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Volumn 216, Issue 4, 2011, Pages 589-599

Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: Participation of 5-HT 2A receptors

Author keywords

Female mice; Forced swimming test; Ginseng root; Menopausal depressive like state; Ovariectomy; Ritanserin

Indexed keywords

CHIKUSETSU SAPONIN; COMPOUND K; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RG 1; GINSENOSIDE RG 3; PROTOPANAXADIOL; RITANSERIN; SAPONIN; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

EID: 79961168468     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2252-1     Document Type: Article
Times cited : (57)

References (50)
  • 1
    • 85009708837 scopus 로고    scopus 로고
    • 1 by intestinal bacteria, in rat plasma after oral administration - Measurement of compound K by enzyme immunoassay
    • 1 by intestinal bacteria, in rat plasma after oral administration: measurement of compound K by enzyme immunoassay Biol Pharm Bull 21 245 249 9556154 1:CAS:528:DyaK1cXit1Kmtb8%3D (Pubitemid 28166911)
    • (1998) Biological and Pharmaceutical Bulletin , vol.21 , Issue.3 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 3
    • 27844485648 scopus 로고    scopus 로고
    • Animal model of menopausal depressive-like state in female mice: Prolongation of immobility time in the forced swimming test following ovariectomy
    • DOI 10.1007/s00213-005-0179-0
    • N Bekku H Yoshimura 2005 Animal model of menopausal depressive-like state in female mice: prolongation of immobility time in the forced swimming test following ovariectomy Psychopharmacol Berl 183 300 307 10.1007/s00213-005-0179-0 1:CAS:528:DC%2BD2MXht1enu7%2FP (Pubitemid 41660415)
    • (2005) Psychopharmacology , vol.183 , Issue.3 , pp. 300-307
    • Bekku, N.1    Yoshimura, H.2
  • 4
    • 33745743469 scopus 로고    scopus 로고
    • Factors producing a menopausal depressive-like state in mice following ovariectomy
    • DOI 10.1007/s00213-006-0395-2
    • N Bekku H Yoshimura H Araki 2006 Factors producing a menopausal depressive-like state in mice following ovariectomy Psychopharmacol Berl 187 170 180 10.1007/s00213-006-0395-2 1:CAS:528:DC%2BD28Xms1Gquro%3D (Pubitemid 44015611)
    • (2006) Psychopharmacology , vol.187 , Issue.2 , pp. 170-180
    • Bekku, N.1    Yoshimura, H.2    Araki, H.3
  • 5
    • 0020540146 scopus 로고
    • Serotonergic and noradrenergic receptors in the rat brain: Modulation by chronic exposure to ovarian hormones
    • A Biegon A Reches L Snyder BS McEwen 1983 Serotonergic and noradrenergic receptors in the rat brain: modulation by chronic exposure to ovarian hormones Life Sci 32 2015 2021 6188018 10.1016/0024-3205(83)90053-X 1:CAS:528: DyaL3sXhvFWqu7Y%3D (Pubitemid 13114082)
    • (1983) Life Sciences , vol.32 , Issue.17 , pp. 2015-2021
    • Biegon, A.1    Reches, A.2    Snyder, L.3    McEwen, B.S.4
  • 6
    • 0037304917 scopus 로고    scopus 로고
    • 1A agonists in the treatment of depression?
    • DOI 10.1016/S0006-3223(02)01643-8
    • 1A agonists in the treatment of depression? Biol Psychiatry 53 193 203 12559651 10.1016/S0006-3223(02)01643-8 1:CAS:528:DC%2BD3sXmsVOruw%3D%3D (Pubitemid 36135929)
    • (2003) Biological Psychiatry , vol.53 , Issue.3 , pp. 193-203
    • Blier, P.1    Ward, N.M.2
  • 7
    • 0023915698 scopus 로고
    • Is the forced swimming test a suitable model for revealing antidepressant activity?
