Cutting edge: RIPK1 kinase inactive mice are viable and protected from TNF-Induced necroptosis in vivo

Journal of Immunology

Volumn 193, Issue 4, 2014, Pages 1539-1543

  Polykratis, Apostolos ^a   Hermance, Nicole ^b   Zelic, Matija ^b   Roderick, Justine ^b   Kim, Chun ^a   Van, Trieu My ^a   Lee, Thomas H ^c   Chan, Francis K M ^b   Pasparakis, Manolis ^a   Kelliher, Michelle A ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENZYME INACTIVATION; GENE EXPRESSION; GENE INACTIVATION; HYPOTHERMIA; IN VIVO STUDY; INFECTION CONTROL; INFECTION PREVENTION; INFLAMMATION; INNATE IMMUNITY; MOUSE; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIPK1 GENE; SEPTIC SHOCK; SURVIVAL; VACCINIA; VACCINIA VIRUS; VIRUS REPLICATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; APOPTOSIS; CELLS, CULTURED; GENE KNOCK-IN TECHNIQUES; HYPOTHERMIA; INFLAMMATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; NECROSIS; NF-KAPPA B; POLY I-C; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; TUMOR NECROSIS FACTOR-ALPHA; VACCINIA; VACCINIA VIRUS; VIRUS REPLICATION;

EID: 84905970879     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400590     Document Type: Article

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