Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats

European Journal of Pharmacology

Volumn 735, Issue 1, 2014, Pages 68-76

  La Fuente, José M ^a   Fernández, Argentina ^b   Cuevas, Pedro ^b   González Corrochano, Rocío ^c   Chen, Mao Xiang ^d   Angulo, Javier ^b  

^a HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Anti muscarinics; Benign prostatic hyperplasia; BK activators; Bladder overactivity; Human bladder

Indexed keywords

2 AMINO 5 (2 FLUOROPHENYL) 4 METHYL 1H PYRROLE 3 CARBONITRILE; ACETIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ATROPINE; CARBACHOL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NS 8; OXYBUTYNIN; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; STEROID 5ALPHA REDUCTASE INHIBITOR; TETRODOTOXIN; UNCLASSIFIED DRUG; URINARY TRACT SPASMOLYTIC AGENT;

ADULT; AGED; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLADDER CONTRACTION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ELECTRIC FIELD; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; MALE; MICTURITION REFLEX; NEUROGENIC BLADDER; NONHUMAN; ORGAN DONOR; OVERACTIVE BLADDER; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RAT; SMOOTH MUSCLE CONTRACTION; URINARY TRACT DISEASE; URODYNAMICS; VERY ELDERLY; ANIMAL; BLADDER; CHEMICALLY INDUCED; ELECTROSTIMULATION; MIDDLE AGED; MUSCLE CONTRACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; YOUNG ADULT;

ACETIC ACID; ADULT; AGED; ANIMALS; CARBACHOL; ELECTRIC STIMULATION; FEMALE; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MIDDLE AGED; MUSCLE CONTRACTION; PROSTATIC HYPERPLASIA; RATS; URINARY BLADDER; URINARY BLADDER, NEUROGENIC; URINARY BLADDER, OVERACTIVE; YOUNG ADULT;

EID: 84899664310     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.03.060     Document Type: Article

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