Glucocorticoid receptor agonist compound K regulates dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species

Life Sciences

Volumn 85, Issue 17-18, 2009, Pages 625-633

  Cuong, Trinh Tat ^a   Yang, Chul Su ^a   Yuk, Jae Min ^a   Lee, Hye Mi ^a   Ko, Sung Ryong ^b   Cho, Byung Goo ^b   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

^b KT and G Corporation   (South Korea)

Author keywords

Compound K; Dexamethasone; Inflammatory responses; Reactive oxygen species; Zymosan

Indexed keywords

20 O DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; DECTIN 1; DEXAMETHASONE; HORMONE RECEPTOR STIMULATING AGENT; INTERLEUKIN 12P40; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PREDNISOLONE SODIUM PHOSPHATE; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; FEMALE; GINSENOSIDES; INFLAMMATION; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NADPH OXIDASE; NERVE TISSUE PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUCOCORTICOID; SEPSIS; SIGNAL TRANSDUCTION; ZYMOSAN;

MURINAE;

EID: 70349757163     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.08.014     Document Type: Article

References (47)

1. Ahn J.Y., Song J.Y., Yun Y.S., Jeong G., and Choi I.S. Protection of Staphylococcus aureus infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunology and Medical Microbiology 46 2 (2006) 187-197
2. Ariizumi K., Shen G.L., Shikano S., Xu S., Ritter III R., Kumamoto T., Edelbaum D., Morita A., Bergstresser P.R., and Takashima A. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. Journal of Biological Chemistry 275 26 (2000) 20157-20167
3. Attele A.S., Wu J.A., and Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology 58 11 (1999) 1685-1693
4. Bailey J.M. New mechanisms for effects of anti-inflammatory glucocorticoids. Biofactors 3 2 (1991) 97-102
5. Brown G.D., and Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 413 6851 (2001) 36-37
6. Clark A.R. Anti-inflammatory functions of glucocorticoid-induced genes. Molecular and Cellular Endocrinology 275 1-2 (2007) 79-97
7. Cuzzocrea S., Filippelli A., Zingarelli B., Falciani M., Caputi A.P., and Rossi F. Role of nitric oxide in a nonseptic shock model induced by zymosan in the rat. Shock 7 5 (1997) 351-357
8. Cuzzocrea S., Di Paola R., Mazzon E., Patel N.S., Genovese T., Muia C., Crisafulli C., Caputi A.P., and Thiemermann C. Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice. Critical Care Medicine 34 4 (2006) 1168-1177
9. Dang P.M., Stensballe A., Boussetta T., Raad H., Dewas C., Kroviarski Y., Hayem G., Jensen O.N., Gougerot-Pocidalo M.A., and El-Benna J. A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. Journal of Clinical Investigation 116 7 (2006) 2033-2043
10. Donini M., Zenaro E., Tamassia N., and Dusi S. NADPH oxidase of human dendritic cells: role in Candida albicans killing and regulation by interferons, dectin-1 and CD206. European Journal of Immunology 37 5 (2007) 1194-1203
11. El Benna J., Faust L.P., and Babior B.M. The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. Journal of Biological Chemistry 269 38 (1994) 23431-23436
12. Esposito E., and Cuzzocrea S. Superoxide, No, peroxynitrite and PARP in circulatory shock and inflammation. Frontiers in Bioscience 14 (2009) 263-296
13. Faist E., Baue A.E., Dittmer H., and Heberer G. Multiple organ failure in polytrauma patients. Journal of Trauma 23 9 (1983) 775-787
14. Gaestel M., Mengel A., Bothe U., and Asadullah K. Protein kinases as small molecule inhibitor targets in inflammation. Current Medicinal Chemistry 14 21 (2007) 2214-2234
15. Gantner B.N., Simmons R.M., Canavera S.J., Akira S., and Underhill D.M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. Journal of Experimental Medicine 197 9 (2003) 1107-1117
16. Giaimis J., Lombard Y., Fonteneau P., Muller C.D., Levy R., Makaya-Kumba M., Lazdins J., and Poindron P. Both mannose and beta-glucan receptors are involved in phagocytosis of unopsonized, heat-killed Saccharomyces cerevisiae by murine macrophages. Journal of Leukocyte Biology 54 6 (1993) 564-571
17. Gillis C.N. Panax ginseng pharmacology: a nitric oxide link?. Biochemical Pharmacology 54 1 (1997) 1-8
18. Glass C.K., and Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nature Reviews Immunology 6 1 (2006) 44-55
19. Goodridge H.S., Simmons R.M., and Underhill D.M. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. Journal of Immunology 178 5 (2007) 3107-3115
20. Hench P.S., Slocumb C.H., Polley H.F., and Kendal E.C. Effect of cortisone and pituitary adrenocorticotropic hormone (ACTH) on rheumatic diseases. Journal of the American Medical Association 144 16 (1950) 1327-1335
21. Hsu B.G., Lee R.P., Yang F.L., Harn H.J., and Chen H.I. Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats. Life Sciences 79 21 (2006) 2010-2016
22. Imperatore F., Cuzzocrea S., Luongo C., Liguori G., Scafuro A., De Angelis A., Rossi F., Caputi A.P., and Filippelli A. Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome. Intensive Care Medicine 30 6 (2004) 1175-1181
