BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output

Nature Neuroscience

Volumn 9, Issue 8, 2006, Pages 1041-1049

  Meredith, Andrea L ^a,c   Wiler, Steven W ^a   Miller, Brooke H ^b   Takahashi, Joseph S ^b   Fodor, Anthony A ^a   Ruby, Norman F ^a   Aldrich, Richard W ^a  

^a STANFORD UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARNTL GENE; ARTICLE; CIRCADIAN RHYTHM; GENE; GENE EXPRESSION; ION CONDUCTANCE; MOUSE; MOUSE MUTANT; NERVE CONDUCTION; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPRACHIASMATIC NUCLEUS;

ANIMALS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; ELECTROPHYSIOLOGY; GENE EXPRESSION PROFILING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SUPRACHIASMATIC NUCLEUS;

EID: 33747624755     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1740     Document Type: Article

References (50)

1. King, D.P. & Takahashi, J.S. Molecular genetics of circadian rhythms in mammals. Annu. Rev. Neurosci. 23, 713-742 (2000).
2. Reppert, S.M. & Weaver, D.R. Coordination of circadian timing in mammals. Nature 418, 935-941 (2002).
3. Hastings, M.H. & Herzog, E.D. Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei. J. Biol. Rhythms 19, 400-413 (2004).
4. Panda, S. et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109, 307-320 (2002).
5. Ueda, H.R. et al. System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat. Genet. 37, 187-192 (2005).
6. Stephan, F.K. & Zucker, I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc. Natl. Acad. Sci. USA 69, 1583-1586 (1972).
7. Moore, R.Y. & Eichler, V.B. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 42, 201-206 (1972).
8. Ralph, M.R., Foster, R.G., Davis, F.C. & Menaker, M. Transplanted suprachiasmatic nucleus determines circadian period. Science 247, 975-978 (1990).
9. Rusak, B. & Zucker, I. Neural regulation of circadian rhythms. Physiol. Rev. 59, 449-526 (1979).
10. Yamazaki, S., Kerbeshian, M.C., Hocker, C.G., Block, G.D. & Menaker, M. Rhythmic properties of the hamster suprachiasmatic nucleus in vivo. J. Neurosci. 18, 10709-10723 (1998).
11. Green, D.J. & Gillette, R. Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice. Brain Res. 245, 198-200 (1982).
12. Groos, G. & Hendriks, J. Circadian rhythms in electrical discharge of rat suprachiasmatic neurones recorded in vitro. Neurosci. Lett. 34, 283-288 (1982).
13. Shibata, S., Oomura, Y., Kita, H. & Hattori, K. Circadian rhythmic changes of neuronal activity in the suprachiasmatic nucleus of the rat hypothalamic slice. Brain Res. 247, 154-158 (1982).
14. Inouye, S.T. & Kawamura, H. Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus. Proc. Natl. Acad. Sci. USA 76, 5962-5966 (1979).
15. 2+ in single suprachiasmatic nucleus neurons. Neuron 38, 253-263 (2003).
16. Earnest, D.J. & Sladek, C.D. Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro. Brain Res. 382, 129-133 (1986).
17. Shinohara, K., Honma, S., Katsuno, Y., Abe, H. & Honma, K. Circadian release of amino acids in the suprachiasmatic nucleus in vitro. Neuroreport 9, 137-140 (1998).
18. Schwartz, W.J., Gross, R.A. & Morton, M.T. The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker. Proc. Natl. Acad. Sci. USA 84, 1694-1698 (1987).
19. Earnest, D.J., Digiorgio, S.M. & Sladek, C.D. Effects of tetrodotoxin on the circadian pacemaker mechanism in suprachiasmatic explants in vitro. Brain Res. Bull. 26, 677-682 (1991).
20. Welsh, D.K., Logothetis, D.E., Meister, M. & Reppert, S.M. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 14, 697-706 (1995).
21. Aton, S.J. & Herzog, E.D. Come together, right...now: synchronization of rhythms in a mammalian circadian clock. Neuron 48, 531-534 (2005).
22. Lundkvist, G.B. & Block, G.D. Role of neuronal membrane events in circadian rhythm generation. Methods Enzymol. 393, 623-642 (2005).
23. Itri, J.N., Michel, S., Vansteensel, M.J., Meijer, J.H. & Colwell, C.S. Fast delayed rectifier potassium current is required for circadian neural activity. Nat. Neurosci. 8, 650-656 (2005).