    • F Borsini A Meli 1988 Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology 94 147 160 3127840 10.1007/BF00176837 1:STN:280:DyaL1c7nslWnsQ%3D%3D (Pubitemid 18040687)
    • (1988) Psychopharmacology , vol.94 , Issue.2 , pp. 147-160
    • Borsini, F.1    Meli, A.2
  • 8
    • 0035100705 scopus 로고    scopus 로고
    • How valuable are animal models in defining antidepressant activity?
    • DOI 10.1002/hup.178
    • M Bourin AJ Fiocco F Clenet 2001 How valuable are animal models in defining antidepressant activity? Hum Psychopharmacol Clin Exp 16 9 21 10.1002/hup.178 1:CAS:528:DC%2BD3MXhvVejsr8%3D (Pubitemid 32218876)
    • (2001) Human Psychopharmacology , vol.16 , Issue.1 , pp. 9-21
    • Mcintyre, J.S.1
  • 9
    • 22144471561 scopus 로고    scopus 로고
    • Anxiolytic-like effect of milnacipran in the four-plate test in mice: Mechanism of action
    • DOI 10.1016/j.pbb.2005.04.015, PII S0091305705001668
    • M Bourin F Masse E Dailly M Hascoet 2005 Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action Pharmacol Biochem Behav 81 645 656 15961146 10.1016/j.pbb.2005.04.015 1:CAS:528: DC%2BD2MXmt1art7w%3D (Pubitemid 40973787)
    • (2005) Pharmacology Biochemistry and Behavior , vol.81 , Issue.3 , pp. 645-656
    • Bourin, M.1    Masse, F.2    Dailly, E.3    Hascoet, M.4
  • 10
    • 32044437560 scopus 로고    scopus 로고
    • Identification of anxiolytic ingredients in ginseng root using the elevated plus-maze test in mice
    • DOI 10.1016/j.ejphar.2005.12.014, PII S0014299905013166
    • MN Carr N Bekku H Yoshimura 2006 Identification of anxiolytic ingredients in ginseng root using the elevated plus-maze test in mice Eur J Pharmacol 531 160 165 16413533 10.1016/j.ejphar.2005.12.014 1:CAS:528:DC%2BD28Xhtlejt7k%3D (Pubitemid 43202229)
    • (2006) European Journal of Pharmacology , vol.531 , Issue.1-3 , pp. 160-165
    • Carr, M.N.1    Bekku, N.2    Yoshimura, H.3
  • 11
    • 0036570222 scopus 로고    scopus 로고
    • Assessing antidepressant activity in rodents: Recent developments and future needs
    • DOI 10.1016/S0165-6147(02)02017-5, PII S0165614702020175
    • JF Cryan A Markou I Lucki 2002 Assessing antidepressant activity in rodents: recent developments and future needs Trends Pharmacol Sci 23 238 245 12008002 10.1016/S0165-6147(02)02017-5 1:CAS:528:DC%2BD38XjsVWjsbo%3D (Pubitemid 34465544)
    • (2002) Trends in Pharmacological Sciences , vol.23 , Issue.5 , pp. 238-245
    • Cryan, J.F.1    Markou, A.2    Lucki, I.3
  • 12
    • 0032484518 scopus 로고    scopus 로고
    • Gonadal hormones modulate 5-hydroxytryptamine(2A) receptors: Emphasis on the rat frontal cortex
    • DOI 10.1016/S0306-4522(97)00445-4, PII S0306452297004454
    • 2A receptors: emphasis on the rat frontal cortex Neuroscience 83 829 836 9483566 10.1016/S0306-4522(97)00445-4 1:CAS:528:DyaK1cXmvVWntg%3D%3D (Pubitemid 28068903)
    • (1998) Neuroscience , vol.83 , Issue.3 , pp. 829-836
    • Cyr, M.1    Bosse, R.2    Di Paolo, T.3
  • 13
    • 0034130235 scopus 로고    scopus 로고
    • Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain
    • DOI 10.1016/S0893-133X(00)00085-3, PII S0893133X00000853
