Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229

Journal of Applied Microbiology

Volumn 104, Issue 3, 2008, Pages 699-706

  Zhou, W ^a   Yan, Q ^a   Li, J Y ^a   Zhang, X C ^a   Zhou, P ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Biotransformation; Ginsenoside compound K; Paecilomyces bainier; Panax notoginseng saponins; Substrate

Indexed keywords

BIOCONVERSION; CHLORINE COMPOUNDS; MAGNESIUM COMPOUNDS; METABOLITES; NITROGEN COMPOUNDS;

BIOTRANSFORMATION; COMPOUND K; CULTURE CONDITIONS; GINSENOSIDE COMPOUND K; GINSENOSIDES; OPTIMISATIONS; PAECILOMYCES; PAECILOMYCES BAINIER; PANAX NOTOGINSENG; PANAX NOTOGINSENG SAPONIN;

SUBSTRATES;

GINSENG SAPONIN; GINSENOSIDE; GINSENOSIDE K; PANAX NOTOGINSENG EXTRACT; SUCROSE; UNCLASSIFIED DRUG;

BIOTRANSFORMATION; FERMENTATION; FUNGUS; HERB; MICROBIAL ACTIVITY; OPTIMIZATION; ORGANIC COMPOUND; PH; PLANT EXTRACT;

ARTICLE; BIOTRANSFORMATION; DRUG MANUFACTURE; NONHUMAN; PAECILOMYCES; PAECILOMYCES BAINIER; PANAX NOTOGINSENG; PH; SOYBEAN; WHEAT;

GLYCINE MAX; PANAX GINSENG; PANAX NOTOGINSENG; TRITICUM AESTIVUM;

EID: 39149144455     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2007.03586.x     Document Type: Article

References (32)

