메뉴 건너뛰기




Volumn 35, Issue 5, 2014, Pages 599-612

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

Author keywords

arthritis; CD28; cytokine; cytotoxic T lymphocyteassociated antigen 4; ginseng; ginsenoside compound K; immunoregulator; programmed death 1; T lymphocyte

Indexed keywords

ANTIRHEUMATIC AGENT; CD28 ANTIGEN; COLLAGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GINSENOSIDE; GINSENOSIDE COMPOUND K; IMMUNOMODULATING AGENT; INTERLEUKIN 4; METHOTREXATE; PROGRAMMED DEATH 1 LIGAND 1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CD3 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PDCD1 PROTEIN, MOUSE; PROGRAMMED DEATH 1 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84927713785     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.5     Document Type: Article
Times cited : (44)

References (49)
  • 1
    • 60549116190 scopus 로고    scopus 로고
    • Developments in the clinical understanding of rheumatoid arthritis
    • Smolen JS, Aletaha D. Developments in the clinical understanding of rheumatoid arthritis. Arthritis Res Ther 2009; 11: 204
    • (2009) Arthritis Res Ther , vol.11 , pp. 204
    • Smolen, J.S.1    Aletaha, D.2
  • 3
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007; 7: 429-42
    • (2007) Nat Rev Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 5
    • 84887189070 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Metabolic reprogramming of T cells in RA
    • Leah E. Rheumatoid arthritis: Metabolic reprogramming of T cells in RA. Nat Rev Rheumatol 2013; 9: 635
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 635
    • Leah, E.1
  • 7
    • 70350743827 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention
    • Kaufmann DE, Walker BD. PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. J Immunol 2009; 182: 5891-7
    • (2009) J Immunol , vol.182 , pp. 5891-5897
    • Kaufmann, D.E.1    Walker, B.D.2
  • 8
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol 2013; 13: 227-42
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 9
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004; 4: 336-47
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 11
    • 84875419278 scopus 로고    scopus 로고
    • T cell receptor signalling networks: Branched, diversified and bounded
    • Brownlie RJ, Zamoyska R. T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol 2013; 13: 257-69
    • (2013) Nat Rev Immunol , vol.13 , pp. 257-269
    • Brownlie, R.J.1    Zamoyska, R.2
  • 13
    • 84898455377 scopus 로고    scopus 로고
    • In vitro generation of mature, naive antigenspecific CD8+ T cells with single T cell receptor by agonist selection
    • Oct 4
    • Snauwaert S, Verstichel G, Bonte S, Goetgeluk G, Vanhee S, Van Caeneghem Y, et al. In vitro generation of mature, naive antigenspecific CD8+ T cells with single T cell receptor by agonist selection. Leukemia 2013 Oct 4. doi: 10.1038/leu.2013.285
    • (2013) Leukemia
    • Snauwaert, S.1    Verstichel, G.2    Bonte, S.3    Goetgeluk, G.4    Vanhee, S.5    Van Caeneghem, Y.6
  • 14
    • 84885843997 scopus 로고    scopus 로고
    • A DNA vaccine against cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) prevents tumor growth
    • Lan KH, Liu YC, Shih YS, Tsaid CL, Yen SH, Lan KL. A DNA vaccine against cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) prevents tumor growth. Biochem Biophys Res Commun 2013; 440: 222-8
    • (2013) Biochem Biophys Res Commun , vol.440 , pp. 222-228
    • Lan, K.H.1    Liu, Y.C.2    Shih, Y.S.3    Tsaid, C.L.4    Yen, S.H.5    Lan, K.L.6
  • 15
    • 84887355083 scopus 로고    scopus 로고
    • Yin and Yang of ginseng pharmacology: Ginsenosides vs gintonin
    • Im DS, Nah SY. Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin. Acta Pharmacol Sin 2013; 34: 1367-73
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 1367-1373
    • Im, D.S.1    Nah, S.Y.2
  • 16
    • 84867680830 scopus 로고    scopus 로고