    • M Cyr M Landry T Di Paolo 2000 Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain Neuropsychopharmacology 23 69 78 10869887 10.1016/S0893-133X(00)00085-3 1:CAS:528:DC%2BD3cXktlKksb8%3D (Pubitemid 30408313)
    • (2000) Neuropsychopharmacology , vol.23 , Issue.1 , pp. 69-78
    • Cyr, M.1    Landry, M.2    Di Paolo, T.3
  • 14
    • 69949190825 scopus 로고    scopus 로고
    • Hormone replacement therapy and the endometrium
    • 19723685 10.1258/mi.2009.009027 1:STN:280:DC%2BD1Mrpslaluw%3D%3D
    • S Daayana CM Holland 2009 Hormone replacement therapy and the endometrium Menopause Int 15 134 138 19723685 10.1258/mi.2009.009027 1:STN:280: DC%2BD1Mrpslaluw%3D%3D
    • (2009) Menopause Int , vol.15 , pp. 134-138
    • Daayana, S.1    Holland, C.M.2
  • 15
    • 71549173390 scopus 로고    scopus 로고
    • Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression
    • 10.1016/j.pnpbp.2009.07.020 1:CAS:528:DC%2BD1MXhtlygtb%2FI
    • H Dang Y Chen X Liu Q Wang L Wang W Jia Y Wang 2009 Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression Prog Neuro-psychopharmacol Biol Psychiatry 33 1417 1424 10.1016/j.pnpbp.2009.07.020 1:CAS:528:DC%2BD1MXhtlygtb%2FI
    • (2009) Prog Neuro-psychopharmacol Biol Psychiatry , vol.33 , pp. 1417-1424
    • Dang, H.1    Chen, Y.2    Liu, X.3    Wang, Q.4    Wang, L.5    Jia, W.6    Wang, Y.7
  • 16
    • 33846604092 scopus 로고    scopus 로고
    • Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders
    • DOI 10.1002/ptr.2024
    • H Einat 2007 Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders Phytother Res 21 62 66 17089329 10.1002/ptr.2024 1:CAS:528: DC%2BD2sXhvFylsLg%3D (Pubitemid 46173911)
    • (2007) Phytotherapy Research , vol.21 , Issue.1 , pp. 62-66
    • Einat, H.1
  • 17
    • 0042336014 scopus 로고    scopus 로고
    • Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women
    • DOI 10.1016/S0015-0282(03)00973-7
    • L Eydie SL Moses-Kolko PJ Berga GS Greer CC Meltzer WC Drevets 2003 Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal Fertil Steril 80 554 559 10.1016/S0015-0282(03)00973-7 (Pubitemid 37102865)
    • (2003) Fertility and Sterility , vol.80 , Issue.3 , pp. 554-559
    • Moses-Kolko, E.L.1    Berga, S.L.2    Greer, P.J.3    Smith, G.4    Meltzer, C.C.5    Drevets, W.C.6
  • 18
    • 21644483307 scopus 로고    scopus 로고
    • The association of perimenopausal mood disorders with other reproductive-related disorders
    • J Feld U Halbreich S Karkun 2005 The association of perimenopausal mood disorders with other reproductive-related disorders CNS Spectr 10 461 470 15908900 (Pubitemid 40934398)
    • (2005) CNS Spectrums , vol.10 , Issue.6 , pp. 461-470
    • Feld, J.1    Halbreich, U.2    Karkun, S.3
  • 19
    • 34447283308 scopus 로고    scopus 로고
    • Botanical and dietary supplements for mood and anxiety in menopausal women
    • 17194961 10.1097/01.gme.0000236934.43701.c5
    • SE Geller L Studee 2007 Botanical and dietary supplements for mood and anxiety in menopausal women Menopause 14 541 549 17194961 10.1097/01.gme. 0000236934.43701.c5
    • (2007) Menopause , vol.14 , pp. 541-549