1. Akao, T., Kida, H., Kanaoka, M., Hattori, M. Kobashi, K. (1998a) Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 50, 1155 1160.
2. Akao, T., Kanaoka, M. Kobashi, K. (1998b) Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacterial, in rat plasma after oral administration - measurement of compound K by enzyme immunoassay. Biol Pharm Bull 21, 245 249.
3. Bae, E.A., Choo, M.K., Park, E.K., Park, S.Y., Shin, H.Y. Kim, D.H. (2002) Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol Pharm Bull 25, 743 747.
4. Bae, E.A., Kim, N.Y., Han, M.J., Choo, M.K. Kim, D.H. (2003) Transformation of ginsenoside to compound K (IH-901) by lactic acid bacteria of human intestine. J Microbiol Biotechnol 13, 9 14.
5. Bakhtiari, M.R., Faezi, M.G., Fallahpour, M., Noohi, A., Moazami, N. Amidi, Z. (2006) Medium optimization by orthogonal array designs for urease production by Aspergillus niger PTCC5011. Process Biochem 41, 547 551.
6. Han, M. Fang, X.L. (2006) Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol Sin 27, 499 505.
7. Hasegawa, H. (2004) Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 95, 153 157.
8. Hasegawa, H. Uchiyama, M. (1998) Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite. Planta Med 64, 696 700.
9. Hasegawa, H., Sung, J.H., Matsumiya, S. Uchiyama, M. (1996) Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 62, 453 457.
10. Hasegawa, H., Sung, J.H. Benno, Y. (1997) Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med 63, 436 440.
11. Humphrey, A. (1998) Shake flasks to fermentor: what have we learnt? Biotechnol Prog 14, 3 7.
12. Jiang, B.H., Han, Y., Zhao, Y.Q., Hu, X.M. Zheng, L.X. (2004) Optimization of enzymatic translation for preparation ginsenoside compound K in total saponins of Panax notoginseng. Chin Tradit Herb Drugs 35, 986 988.
13. Karikura, M., Miyase, T., Tanizawa, H., Takino, Y., Taniyama, T. Hayashi, T. (1990) Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition product of ginsenoside Rb2 in the large intestine of rats. Chem Pharm Bull 38, 2859 2861.
14. Kasai, R., Besso, H., Tanaka, O., Saruwatari, Y.I. Fuwa, T. (1983) Saponins of red ginseng. Chem Pharm Bull 31, 2120 2125.
15. Kim, S.K., Kang, B.Y., Cho, S.Y., Sung, D.S., Chang, H.K., Yeom, M.H., Kim, D.H., Sim, Y.C. et al. (2004) Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increase hyaluronan in hairless mouse shin. Biochem Biophys Res Commun 316, 348 355.
16. King, A.T., Davey, M.R., Mellor, I.R., Mulligan, B.J. Lowe, K.C. (1991) Surfactant effects on yeast-cells. Enzyme Microb Technol 13, 148 153.
17. Lee, B.H., Lee, S.J., Hur, J.H., Lee, S., Sung, J.H., Huh, J.D. Moon, C.K. (1998) In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med 64, 500 503.
18. Lee, H.U., Bae, E.A., Han, M.J. Kim, D.H. (2005a) Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury. Biol Pharm Bull 28, 1992 1994.
19. Lee, Y.J., Shin, J.W., Chun, K.S., Park, K.K., Chung, W.Y., Bang, Y.J., Sung, J.H. Surh, Y.J. (2005b) Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin. Carcinogenesis 26, 359 367.
20. Lee, H.U., Bae, E.A., Han, M.J. Kim, D.H. (2005c) Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 25, 1069 1073.
21. Ma, W.G., Mizutani, M., Malterud, K.E., Lu, S.L., Ducrey, B. Tahara, S. (1999) Saponins from the roots of Pananx notoginseng. Phytochemistry 52, 1133 1139.
22. Odani, T., Tanizawa, H. Takino, Y. (1983) Studies on the absorption, distribution, ginseng saponin. III. The absorption, excretion of ginsenoside Rb1 in the rat. Chem Pharm Bull 31, 1059 1066.
23. Oh, S.H. Lee, B.H. (2004) A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharm 194, 221 229.
24. Paek, I.B., Moon, Y., Kim, J., Ji, H.Y., Kim, S.A., Sohn, D.H., Kim, J.B. Lee, H.S. (2006) Pharmacokinetics of a ginseng saponin metabolite compound K in rats. Biopharm Drug Dispos 27, 39 45.
25. Park, E.K., Shin, Y.W., Lee, H.U., Kim, S.S., Lee, Y.C., Lee, B.Y. Kim, D.H. (2005) Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biol Pharm Bull 28, 652 656.
26. Park, W., Lim, W., Cho, J., Inoue, H., Rhyu, M.R. Lee, Y. (2006) Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O- tetradecanoylphorbol 13-acetate-induced cyclooxygenase-2 promoter. Planta Med 72, 272 275.
27. Tawab, M.A., Bahr, U., Karas, M., Wurglics, M. Schubert-Zsilavecz, M. (2003) Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 31, 1065 1071.
28. Tian, J.W. Fu, F.H. (2005) Neuroprotective effect of ginsenoside Rb-3 on cerebral ischemia in rats. Ann Neurol 58, S11.
29. Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J. Saiki, I. (1998) An intestinal bacterial metabolite of ginseng protopanaxdiol saponins has the activity to induce apoptosis in tumor cells. Biochem Biophys Res Commun 246, 725 730.
30. Xu, Z.N. Yang, S.T. (2007) Production of mycophenolic acid by Penicillium brevicompactum immobilized in a rotating fibrous-bed bioreactor. Enzyme Microb Technol 40, 623 628.
31. Yahara, S., Kaji, K. Tanaka, O. (1979) Further study on damarane-type saponins of roots, leaves, flower buds, and fruits of Panax ginseng C.A. Maeyer. Chem Pharm Bull 27, 99 92.
32. Zhang, H.S. Wang, S.Q. (2006) Ginsenoside Rg1 inhibits tumor necrosis factor-alpha (TNF-alpha)-induced human arterial smooth muscle cells (HASMCs) proliferation. J Cell Biochem 98, 1471 1481.