Hasegawa, H.1    Sung, J.H.2    Benno, Y.3
  • 20
    • 85009708837 scopus 로고    scopus 로고
    • Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration-measurement of compound K by enzyme immunoassay
    • T. Akao, M. Kanaoka, and K. Kobashi Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration-measurement of compound K by enzyme immunoassay Biol Pharm Bull 21 3 1998 245 249
    • (1998) Biol Pharm Bull , vol.21 , Issue.3 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 21
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • T Akao, H Kida, M Kanaoka, M Hattori, and K Kobashi Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng J Pharm Pharmacol 50 10 1998 1155 1160
    • (1998) J Pharm Pharmacol , vol.50 , Issue.10 , pp. 1155-1160
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 22
    • 0031303557 scopus 로고    scopus 로고
    • In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration
    • C Wakabayashi, H Hasegawa, J Murata, and I Saiki In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration Oncol Res 9 8 1997 411 417
    • (1997) Oncol Res , vol.9 , Issue.8 , pp. 411-417
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4
  • 23
    • 0036594246 scopus 로고    scopus 로고
    • Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity
    • EA Bae, MK Choo, EK Park, SY Park, HY Shin, and D.H. Kim Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity Biol Pharm Bull 25 6 2002 743 747
    • (2002) Biol Pharm Bull , vol.25 , Issue.6 , pp. 743-747
    • Bae, E.A.1    Choo, M.K.2    Park, E.K.3    Park, S.Y.4    Shin, H.Y.5    Kim, D.H.6
  • 24
    • 0032577217 scopus 로고    scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells
    • C Wakabayashi, K Murakami, H Hasegawa, J Murata, and I Saiki An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells Biochem Biophys Res Commun 246 3 1998 725 730
    • (1998) Biochem Biophys Res Commun , vol.246 , Issue.3 , pp. 725-730
    • Wakabayashi, C.1    Murakami, K.2    Hasegawa, H.3    Murata, J.4    Saiki, I.5
  • 25
    • 0032782069 scopus 로고    scopus 로고
    • Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin
    • SJ Lee, JH Sung, SJ Lee, CK Moon, and BH Lee Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin Cancer Lett 144 1 1999 39 43
    • (1999) Cancer Lett , vol.144 , Issue.1 , pp. 39-43
    • Lee, S.J.1    Sung, J.H.2    Lee, S.J.3    Moon, C.K.4    Lee, B.H.5
  • 26
    • 33846953249 scopus 로고    scopus 로고
    • Purification and characterization of new special ginsenosidase hydrolyzing multi-glycisides of protopanaxadiol ginsenosides, ginsenosidase type i
    • H Yu, C Zhang, M Lu, F Sun, Y Fu, and F Jin Purification and characterization of new special ginsenosidase hydrolyzing multi-glycisides of protopanaxadiol ginsenosides, ginsenosidase type I Chem Pharm Bull (Tokyo) 55 2 2007 231 235
    • (2007) Chem Pharm Bull (Tokyo) , vol.55 , Issue.2 , pp. 231-235
    • Yu, H.1    Zhang, C.2    Lu, M.3    Sun, F.4    Fu, Y.5    Jin, F.6
  • 27
    • 26444489991 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect
    • E.A. Bae, JE Shin, and DH Kim Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect Biol Pharm Bull 28 10 2005 1903 1908
    • (2005) Biol Pharm Bull , vol.28 , Issue.10 , pp. 1903-1908
    • Bae, E.A.1    Shin, J.E.2    Kim, D.H.3
  • 28
    • 0034521401 scopus 로고    scopus 로고
    • Steaming of ginseng at high temperature enhances biological activity
    • WY Kim, JM Kim, SB Han, SK Lee, ND Kim, and MK Park Steaming of ginseng at high temperature enhances biological activity J Nat Prod 63 12 2000 1702 1704
    • (2000) J Nat Prod , vol.63 , Issue.12 , pp. 1702-1704
    • Kim, W.Y.1    Kim, J.M.2    Han, S.B.3    Lee, S.K.4    Kim, N.D.5    Park, M.K.6
  • 31
    • 0034536269 scopus 로고    scopus 로고
    • Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
    • EA Bae, SY Park, and DH Kim Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria Biol Pharm Bull 23 12 2000 1481 1485
    • (2000) Biol Pharm Bull , vol.23 , Issue.12 , pp. 1481-1485
    • Bae, E.A.1    Park, S.Y.2    Kim, D.H.3
  • 32
    • 53149152288 scopus 로고    scopus 로고
    • Purification and properties of a novel beta-glucosidase, hydrolyzing ginsenoside Rb1 to CK, from Paecilomyces bainier
