메뉴 건너뛰기




Volumn 31, Issue 10, 2007, Pages 1265-1273

Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells

Author keywords

Anti proliferation; Apoptosis; Human hepatocellular carcinoma cells; IH 901; SMMC7721

Indexed keywords

20 O (BETA DEXTRO GLUCOPYRANOSYL)PROTOPANAXADIOL; GINSENG SAPONIN; UNCLASSIFIED DRUG;

EID: 34447288092     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2007.05.005     Document Type: Article
Times cited : (44)

References (41)
  • 1
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: arbiters of cell survival
    • Adams J.M., and Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281 (1998) 1322-1326
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 2
    • 85009708837 scopus 로고    scopus 로고
    • Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration-measurement of compound K by enzyme immunoassay
    • Akao T., Kanaoka M., and Kobashi K. Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration-measurement of compound K by enzyme immunoassay. Biol Pharm Bull 21 (1998) 245-249
    • (1998) Biol Pharm Bull , vol.21 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 3
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • Akao T., Kida H., Kanaoka M., Hattori M., and Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 50 (1998) 1155-1160
    • (1998) J Pharm Pharmacol , vol.50 , pp. 1155-1160
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 4
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology, multiple constitutes and multiple actions
    • Attele S.A., Wu J.A., and Yuan C.S. Ginseng pharmacology, multiple constitutes and multiple actions. Biochem Pharmacol 58 (1999) 1685-1693
    • (1999) Biochem Pharmacol , vol.58 , pp. 1685-1693
    • Attele, S.A.1    Wu, J.A.2    Yuan, C.S.3
  • 5
    • 0036594246 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity
    • Bae E.A., Choo M.K., Park E.K., Park S.Y., Shin H.Y., and Kim D.H. Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol Pharm Bull 25 (2002) 743-747
    • (2002) Biol Pharm Bull , vol.25 , pp. 743-747
    • Bae, E.A.1    Choo, M.K.2    Park, E.K.3    Park, S.Y.4    Shin, H.Y.5    Kim, D.H.6
  • 6
    • 0034536269 scopus 로고    scopus 로고
    • Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
    • Bae E.A., Park S.Y., and Kim D.H. Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull 23 (2000) 1481-1485
    • (2000) Biol Pharm Bull , vol.23 , pp. 1481-1485
    • Bae, E.A.1    Park, S.Y.2    Kim, D.H.3
  • 7
    • 3042519041 scopus 로고    scopus 로고
    • A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells
    • Choi H.H., Jong H.S., Park J.H., Choi S., Lee J.W., Kim Y.Y., et al. A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. Int J Oncol 23 (2003) 1087-1093
    • (2003) Int J Oncol , vol.23 , pp. 1087-1093
    • Choi, H.H.1    Jong, H.S.2    Park, J.H.3    Choi, S.4    Lee, J.W.5    Kim, Y.Y.6
  • 8
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-Serag H.B., and Mason A.C. Rising incidence of hepatocellular carcinoma in the United States. New Engl J Med 340 (1999) 745-750
    • (1999) New Engl J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 9
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A., McDonnell J.M., and Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13 (1999) 1899-1911
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 10
    • 3142621044 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid
    • Hasegawa H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 95 (2004) 153-157
    • (2004) J Pharmacol Sci , vol.95 , pp. 153-157
    • Hasegawa, H.1
  • 11
    • 0028362213 scopus 로고
    • Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities
    • Hasegawa H., Matsumiya S., Uchiyama M., Kurokawa T., Inouye Y., Kasai R., et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med 60 (1994) 240-243
    • (1994) Planta Med , vol.60 , pp. 240-243
    • Hasegawa, H.1    Matsumiya, S.2    Uchiyama, M.3    Kurokawa, T.4    Inouye, Y.5    Kasai, R.6
  • 12
    • 0010098211 scopus 로고    scopus 로고
    • Ginseng intestinal bacteria metabolite IH-901 as a new antimetastatic agent
    • Hasegawa H., Sung J.H., and Huh J.D. Ginseng intestinal bacteria metabolite IH-901 as a new antimetastatic agent. Arch Pharm Res 20 (1997) 539-544
    • (1997) Arch Pharm Res , vol.20 , pp. 539-544
    • Hasegawa, H.1    Sung, J.H.2    Huh, J.D.3
  • 13
    • 0029840531 scopus 로고    scopus 로고
    • Main ginseng saponin metabolites formed by intestinal bacteria
    • Hasegawa H., Sung J.H., Matsumiya S., and Uchiyama M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 62 (1996) 453-457
    • (1996) Planta Med , vol.62 , pp. 453-457
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4
  • 14
    • 0028853696 scopus 로고
