Effect of compound K, a metabolite of ginseng saponin, combined with γ-ray radiation in human lung cancer cells in vitro and in vivo

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 13, 2009, Pages 5777-5782

  Chae, Sungwook ^a   Kang, Kyoung Ah ^b   Chang, Weon Young ^b   Kim, Min Jung ^c   Lee, Su Jae ^c   Lee, Yun Sil ^d   Kim, Hee Sun ^e   Kim, Dong Hyun ^f   Hyun, Jin Won ^b,g  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Jeju National University   (South Korea)

^c Hanyang University   (South Korea)

^d Korea Institute of Radiation and Medical Science   (South Korea)

^e Ewha Womans University School of Medicine   (South Korea)

^f Kyung Hee University   (South Korea)

^g Jeju National University School of Medicine   (South Korea)

Author keywords

Apoptosis; Cancer therapy; Compound K; Radiation; ROS; Tumor xenograft

Indexed keywords

GINSENOSIDE; GINSENOSIDE M1; SAPONIN;

ANIMAL; APOPTOSIS; ARTICLE; CHEMISTRY; DRUG EFFECT; GAMMA RADIATION; GINSENG; HUMAN; LUNG TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MULTIMODALITY CANCER THERAPY; NUDE MOUSE; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; GAMMA RAYS; GINSENOSIDES; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; PANAX; SAPONINS;

MUS MUSCULUS; PANAX GINSENG;

EID: 67649865855     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf900331g     Document Type: Article

References (30)

