Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosisviaBid-mediated mitochondrial pathway

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 1, 2012, Pages 96-106

  Hu, Chun ^a   Song, Gang ^a   Zhang, Bing ^a   Liu, Zhongchen ^a   Chen, Rong ^b   Zhang, Hong ^a,c   Hu, Tianhui ^a  

^a XIAMEN UNIVERSITY   (China)

^b WUHAN INSTITUTE OF TECHNOLOGY   (China)

^c UNIVERSITY OF SKÖVDE   (Sweden)

Author keywords

Apoptosis; Bid; Compound K; Gastric carcinoma

Indexed keywords

BID PROTEIN, HUMAN; GINSENOSIDE; GINSENOSIDE M1; PROTEIN BID;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CYCLE CHECKPOINT; CELL SURVIVAL; DRUG EFFECT; FEMALE; HUMAN; INTESTINE; METABOLISM; MITOCHONDRION; MOUSE; NUDE MOUSE; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GINSENOSIDES; HUMANS; INTESTINES; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; STOMACH NEOPLASMS;

BACTERIA (MICROORGANISMS); MUS MUSCULUS;

EID: 84855174764     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01278.x     Document Type: Article

References (43)

1. Parkin DM, Bray F, Ferlay J, et al Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55: 74-108.
2. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer. 1999; 80: 827-41.
3. Siewert JR, Bottcher K, Stein HJ, et al Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg. 1998; 228: 449-61.
4. Chan AO, Luk JM, Hui WM, et al Molecular biology of gastric carcinoma: from laboratory to bedside. J Gastroenterol Hepatol. 1999; 14: 1150-60.
5. Zheng L, Wang L, Ajani J, et al Molecular basis of gastric cancer development and progression. Gastric Cancer. 2004; 7: 61-77.
6. Xie K, Wei D, Huang S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev. 2006; 17: 147-56.
7. Akao T, Kida H, Kanaoka M, et al Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 1998; 50: 1155-60.
8. Choi K, Kim M, Ryu J, et al Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells. Neurosci Lett. 2007; 421: 37-41.
9. Shin YW, Bae EA, Kim SS, et al Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. Int Immunopharmacol. 2005; 5: 1183-91.
10. Yoon SH, Han EJ, Sung JH, et al Anti-diabetic effects of compound Kversusmetforminversuscompound K-metformin combination therapy in diabetic db/db mice. Biol Pharm Bull. 2007; 30: 2196-200.
11. Kim do Y, Yuan HD, Chung IK, et al Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulationviaAMPK activation in human hepatoma cells. J Agric Food Chem. 2009; 57: 1532-7.
12. Oh SH, Lee BH. A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharmacol. 2004; 194: 221-9.
13. Ming YL, Song G, Chen LH, et al Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells. Cell Biol Int. 2007; 31: 1265-73.
14. Chae S, Kang KA, Chang WY, et al Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cellsin vitroandin vivo. J Agric Food Chem. 2009; 57: 5777-82.
15. Kim do Y, Park MW, Yuan HD, et al Compound K induces apoptosisviaCAMK-IV/AMPK pathways in HT-29 colon cancer cells. J Agric Food Chem. 2009; 57: 10573-8.
16. Jung SH, Woo MS, Kim SY, et al Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Int J Cancer. 2006; 118: 490-7.
17. Wakabayashi C, Murakami K, Hasegawa H, et al An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun. 1998; 246: 725-30.
18. Lee SJ, Ko WG, Kim JH, et al Induction of apoptosis by a novel intestinal metabolite of ginseng saponinviacytochrome c-mediated activation of caspase-3 protease. Biochem Pharmacol. 2000; 60: 677-85.
19. Choi HH, Jong HS, Park JH, et al A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. Int J Oncol. 2003; 23: 1087-93.
20. Park EJ, Zhao YZ, Kim J, et al A ginsenoside metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cellsviacaspase-3 activation. Planta Med. 2006; 72: 1250-3.
21. Wang K, Yin XM, Chao DT, et al BID: a novel BH3 domain-only death agonist. Genes Dev. 1996; 10: 2859-69.
22. Yin XM. Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene. 2006; 369: 7-19.
23. Li H, Zhu H, Xu CJ, et al Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998; 94: 491-501.
24. Luo X, Budihardjo I, Zou H, et al Bid, a Bcl2 interacting protein, mediates cytochromecrelease from mitochondria in response to activation of cell surface death receptors. Cell. 1998; 94: 481-90.
25. Sarig R, Zaltsman Y, Marcellus RC, et al BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts. J Biol Chem. 2003; 278: 10707-15.
26. Valentijn AJ, Gilmore AP. Translocation of full-length Bid to mitochondria during anoikis. J Biol Chem. 2004; 279: 32848-57.
27. Song G, Chen GG, Chau DK, et al Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. Apoptosis. 2008; 13: 693-701.
28. Kamer I, Sarig R, Zaltsman Y, et al Proapoptotic BID is an ATM effector in the DNA-damage response. Cell. 2005; 122: 593-603.
29. Zinkel SS, Hurov KE, Ong C, et al A role for proapoptotic BID in the DNA-damage response. Cell. 2005; 122: 579-91.
30. Song G, Chen GG, Hu T, et al Bid stands at the crossroad of stress-response pathways. Curr Cancer Drug Target. 2010; 10: 584-92.
31. Miao J, Chen GG, Chun SY, et al Bid sensitizes apoptosis induced by chemotherapeutic drugs in hepatocellular carcinoma. Int J Oncol. 2004; 25: 651-9.
32. Miao J, Chen GG, Chun SY, et al Adenovirus-mediated tBid overexpression results in therapeutic effects on p53-resistant hepatocellular carcinoma. Int J Cancer. 2006; 119: 1985-93.
33. Song G, Chen GG, Yun JP, et al Association of p53 with Bid induces cell death in response to etoposide treatment in hepatocellular carcinoma. Curr Cancer Drug Target. 2009; 9: 871-80.
34. Song G, Mao YB, Cai QF, et al Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression. Braz J Med Biol Res. 2005; 38: 1791-8.
35. Karikura M, Miyase T, Tanizawa H, et al Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Chem Pharm Bull. 1991; 39: 2357-61.
36. Hasegawa H, Sung JH, Matsumiya S, et al Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 1996; 62: 453-7.
37. Akao T, Kanaoka M, Kobashi K. Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration-measurement of compound K by enzyme immunoassay. Biol Pharm Bull. 1998; 21: 245-9.
38. Hasegawa H, Sung JH, Huh JH. Ginseng intestinal bacterial metabolite IH901 as a new anti-metastatic agent. Arch Pharm Res. 1997; 20: 539-44.
39. Choo MK, Sakurai H, Kim DH, et al A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Oncol Rep. 2008; 19: 595-600.
40. Oh SH, Yin HQ, Lee BH. Role of the Fas/Fas ligand death receptor pathway in ginseng saponin metabolite-induced apoptosis in HepG2 cells. Arch Pharm Res. 2004; 27: 402-6.
41. Kang KA, Kim YW, Kim SU, et al G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells. Arch Pharm Res. 2005; 28: 685-90.
42. Breitschopf K, Zeiher AM, Dimmeler S. Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. J Biol Chem. 2000; 275: 21648-52.
43. Konig HG, Rehm M, Gudorf D, et al Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons. BMC Cell Biol. 2007; 8: 7.