    • Q Yan, XW Zhou, W Zhou, XW Li, MQ Feng, and P Zhou Purification and properties of a novel beta-glucosidase, hydrolyzing ginsenoside Rb1 to CK, from Paecilomyces bainier J Microbiol Biotechnol 18 6 2008 1081 1089
    • (2008) J Microbiol Biotechnol , vol.18 , Issue.6 , pp. 1081-1089
    • Yan, Q.1    Zhou, X.W.2    Zhou, W.3    Li, X.W.4    Feng, M.Q.5    Zhou, P.6
  • 33
    • 0034047551 scopus 로고    scopus 로고
    • Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng
    • YS Keum, KK Park, JM Lee, KS Chun, JH Park, and SK Lee Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng Cancer Lett 150 1 2000 41 48
    • (2000) Cancer Lett , vol.150 , Issue.1 , pp. 41-48
    • Keum, Y.S.1    Park, K.K.2    Lee, J.M.3    Chun, K.S.4    Park, J.H.5    Lee, S.K.6
  • 34
    • 67349263443 scopus 로고    scopus 로고
    • Highly selective biotransformation of ginsenoside Rb1 to Rd by the phytopathogenic fungus Cladosporium fulvum (syn. Fulvia fulva)
    • X Zhao, J Wang, J Li, L Fu, J Gao, J Gao, and X Du Highly selective biotransformation of ginsenoside Rb1 to Rd by the phytopathogenic fungus Cladosporium fulvum (syn. Fulvia fulva) J Ind Microbiol Biotechnol 36 5 2009 721 726
    • (2009) J Ind Microbiol Biotechnol , vol.36 , Issue.5 , pp. 721-726
    • Zhao, X.1    Wang, J.2    Li, J.3    Fu, L.4    Gao, J.5    Gao, J.6    Du, X.7
  • 35
    • 0035346143 scopus 로고    scopus 로고
    • Purification and characterization of ginsenoside Rb1-metabolizing beta-glucosidase from Fusobacterium K-60, a human intestinal anaerobic bacterium
    • SY Park, EA Bae, JH Sung, SK Lee, and DH Kim Purification and characterization of ginsenoside Rb1-metabolizing beta-glucosidase from Fusobacterium K-60, a human intestinal anaerobic bacterium Biosci Biotechnol Biochem 65 5 2001 1163 1169
    • (2001) Biosci Biotechnol Biochem , vol.65 , Issue.5 , pp. 1163-1169
    • Park, S.Y.1    Bae, E.A.2    Sung, J.H.3    Lee, S.K.4    Kim, D.H.5
  • 36
    • 77956563577 scopus 로고    scopus 로고
    • Identification and characterization of a novel Terrabacter ginsenosidimutans sp. Nov. Beta-glucosidase that transforms ginsenoside Rb1 into the rare gypenosides XVII and LXXV
    • DS An, CH Cui, HG Lee, L Wang, SC Kim, and ST Lee Identification and characterization of a novel Terrabacter ginsenosidimutans sp. nov. beta-glucosidase that transforms ginsenoside Rb1 into the rare gypenosides XVII and LXXV Appl Environ Microbiol 76 17 2010 5827 5836
    • (2010) Appl Environ Microbiol , vol.76 , Issue.17 , pp. 5827-5836
    • An, D.S.1    Cui, C.H.2    Lee, H.G.3    Wang, L.4    Kim, S.C.5    Lee, S.T.6
  • 37
    • 84859600258 scopus 로고    scopus 로고
    • Enzymatic biotransformation of ginsenoside Rb1 to compound K by recombinant beta-glucosidase from Microbacterium esteraromaticum
    • LH Quan, JW Min, Y Jin, C Wang, YJ Kim, and DC Yang Enzymatic biotransformation of ginsenoside Rb1 to compound K by recombinant beta-glucosidase from Microbacterium esteraromaticum J Agric Food Chem 60 14 2012 3776 3781
    • (2012) J Agric Food Chem , vol.60 , Issue.14 , pp. 3776-3781
    • Quan, L.H.1    Min, J.W.2    Jin, Y.3    Wang, C.4    Kim, Y.J.5    Yang, D.C.6
  • 38
    • 84893009884 scopus 로고    scopus 로고
    • Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3
    • KH Chang, MN Jo, KT Kim, and HD Paik Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3 J Ginseng Res 38 1 2014 47 51
    • (2014) J Ginseng Res , vol.38 , Issue.1 , pp. 47-51
    • Chang, K.H.1    Jo, M.N.2    Kim, K.T.3    Paik, H.D.4
  • 39
    • 65249087954 scopus 로고    scopus 로고
    • Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus
    • KH Noh, JW Son, HJ Kim, and DK Oh Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus Biosci Biotechnol Biochem 73 2 2009 316 321
    • (2009) Biosci Biotechnol Biochem , vol.73 , Issue.2 , pp. 316-321
    • Noh, K.H.1    Son, J.W.2    Kim, H.J.3    Oh, D.K.4
  • 40
    • 70350710163 scopus 로고    scopus 로고
    • Production of the rare ginsenosides compound K, compound Y, and compound Mc by a thermostable beta-glycosidase from Sulfolobus acidocaldarius
