DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA

Cell Host and Microbe

Volumn 11, Issue 3, 2012, Pages 290-297

  Upton, Jason W ^a   Kaiser, William J ^a   Mocarski, Edward S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT ACTIVATOR OF INTERFERON REGULATORY FACTORS; RECEPTOR INTERACTING PROTEIN KINASE 3; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VIRAL INHIBITOR OF RIP ACTIVATION; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; COMPLEX FORMATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; VIRUS CELL INTERACTION;

ANIMALS; APOPTOSIS; GLYCOPROTEINS; HERPESVIRIDAE INFECTIONS; HOST-PATHOGEN INTERACTIONS; INFLAMMATION; INTERFERON-BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; MUROMEGALOVIRUS; NECROSIS; NF-KAPPA B; NIH 3T3 CELLS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; VIRAL LOAD; VIRAL PROTEINS;

MAIZE CHLOROTIC MOTTLE VIRUS; MURID HERPESVIRUS 1; MUS; VIRUSES;

EID: 84858420051     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.01.016     Document Type: Article

References (43)

1. G.N. Barber Cytoplasmic DNA innate immune pathways Immunol. Rev. 243 2011 99 108
2. C.A. Benedict, A. Angulo, G. Patterson, S. Ha, H. Huang, M. Messerle, C.F. Ware, and P. Ghazal Neutrality of the canonical NF-kappaB-dependent pathway for human and murine cytomegalovirus transcription and replication in vitro J. Virol. 78 2004 741 750 (Pubitemid 38067596)
3. S.M. Best Viral subversion of apoptotic enzymes: escape from death row Annu. Rev. Microbiol. 62 2008 171 192
4. W. Brune, C. Menard, J. Heesemann, and U.H. Koszinowski A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism Science 291 2001 303 305
5. J.R. Burke, M.A. Pattoli, K.R. Gregor, P.J. Brassil, J.F. MacMaster, K.W. McIntyre, X. Yang, V.S. Iotzova, W. Clarke, and J. Strnad BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice J. Biol. Chem. 278 2003 1450 1456 (Pubitemid 36801370)
6. M. Cam, W. Handke, M. Picard-Maureau, and W. Brune Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins Cell Death Differ. 17 2010 655 665
7. Y.S. Cho, S. Challa, D. Moquin, R. Genga, T.D. Ray, M. Guildford, and F.K. Chan Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation Cell 137 2009 1112 1123
8. V.R. DeFilippis, D. Alvarado, T. Sali, S. Rothenburg, and K. Fruh Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1 J. Virol. 84 2010 585 598
9. V.R. DeFilippis, T. Sali, D. Alvarado, L. White, W. Bresnahan, and K.J. Fruh Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B J. Virol. 84 2010 8913 8925
10. A. Degterev, J. Hitomi, M. Germscheid, I.L. Ch'en, O. Korkina, X. Teng, D. Abbott, G.D. Cuny, C. Yuan, and G. Wagner Identification of RIP1 kinase as a specific cellular target of necrostatins Nat. Chem. Biol. 4 2008 313 321 (Pubitemid 351550892)
11. M. Feoktistova, P. Geserick, B. Kellert, D.P. Dimitrova, C. Langlais, M. Hupe, K. Cain, M. Macfarlane, G. Hacker, and M. Leverkus cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms Mol. Cell 43 2011 449 463
12. Y. Fu, N. Comella, K. Tognazzi, L.F. Brown, H.F. Dvorak, and O. Kocher Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display Gene 240 1999 157 163 (Pubitemid 29516443)
13. S.R. Furr, V.S. Chauhan, M.J. Moerdyk-Schauwecker, and I. Marriott A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells J. Neuroinflammation 8 2011 99
14. S. He, L. Wang, L. Miao, T. Wang, F. Du, L. Zhao, and X. Wang Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha Cell 137 2009 1100 1111
15. S. He, Y. Liang, F. Shao, and X. Wang Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway Proc. Natl. Acad. Sci. USA 108 2011 20054 20059
16. M.O. Hengartner The biochemistry of apoptosis Nature 407 2000 770 776
17. K.J. Ishii, T. Kawagoe, S. Koyama, K. Matsui, H. Kumar, T. Kawai, S. Uematsu, O. Takeuchi, F. Takeshita, and C. Coban TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines Nature 451 2008 725 729 (Pubitemid 351220566)
18. W.J. Kaiser, J.W. Upton, and E.S. Mocarski Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors J. Immunol. 181 2008 6427 6434
19. W.J. Kaiser, J.W. Upton, A.B. Long, D. Livingston-Rosanoff, L.P. Daley-Bauer, R. Hakem, T. Caspary, and E.S. Mocarski RIP3 mediates the embryonic lethality of caspase-8-deficient mice Nature 471 2011 368 372
20. E. Karayel, T. Burckstummer, M. Bilban, G. Durnberger, S. Weitzer, J. Martinez, and G. Superti-Furga The TLR-independent DNA recognition pathway in murine macrophages: ligand features and molecular signature Eur. J. Immunol. 39 2009 1929 1936
