CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Moquin, David M ^a   McQuade, Thomas ^a   Chan, Francis Ka Ming ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; CYCLOHEXIMIDE; NECROSOME; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 2; RECEPTOR INTERACTING PROTEIN KINASE 3; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ADENOID CYSTIC CARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; CYLD GENE; CYTOSOL; DEUBIQUITINATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; MOUSE; NECROPTOSIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

ANIMALS; CELL LINE, TUMOR; CYCLOHEXIMIDE; CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GTPASE-ACTIVATING PROTEINS; HUMANS; MICE; NECROSIS; OLIGOPEPTIDES; PHOSPHORYLATION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINATION;

EID: 84884823502     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076841     Document Type: Article

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