메뉴 건너뛰기




Volumn 57, Issue 4, 2009, Pages 1532-1537

Compound k, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK Activation in human hepatoma cells

Author keywords

ACC; AMPK; Compound K; Diabetes; Hepg2 hepatoma cells; Hyperlipidemia; PPAR R; SREBP1c

Indexed keywords

GINSENOSIDE; GINSENOSIDE M1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

EID: 64549086074     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf802867b     Document Type: Article
Times cited : (103)

References (20)
  • 2
    • 0038199737 scopus 로고    scopus 로고
    • Management of cellular energy by the AMP-activated protein kinase system
    • Hardie, D. G; Scott, J. W.; Pan, D. A.; Hudson, E. R. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 2003, 546, 113-120.
    • (2003) FEBS Lett , vol.546 , pp. 113-120
    • Hardie, D.G.1    Scott, J.W.2    Pan, D.A.3    Hudson, E.R.4
  • 3
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase. Fuel gauge of the mammalian cell?
    • Hardie, D. H.; Carling, D. The AMP-activated protein kinase. Fuel gauge of the mammalian cell? Eur. J. Biochem. 1997, 246, 259-273.
    • (1997) Eur. J. Biochem , vol.246 , pp. 259-273
    • Hardie, D.H.1    Carling, D.2
  • 4
    • 33745196745 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase in the liver:a new strategy for the management of metabolic hepatic disorders
    • Viollet, B.; Foretz, M.; Guigas, B.; Horman, S.; Dentin, R.; Bertrand, L.; Hue, L.; Andreelli, F. Activation of AMP-activated protein kinase in the liver:a new strategy for the management of metabolic hepatic disorders. J. Physiol. 2006, 574, 41-53.
    • (2006) J. Physiol , vol.574 , pp. 41-53
    • Viollet, B.1    Foretz, M.2    Guigas, B.3    Horman, S.4    Dentin, R.5    Bertrand, L.6    Hue, L.7    Andreelli, F.8
  • 5
    • 33744804815 scopus 로고    scopus 로고
    • Inhibition of lipid synthesis through activation of AMP kinase; an additional mechanism for the hypolipidemic effects of berberine
    • Brusq, J. M.; Ancellin, N.; Grondin, P.; Guillard, R.; Martin, S.; Saintillan, Y.; Issandou, M. Inhibition of lipid synthesis through activation of AMP kinase; an additional mechanism for the hypolipidemic effects of berberine. J. Lipid. Res. 2006, 47 (6), 1281-1288.
    • (2006) J. Lipid. Res , vol.47 , Issue.6 , pp. 1281-1288
    • Brusq, J.M.1    Ancellin, N.2    Grondin, P.3    Guillard, R.4    Martin, S.5    Saintillan, Y.6    Issandou, M.7
  • 6
    • 0032577217 scopus 로고    scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanaxa-diol saponins has the ability to induce apoptosis in tumor cells
    • Wakabayashi, C.; Murakami, K.; Hasegawa, H; Murata, H. J.; Saiki, I. An intestinal bacterial metabolite of ginseng protopanaxa-diol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun. 1998, 246 (3), 725-730.
    • (1998) Biochem. Biophys. Res. Commun , vol.246 , Issue.3 , pp. 725-730
    • Wakabayashi, C.1    Murakami, K.2    Hasegawa, H.3    Murata, H.J.4    Saiki, I.5
  • 7
    • 0034284840 scopus 로고    scopus 로고
    • Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease
    • Lee, S. J.; Ko, W. G.; Km, J. H.; Sung, J. H.; Moon, C. K.; Lee, B. H. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem. Pharmacol. 2000, 60 (5), 677-85.
    • (2000) Biochem. Pharmacol , vol.60 , Issue.5 , pp. 677-685
    • Lee, S.J.1    Ko, W.G.2    Km, J.H.3    Sung, J.H.4    Moon, C.K.5    Lee, B.H.6
  • 8
    • 34250161282 scopus 로고    scopus 로고
    • Ginsenosides compound K and Rh (2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells
    • Choi, K.; Kim, M.; Rhy, J.; Choi, C. Ginsenosides compound K and Rh (2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells. Neurosci. Lett. 2007, 421 (1), 37-41.