23. Jo E.K., Yang C.S., Choi C.H., and Harding C.V. Intracellular signaling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors. Cellular Microbiology 9 5 (2007) 1087-1098
24. Jung S.H., Woo M.S., Kim S.Y., Kim W.K., Hyun J.W., Kim E.J., Kim D.H., and Kim H.S. Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. International Journal of Cancer 118 2 (2006) 490-497
25. Kennedy A.D., Willment J.A., Dorward D.W., Williams D.L., Brown G.D., and DeLeo F.R. Dectin-1 promotes fungicidal activity of human neutrophils. European Journal of Immunology 37 2 (2007) 467-478
26. Lee H.U., Bae E.A., Han M.J., Kim N.J., and Kim D.H. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver International 25 5 (2005) 1069-1073
27. Lim D.S., Bae K.G., Jung I.S., Kim C.H., Yun Y.S., and Song J.Y. Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation. Journal of Infection 45 1 (2002) 32-38
28. Lim T.S., Na K., Choi E.M., Chung J.Y., and Hwang J.K. Immunomodulating activities of polysaccharides isolated from Panax ginseng. Journal of Medicinal Food 7 1 (2004) 1-6
29. Mochizuki M., Yoo Y.C., Matsuzawa K., Sato K., Saiki I., Tono-oka S., Samukawa K., and Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of Red ginseng. Biological and Pharmaceutical Bulletin 18 9 (1995) 1197-1202
30. O'Connor T.M., O'Halloran D.J., and Shanahan F. The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia. QJM: An International Journal of Medicine 93 6 (2000) 323-333
31. Park E.K., Shin Y.W., Lee H.U., Kim S.S., Lee Y.C., Lee B.Y., and Kim D.H. Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biological and Pharmaceutical Bulletin 28 4 (2005) 652-656
32. Park J.S., Park E.M., Kim D.H., Jung K., Jung J.S., Lee E.J., Hyun J.W., Kang J.L., and Kim H.S. Anti-inflammatory mechanism of ginseng saponins in activated microglia. Journal of Neuroimmunology 209 1 (2009) 40-49
33. Preusch M.R., Rattazzi M., Albrecht C., Merle U., Tuckermann J., Schutz G., Blessing E., Zoppellaro G., Pauletto P., Krempien R., Rosenfeld M.E., Katus H.A., and Bea F. Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 28 12 (2008) 2158-2164
34. Reid D.M., Montoya M., Taylor P.R., Borrow P., Gordon S., Brown G.D., and Wong S.Y. Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. Journal of Leukocyte Biology 76 1 (2004) 86-94
35. Rothfuchs A.G., Bafica A., Feng C.G., Egen J.G., Williams D.L., Brown G.D., and Sher A. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. Journal of Immunology 179 6 (2007) 3463-3471
36. Shayevitz J.R., Miller C., Johnson K.J., and Rodriguez J.L. Multiple organ dysfunction syndrome: end organ and systemic inflammatory response in a mouse model of nonseptic origin. Shock 4 6 (1995) 389-396
37. Sun L., and Zhao Y. The biological role of dectin-1 in immune response. International Reviews of Immunology 26 5-6 (2007) 349-364
38. Tait A.S., Butts C.L., and Sternberg E.M. The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease. Journal of Leukocyte Biology 84 4 (2008) 924-931
39. Taylor P.R., Tsoni S.V., Willment J.A., Dennehy K.M., Rosas M., Findon H., Haynes K., Steele C., Botto M., Gordon S., and Brown G.D. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nature Immunology 8 1 (2007) 31-38
40. Teixeira M.M., Williams T.J., and Hellewell P.G. Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin. British Journal of Pharmacology 110 4 (1993) 1515-1521
41. Tuckermann J.P., Kleiman A., McPherson K.G., and Reichardt H.M. Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Critical Reviews in Clinical Laboratory Sciences 42 1 (2005) 71-104
42. Volman T.J., Goris R.J., van der Jagt M., van de Loo F.A., and Hendriks T. Organ damage in zymosan-induced multiple organ dysfunction syndrome in mice is not mediated by inducible nitric oxide synthase. Critical Care Medicine 30 7 (2002) 1553-1559
43. Volman T.J., Hendriks T., and Goris R.J. Zymosan-induced generalized inflammation: experimental studies into mechanisms leading to multiple organ dysfunction syndrome. Shock 23 4 (2005) 291-297
44. Willment J.A., Lin H.H., Reid D.M., Taylor P.R., Williams D.L., Wong S.Y., Gordon S., and Brown G.D. Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide. Journal of Immunology 171 9 (2003) 4569-4573
45. Wu J.Y., Gardner B.H., Murphy C.I., Seals J.R., Kensil C.R., Recchia J., Beltz G.A., Newman G.W., and Newman M.J. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. Journal of Immunology 148 5 (1992) 1519-1525
46. Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., and Jo E.K. Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. Journal of Experimental Medicine 204 3 (2007) 583-594
47. Yang C.S., Ko S.R., Cho B.G., Shin D.M., Yuk J.M., Li S., Kim J.M., Evans R.M., Jung J.S., Song D.K., and Jo E.K. The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock. Journal of Cellular and Molecular Medicine 12 5A (2008) 1739-1753