    • Reversal of daunomycin and vinblastine resistance in multidrug-resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids
    • Hasegawa H., Sung J.H., Matsumiya S., Uchiyama M., Inouye Y., Kasai R., et al. Reversal of daunomycin and vinblastine resistance in multidrug-resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids. Planta Med 61 (1995) 409-413
    • (1995) Planta Med , vol.61 , pp. 409-413
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4    Inouye, Y.5    Kasai, R.6
  • 15
    • 0036633130 scopus 로고    scopus 로고
    • Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol
    • Hasegawa H., Suzuki R., Nagaoka T., Tezuka Y., Kadota S., and Saiki I. Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol Pharm Bull 25 (2002) 861-866
    • (2002) Biol Pharm Bull , vol.25 , pp. 861-866
    • Hasegawa, H.1    Suzuki, R.2    Nagaoka, T.3    Tezuka, Y.4    Kadota, S.5    Saiki, I.6
  • 16
    • 0035525733 scopus 로고    scopus 로고
    • Cellular stress response and apoptosis in cancer therapy
    • Herr I., and Debatin K.M. Cellular stress response and apoptosis in cancer therapy. Blood 98 (2001) 2603-2614
    • (2001) Blood , vol.98 , pp. 2603-2614
    • Herr, I.1    Debatin, K.M.2
  • 17
    • 0035815923 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends
    • Howe H.L., Wingo P.A., Thun M.J., Ries L.A., Rosenberg H.M., Feigal E.G., et al. Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends. J Natl Cancer Inst 93 (2001) 824-842
    • (2001) J Natl Cancer Inst , vol.93 , pp. 824-842
    • Howe, H.L.1    Wingo, P.A.2    Thun, M.J.3    Ries, L.A.4    Rosenberg, H.M.5    Feigal, E.G.6
  • 19
    • 0001833433 scopus 로고    scopus 로고
    • Relation of intestinal bacteria to pharmacological effects of glycosides
    • Kobashi K., and Akao T. Relation of intestinal bacteria to pharmacological effects of glycosides. Biosci Microflora 16 (1997) 1-7
    • (1997) Biosci Microflora , vol.16 , pp. 1-7
    • Kobashi, K.1    Akao, T.2
  • 20
    • 0034523818 scopus 로고    scopus 로고
    • Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
    • Korsmeyer S.J., Wei M.C., Saito M., Weiler S., Oh K.J., and Schlesinger P.H. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 7 (2000) 1166-1173
    • (2000) Cell Death Differ , vol.7 , pp. 1166-1173
    • Korsmeyer, S.J.1    Wei, M.C.2    Saito, M.3    Weiler, S.4    Oh, K.J.5    Schlesinger, P.H.6
  • 21
    • 0033203595 scopus 로고    scopus 로고
    • Ginsenoside Rh2 induces apoptosis independently of Bcl-2, Bcl-xL, or Bax in C6Bu-1 cells
    • Kim Y.S., Jin S.H., Lee Y.H., Kim S.I., and Park J.D. Ginsenoside Rh2 induces apoptosis independently of Bcl-2, Bcl-xL, or Bax in C6Bu-1 cells. Arch Pharm Res 22 (1999) 448-453
    • (1999) Arch Pharm Res , vol.22 , pp. 448-453
    • Kim, Y.S.1    Jin, S.H.2    Lee, Y.H.3    Kim, S.I.4    Park, J.D.5
  • 22
    • 0031830686 scopus 로고    scopus 로고
    • In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria
    • Lee B.H., Lee S.J., Hur J.H., Lee S., Sung J.H., Huh J.D., et al. In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med 64 (1998) 500-503
    • (1998) Planta Med , vol.64 , pp. 500-503
    • Lee, B.H.1    Lee, S.J.2    Hur, J.H.3    Lee, S.4    Sung, J.H.5    Huh, J.D.6
  • 23
    • 13844280922 scopus 로고    scopus 로고
    • Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin
    • Lee J.Y., Shin J.W., Chun K.S., Park K.K., Chung W.Y., Bang Y.J., et al. Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin. Carcinogenesis 26 (2005) 359-367
    • (2005) Carcinogenesis , vol.26 , pp. 359-367
    • Lee, J.Y.1    Shin, J.W.2    Chun, K.S.3    Park, K.K.4    Chung, W.Y.5    Bang, Y.J.6
  • 24
    • 0034284840 scopus 로고    scopus 로고
    • Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease
    • Lee S.J., Ko W.G., Kim J.H., Sung J.H., Moon C.K., and Lee B.H. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem Pharmacol 60 (2000) 677-685
    • (2000) Biochem Pharmacol , vol.60 , pp. 677-685
    • Lee, S.J.1    Ko, W.G.2    Kim, J.H.3    Sung, J.H.4    Moon, C.K.5    Lee, B.H.6
  • 25
    • 0032782069 scopus 로고    scopus 로고
    • Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin
    • Lee S.J., Sung J.H., Lee S.J., Moon C.K., and Lee B.H. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett 144 (1999) 39-43
    • (1999) Cancer Lett , vol.144 , pp. 39-43
    • Lee, S.J.1    Sung, J.H.2    Lee, S.J.3    Moon, C.K.4    Lee, B.H.5
  • 26
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
    • Liu X., Kim C.N., Yang J., Jemmerson R., and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 (1996) 147-157
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 27
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T., Krajewski S., Krajewska M., Wang H.G., Lin H.K., Liebermann D.A., et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9 (1994) 1799-1805