    • K.H. Noh, and D.K. Oh Production of the rare ginsenosides compound K, compound Y, and compound Mc by a thermostable beta-glycosidase from Sulfolobus acidocaldarius Biol Pharm Bull 32 11 2009 1830 1835
    • (2009) Biol Pharm Bull , vol.32 , Issue.11 , pp. 1830-1835
    • Noh, K.H.1    Oh, D.K.2
  • 41
    • 84867335350 scopus 로고    scopus 로고
    • Enzymatic transformation of the major ginsenoside Rb2 to minor compound y and compound K by a ginsenoside-hydrolyzing beta-glycosidase from Microbacterium esteraromaticum
    • LH Quan, Y Jin, C Wang, JW Min, YJ Kim, and DC Yang Enzymatic transformation of the major ginsenoside Rb2 to minor compound Y and compound K by a ginsenoside-hydrolyzing beta-glycosidase from Microbacterium esteraromaticum J Ind Microbiol Biotechnol 39 10 2012 1557 1562
    • (2012) J Ind Microbiol Biotechnol , vol.39 , Issue.10 , pp. 1557-1562
    • Quan, L.H.1    Jin, Y.2    Wang, C.3    Min, J.W.4    Kim, Y.J.5    Yang, D.C.6
  • 42
    • 79952532922 scopus 로고    scopus 로고
    • Production of aglycon protopanaxadiol via compound K by a thermostable beta-glycosidase from Pyrococcus furiosus
    • MH Yoo, SJ Yeom, CS Park, KW Lee, and DK Oh Production of aglycon protopanaxadiol via compound K by a thermostable beta-glycosidase from Pyrococcus furiosus Appl Microbiol Biotechnol 89 4 2011 1019 1028
    • (2011) Appl Microbiol Biotechnol , vol.89 , Issue.4 , pp. 1019-1028
    • Yoo, M.H.1    Yeom, S.J.2    Park, C.S.3    Lee, K.W.4    Oh, D.K.5
  • 43
    • 35648987941 scopus 로고    scopus 로고
    • Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method
    • SR Ko, Y Suzuki, K Suzuki, KJ Choi, and BG. Cho Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method Chem Pharm Bull (Tokyo) 55 10 2007 1522 1527
    • (2007) Chem Pharm Bull (Tokyo) , vol.55 , Issue.10 , pp. 1522-1527
    • Ko, S.R.1    Suzuki, Y.2    Suzuki, K.3    Choi, K.J.4    Cho, B.G.5
  • 45
    • 33745727082 scopus 로고    scopus 로고
    • Conversion of major ginsenoside Rb1 to ginsenoside F2 by Caulobacter leidyia
    • LQ, Cheng, MK Kim, JW Lee, YJ Lee, and DC Yang Conversion of major ginsenoside Rb1 to ginsenoside F2 by Caulobacter leidyia Biotechnol Lett 28 14 2006 1121 1127
    • (2006) Biotechnol Lett , vol.28 , Issue.14 , pp. 1121-1127
    • Cheng, L.1    Kim, M.K.2    Lee, J.W.3    Lee, Y.J.4    Yang, D.C.5
  • 46
    • 36749053972 scopus 로고    scopus 로고
    • Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng
    • Y Han, B Sun, X Hu, H Zhang, B Jiang, and MI Spranger Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng J Agric Food Chem 55 23 2007 9373 9379
    • (2007) J Agric Food Chem , vol.55 , Issue.23 , pp. 9373-9379
    • Han, Y.1    Sun, B.2    Hu, X.3    Zhang, H.4    Jiang, B.5    Spranger, M.I.6
  • 48
    • 84878111953 scopus 로고    scopus 로고
    • Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius
    • LH Quan, YJ Kim, GH Li, KT Choi, and DC Yang Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius World J Microbiol Biotechnol 29 6 2013 1001 1007
    • (2013) World J Microbiol Biotechnol , vol.29 , Issue.6 , pp. 1001-1007
    • Quan, L.H.1    Kim, Y.J.2    Li, G.H.3    Choi, K.T.4    Yang, D.C.5
  • 49
    • 84876909292 scopus 로고    scopus 로고
    • Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K
    • KA Kim, IH Jung, SH Park, YT Ahn, CS Huh, and DH. Kim Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K PLoS One 8 4 2013 e62409
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e62409
    • Kim, K.A.1    Jung, I.H.2    Park, S.H.3    Ahn, Y.T.4    Huh, C.S.5    Kim, D.H.6
  • 50
    • 39149144455 scopus 로고    scopus 로고
    • Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229
    • W Zhou, Q Yan, JY Li, XC Zhang, and P Zhou Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229 J Appl Microbiol 104 3 2008 699 706
    • (2008) J Appl Microbiol , vol.104 , Issue.3 , pp. 699-706
    • Zhou, W.1    Yan, Q.2    Li, J.Y.3    Zhang, X.C.4    Zhou, P.5
  • 51
    • 23944459284 scopus 로고    scopus 로고
    • Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms
    • H Chi, and G.E. Ji Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms Biotechnol Lett 27 11 2005 765 771
    • (2005) Biotechnol Lett , vol.27 , Issue.11 , pp. 765-771
