Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3573-3578

  Gore, Vijay K ^a   Ma, Vu V ^a   Yin, Ruoyuan ^a   Ligutti, Joe ^a   Immke, David ^a   Doherty, Elizabeth M ^a   Norman, Mark H ^a  

^a AMGEN INC   (United States)

Author keywords

BKCa; BKCa agonists; Calcium activated potassium channel

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; IBERIOTOXIN; POTASSIUM CHANNEL STIMULATING AGENT; TETRAHYDROQUINOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROPHYSIOLOGY; FEMALE; HYDROLYSIS; MALE; MIGRAINE; NERVE CELL; NEWBORN; NONHUMAN; ROOM TEMPERATURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MIGRAINE DISORDERS; MODELS, BIOLOGICAL; NEURONS; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGEMINAL NUCLEI;

EID: 77954218688     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.125     Document Type: Article

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