Large conductance Ca2+-activated K+ channel (BK Ca) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4186-4191

  Kirby, R W ^a,c   Martelli, A ^b   Calderone, V ^b   McKay, N G ^a   Lawson, K ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF PISA   (Italy)

^c Xention Limited   (United Kingdom)

Author keywords

Calcium activated potassium channels; HEK293 cells; N Arylbenzamide; Rubidium efflux; Subtype configuration

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; N ARYLBENZAMIDE DERIVATIVE; RUBIDIUM; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; EMBRYO; FLUORESCENCE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

BENZAMIDES; BENZIMIDAZOLES; HEK293 CELLS; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MOLECULAR STRUCTURE; PROTEIN SUBUNITS;

EID: 84879019094     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.003     Document Type: Article

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