    • Geller, S.E.1    Studee, L.2
  • 20
    • 0034231482 scopus 로고    scopus 로고
    • Women's issues in mood disorders
    • 11249499 10.1517/14656566.1.5.903 1:CAS:528:DC%2BD3cXlslensLw%3D
    • PJ Goodnick T Chaudry J Artadi S Arcey 2000 Women's issues in mood disorders Expert Opin Pharmacother 1 903 916 11249499 10.1517/14656566.1.5.903 1:CAS:528:DC%2BD3cXlslensLw%3D
    • (2000) Expert Opin Pharmacother , vol.1 , pp. 903-916
    • Goodnick, P.J.1    Chaudry, T.2    Artadi, J.3    Arcey, S.4
  • 21
    • 0033952432 scopus 로고    scopus 로고
    • Anxiolytic-like effects of antidepressants after acute administration in a four-plate test in mice
    • DOI 10.1016/S0091-3057(99)00191-4, PII S0091305799001914
    • M Hascoet M Bourin M Claude-Colombel AJ Fiocco GB Baker 2000 Anxiolytic-like effects of antidepressants after acute administration in a four-plate test in mice Pharmacol Biochem Behav 65 339 344 10672988 10.1016/S0091-3057(99)00191-4 1:CAS:528:DC%2BD3cXhtVaisLs%3D (Pubitemid 30100282)
    • (2000) Pharmacology Biochemistry and Behavior , vol.65 , Issue.2 , pp. 339-344
    • Hascoet, M.1    Bourin, M.2    Colombel, M.C.3    Fiocco, A.J.4    Baker, G.B.5
  • 22
    • 0029840531 scopus 로고    scopus 로고
    • Main Ginseng saponin metabolites formed by intestinal bacteria
    • DOI 10.1055/s-2006-957938
    • H Hasegawa JH Sung S Matsumiya M Uchiyama 1996 Main ginseng saponin metabolites formed by intestinal bacteria Planta Med 62 453 457 8923812 10.1055/s-2006-957938 1:CAS:528:DyaK28XnsVyhsb0%3D (Pubitemid 26370341)
    • (1996) Planta Medica , vol.62 , Issue.5 , pp. 453-457
    • Hasegawa, H.1    Sung, J.-H.2    Matsumiya, S.3    Uchiyama, M.4
  • 24
    • 0023259999 scopus 로고
    • Chemical studies on crude drug processing. V. On the constituents of Ginseng Radix Rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root
    • I Kitagawa T Taniyama H Shibuya T Noda M Yoshikawa 1987 Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root Yakugaku Zasshi 107 495 505 3694458 1:CAS:528:DyaL2sXmtVGjsr0%3D (Pubitemid 17130807)
    • (1987) Yakugaku Zasshi , vol.107 , Issue.7 , pp. 495-505
    • Kitagawa, I.1    Taniyama, T.2    Shibuya, H.3
  • 26
    • 0023754894 scopus 로고
    • Receptor interactions of dopamine and serotonin antagonists: Binding in vitro and vivo and receptor regulation
    • 3045796 1:STN:280:DyaL1czitVaquw%3D%3D
    • JE Leysen W Gommeren PF Janssen P Van Gompel PA Janssen 1988 Receptor interactions of dopamine and serotonin antagonists: binding in vitro and vivo and receptor regulation Psychopharmacol Ser 5 12 26 3045796 1:STN:280: DyaL1czitVaquw%3D%3D
    • (1988) Psychopharmacol ser , vol.5 , pp. 12-26
    • Leysen, J.E.1    Gommeren, W.2    Janssen, P.F.3    Van Gompel, P.4    Janssen, P.A.5
  • 27
    • 0026342262 scopus 로고
    • Behavioral studies of serotonin receptor agonists as antidepressant drugs
    • 1684363
    • I Lucki 1991 Behavioral studies of serotonin receptor agonists as antidepressant drugs J Clin Psychiatry 52 Suppl 24 31 1684363
    • (1991) J Clin Psychiatry , vol.52 , Issue.SUPPL. , pp. 24-31
    • Lucki, I.1
