Pharmacological options to protect the aged heart from ischemia and reperfusion injury by targeting the PKA-BKCa signaling pathway

Experimental Gerontology

Volumn 56, Issue , 2014, Pages 99-105

  Heinen, Andre ^a,b   Ströthoff, Martin ^b   Schmidt, Anika ^b   Stracke, Nadine ^b   Behmenburg, Friederike ^b   Bauer, Inge ^b   Hollmann, Markus W ^c   Huhn, Ragnar ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Aging; Cardioprotection; Myocardial infarction; Protein kinase A

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; CONNEXIN 43; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; BENZIMIDAZOLE DERIVATIVE; ENZYME ACTIVATOR; POTASSIUM CHANNEL BLOCKING AGENT;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG TARGETING; ENZYME ACTIVATION; ENZYME REGULATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; AGE; AGONISTS; ANIMAL; CELL PROTECTION; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; HEART MUSCLE; METABOLISM; MOLECULARLY TARGETED THERAPY; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; WISTAR RAT;

AGE FACTORS; AGING; ANIMALS; BENZIMIDAZOLES; COLFORSIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME ACTIVATORS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MOLECULAR TARGETED THERAPY; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; POTASSIUM CHANNEL BLOCKERS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84901757949     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.03.029     Document Type: Article

References (35)

1. + channel opening. Am. J. Physiol. Cell Physiol. 2010, 298:C530-C541.
2. Boengler K., Heusch G., Schulz R. Connexin 43 and ischemic preconditioning: effects of age and disease. Exp. Gerontol. 2006, 41:485-488.
3. Boengler K., Konietzka I., Buechert A., Heinen Y., Garcia-Dorado D., Heusch G., Schulz R. Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H1764-H1769.
4. Boengler K., Stahlhofen S., van de Sand A., Gres P., Ruiz-Meana M., Garcia-Dorado D., Heusch G., Schulz R. Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res. Cardiol. 2009, 104:141-147.
5. Boengler K., Ungefug E., Heusch G., Leybaert L., Schulz R. Connexin 43 impacts on mitochondrial potassium uptake. Front. Pharmacol. 2013, 4:73.
6. Callewaert G., Vereecke J., Carmeliet E. Existence of a calcium-dependent potassium channel in the membrane of cow cardiac Purkinje cells. Pflugers Arch. Eur. J. Physiol. 1986, 406:424-426.
7. + channel activity in isolated heart mitochondria. Cardiovasc. Res. 2007, 73:720-728.
8. Cao C.M., Xia Q., Gao Q., Chen M., Wong T.M. Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning. J. Pharmacol. Exp. Ther. 2005, 312:644-650.
9. + channel contributes to cardioprotection by limb remote ischemic preconditioning in rat. Life Sci. 2011, 88:1026-1030.
10. + channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem. Pharmacol. 2003, 65:1827-1834.
11. Franciolini F., Hogg R., Catacuzzeno L., Petris A., Trequattrini C., Adams D.J. Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons. Pflugers Arch. Eur. J. Physiol. 2001, 441:629-638.
12. + channels. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H1400-H1407.
13. + influx increases respiration and enhances ROS production while maintaining membrane potential. Am. J. Physiol. Cell Physiol. 2007, 292:C148-C156.
14. 2+-sensitive potassium channel activation. Anesthesiology 2008, 109:830-836.
15. 2+ overload in rat cardiac mitochondria. J. Physiol. 1999, 519(Pt 2):347-360.
16. Ca channels. Br. J. Anaesth. 2010, 105:589-595.
17. Huhn R., Weber N.C., Preckel B., Schlack W., Bauer I., Hollmann M.W., Heinen A. Age-related loss of cardiac preconditioning: impact of protein kinase A. Exp. Gerontol. 2012, 47:116-121.
18. Juhaszova M., Rabuel C., Zorov D.B., Lakatta E.G., Sollott S.J. Protection in the aged heart: preventing the heart-break of old age?. Cardiovasc. Res. 2005, 66:233-244.
19. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
20. Maggioni A.P., Maseri A., Fresco C., Franzosi M.G., Mauri F., Santoro E., Tognoni G. Age-related increase in mortality among patients with first myocardial infarctions treated with thrombolysis. The Investigators of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2). N. Engl. J. Med. 1993, 329:1442-1448.
21. Makaula S., Lochner A., Genade S., Sack M.N., Awan M.M., Opie L.H. H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size. J. Cardiovasc. Pharmacol. 2005, 45:341-347.
22. Murphy E., Steenbergen C. Preconditioning: the mitochondrial connection. Annu. Rev. Physiol. 2007, 69:51-67.
23. Ca channels. Cardiovasc. Res. 2008, 77:398-405.
24. Przyklenk K., Maynard M., Darling C.E., Whittaker P. Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: role of inositol trisphosphate receptors and gap junctions in triggering protection. J. Pharmacol. Exp. Ther. 2005, 314:1386-1392.
25. + channels via protein kinase A mediates desflurane-induced preconditioning. Anesth. Analg. 2008, 106:384-391. (table).
26. + channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A. Circulation 2005, 111:198-203.
27. 2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line. Biochem. Biophys. Res. Commun. 1999, 257:549-554.
28. Ca) channels. J. Physiol. 2012, 590:5937-5947.
29. Ca is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:10836-10841.
30. Solan J.L., Lampe P.D. Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. Biochim. Biophys. Acta 2005, 1711:154-163.
31. + channel opening requires superoxide radical generation. Am. J. Physiol. Heart Circ. Physiol. 2006, 290:H434-H440.
32. TenBroek E.M., Lampe P.D., Solan J.L., Reynhout J.K., Johnson R.G. Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP. J. Cell Biol. 2001, 155:1307-1318.
33. Wojtovich A.P., Nadtochiy S.M., Brookes P.S., Nehrke K. Ischemic preconditioning: the role of mitochondria and aging. Exp. Gerontol. 2012, 47:1-7.
34. Wojtovich A.P., Nadtochiy S.M., Urciuoli W.R., Smith C.O., Grunnet M., Nehrke K., Brookes P.S. A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel. Peer J. 2013, 1:e48.
35. + channels in the cardiac inner mitochondrial membrane. Science 2002, 298:1029-1033.