    • Chi, H.1    Ji, G.E.2
  • 52
    • 80052458502 scopus 로고    scopus 로고
    • Screening of plant pathogenic fungi by ginsenoside compound K production
    • Y Yang, Y Wang, M Yan, C Sun, and P Zheng Screening of plant pathogenic fungi by ginsenoside compound K production Zhong guo Zhong Yao Za Zhi 36 12 2011 1596 1598
    • (2011) Zhong Guo Zhong Yao Za Zhi , vol.36 , Issue.12 , pp. 1596-1598
    • Yang, Y.1    Wang, Y.2    Yan, M.3    Sun, C.4    Zheng, P.5
  • 53
    • 27744444744 scopus 로고    scopus 로고
    • Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms
    • H Chi, DH Kim, and GE Ji Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms Biol Pharm Bull 28 11 2005 2102 2105
    • (2005) Biol Pharm Bull , vol.28 , Issue.11 , pp. 2102-2105
    • Chi, H.1    Kim, D.H.2    Ji, G.E.3
  • 54
    • 80053369117 scopus 로고    scopus 로고
    • Biotransformation of ginsenoside Rb1 to prosapogenins, gypenoside XVII, ginsenoside Rd, ginsenoside F2, and compound K by Leuconostoc mesenteroides DC102
    • LH Quan, JY Piao, JW Min, HB Kim, SR Kim, and DU Yang Biotransformation of ginsenoside Rb1 to prosapogenins, gypenoside XVII, ginsenoside Rd, ginsenoside F2, and compound K by Leuconostoc mesenteroides DC102 J Ginseng Res 35 3 2011 344 351
    • (2011) J Ginseng Res , vol.35 , Issue.3 , pp. 344-351
    • Quan, L.H.1    Piao, J.Y.2    Min, J.W.3    Kim, H.B.4    Kim, S.R.5    Yang, D.U.6
  • 55
    • 83455230662 scopus 로고    scopus 로고
    • Bioconversion of ginsenoside rb1 into compound k by Leuconostoc citreum LH1 isolated from kimchi
    • LH Quan, JY Piao, JW Min, DU Yang, HN Lee, and DC Yang Bioconversion of ginsenoside rb1 into compound k by Leuconostoc citreum LH1 isolated from kimchi Braz J Microbiol 42 3 2011 1227 1237
    • (2011) Braz J Microbiol , vol.42 , Issue.3 , pp. 1227-1237
    • Quan, L.H.1    Piao, J.Y.2    Min, J.W.3    Yang, D.U.4    Lee, H.N.5    Yang, D.C.6
  • 56
    • 84901857149 scopus 로고    scopus 로고
    • Production of bioactive ginsenoside compound K in metabolically engineered yeast
    • X Yan, Y Fan, W Wei, P Wang, Q Liu, and Y. Wei Production of bioactive ginsenoside compound K in metabolically engineered yeast Cell Res 24 6 2014 770 773
    • (2014) Cell Res , vol.24 , Issue.6 , pp. 770-773
    • Yan, X.1    Fan, Y.2    Wei, W.3    Wang, P.4    Liu, Q.5    Wei, Y.6
  • 57
    • 80052835896 scopus 로고    scopus 로고
    • Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-alpha-induced monocyte-endothelial trafficking
    • ES Lee, JS Choi, MS Kim, HJ You, GE Ji, and YH Kang Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-alpha-induced monocyte-endothelial trafficking Chem Biol Interact 194 1 2011 13 22
    • (2011) Chem Biol Interact , vol.194 , Issue.1 , pp. 13-22
    • Lee, E.S.1    Choi, J.S.2    Kim, M.S.3    You, H.J.4    Ji, G.E.5    Kang, Y.H.6
  • 58
    • 36048962905 scopus 로고    scopus 로고
    • Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice
    • SH Yoon, EJ Han, JH Sung, and SH Chung Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice Biol Pharm Bull 30 11 2007 2196 2200
    • (2007) Biol Pharm Bull , vol.30 , Issue.11 , pp. 2196-2200
    • Yoon, S.H.1    Han, E.J.2    Sung, J.H.3    Chung, S.H.4
  • 59
    • 85040682761 scopus 로고    scopus 로고
    • Anti-cancer effects of ginsenoside compound k on pediatric acute myeloid leukemia cells
    • Y Chen, Y Xu, Y Zhu, and X. Li Anti-cancer effects of ginsenoside compound k on pediatric acute myeloid leukemia cells Cancer Cell Int 13 1 2013 24
    • (2013) Cancer Cell Int , vol.13 , Issue.1 , pp. 24
    • Chen, Y.1    Xu, Y.2    Zhu, Y.3    Li, X.4
  • 60
    • 84861767051 scopus 로고    scopus 로고
    • Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer
    • CZ Wang, GJ Du, Z Zhang, XD Wen, T Calway, and Z Zhen Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer Int J Oncol 40 6 2012 1970 1976
    • (2012) Int J Oncol , vol.40 , Issue.6 , pp. 1970-1976
    • Wang, C.Z.1    Du, G.J.2    Zhang, Z.3    Wen, X.D.4    Calway, T.5    Zhen, Z.6
  • 61
    • 78650987480 scopus 로고    scopus 로고
    • Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells
    • IK Lee, KA Kang, CM Lim, KC Kim, HS Kim, and DH Kim Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells Int J Mol Sci 11 12 2010 4916 4931