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3    Wang, H.G.4    Lin, H.K.5    Liebermann, D.A.6
  • 28
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T., and Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 (1995) 293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 29
    • 0035045662 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in the developing world
    • Ogunbiyi J.O. Hepatocellular carcinoma in the developing world. Semin Oncol 28 (2001) 179-187
    • (2001) Semin Oncol , vol.28 , pp. 179-187
    • Ogunbiyi, J.O.1
  • 30
    • 0842264760 scopus 로고    scopus 로고
    • A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage
    • Oh S.H., and Lee B.H. A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharmacol 194 (2004) 221-229
    • (2004) Toxicol Appl Pharmacol , vol.194 , pp. 221-229
    • Oh, S.H.1    Lee, B.H.2
  • 31
    • 6944247483 scopus 로고    scopus 로고
    • Role of the Fas/Fas ligand death receptor pathway in ginseng saponin metabolite-induced apoptosis in HepG2 cells
    • Oh S.H., Yin H.Q., and Lee B.H. Role of the Fas/Fas ligand death receptor pathway in ginseng saponin metabolite-induced apoptosis in HepG2 cells. Arch Pharm Res 27 (2004) 402-406
    • (2004) Arch Pharm Res , vol.27 , pp. 402-406
    • Oh, S.H.1    Yin, H.Q.2    Lee, B.H.3
  • 32
    • 1542376726 scopus 로고    scopus 로고
    • Antiallergic and antiinflammatory activities of ginsenoside Rh1
    • Park E.K., Choo M.K., Han M.J., and Kim D.H. Antiallergic and antiinflammatory activities of ginsenoside Rh1. Int Arch Allergy Immunol 133 (2004) 113-120
    • (2004) Int Arch Allergy Immunol , vol.133 , pp. 113-120
    • Park, E.K.1    Choo, M.K.2    Han, M.J.3    Kim, D.H.4
  • 33
    • 0034075605 scopus 로고    scopus 로고
    • The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence
    • Shin H.R., Kim J.Y., Yun T.K., Morgan G., and Vainio H. The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Cause Control 11 (2000) 565-576
    • (2000) Cancer Cause Control , vol.11 , pp. 565-576
    • Shin, H.R.1    Kim, J.Y.2    Yun, T.K.3    Morgan, G.4    Vainio, H.5
  • 35
    • 0033601746 scopus 로고    scopus 로고
    • Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
    • Slee E.A., Harte M.T., Kluck R.M., Wolf B.B., Casiano C.A., Newmeyer D.D., et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144 (1999) 281-292
    • (1999) J Cell Biol , vol.144 , pp. 281-292
    • Slee, E.A.1    Harte, M.T.2    Kluck, R.M.3    Wolf, B.B.4    Casiano, C.A.5    Newmeyer, D.D.6
  • 36
    • 85008118525 scopus 로고
    • Chemical studies on the Oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng: stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc
    • Tanaka N., Tanaka O., and Shibata S. Chemical studies on the Oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng: stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc. Chem Pharm Bull 20 (1972) 1212-1216
    • (1972) Chem Pharm Bull , vol.20 , pp. 1212-1216
    • Tanaka, N.1    Tanaka, O.2    Shibata, S.3
  • 38
    • 0031303557 scopus 로고    scopus 로고
    • In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration
    • Wakabayashi C., Hasegawa H., Murata J., and Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 9 (1997) 411-417
    • (1997) Oncol Res , vol.9 , pp. 411-417
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4
  • 39
    • 0000424907 scopus 로고    scopus 로고
    • The expression of in vivo anti-metastatic effect of ginseng protopanaxatriol saponins is mediated by their intestinal bacterial metabolites after oral administration
    • Wakabayashi C., Hasegawa H., Murata J., and Saiki I. The expression of in vivo anti-metastatic effect of ginseng protopanaxatriol saponins is mediated by their intestinal bacterial metabolites after oral administration. J Trad Med 14 (1997) 180-185
    • (1997) J Trad Med , vol.14 , pp. 180-185
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4
  • 40
    • 0032577217 scopus 로고    scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells
    • Wakabayashi C., Murakami K., Hasegawa H., Murata J., and Saiki I. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 246 (1998) 725-730
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 725-730
    • Wakabayashi, C.1    Murakami, K.2    Hasegawa, H.3    Murata, J.4    Saiki, I.5
  • 41
    • 20144388887 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis
    • Yim H.W., Jong H.S., Kim T.Y., Choi H.H., Kim S.G., Song S.H., et al. Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res 65 (2005) 1952-1960
    • (2005) Cancer Res , vol.65 , pp. 1952-1960
    • Yim, H.W.1    Jong, H.S.2    Kim, T.Y.3    Choi, H.H.4    Kim, S.G.5    Song, S.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.