Aβ(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by MI, A metabolite of protopanaxadiol-type saponins

Neuropsychopharmacology

Volumn 29, Issue 5, 2004, Pages 860-868

  Tohda, Chihiro ^a   Matsumoto, Noriaki ^a   Zou, Kun ^a   Meselhy, Meselhy R ^a   Komatsu, Katsuko ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Alzheimer's disease; Axonal atrophy; Ginseng; Ginsenoside Rb1; MI; Synaptic loss

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; AMYLOID BETA PROTEIN[25-35]; GINSENOSIDE RB 1; NEUROFILAMENT H PROTEIN; NEUROFILAMENT PROTEIN; PHOSPHOPROTEIN; PROTOPANAXADIOL; SAPONIN DERIVATIVE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (25 35); AMYLOID BETA-PROTEIN (25-35); GINSENOSIDE; PEPTIDE FRAGMENT; SAPOGENIN; SAPONIN; TRITERPENE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ATROPHY; BRAIN CELL; BRAIN CORTEX; BRAIN NERVE CELL; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; DENDRITE; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; GINSENG; HIPPOCAMPUS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMORY DISORDER; MOUSE; NERVE FIBER; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SPATIAL MEMORY; SYNAPSE; ANIMAL; ATROPHY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; MAZE TEST; MOTOR ACTIVITY; PATHOLOGY; PREGNANCY; PSYCHOLOGICAL ASPECT; RAT; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

AMYLOID BETA-PROTEIN; ANIMALS; ATROPHY; AXONS; FEMALE; GINSENOSIDES; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MOTOR ACTIVITY; NEURITES; PEPTIDE FRAGMENTS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SAPOGENINS; SAPONINS; SYNAPSES; TRITERPENES;

EID: 1942420868     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300388     Document Type: Article

References (34)

1. Casley CS, Land JM, Sharpe MA, Clark JB, Duchen MR, Canevari L (2002). Amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis 10: 258-267.
2. Chan-Palay V (1991). Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease. Prog Brain Res 88: 625-630.
3. DeKosky ST, Scheff SW (1990). Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 27: 457-464.
4. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C et al (1995). Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373: 523-527.
5. Geddes JW, Anderson KJ, Cotman CW (1986). Senile plaques as aberrant sprout-stimulating structures. Exp Neurol 94: 767-776.
6. Gordon MN, Holcomb LA, Jantzen PT, DiCarlo G, Wilcock D, Boyett KW et al (2002). Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Exp Neurol 173: 183-195.
7. Grace EA, Busciglio J (2003). Aberrant activation of focal adhesion proteins mediates fibrillar amyloid β-induced neuronal dystrophy. J Neurosci 23: 493-502.
8. Grace EA, Rabiner CA, Busciglio J (2002). Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease. J Neurosci 114: 265-273.
9. Hardy J, Cowburn R, Barton A, Reynolds G, Dodd P, Wester P et al (1987). A disorder of cortical GABAergic innervation in Alzheimer's disease. Neurosci Lett 73: 192-196.
10. Hasegawa H, Sung J-H, Benno Y (1997). Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponins. Planta Med 63: 436-440.
11. Heinonen O, Soininen H, Sorvari H, Kosunen O, Paljarvi L, Koivisto E et al (1995). Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease. Neuroscience 64: 375-384.
12. Ikegaya Y, Matsuura S, Ueno S, Baba A, Yamada MK, Nishiyama N et al (2002). Amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy. J Biol Chem 277: 32180-32186.
13. 2 in the digestive tract of rats. Chem Pharm Bull 39: 2357-2361.
14. Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT et al (2002). Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 22: 6331-6335.
15. Lin H, Bhatia R, Lal R (2001). Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology. FASEB J 15: 2433-2444.
16. 1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res 63: 509-515.
17. 1 potetiated nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia. Biol Pharm Bull 17: 509-513.
18. 1 in the rat. Chem Pharm Bull 31: 1059-1066.
19. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R et al (2003). Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron 39: 409-421.
20. Ogura H, Kosasa T, Kuriya Y, Yamanishi Y (2000). Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats. Methods Find Exp Clin Pharmacol 22: 89-95.
21. Postuma RB, He W, Nunan J, Beyreuther K, Masters CL, Barrow CJ et al (2000). Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures. J Neurochem 74: 1122-1130.
22. Rathbone MP, Middlemiss PJ, Gysbers JW, Andrew C, Herman MA, Reed JK et al (1999). Trophic effects of purines in neurons and glial cells. Prog Neurobiol 59: 663-690.
23. Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT (1998). A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 50: 136-145.
24. 1 in organ cultures of chicken dorsal root ganglia. Jpn J Pharmacol 27: 445-451.
25. Sugaya A, Yuzurihara M, Tsuda T, Yasuda K, Kajiwara K, Sugaya E (1988). Proliferative effect of ginseng saponin on neurite extension of primary cultured neurons of the rat cerebral cortex. J Ethnopharmacol 22: 173-181.
26. Tawab MA, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M (2003). Degeneration of ginsenosides in humans after oral administration. Drug Metab Dispos 31: 1065-1071.
27. Tohda C, Matsumoto N, Zou K, Meselhy RM, Komatsu K (2002). Axonal and dendritic extension by protopanaxadiol-type saponins from Ginseng drugs in SK-N-SH cells. Jpn J Pharmacol 90: 254-262.
28. Tohda C, Tamura T, Komatsu K (2003). Repair of amyloid β(25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to. Brain Res 990: 141-147.
29. Valouskova V, Gschanes A (1999). Effects of NGF, b-FGF, and cerebrolysin on water maze performance and on motor activity of rats: short- and long-term study. Neurobiol Learn Mem 71: 132-149.
30. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS et al (2002). Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-539.
31. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE et al (2002). Peroxynitrite mediates neurotoxicity of amyloid β-peptide 1-42 and lipopolysaccharide-activated microglia. J Neuro Sci 22: 3484-3492.
32. Yamada K, Nabeshima T (2000). Animal models of Alzheimer's disease and evaluation of anti-dementia drugs. Pharmacol Ther 88: 93-113.
33. Zhao R, McDaniel WF (1998). Ginseng improves strategic learning by normal and brain-damaged rats. Neuroreport 9: 1618-1624.
34. Zhong YM, Nishijo H, Uwano T, Tamura R, Kawanishi K, Ono T (2000). Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol Behav 69: 511-525.