β1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle

Journal of Physiology

Volumn 537, Issue 2, 2001, Pages 443-452

  Petkov, Georgi V ^a   Bonev, Adrian D ^a   Heppner, Thomas J ^a   Brenner, Robert ^b   Aldrich, Richard W ^b   Nelson, Mark T ^b,c  

^a UNIVERSITY OF VERMONT   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CALCIUM ION; IBERIOTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA1 SUBUNIT; UNCLASSIFIED DRUG; ISOPROTEIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ALPHA CHAIN; AMPLITUDE MODULATION; ANIMAL TISSUE; ARTICLE; BETA CHAIN; BLADDER; CONTROLLED STUDY; GENE LOCUS; GENE TARGETING; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SMOOTH MUSCLE CONTRACTILITY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; BLADDER MUSCLE; FEMALE; GENE DELETION; GENE EXPRESSION; GENETIC ANALYSIS; LACZ GENE; MALE; MUSCLE CONTRACTION; PROTEIN FUNCTION; REGULATORY MECHANISM; URINARY BLADDER SMOOTH MUSCLE; ANIMAL; GENETICS; IN VITRO STUDY; MOUSE MUTANT; PHYSIOLOGY; POTASSIUM CHANNEL; SMOOTH MUSCLE;

ANIMAL; BLADDER; FEMALE; IN VITRO; MALE; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POTASSIUM CHANNELS; PROTEIN ISOFORMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035529041     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.00443.x     Document Type: Article

References (29)

1. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel β subunit family
2. Ion channels and control of contractile activity in urinary bladder smooth muscle
3. A myogenic basis for the overactive bladder
4. Cloning and functional characterization of novel large conductance calcium-activated potassium channel β subunits, hKCNMB3 and hKCNMB4
5. Vasoregulation by the β1 subunit of the calcium-activated potassium channel
6. 2+ sensitivity
7. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus
8. Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle
9. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
10. Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder
11. + channels regulate action potential repolarization in urinary bladder smooth muscle
12. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels
13. Human and rodent MaxiK channel β-subunit genes: Cloning and characterization
14. Action potentials and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea-pig)
15. + channel from smooth muscle
16. Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels
17. Functional role of the β subunit of high conductance calcium-activated potassium channels
18. 2+ concentration jumps in excised inside-out multi-channel patches (myocytes from guinea-pig urinary bladder)
19. + channel resistant to charybdotoxin and iberiotoxin
20. 2+ channels in smooth muscle cells isolated from the guinea-pig detrusor
21. 2+-activated potassium channels by retaining the gating in the bursting states
22. 2+-independent mechanism
23. ATP channel activation decrease excitability and contractility of urinary bladder
24. 2+ spark/STOC coupling and elevated blood pressure
25. Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2
26. Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea-pig smooth muscle tissues
27. Molecular constituents of maxi KCa channels in human coronary smooth muscle: Predominant α + β subunit complexes
28. + channels: A transmembrane β-subunit homolog