Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells

International Journal of Molecular Sciences

Volumn 11, Issue 12, 2010, Pages 4916-4931

  Lee, In Kyung ^a   Kang, Kyoung Ah ^b   Lim, Chae Moon ^b   Kim, Ki Cheon ^b   Kim, Hee Sun ^c   Kim, Dong Hyun ^d   Kim, Bum Joon ^a   Chang, Weon Young ^b   Choi, Jae Hyuck ^b   Hyun, Jin Won ^b  

^a Seoul National University College of Medicine   (South Korea)

^b Jeju National University School of Medicine   (South Korea)

^c Ewha Womans University School of Medicine   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

c Jun NH 2 terminal kinase; Compound K; Mitochondrial membrane potential; p38 mitogen activated protein kinase; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 9; CELL PROTEIN; COMPOUND K; CYTOCHROME C; DRUG METABOLITE; GINSENG SAPONIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CASPASE; GINSENOSIDE; GINSENOSIDE M1; SAPONIN; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DISRUPTION; CELL STRAIN HT29; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MITOCHONDRION; PANAX; PATHOLOGY;

PANAX GINSENG;

APOPTOSIS; CASPASES; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; GINSENOSIDES; HUMANS; MITOCHONDRIA; NEOPLASM PROTEINS; PANAX; REACTIVE OXYGEN SPECIES; SAPONINS;

EID: 78650987480     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms11124916     Document Type: Article

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