24. Kuhlman, S.J. & McMahon, D.G. Rhythmic regulation of membrane potential and potassium current persists in SCN neurons in the absence of environmental input. Eur. J. Neurosci. 20, 1113-1117 (2004).
25. de Jeu, M., Hermes, M. & Pennartz, C. Circadian modulation of membrane properties in slices of rat suprachiasmatic nucleus. Neuroreport 9, 3725-3729 (1998).
26. Zheng, B. et al. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169-173 (1999).
27. Antle, M.C., LeSauter, J. & Silver, R. Neurogenesis and ontogeny of specific cell phenotypes within the hamster suprachiasmatic nucleus. Brain Res. Dev. Brain Res. 157, 8-18 (2005).
28. Pennartz, C.M., De Jeu, M.T., Geurtsen, A.M., Sluiter, A.A. & Hermes, M.L. Electrophysiological and morphological heterogeneity of neurons in slices of rat suprachiasmatic nucleus. J. Physiol. (Lond.) 506, 775-793 (1998).
29. van den Pol, A.N. & Tsujimoto, K.L. Neurotransmitters of the hypothalamic suprachiasmatic nucleus: immunocytochemical analysis of 25 neuronal antigens. Neuroscience 15, 1049-1086 (1985).
30. + channel. J. Biol. Chem. 279, 36746-36752 (2004).
31. Pittendrigh, C.S. & Daan, S. A Functional analysis of circadian pacemakers in nocturnal rodents. I. The stability and lability of spontaneous frequency. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 106, 223-252 (1976).
32. Sokolove, P.G. & Bushell, W.N. The chi square periodogram: its utility for analysis of circadian rhythms. J. Theor. Biol. 72, 131-160 (1978).
33. + channel deficiency. Proc. Natl. Acad. Sci. USA 101, 9474-9478 (2004).
34. Honma, S. et al. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus. Biochem. Biophys. Res. Commun. 250, 83-87 (1998).
35. Low-Zeddies, S.S. & Takahashi, J.S. Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior. Cell 105, 25-42 (2001).
36. Ceriani, M.F. et al. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J. Neurosci. 22, 9305-9319 (2002).
37. Herzog, E.D., Takahashi, J.S. & Block, G.D. Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat. Neurosci. 1, 708-713 (1998).
38. Nakamura, W., Honma, S., Shirakawa, T. & Honma, K. Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons. Nat. Neurosci. 5, 399-400 (2002).
39. Albus, H. et al. Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei. Curr. Biol. 12, 1130-1133 (2002).
40. Yamaguchi, S. et al. Synchronization of cellular clocks in the suprachiasmatic nucleus. Science 302, 1408-1412 (2003).
41. Kuhlman, S.J., Silver, R., Le Sauter, J., Bult-Ito, A. & McMahon, D.G. Phase resetting light pulses induce Per1 and persistent spike activity in a subpopulation of biological clock neurons. J. Neurosci. 23, 1441-1450 (2003).
42. Nitabach, M.N., Blau, J. & Holmes, T.C. Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell 109, 485-495 (2002).
43. Harmar, A.J. et al. The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell 109, 497-508 (2002).
44. Cutler, D.J. et al. The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro. Eur. J. Neurosci. 17, 197-204 (2003).
45. Nitabach, M.N., Sheeba, V., Vera, D.A., Blau, J. & Holmes, T.C. Membrane electrical excitability is necessary for the free-running larval Drosophila circadian clock. J. Neurobiol. 62, 1-13 (2005).
46. Pitts, G.R., Ohta, H. & McMahon, D.G. Daily rhythmicity of large-conductance Ca(2+)-activated K(+) currents in suprachiasmatic nucleus neurons. Brain Res. 1071, 54-62 (2006).
47. Cloues, R.K. & Sather, W.A. Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus. J. Neurosci. 23, 1593-1604 (2003).
48. Misonou, H. et al. Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons. J. Comp. Neurol. 496, 289-302 (2006).
49. Rattray, M. & Michael, G.J. Oligonucleotide probes for in situ hybridization. in In Situ Hybridization: A Practical Approach 2nd edn. (ed. Wilkinson, D.G.) 23-67 (Oxford Univ. Press, Oxford, 1998).
50. Siepka, S.M. & Takahashi, J.S. Methods to record circadian rhythm wheel running activity in mice. Methods Enzymol. 393, 230-239 (2005).