1. 3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. Clin. Exp. Metastasis 1997, 15, 603-611.
2. 2 and adjuvant effects to cisplatin in vivo. Anticancer Drugs 1991, 2, 63-67.
3. Lee, Y. N.; Lee, H. Y.; Chung, H. Y.; Kim, S. I.; Lee, S. K.; Park, B. C.; Kim, K. W, In vitro induction of differentiation by ginsenoides in F9 teratocarcinoma cells. Eur. J. Cancer 1996, 32A, 1420-1428.
4. 2-induced apoptosis. Officer Lett. 1997, 121, 73-81.
5. 3. Jpn. J. Cancer Res. 1996, 87, 357-362.
6. Hasegawa, H.; Sung, J. H.; Matsumiya, S.; Uchiyama, M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 1996, 62, 453-457.
7. Hasegawa, H.; Matsumiya, S.; Uchiyama, M.; Kurokawa, T.; Inouye, Y.; Kasai, R.; Ishibashi, S.; Yamasaki, K. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994, 60, 240-243.
8. Lee, B. H.; Lee, S. J.; Hur, J. H.; Lee, S.; Sung, J. H.; Huh, J. D.; Moon, C. K. In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 1998, 64, 500-503.
9. Hasegawa, H.; Sung, J. H.; Huh, J. D. Ginseng intestinal bacterial new anti-metastatic agent metabolite IH901 as a new anti-metastatic agent. Arch. Pharm. Res. 1997, 20, 539-544.
10. Lee, J. Y.; Shin, J. W.; Chun, K. S.; Park, K. K.; Chung, W. Y.; Bang, Y. J.; Sung, J. H.; Surh, Y. J. Antitumor promotional effects of a novel intestinal bacterial metabolite (1H-901) derived from the protopanaxadiol-type ginsenosides in mouse skin. Carcinogenesis 2005, 26, 359-367.
11. Yim, H. W.; Jong, H, S.; Kim, T. Y.; Choi, H. H.; Kim, S. G.; Song, S. H.; Kim, L.; Ko, S. G.; Lee, J. W.; Kim, T. Y.; Bang, Y. J. Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res. 2005, 65, 1952-1960.
12. Choo, M. K.; Sakurai, H.; Kim, D. H.; Saiki, I. A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappa B signaling in murine colon cancer cells. Oncol. Rep. 2008, 19, 595-600.
13. Lei, J.; Li, X.; Gong, X, J.; Zheng, Y. N. Isolation, synthesis and structures of cytotoxic ginsenoside derivatives. Molecules 2007, 12, 2140-2150.
14. Lee, S. J.; Sung, J. H.; Lee, S. J.; Moon, C. K.; Lee, B. H. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett. 1999, 144, 39-43.
15. Jung, S. H.; Woo, M. S.; Kim, S. Y.; Kim, W. K.; Hyun, J. W.; Kim, E. J.; Kim, D. H.; Kim, H. S. Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Int. J. Cancer 2006, 118, 490-497.
16. 1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells. Arch. Pharm. Res. 2005, 28, 685-690.
17. Kang, K. A.; Lim, H. K.; Kim, S. U.; Kim, Y. W.; Kim, W. T.; Chung, H. S.; Choo, M. K.; Kim, D. H.; Kim, H. S.; Shim, M. J.; Chung, M. H.; Hyun, J. W. Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells. J. Food Biochem. 2005, 29, 27-40.
18. Kang, K. A.; Lim, H. K.; Chae, S.; Kim, J. K.; Seo, J. Y.; Ham, Y. H.; Lee, K. H.; Kim, B. J.; Kim, H. S.; Kim, D. H.; Hyun, J. W. Inhibition of telomerase activity in U937 human monocytic leukemia cells by compound K, a ginseng saponin metabolite. Biotechnol. Bioprocess Eng. 2006, 11, 7-12.
19. Carmichael, J.; DeGraff, W. G.; Gazdar, A. F. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cacer Res. 1987, 47, 936-941.
20. Troiano, L.; Ferraresi, R.; Lugli, E.; Nemes, E.; Roat, E.; Nasi, M.; Pinti, M.; Cossarizza, A. Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry. Nat. Protoc. 2007, 2, 2719-2727.
21. Zhang, R.; Kang, K. A.; Piao, M. J.; Ko, D. O.; Wang, Z. H.; Lee, I. K.; Kim, B. J. Jeong, I. Y.; Shin, T.; Park, J. W.; Lee, N. H.; Hyun, J. W. Eckol protects V79-4 lung fibroblast cells against gamma-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH(2)-terminal kinase pathway. Eur. J. Pharmacol. 2008, 591, 114-123.
22. Lin, X.; Zhang, F.; Bradbury, C. M.; Kaushal, A.; Li, L.; Spitz, D. R.; Aft, R. L.; Gius, D. 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res. 2003, 63, 3413-3417.
23. Verheij, M.; Bartelink, H. Radiation-induced apoptosis. Cell Tissue Res. 2000, 301, 133-142.
24. Brenner, D.; Kroemer, G. Apoptosis. Mitochondria - the death signal integrators. Science 2000, 289, 1150-1151.
25. Chipuk, J. E.; Bouchier-Hayes, L.; Green, D. R. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Ce11 Death Differ. 2006, 13, 1396-1402.
26. Green, D. R.; Reed, J. C. Mitochondria and apoptosis. Science 1998, 281, 1309-1312.
27. Kvols, L. K. Radiation sensitizers: a selective review of molecules targeting DNA and non-DNA targets. J. Nucl. Med. 2005, 46 (Suppl. 1), 187S-190S.
28. Park, J. K.; Chung, Y. M.; Kim, B. G.; Yoo, Y. A.; Yang, B. S.; Kim, J. S.; Yoo, Y. D. N′-(Phenyl-pyridm-2-yl-methylene)-hydrazme carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells. Mol. Cancer Ther. 2004, 3, 403-407.
29. Stevens, C. W.; Lee, J. S.; Cox, J.; Komaki, R. Novel approaches to locally advanced unresectable non-small cell lung cancer. Radiother. Oncol. 2000, 55, 11-18.
30. Assefa, Z.; Garmyn, M.; Vantieghem, A.; Dedercq, W.; Vandena-beele, P.; Vandenheede, J. R.; Agostinis, P. Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bc1-2. FEES Lett. 2003, 540, 125-132.