  • 28
    • 54449097080 scopus 로고    scopus 로고
    • Association of ovarian and uterine cancers with postmenopausal hormonal treatments
    • 18677154 10.1097/GRF.0b013e318180b988
    • M Neves-E-Castro 2008 Association of ovarian and uterine cancers with postmenopausal hormonal treatments Clin Obstet Gynecol 51 607 617 18677154 10.1097/GRF.0b013e318180b988
    • (2008) Clin Obstet Gynecol , vol.51 , pp. 607-617
    • Neves-E-Castro, M.1
  • 30
    • 12344283814 scopus 로고    scopus 로고
    • Forced swimming test in mice: A review of antidepressant activity
    • DOI 10.1007/s00213-004-2048-7
    • B Petit-Demouliere F Chenu M Bourin 2005 Forced swimming test in mice: a review of antidepressant activity Psychopharmacol Berl 177 245 255 10.1007/s00213-004-2048-7 1:CAS:528:DC%2BD2cXhtVyltLrE (Pubitemid 40137284)
    • (2005) Psychopharmacology , vol.177 , Issue.3 , pp. 245-255
    • Petit-Demouliere, B.1    Chenu, F.2    Bourin, M.3
  • 31
    • 27944470411 scopus 로고    scopus 로고
    • 2A subtype receptors in DOI activity in the four-plates test-retest paradigm in mice
    • DOI 10.1016/j.bbr.2005.07.013, PII S0166432805003293
    • 2A subtype receptors in DOI activity in the four-plates test-retest paradigm in mice Behav Brain Res 166 131 139 16154212 10.1016/j.bbr.2005.07.013 1:CAS:528: DC%2BD2MXht1GgtbzP (Pubitemid 41677369)
    • (2006) Behavioural Brain Research , vol.166 , Issue.1 , pp. 131-139
    • Ripoll, N.1    Hascoet, M.2    Bourin, M.3
  • 33
    • 0032782676 scopus 로고    scopus 로고
    • Anxiety with depression: A treatment need
    • DOI 10.1016/S0924-977X(99)00027-9, PII S0924977X99000279
    • F Rouillon 1999 Anxiety with depression: a treatment need Eur Neuropsychopharmacol 9 suppl 3 87 92 10.1016/S0924-977X(99)00027-9 (Pubitemid 29333167)
    • (1999) European Neuropsychopharmacology , vol.9 , Issue.SUPPL. 3
    • Rouillon, F.1
  • 34
    • 0028965624 scopus 로고
    • Simultaneous analysis of ginsenosides of various ginseng radix by HPLC
    • 7738782 1:CAS:528:DyaK2MXmvFWksL0%3D
    • K Samukawa H Yamashita H Matsuda M Kubo 1995 Simultaneous analysis of ginsenosides of various ginseng radix by HPLC Yakugaku Zasshi 115 241 249 7738782 1:CAS:528:DyaK2MXmvFWksL0%3D
    • (1995) Yakugaku Zasshi , vol.115 , pp. 241-249
    • Samukawa, K.1    Yamashita, H.2    Matsuda, H.3    Kubo, M.4
  • 35
    • 0028847493 scopus 로고
    • Simultaneous analysis of saponins in ginseng radix by high performance liquid chromatography
    • 1:CAS:528:DyaK2MXksVSqtLg%3D
    • K Samukawa H Yamashita H Matsuda M Kubo 1995 Simultaneous analysis of saponins in ginseng radix by high performance liquid chromatography Chem Pharm Bull 43 137 141 1:CAS:528:DyaK2MXksVSqtLg%3D
    • (1995) Chem Pharm Bull , vol.43 , pp. 137-141
    • Samukawa, K.1    Yamashita, H.2    Matsuda, H.3    Kubo, M.4
  • 36
    • 67849124851 scopus 로고    scopus 로고
    • Sex steroids, response to stress and susceptibility to depression
    • Fink George (ed.) 2nd ed. Elsevier, Inc
    • Seeman MV, Ross LE (2007) Sex steroids, response to stress and susceptibility to depression. In: Fink George (ed.) Encyclopedia of stress, 2nd ed. Elsevier, Inc, pp 474-479