    • (2010) Int J Mol Sci , vol.11 , Issue.12 , pp. 4916-4931
    • Lee, I.K.1    Kang, K.A.2    Lim, C.M.3    Kim, K.C.4    Kim, H.S.5    Kim, D.H.6
  • 62
    • 72449153399 scopus 로고    scopus 로고
    • Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells
    • DY Kim, MW Park, HD Yuan, HJ Lee, SH Kim, and SH Chung Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells J Agric Food Chem 57 22 2009 10573 10578
    • (2009) J Agric Food Chem , vol.57 , Issue.22 , pp. 10573-10578
    • Kim, D.Y.1    Park, M.W.2    Yuan, H.D.3    Lee, H.J.4    Kim, S.H.5    Chung, S.H.6
  • 63
    • 84897554978 scopus 로고    scopus 로고
    • Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor
    • CK Law, HH Kwok, PY Poon, CC Lau, ZH Jiang, and WC Tai Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor Chin Med 9 1 2014 11
    • (2014) Chin Med , vol.9 , Issue.1 , pp. 11
    • Law, C.K.1    Kwok, H.H.2    Poon, P.Y.3    Lau, C.C.4    Jiang, Z.H.5    Tai, W.C.6
  • 64
    • 67649865855 scopus 로고    scopus 로고
    • Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo
    • S Chae, KA Kang, WY Chang, MJ Kim, SJ Lee, and YS Lee Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo J Agric Food Chem 57 13 2009 5777 5782
    • (2009) J Agric Food Chem , vol.57 , Issue.13 , pp. 5777-5782
    • Chae, S.1    Kang, K.A.2    Chang, W.Y.3    Kim, M.J.4    Lee, S.J.5    Lee, Y.S.6
  • 65
    • 0842264760 scopus 로고    scopus 로고
    • A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage
    • S.H. Oh, and B.H. Lee A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage Toxicol Appl Pharmacol 194 3 2004 221 229
    • (2004) Toxicol Appl Pharmacol , vol.194 , Issue.3 , pp. 221-229
    • Oh, S.H.1    Lee, B.H.2
  • 66
    • 34447288092 scopus 로고    scopus 로고
    • Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells
    • YL Ming, G Song, LH Chen, ZZ Zheng, ZY Chen, and GL Ouyang Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells Cell Biol Int 31 10 2007 1265 1273
    • (2007) Cell Biol Int , vol.31 , Issue.10 , pp. 1265-1273
    • Ming, Y.L.1    Song, G.2    Chen, L.H.3    Zheng, Z.Z.4    Chen, Z.Y.5    Ouyang, G.L.6
  • 67
    • 84855174764 scopus 로고    scopus 로고
    • Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway
    • C Hu, G Song, B Zhang, Z Liu, R Chen, and H Zhang Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway J Cell Mol Med 16 1 2012 96 106
    • (2012) J Cell Mol Med , vol.16 , Issue.1 , pp. 96-106
    • Hu, C.1    Song, G.2    Zhang, B.3    Liu, Z.4    Chen, R.5    Zhang, H.6
  • 68
    • 24944471446 scopus 로고    scopus 로고
    • G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells
    • KA Kang, YW Kim, SU Kim, S Chae, YS Koh, and HS Kim G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells Arch Pharm Res 28 6 2005 685 690
    • (2005) Arch Pharm Res , vol.28 , Issue.6 , pp. 685-690
    • Kang, K.A.1    Kim, Y.W.2    Kim, S.U.3    Chae, S.4    Koh, Y.S.5    Kim, H.S.6
  • 70
    • 0025341039 scopus 로고
    • Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells
    • I Saiki, J Murata, M Nakajima, S Tokura, and I. Azuma Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells Cancer Res 50 12 1990 3631 3637
    • (1990) Cancer Res , vol.50 , Issue.12 , pp. 3631-3637
    • Saiki, I.1    Murata, J.2    Nakajima, M.3    Tokura, S.4    Azuma, I.5
  • 71
    • 79953027917 scopus 로고    scopus 로고
    • Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which is associated with the translocation of nuclear factor-kappaB p65 and reduction of matrix metalloproteinase-2/9
    • Y Ming, Z Chen, L Chen, D Lin, Q Tong, and Z Zheng Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which is associated with the translocation of nuclear factor-kappaB p65 and reduction of matrix metalloproteinase-2/9 Planta Med 77 5 2011 428 433
    • (2011) Planta Med , vol.77 , Issue.5 , pp. 428-433
    • Ming, Y.1    Chen, Z.2    Chen, L.3    Lin, D.4    Tong, Q.5    Zheng, Z.6
  • 72
    • 28844468779 scopus 로고    scopus 로고
    • Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells
    • SH Jung, MS Woo, SY Kim, WK Kim, JW Hyun, and EJ Kim Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells Int J Cancer 118 2 2006 490 497
    • (2006) Int J Cancer , vol.118 , Issue.2 , pp. 490-497
    • Jung, S.H.1    Woo, M.S.2    Kim, S.Y.3    Kim, W.K.4    Hyun, J.W.5    Kim, E.J.6
  • 73
    • 21144444049 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide
    • EK Park, YW Shin, HU Lee, SS Kim, YC Lee, and BY Lee Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide Biol Pharm Bull 28 4 2005 652 656
    • (2005) Biol Pharm Bull , vol.28 , Issue.4 , pp. 652-656
    • Park, E.K.1    Shin, Y.W.2    Lee, H.U.3    Kim, S.S.4    Lee, Y.C.5    Lee, B.Y.6
  • 74
    • 54049137982 scopus 로고    scopus 로고
    • The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock
    • CS Yang, SR Ko, BG Cho, DM Shin, JM Yuk, and S Li The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock J Cell Mol Med 12 5A 2008 1739 1753
    • (2008) J Cell Mol Med , vol.12 , pp. 1739-1753
    • Yang, C.S.1    Ko, S.R.2    Cho, B.G.3    Shin, D.M.4    Yuk, J.M.5    Li, S.6
  • 75
    • 70349757163 scopus 로고    scopus 로고
    • Glucocorticoid receptor agonist compound K regulates Dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species
    • TT Cuong, CS Yang, JM Yuk, HM Lee, SR Ko, and BG Cho Glucocorticoid receptor agonist compound K regulates Dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species Life Sci 85 17-18 2009 625 633
    • (2009) Life Sci , vol.85 , Issue.1718 , pp. 625-633
    • Cuong, T.T.1    Yang, C.S.2    Yuk, J.M.3    Lee, H.M.4    Ko, S.R.5    Cho, B.G.6
  • 76
    • 84863388195 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice
    • JS Park, JA Shin, JS Jung, JW Hyun, TK Van Le, and DH Kim Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice J Pharmacol Exp Ther 341 1 2012 59 67
    • (2012) J Pharmacol Exp Ther , vol.341 , Issue.1 , pp. 59-67
    • Park, J.S.1    Shin, J.A.2    Jung, J.S.3    Hyun, J.W.4    Van Le, T.K.5    Kim, D.H.6
  • 77
    • 13844280922 scopus 로고    scopus 로고
    • Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin
    • JY Lee, JW Shin, KS Chun, KK Park, WY Chung, and YJ Bang Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin Carcinogenesis 26 2 2005 359 367
    • (2005) Carcinogenesis , vol.26 , Issue.2 , pp. 359-367
    • Lee, J.Y.1    Shin, J.W.2    Chun, K.S.3    Park, K.K.4    Chung, W.Y.5    Bang, Y.J.6
  • 78
    • 84895195545 scopus 로고    scopus 로고
    • Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-kappaB activation
    • J Li, W Zhong, W Wang, S Hu, J Yuan, and B Zhang Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-kappaB activation PLoS One 9 2 2014 e87810
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e87810
    • Li, J.1    Zhong, W.2    Wang, W.3    Hu, S.4    Yuan, J.5    Zhang, B.6
  • 79
    • 0038163804 scopus 로고    scopus 로고
    • Antiallergic activity of ginseng and its ginsenosides
    • MK Choo, EK Park, MJ Han, and DH Kim Antiallergic activity of ginseng and its ginsenosides Planta Med 69 6 2003 518 522
    • (2003) Planta Med , vol.69 , Issue.6 , pp. 518-522
    • Choo, M.K.1    Park, E.K.2    Han, M.J.3    Kim, D.H.4
  • 80
    • 84897908069 scopus 로고    scopus 로고
    • Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis rats
    • H Wu, J Chen, Q Wang, X Jia, S Song, and P Yuan Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis rats Immunopharmacol Immunotoxicol 36 2 2014 124 129
    • (2014) Immunopharmacol Immunotoxicol , vol.36 , Issue.2 , pp. 124-129
    • Wu, H.1    Chen, J.2    Wang, Q.3    Jia, X.4    Song, S.5    Yuan, P.6
  • 81
    • 84927713785 scopus 로고    scopus 로고
    • Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis
    • KK Liu, QT Wang, SM Yang, JY Chen, HX Wu, and W Wei Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis Acta Pharmacol Sin 35 5 2014 599 612
    • (2014) Acta Pharmacol Sin , vol.35 , Issue.5 , pp. 599-612
    • Liu, K.K.1    Wang, Q.T.2    Yang, S.M.3    Chen, J.Y.4    Wu, H.X.5    Wei, W.6
  • 82
    • 84880917448 scopus 로고    scopus 로고
    • Joint-protective effects of compound K, a major ginsenoside metabolite, in rheumatoid arthritis: In vitro evidence