    • (2007) Neurosci. Lett , vol.421 , Issue.1 , pp. 37-41
    • Choi, K.1    Kim, M.2    Rhy, J.3    Choi, C.4
  • 9
    • 36048962905 scopus 로고    scopus 로고
    • Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice
    • Yoon, S. H.; Han, E. J.; Sung, J. H.; Chung, S. H. Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice. Biol. Pharm. Bull. 2007, 30 (11), 2196-2200. (
    • (2007) Biol. Pharm. Bull , vol.30 , Issue.11 , pp. 2196-2200
    • Yoon, S.H.1    Han, E.J.2    Sung, J.H.3    Chung, S.H.4
  • 10
    • 38049083706 scopus 로고    scopus 로고
    • Han, G. C.; Ko, S. K; Sung, J. H; Chung, S. H. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. J. Agric. Food. Chem. 2007, 55 (26), 10641-10648.
    • 10) Han, G. C.; Ko, S. K; Sung, J. H; Chung, S. H. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. J. Agric. Food. Chem. 2007, 55 (26), 10641-10648.
  • 11
    • 0025944668 scopus 로고
    • Seven novel Tay-Sachs mutations detected by chemical mismatch cleavage of PCR-amplified cDNA fragments
    • Akli, S.; Chelly, J.; Lacorte, J. M.; Poenaru, L.; Kahn, A. Seven novel Tay-Sachs mutations detected by chemical mismatch cleavage of PCR-amplified cDNA fragments. Genomics 1991, 11, 12-134.
    • (1991) Genomics , vol.11 , pp. 12-134
    • Akli, S.1    Chelly, J.2    Lacorte, J.M.3    Poenaru, L.4    Kahn, A.5
  • 12
    • 33745196745 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders
    • Viollet, B.; Foretz, M.; Guigas, B.; Horman, S.; Dentin, R.; Bertrand, L.; Hue, L.; Andreelli, F. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J. Physiol. 2006, 574, 41-53.
    • (2006) J. Physiol , vol.574 , pp. 41-53
    • Viollet, B.1    Foretz, M.2    Guigas, B.3    Horman, S.4    Dentin, R.5    Bertrand, L.6    Hue, L.7    Andreelli, F.8
  • 13
    • 0036627883 scopus 로고    scopus 로고
    • Hepatic steatosis and type 2 diabetes mellitus
    • Clark, J.; Diehl, A. Hepatic steatosis and type 2 diabetes mellitus. Curr. Diabetes Rep. 2002, 2, 210-215.
    • (2002) Curr. Diabetes Rep , vol.2 , pp. 210-215
    • Clark, J.1    Diehl, A.2
  • 14
  • 16
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway-new players upstream and downstream
    • Hardie, D. G. The AMP-activated protein kinase pathway-new players upstream and downstream. J. Cell Sci. 2004, 117, 5479-5487.
    • (2004) J. Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 17
    • 10744230065 scopus 로고    scopus 로고
    • Woods, A.; Johnstone, S. R.; Dickerson, K; Leiper, F. C.; Fryer, L. G.; Neumann, D.; schlattner, U.; Wallimann, T.; Carison, M.; Carling, D. LKB1 is the upstream kinase in the AMP-activated protein kinase in the AMP-activated protein kinase cascade. Curr. Biol. 2003, 13, 2004-2008.
    • Woods, A.; Johnstone, S. R.; Dickerson, K; Leiper, F. C.; Fryer, L. G.; Neumann, D.; schlattner, U.; Wallimann, T.; Carison, M.; Carling, D. LKB1 is the upstream kinase in the AMP-activated protein kinase in the AMP-activated protein kinase cascade. Curr. Biol. 2003, 13, 2004-2008.
  • 19
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • Eberle, D.; Heqarty, B.; Bossard, P.; Ferre, P.; Foufelle, F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 2004, 86, 839-848.
    • (2004) Biochimie , vol.86 , pp. 839-848
    • Eberle, D.1    Heqarty, B.2    Bossard, P.3    Ferre, P.4    Foufelle, F.5
  • 20
    • 39849102805 scopus 로고    scopus 로고
    • Regulation of Sterol Synthesis in Eukaryotes
    • Expenshade, P. J.; Hughes, A. L. Regulation of Sterol Synthesis in Eukaryotes. Annu. Rev. Genet. 2007, 41, 401-427.
    • (2007) Annu. Rev. Genet , vol.41 , pp. 401-427
    • Expenshade, P.J.1    Hughes, A.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.