    • (2007) Encyclopedia of Stress , pp. 474-479
    • Seeman, M.V.1    Ross, L.E.2
  • 37
    • 7444243779 scopus 로고    scopus 로고
    • Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction
    • DOI 10.1016/j.brainres.2004.09.012, PII S0006899304015331
    • K Sipe L Leventhal K Burroughs S Cosmi GH Johnston DC Deecher 2004 Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction Brain Res 1028 191 202 15527744 10.1016/j.brainres.2004.09.012 1:CAS:528:DC%2BD2cXpsFSrtbs%3D (Pubitemid 39446630)
    • (2004) Brain Research , vol.1028 , Issue.2 , pp. 191-202
    • Sipe, K.1    Leventhal, L.2    Burroughs, K.3    Cosmi, S.4    Johnston, G.H.5    Deecher, D.C.6
  • 38
    • 0141843500 scopus 로고    scopus 로고
    • Gender differences in depression and response to antidepressant treatment
    • DOI 10.1016/S0193-953X(03)00044-3
    • DM Sloan SG Kornstein 2003 Gender differences in depression and response to antidepressant treatment Psychiatr Clin North Am 26 581 594 14563099 10.1016/S0193-953X(03)00044-3 (Pubitemid 37175497)
    • (2003) Psychiatric Clinics of North America , vol.26 , Issue.3 , pp. 581-594
    • Sloan, D.M.E.1    Kornstein, S.G.2
  • 39
    • 0021217443 scopus 로고
    • Panax ginseng: Relation between age of plant and content of ginsenosides
    • DOI 10.1055/s-2007-969729
    • F Soldati O Tanaka 1984 Panax ginseng: relation between age of plant and content of ginsenosides Planta Med 50 351 352 17340326 10.1055/s-2007-969729 1:CAS:528:DyaL2MXhs1eksb8%3D (Pubitemid 14008718)
    • (1984) Planta Medica , vol.50 , Issue.4 , pp. 351-352
    • Soldati, F.1    Tanaka, O.2
  • 40
    • 58249086970 scopus 로고    scopus 로고
    • Are oestrogens useful for the treatment of depression in women?
    • 19110473 10.1016/j.bpobgyn.2008.11.001
    • J Studd N Panay 2009 Are oestrogens useful for the treatment of depression in women? Best Pract Res Clin Obstet Gynaecol 23 63 71 19110473 10.1016/j.bpobgyn.2008.11.001
    • (2009) Best Pract Res Clin Obstet Gynaecol , vol.23 , pp. 63-71
    • Studd, J.1    Panay, N.2
  • 43
    • 0032743041 scopus 로고    scopus 로고
    • Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes
    • 10.1016/S0020-7292(99)00168-X 1:STN:280:DC%2BD3c7itlaqtA%3D%3D
    • T Tode Y Kikuchi J Hirata T Kita H Nakata I Nagata 1999 Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes Int J Gynecol Obstet 67 169 174 10.1016/S0020-7292(99)00168-X 1:STN:280:DC%2BD3c7itlaqtA%3D%3D
    • (1999) Int J Gynecol Obstet , vol.67 , pp. 169-174
    • Tode, T.1    Kikuchi, Y.2    Hirata, J.3    Kita, T.4    Nakata, H.5    Nagata, I.6
  • 44
    • 0024375752 scopus 로고
    • Problems with the differentiation of anxiety and depression
    • DOI 10.1016/0022-3956(89)90013-7
    • S Wetzler MM Katz 1989 Problems with the differentiation of anxiety and depression J Psychiatr Res 23 1 12 2666646 10.1016/0022-3956(89)90013-7 1:STN:280:DyaL1MzivVynsw%3D%3D (Pubitemid 19191580)
    • (1989) Journal of Psychiatric Research , vol.23 , Issue.1 , pp. 1-12
    • Wetzler, S.1    Katz, M.M.2
  • 45