    • YS Choi, EH Kang, EY Lee, HS Gong, HS Kang, and K Shin Joint-protective effects of compound K, a major ginsenoside metabolite, in rheumatoid arthritis: in vitro evidence Rheumatol Int 33 8 2013 1981 1990
    • (2013) Rheumatol Int , vol.33 , Issue.8 , pp. 1981-1990
    • Choi, Y.S.1    Kang, E.H.2    Lee, E.Y.3    Gong, H.S.4    Kang, H.S.5    Shin, K.6
  • 83
    • 38049083706 scopus 로고    scopus 로고
    • Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice
    • GC Han, SK Ko, JH Sung, and SH Chung Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice J Agric Food Chem 55 26 2007 10641 10648
    • (2007) J Agric Food Chem , vol.55 , Issue.26 , pp. 10641-10648
    • Han, G.C.1    Ko, S.K.2    Sung, J.H.3    Chung, S.H.4
  • 84
    • 77952648583 scopus 로고    scopus 로고
    • Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3 T3-L1 adipocytes
    • YC Huang, CY Lin, SF Huang, HC Lin, WL Chang, and TC Chang Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3 T3-L1 adipocytes J Agric Food Chem 58 10 2010 6039 6047
    • (2010) J Agric Food Chem , vol.58 , Issue.10 , pp. 6039-6047
    • Huang, Y.C.1    Lin, C.Y.2    Huang, S.F.3    Lin, H.C.4    Chang, W.L.5    Chang, T.C.6
  • 85
    • 64549086074 scopus 로고    scopus 로고
    • Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells
    • DY Kim, HD Yuan, IK Chung, and SH Chung Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells J Agric Food Chem 57 4 2009 1532 1537
    • (2009) J Agric Food Chem , vol.57 , Issue.4 , pp. 1532-1537
    • Kim, D.Y.1    Yuan, H.D.2    Chung, I.K.3    Chung, S.H.4
  • 86
    • 83055168498 scopus 로고    scopus 로고
    • Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis
    • W Li, M Zhang, J Gu, ZJ Meng, LC Zhao, and YN Zheng Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis Fitoterapia 83 1 2012 192 198
    • (2012) Fitoterapia , vol.83 , Issue.1 , pp. 192-198
    • Li, W.1    Zhang, M.2    Gu, J.3    Meng, Z.J.4    Zhao, L.C.5    Zheng, Y.N.6
  • 87
    • 78649904999 scopus 로고    scopus 로고
    • Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways
    • HD Yuan, SJ Kim, and SH Chung Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways Metabolism 60 1 2011 43 51
    • (2011) Metabolism , vol.60 , Issue.1 , pp. 43-51
    • Yuan, H.D.1    Kim, S.J.2    Chung, S.H.3
  • 88
    • 77951929835 scopus 로고    scopus 로고
    • Compound K protects MIN6N8 pancreatic beta-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation
    • K. Kim, DH Kim, and HY Kim Compound K protects MIN6N8 pancreatic beta-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation Cell Biol Int 34 1 2010 75 80
    • (2010) Cell Biol Int , vol.34 , Issue.1 , pp. 75-80
    • Kim, K.1    Kim, D.H.2    Kim, H.Y.3
  • 89
    • 77953160144 scopus 로고    scopus 로고
    • Minireview: Update on incretin biology: Focus on glucagon-like peptide-1
    • PL Brubaker Minireview: update on incretin biology: focus on glucagon-like peptide-1 Endocrinology 151 5 2010 1984 1989
    • (2010) Endocrinology , vol.151 , Issue.5 , pp. 1984-1989
    • Brubaker, P.L.1
  • 91
    • 84879148677 scopus 로고    scopus 로고
    • Compound K is able to ameliorate the impaired cognitive function and hippocampal neurogenesis following chemotherapy treatment
    • JG Hou, JJ Xue, MR Lee, MQ Sun, XH Zhao, and YN Zheng Compound K is able to ameliorate the impaired cognitive function and hippocampal neurogenesis following chemotherapy treatment Biochem Biophys Res Commun 436 1 2013 104 109
    • (2013) Biochem Biophys Res Commun , vol.436 , Issue.1 , pp. 104-109
    • Hou, J.G.1    Xue, J.J.2    Lee, M.R.3    Sun, M.Q.4    Zhao, X.H.5    Zheng, Y.N.6
  • 92
    • 79961168468 scopus 로고    scopus 로고
    • Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: Participation of 5-HT2A receptors
    • N. Yamada, H. Araki, and H. Yoshimura Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors Psychopharmacology (Berl) 216 4 2011 589 599
    • (2011) Psychopharmacology (Berl) , vol.216 , Issue.4 , pp. 589-599
    • Yamada, N.1    Araki, H.2    Yoshimura, H.3
  • 93
    • 64549126462 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of ginseng saponins in activated microglia