    • Ginsenoside Rp1 exerts antiinflammatory effects via activation of dendritic cells and regulatory T cells
    • Bae J, Koo J, Kim S, Park TY, Kim MY. Ginsenoside Rp1 exerts antiinflammatory effects via activation of dendritic cells and regulatory T cells. J Ginseng Res 2012; 36: 375-82
    • (2012) J Ginseng Res , vol.36 , pp. 375-382
    • Bae, J.1    Koo, J.2    Kim, S.3    Park, T.Y.4    Kim, M.Y.5
  • 17
    • 84873549615 scopus 로고    scopus 로고
    • Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats
    • Shi J, Xue W, Zhao WJ, Li KX. Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats. Acta Pharmacol Sin 2013; 34: 214-20
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 214-220
    • Shi, J.1    Xue, W.2    Zhao, W.J.3    Li, K.X.4
  • 18
    • 0029098678 scopus 로고
    • Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)-And 20(S)-ginsenoside-Rg3 of red ginseng
    • Mochizuki M, Yoo YC, Matsuzawa K, SatoK, Saiki I, Tono-oka S, Samukawa K, et al. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)-And 20(S)-ginsenoside-Rg3 of red ginseng. Biol Pharm Bull 1995; 18: 1197-202
    • (1995) Biol Pharm Bull , vol.18 , pp. 1197-1202
    • Mochizuki, M.1    Yoo, Y.C.2    Matsuzawa, K.3    Satok Saiki, I.4    Tono-Oka, S.5    Samukawa, K.6
  • 19
    • 40449126802 scopus 로고    scopus 로고
    • Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice
    • Sun J, Song X, Hu S. Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin Vaccine Immunol 2008; 15: 303-7
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 303-307
    • Sun, J.1    Song, X.2    Hu, S.3
  • 20
    • 84872247255 scopus 로고    scopus 로고
    • Development and validation of an LC-MS/MS method for determination of compound K in human plasma and clinical application
    • Kim JS, Kim Y, Han SH, Jeon JY, Hwang M, Im YJ, et al. Development and validation of an LC-MS/MS method for determination of compound K in human plasma and clinical application. J Ginseng Res 2013; 37: 135-41
    • (2013) J Ginseng Res , vol.37 , pp. 135-141
    • Kim, J.S.1    Kim, Y.2    Han, S.H.3    Jeon, J.Y.4    Hwang, M.5    Im, Y.J.6
  • 21
    • 83455230662 scopus 로고    scopus 로고
    • Bioconversion of ginsenoside Rb1 into compound K by Leuconostoccitreum LH1 isolated from kimchi
    • Quan LH, Piao JY, Min JW, Yang DU, Lee HN, Yang DC. Bioconversion of ginsenoside Rb1 into compound K by Leuconostoccitreum LH1 isolated from kimchi. Braz J Microbiol 2011; 42: 1227-37
    • (2011) Braz J Microbiol , vol.42 , pp. 1227-1237
    • Quan, L.H.1    Piao, J.Y.2    Min, J.W.3    Yang, D.U.4    Lee, H.N.5    Yang, D.C.6
  • 22
    • 74549165964 scopus 로고    scopus 로고
    • Compound K a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells
    • Cho SH, Chung KS, Choi JH, Kim DH, Lee KT. Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells. BMC Cancer 2009; 9: 449
    • (2009) BMC Cancer , vol.9 , pp. 449
    • Cho, S.H.1    Chung, K.S.2    Choi, J.H.3    Kim, D.H.4    Lee, K.T.5
  • 23
    • 51349106992 scopus 로고    scopus 로고
    • Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer
    • Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008; 29: 1109-18
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1109-1118
    • Choi, K.T.1
  • 24
    • 40249098050 scopus 로고    scopus 로고
    • A ginseng saponin metabolite suppresses tumor necrosis factor-promoted metastasis by suppressing nuclear factor-B signaling in murine colon cancer cells
    • Choo MK, Sakurai H, Kim DH, Saiki I. A ginseng saponin metabolite suppresses tumor necrosis factor-promoted metastasis by suppressing nuclear factor-B signaling in murine colon cancer cells. Oncol Rep 2008; 19: 595-600
    • (2008) Oncol Rep , vol.19 , pp. 595-600
    • Choo, M.K.1    Sakurai, H.2    Kim, D.H.3    Saiki, I.4
  • 25
    • 64549086074 scopus 로고    scopus 로고
    • Compound K intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells
    • Kim DY, Yuan HD, Chung IK, Chung SH. Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells. J Agric Food Chem 2009; 57: 1532-7
    • (2009) J Agric Food Chem , vol.57 , pp. 1532-1537
    • Kim, D.Y.1    Yuan, H.D.2    Chung, I.K.3    Chung, S.H.4
  • 26
    • 0017657009 scopus 로고
    • Autoimmunity to type II collagen an experimental model of arthritis
    • Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 1977; 146: 857-68
    • (1977) J Exp Med , vol.146 , pp. 857-868
    • Trentham, D.E.1    Townes, A.S.2    Kang, A.H.3
  • 28
    • 84868007895 scopus 로고    scopus 로고
    • Combined use of etanercept and MTX restores CD4+/CD8+ ratio and Tregs in spleen and thymus in collagen-induced arthritis
    • Huang B, Wang QT, Song SS, Wu YJ, Ma YK, Zhang LL, et al. Combined use of etanercept and MTX restores CD4+/CD8+ ratio and Tregs in spleen and thymus in collagen-induced arthritis. Inflamm Res 2012; 61: 1229-39
    • (2012) Inflamm Res , vol.61 , pp. 1229-1239
    • Huang, B.1    Wang, Q.T.2    Song, S.S.3    Wu, Y.J.4    Ma, Y.K.5    Zhang, L.L.6
  • 29
    • 77953364242 scopus 로고    scopus 로고
    • Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collageninduced arthritis
    • Tong T, Zhao W, Wu YQ, Chang Y, Wang QT, Zhang LL, et al. Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collageninduced arthritis. Inflamm Res 2010; 59: 369-77
    • (2010) Inflamm Res , vol.59 , pp. 369-377
    • Tong, T.1    Zhao, W.2    Wu, Y.Q.3    Chang, Y.4    Wang, Q.T.5    Zhang, L.L.6
  • 30
    • 84872299740 scopus 로고    scopus 로고
    • Etanercept attenuates collagen-induced arthritis by modulating the association between BAFFR expression and the production of splenic memory B cells
    • Wang QT, Wu YJ, Huang B, Ma YK, Song SS, Zhang LL, et al. Etanercept attenuates collagen-induced arthritis by modulating the association between BAFFR expression and the production of splenic memory B cells. Pharmacol Res 2013; 68: 38-45
    • (2013) Pharmacol Res , vol.68 , pp. 38-45
    • Wang, Q.T.1    Wu, Y.J.2    Huang, B.3    Ma, Y.K.4    Song, S.S.5    Zhang, L.L.6
  • 31
    • 84860338292 scopus 로고    scopus 로고
    • Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL30
    • DibraD, CutreraJJ, Li S. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL30. J Immunol 2012; 188: 3709-15
    • (2012) J Immunol , vol.188 , pp. 3709-3715
    • Cutrerajj, D.1    Li, S.2
  • 32
    • 84862811832 scopus 로고    scopus 로고
    • Expression and function of-Arrestin 2 stimulated by IL-1 in human fibroblastlike synoviocytes and the effect of paeoniflorin
    • Wu HX, Chen JY, Wang QT, Sun WY, Liu LH, Zhang LL, et al. Expression and function of-Arrestin 2 stimulated by IL-1? in human fibroblastlike synoviocytes and the effect of paeoniflorin. Int Immunopharmacol 2012; 12: 701-6
    • (2012) Int Immunopharmacol , vol.12 , pp. 701-706
    • Wu, H.X.1    Chen, J.Y.2    Wang, Q.T.3    Sun, W.Y.4    Liu, L.H.5    Zhang, L.L.6
  • 33
    • 82455192382 scopus 로고    scopus 로고
    • Effect of rhTACI-Ig fusion protein on antigen-specific T cell responses from keyhole limpet haemocyanin challenged mice
    • Wang QT, Ma YK, Huang B, Liu DD, Wei W. Effect of rhTACI-Ig fusion protein on antigen-specific T cell responses from keyhole limpet haemocyanin challenged mice. Mol Immunol 2011; 49: 380-6
    • (2011) Mol Immunol , vol.49 , pp. 380-386
    • Wang, Q.T.1    Ma, Y.K.2    Huang, B.3    Liu, D.D.4    Wei, W.5
  • 34
    • 84858695978 scopus 로고    scopus 로고
    • T-cell receptor signaling and the pathogenesis of autoimmune arthritis: Insights from mouse and man
    • Sakaguchi S, Benham H, Cope AP, Thomas R. T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. Immunol Cell Biol 2012; 90: 277-87
    • (2012) Immunol Cell Biol , vol.90 , pp. 277-287
    • Sakaguchi, S.1    Benham, H.2    Cope, A.P.3    Thomas, R.4
  • 35
    • 78651407340 scopus 로고    scopus 로고
