Spontaneous phasic activity of the pig urinary bladder smooth muscle: Characteristics and sensitivity to potassium channel modulators

British Journal of Pharmacology

Volumn 135, Issue 3, 2002, Pages 639-648

  Buckner, Steven A ^a   Milicic, Ivan ^a   Daza, Anthony V ^a   Coghlan, Michael J ^a   Gopalakrishnan, Murali ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Apamin; Glyburide; Iberiotoxin; Myogenic; Overactive bladder; Pig urinary bladder smooth muscle; Potassium channels; Spontaneous phasic activity

Indexed keywords

1,2 DIAMINOCYCLOBUTENE 3,4 DIONE 4 [3,4 DIOXO 2 (1,2,2 TRIMETHYLPROPYLAMINO)CYCLOBUT 1 ENYLAMINO] 3 ETHYLBENZONITRILE; 2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; 4 [3,4 DIOXO 2 (1,2,2 TRIMETHYLPROPYLAMINO) 1 CYCLOBUTENYLAMINO] 3 ETHYLBENZONITRILE; 9 (3 CYANOPHENYL) 3,4,6,7,9,10 HEXAHYDRO 1,8(2H,5H) ACRIDINEDIONE; ACRIDINE DERIVATIVE; ALCIAN BLUE; APAMIN; ATROPINE; BENZONITRILE; CALCIUM CHANNEL; GLIBENCLAMIDE; IBERIOTOXIN; LEIUROTOXIN I; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; NIFEDIPINE; OXYBUTYNIN; POTASSIUM CHANNEL; RYANODINE; RYANODINE RECEPTOR; TOLTERODINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLADDER CONTRACTION; BLADDER FUNCTION; BLADDER MUSCLE; ELECTRIC FIELD; FEMALE; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SWINE; URINE INCONTINENCE; UROTHELIUM;

EID: 0036176599     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704499     Document Type: Article

References (34)

1. Clinical pharmacology of potassium channel openers
2. Ion channels and control of contractile activity in urinary bladder smooth muscle
3. The pathophysiological changes in the bladder obstructed by benign prostatic hyperplasia
4. A myogenic basis for the overactive bladder
5. Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor
6. Atropine resistant excitation of the urinary bladder: The possibility of transmission via nerves releasing a purine nucleotide
7. Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progress
8. A histochemical and immunohistochemical study of the autonomic innervation of the lower urinary tract of the female pig. Is the pig a good model for the human bladder and urethra?
9. Contribution of adrenergic and "purinergic" neurotransmission to contraction in rabbit detrusor
10. A neurologic basis for the overactive bladder
11. Muscarinic receptor ligands and their therapeutic potential
12. Potassium channel blockers and the effects of cromakalim on the smooth muscle of the guinea pig bladder
13. 2+]I transients in myocytes from guinea pig urinary bladder
14. + channels
15. Origin and propagation of spontaneous excitation in smooth muscle of the guinea pig urinary bladder
16. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility
17. + channels regulate action potential repolarization in urinary bladder smooth muscle
18. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels
19. 2x-purinoceptors and for purinergic transmission
20. 2+ transients of myocytes from guinea pig urinary bladder myocytes
21. Pathophysiology of idiopathic detrusor instability and detrusor hyperreflexia. An in vitro study of human detrusor muscle
22. Everything you wanted to know about the bladder epithelium but were afraid to ask
23. Effects of hypoxia, calcium, carbachol, atropine and tetrodotoxin on the filling of the in-vitro rabbit whole bladder
24. Relevance of spontaneous activity to urinary bladder function: An in vitro and in vivo study
25. Studies of the pathophysiology of idiopathic detrusor instability: The physiological properties of the detrusor smooth muscle and its pattern of innervation
26. Idiopathic bladder hyperactivity treated with Ditropan (oxybutynin)
27. Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder
28. Frequency of spontaneous contractions in longitudinal and transverse bladder strips
29. + channels in bladder smooth muscle cells
30. A comparison of spontaneous and nerve mediated activity in bladder muscle from man, pig and rabbit
31. Effect of charybdotoxin on spontaneous motility and tonus of different guinea pig smooth muscle tissues
32. Inward calcium currents in cultured and freshly isolated detrusor muscle cells: Evidence of a T-type calcium current
33. Pharmacological agents for the treatment of urinary bladder incontinence due to overactive bladder
34. AGANTG: A Microsoft Excel 5.0-visual basic routine for the analysis of dose-response data