    • JS Park, EM Park, DH Kim, K Jung, JS Jung, and EJ Lee Anti-inflammatory mechanism of ginseng saponins in activated microglia J Neuroimmunol 209 1-2 2009 40 49
    • (2009) J Neuroimmunol , vol.209 , Issue.12 , pp. 40-49
    • Park, J.S.1    Park, E.M.2    Kim, D.H.3    Jung, K.4    Jung, J.S.5    Lee, E.J.6
  • 94
    • 34250161282 scopus 로고    scopus 로고
    • Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells
    • K Choi, M Kim, J Ryu, and C. Choi Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells Neurosci Lett 421 1 2007 37 41
    • (2007) Neurosci Lett , vol.421 , Issue.1 , pp. 37-41
    • Choi, K.1    Kim, M.2    Ryu, J.3    Choi, C.4
  • 95
    • 77954740466 scopus 로고    scopus 로고
    • Compound K, a metabolite of ginsenosides, facilitates spontaneous GABA release onto CA3 pyramidal neurons
    • MY Bae, JH Cho, IS Choi, HM Park, MG Lee, and DH Kim Compound K, a metabolite of ginsenosides, facilitates spontaneous GABA release onto CA3 pyramidal neurons J Neurochem 114 4 2010 1085 1096
    • (2010) J Neurochem , vol.114 , Issue.4 , pp. 1085-1096
    • Bae, M.Y.1    Cho, J.H.2    Choi, I.S.3    Park, H.M.4    Lee, M.G.5    Kim, D.H.6
  • 96
    • 11144285485 scopus 로고    scopus 로고
    • Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of transformed ginsenosides
    • S Jang, JH Ryu, DH Kim, and S. Oh Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of transformed ginsenosides Neurochem Res 29 12 2004 2257 2266
    • (2004) Neurochem Res , vol.29 , Issue.12 , pp. 2257-2266
    • Jang, S.1    Ryu, J.H.2    Kim, D.H.3    Oh, S.4
  • 97
    • 84877999430 scopus 로고    scopus 로고
    • Inhibitory effects of ginsenoside metabolites, compound K and protopanaxatriol, on GABAC receptor-mediated ion currents
    • BH Lee, SH Hwang, SH Choi, HJ Kim, JH Lee, and SM Lee Inhibitory effects of ginsenoside metabolites, compound K and protopanaxatriol, on GABAC receptor-mediated ion currents Korean J Physiol Pharmacol 17 2 2013 127 132
    • (2013) Korean J Physiol Pharmacol , vol.17 , Issue.2 , pp. 127-132
    • Lee, B.H.1    Hwang, S.H.2    Choi, S.H.3    Kim, H.J.4    Lee, J.H.5    Lee, S.M.6
  • 98
    • 77953380246 scopus 로고    scopus 로고
    • Compound K inhibits basic fibroblast growth factor-induced angiogenesis via regulation of p38 mitogen activated protein kinase and AKT in human umbilical vein endothelial cells
    • A Jeong, HJ Lee, SJ Jeong, HJ Lee, EO Lee, and H Bae Compound K inhibits basic fibroblast growth factor-induced angiogenesis via regulation of p38 mitogen activated protein kinase and AKT in human umbilical vein endothelial cells Biol Pharm Bull 33 6 2010 945 950
    • (2010) Biol Pharm Bull , vol.33 , Issue.6 , pp. 945-950
    • Jeong, A.1    Lee, H.J.2    Jeong, S.J.3    Lee, H.J.4    Lee, E.O.5    Bae, H.6
  • 99
    • 84906936242 scopus 로고    scopus 로고
    • Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells
    • KO Shin, CH Seo, HH Cho, S Oh, SP Hong, and HS Yoo Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells Arch Pharm Res 37 9 2014 1183 1192
    • (2014) Arch Pharm Res , vol.37 , Issue.9 , pp. 1183-1192
    • Shin, K.O.1    Seo, C.H.2    Cho, H.H.3    Oh, S.4    Hong, S.P.5    Yoo, H.S.6
  • 100
    • 84861705073 scopus 로고    scopus 로고
    • Compound K, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3 T3-L1 cells: Involvement of angiogenesis and MMPs
    • D Park, and M. Yoon Compound K, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3 T3-L1 cells: involvement of angiogenesis and MMPs Biochem Biophys Res Commun 422 2 2012 263 267
    • (2012) Biochem Biophys Res Commun , vol.422 , Issue.2 , pp. 263-267
    • Park, D.1    Yoon, M.2
  • 101
    • 79955616811 scopus 로고    scopus 로고
    • Compound K increases type i procollagen level and decreases matrix metalloproteinase-1 activity and level in ultraviolet-A-irradiated fibroblasts
    • D He, J Sun, X Zhu, S Nian, and J Liu Compound K increases type I procollagen level and decreases matrix metalloproteinase-1 activity and level in ultraviolet-A-irradiated fibroblasts J Formos Med Assoc 110 3 2011 153 160
    • (2011) J Formos Med Assoc , vol.110 , Issue.3 , pp. 153-160
    • He, D.1    Sun, J.2    Zhu, X.3    Nian, S.4    Liu, J.5


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