    • The expression change of-Arrestins in fibroblast-like synoviocytes from rats with collageninduced arthritis and the effect of total glucosides of paeony
    • Wang QT, Zhang LL, Wu HX, Wei W. The expression change of-Arrestins in fibroblast-like synoviocytes from rats with collageninduced arthritis and the effect of total glucosides of paeony. J Ethnopharmacol 2011; 133: 511-6
    • (2011) J Ethnopharmacol , vol.133 , pp. 511-516
    • Wang, Q.T.1    Zhang, L.L.2    Wu, H.X.3    Wei, W.4
  • 38
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007; 7: 429-42
    • (2007) Nat Rev Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 39
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF? Therapy
    • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF? therapy. J Exp Med 2004; 200: 277-85
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 40
    • 10744231155 scopus 로고    scopus 로고
    • Ginsenoside Rg1 enhances CD4+ T-cell activities and modulates Th1/Th2 differentiation
    • Lee EJ, Ko E, Lee J, Pho S, Ko S, Shin MK, et al. Ginsenoside Rg1 enhances CD4+ T-cell activities and modulates Th1/Th2 differentiation. Int Immunopharmacol 2004; 4: 235-44
    • (2004) Int Immunopharmacol , vol.4 , pp. 235-244
    • Lee, E.J.1    Ko, E.2    Lee, J.3    Pho, S.4    Ko, S.5    Shin, M.K.6
  • 41
    • 19544386842 scopus 로고    scopus 로고
    • Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis
    • Shin YW, Bae EA, Kim SS, Lee YC, Kim DH. Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. Int Immunopharmacol 2005; 5: 1183-91
    • (2005) Int Immunopharmacol , vol.5 , pp. 1183-1191
    • Shin, Y.W.1    Bae, E.A.2    Kim, S.S.3    Lee, Y.C.4    Kim, D.H.5
  • 42
    • 33947431324 scopus 로고    scopus 로고
    • Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-Adrenergic receptor desensitization in rats with adjuvant arthritis
    • Wu H, Wei W, Song L, Zhang L, Chen Y, Hu X. Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-Adrenergic receptor desensitization in rats with adjuvant arthritis. Int Immunopharmacol 2007; 7: 662-73
    • (2007) Int Immunopharmacol , vol.7 , pp. 662-673
    • Wu, H.1    Wei, W.2    Song, L.3    Zhang, L.4    Chen, Y.5    Hu, X.6
  • 43
    • 64849107635 scopus 로고    scopus 로고
    • Neonatal bacillus Calmette-Guerin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells
    • Li Q, Shen HH. Neonatal bacillus Calmette-Guerin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells. Acta Pharmacol Sin 2009; 30: 125-33
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 125-133
    • Li, Q.1    Shen, H.H.2
  • 45
    • 0032951538 scopus 로고    scopus 로고
    • Production of cytokines and metalloproteinases in rheumatoid synovitis is T cell dependent
    • Klimiuk PA, Yang H, Goronzy JJ, Weyand CM. Production of cytokines and metalloproteinases in rheumatoid synovitis is T cell dependent. Clin Immunol 1999; 90: 65-78
    • (1999) Clin Immunol , vol.90 , pp. 65-78
    • Klimiuk, P.A.1    Yang, H.2    Goronzy, J.J.3    Weyand, C.M.4
  • 46
    • 84875419278 scopus 로고    scopus 로고
    • T cell receptor signalling networks: Branched, diversified and bounded
    • Brownlie RJ, Zamoyska R. T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol 2013; 13: 257-69
    • (2013) Nat Rev Immunol , vol.13 , pp. 257-269
    • Brownlie, R.J.1    Zamoyska, R.2
  • 47
    • 42449155034 scopus 로고    scopus 로고
    • Viral modulation of T-cell receptor signaling
    • Jerome KR. Viral modulation of T-cell receptor signaling. J Virol 2008; 82: 4194-204
    • (2008) J Virol , vol.82 , pp. 4194-4204
    • Jerome, K.R.1
  • 48
    • 11144230063 scopus 로고    scopus 로고
    • The CD28 family: A T-cell rheostat for therapeutic control of T-cell activation
    • Riley JL, June CH. The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. Blood 2005; 105: 13-21
    • (2005) Blood , vol.105 , pp. 13-21
    • Riley, J.L.1    June, C.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.