21. M. Katdare, E.V. Efimova, E. Labay, N.N. Khodarev, T.E. Darga, M. Garofalo, S. Nakamura, D.W. Kufe, M.C. Posner, and R.R. Weichselbaum Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB Int. J. Oncol. 31 2007 1519 1528
22. M. Lamkanfi, and V.M. Dixit Manipulation of host cell death pathways during microbial infections Cell Host Microbe 8 2010 44 54
23. D. Lembo, M. Donalisio, A. Hofer, M. Cornaglia, W. Brune, U. Koszinowski, L. Thelander, and S. Landolfo The ribonucleotide reductase R1 homolog of murine cytomegalovirus is not a functional enzyme subunit but is required for pathogenesis J. Virol. 78 2004 4278 4288 (Pubitemid 38437231)
24. M. Li, and A.A. Beg Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells J. Virol. 74 2000 7470 7477 (Pubitemid 30613092)
25. J. Lippmann, S. Rothenburg, N. Deigendesch, J. Eitel, K. Meixenberger, V. van Laak, H. Slevogt, P.D. N'Guessan, S. Hippenstiel, and T. Chakraborty IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI) Cell. Microbiol. 10 2008 2579 2588
26. C. Mack, A. Sickmann, D. Lembo, and W. Brune Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein Proc. Natl. Acad. Sci. USA 105 2008 3094 3099 (Pubitemid 351723673)
27. A.L. McCormick, A. Skaletskaya, P.A. Barry, E.S. Mocarski, and V.S. Goldmacher Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses Virology 316 2003 221 233 (Pubitemid 37468526)
28. A.L. McCormick, C.D. Meiering, G.B. Smith, and E.S. Mocarski Mitochondrial cell death suppressors carried by human and murine cytomegalovirus confer resistance to proteasome inhibitor-induced apoptosis J. Virol. 79 2005 12205 12217 (Pubitemid 41346082)
29. C. Menard, M. Wagner, Z. Ruzsics, K. Holak, W. Brune, A.E. Campbell, and U.H. Koszinowski Role of murine cytomegalovirus US22 gene family members in replication in macrophages J. Virol. 77 2003 5557 5570 (Pubitemid 36538948)
30. E.S. Mocarski, J.W. Upton, and W.J. Kaiser Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways Nat. Rev. Immunol. 12 2011 79 88
31. K. Newton, X. Sun, and V.M. Dixit Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4 Mol. Cell. Biol. 24 2004 1464 1469 (Pubitemid 38167070)
32. A. Oberst, C.P. Dillon, R. Weinlich, L.L. McCormick, P. Fitzgerald, C. Pop, R. Hakem, G.S. Salvesen, and D.R. Green Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis Nature 47 2011 363 367
33. M. Rebsamen, L.X. Heinz, E. Meylan, M.C. Michallet, K. Schroder, K. Hofmann, J. Vazquez, C.A. Benedict, and J. Tschopp DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB EMBO Rep. 10 2009 916 922
34. A. Skaletskaya, L.M. Bartle, T. Chittenden, A.L. McCormick, E.S. Mocarski, and V.S. Goldmacher A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation Proc. Natl. Acad. Sci. USA 98 2001 7829 7834 (Pubitemid 32642646)
35. A. Strasser, L. O'Connor, and V.M. Dixit Apoptosis signaling Annu. Rev. Biochem. 69 2000 217 245
36. A. Takaoka, Z. Wang, M.K. Choi, H. Yanai, H. Negishi, T. Ban, Y. Lu, M. Miyagishi, T. Kodama, and K. Honda DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response Nature 448 2007 501 505 (Pubitemid 47123520)
37. T. Tenev, K. Bianchi, M. Darding, M. Broemer, C. Langlais, F. Wallberg, A. Zachariou, J. Lopez, M. Macfarlane, and K. Cain The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs Mol. Cell 43 2011 432 448
38. J.W. Upton, W.J. Kaiser, and E.S. Mocarski Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1 J. Biol. Chem. 283 2008 16966 16970
39. J.W. Upton, W.J. Kaiser, and E.S. Mocarski Virus inhibition of RIP3-dependent necrosis Cell Host Microbe 7 2010 302 313
40. T. Vanden Berghe, M. Kalai, G. Denecker, A. Meeus, X. Saelens, and P. Vandenabeele Necrosis is associated with IL-6 production but apoptosis is not Cell. Signal. 18 2006 328 335 (Pubitemid 41661348)
41. Z. Wang, M.K. Choi, T. Ban, H. Yanai, H. Negishi, Y. Lu, T. Tamura, A. Takaoka, K. Nishikura, and T. Taniguchi Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules Proc. Natl. Acad. Sci. USA 105 2008 5477 5482 (Pubitemid 351753888)
42. D.W. Zhang, J. Shao, J. Lin, N. Zhang, B.J. Lu, S.C. Lin, M.Q. Dong, and J. Han RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis Science 325 2009 332 336
43. D.W. Zhang, M. Zheng, J. Zhao, Y.Y. Li, Z. Huang, Z. Li, and J. Han Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes Cell Res. 21 2011 368 371