    • 0033509909 scopus 로고    scopus 로고
    • Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: A double-blind, placebo-controlled trial
    • IK Wiklund LA Mattsson R Lindgren C Limoni 1999 Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group Int J Clin Pharmacol Res 19 89 99 10761538 1:STN:280:DC%2BD3c3isVKjtg%3D%3D (Pubitemid 30162680)
    • (1999) International Journal of Clinical Pharmacology Research , vol.19 , Issue.3 , pp. 89-99
    • Wiklund, I.K.1    Mattsson, L.-A.2    Lindgren, R.3    Limoni, C.4
  • 46
    • 0011981056 scopus 로고
    • Studies contrasting drug effects on reproduction induced agonistic behaviour in male and female mice
    • B. Olivier J. Mos P.F. Brain (eds). Martinus Nijhoff Dordrecht
    • Yoshimura H (1987) Studies contrasting drug effects on reproduction induced agonistic behaviour in male and female mice. In: Olivier B, Mos J, Brain PF (eds) Ethopharmacology of agonistic behaviour in animals and humans. Martinus Nijhoff, Dordrecht, pp 94-109
    • (1987) Ethopharmacology of Agonistic Behaviour in Animals and Humans , pp. 94-109
    • Yoshimura, H.1
  • 47
    • 0024591726 scopus 로고
    • Acute and chronic effects of psychotropic drugs on maternal aggression in mice
    • DOI 10.1007/BF00439447
    • H Yoshimura N Ogawa 1989 Acute and chronic effects of psychotropic drugs on maternal aggression in mice Psychopharmacol Berl 97 339 342 10.1007/BF00439447 1:CAS:528:DyaL1MXhs1Kjsbs%3D (Pubitemid 19103425)
    • (1989) Psychopharmacology , vol.97 , Issue.3 , pp. 339-342
    • Yoshimura, H.1    Ogawa, N.2
  • 48
    • 0025768954 scopus 로고
    • Ethopharmacology of maternal aggression in mice: Effects of diazepam and SM-3997
    • 1685120 10.1016/0014-2999(91)90677-I 1:CAS:528:DyaK3MXlsFSht70%3D
    • H Yoshimura N Ogawa 1991 Ethopharmacology of maternal aggression in mice: effects of diazepam and SM-3997 Eur J Pharmacol 200 147 153 1685120 10.1016/0014-2999(91)90677-I 1:CAS:528:DyaK3MXlsFSht70%3D
    • (1991) Eur J Pharmacol , vol.200 , pp. 147-153
    • Yoshimura, H.1    Ogawa, N.2
  • 49
    • 0023858522 scopus 로고
    • Psychotropic effects of ginseng saponins on agonistic behavior between resident and intruder mice
    • H Yoshimura K Watanabe N Ogawa 1988 Psychotropic effects of ginseng saponins on agonistic behavior between resident and intruder mice Eur J Pharmacol 146 291 297 3371400 10.1016/0014-2999(88)90305-6 1:CAS:528: DyaL1cXht1Cnsr4%3D (Pubitemid 18068504)
    • (1988) European Journal of Pharmacology , vol.146 , Issue.2-3 , pp. 291-297
    • Yoshimura, H.1    Watanabe, K.2    Ogawa, N.3
  • 50
    • 0023891123 scopus 로고
    • Acute and chronic effects of ginseng saponins on maternal aggression in mice
    • 3416912 10.1016/0014-2999(88)90013-1 1:CAS:528:DyaL1cXksVygt7c%3D
    • H Yoshimura K Watanabe N Ogawa 1988 Acute and chronic effects of ginseng saponins on maternal aggression in mice Eur J Pharmacol 150 319 324 3416912 10.1016/0014-2999(88)90013-1 1:CAS:528:DyaL1cXksVygt7c%3D
    • (1988) Eur J Pharmacol , vol.150 , pp. 319-324
    • Yoshimura, H.1    Watanabe, K.2    Ogawa, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.