RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

Nature Immunology

Volumn 15, Issue 12, 2014, Pages 1126-1133

  Wang, Xiaqiong ^a   Jiang, Wei ^a   Yan, Yiqing ^a   Gong, Tao ^a   Han, Jiahuai ^b   Tian, Zhigang ^a,c   Zhou, Rongbin ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b XIAMEN UNIVERSITY   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CRYOPYRIN; DOUBLE STRANDED RNA; GUANOSINE TRIPHOSPHATASE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA; PROTEIN DRP1; PROTEIN RIP1; PROTEIN RIP3; PROTEIN SERINE THREONINE KINASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; VIRUS RNA; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; DNM1L PROTEIN, HUMAN; DNM1L PROTEIN, MOUSE; DYNAMIN; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK1 PROTEIN, MOUSE; RIPK3 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL DEATH; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; INFLUENZA VIRUS; INNATE IMMUNITY; KIDNEY CELL; LUNG LAVAGE; MITOCHONDRION; MOUSE; NONHUMAN; OUTER MEMBRANE; OXIDATIVE PHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RNA VIRUS; SENDAI VIRUS; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL LINE; CONFOCAL MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; IMMUNOLOGY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; REAL TIME POLYMERASE CHAIN REACTION; RNA VIRUS INFECTION;

ANIMALS; CARRIER PROTEINS; CELL LINE; DYNAMINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GTP PHOSPHOHYDROLASES; HUMANS; IMMUNOPRECIPITATION; INFLAMMASOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIAL PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA VIRUS INFECTIONS; RNA VIRUSES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84911192502     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3015     Document Type: Article

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