Single-channel biophysical and pharmacological characterizations of native human large-conductance calcium-activated potassium channels in freshly isolated detrusor smooth muscle cells

Pflugers Archiv European Journal of Physiology

Volumn 465, Issue 7, 2013, Pages 965-975

  Malysz, John ^a   Rovner, Eric S ^b   Petkov, Georgi V ^a,b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Calcium; Conductance; Large conductance Ca2+ activated K+ channel; NS1619; Open probability; Paxilline; Urinary bladder

Indexed keywords

CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ADULT; AGED; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL ISOLATION; CHANNEL GATING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PHARMACOLOGICAL BLOCKING; PHARMACOLOGICAL STIMULATION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER;

ACTION POTENTIALS; AGED; CALCIUM; CELLS, CULTURED; FEMALE; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; URINARY BLADDER;

EID: 84879844447     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1214-8     Document Type: Article

References (52)

1. Afeli SA, Hristov KL, Petkov GV (2012) Do beta3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility? Am J Physiol Renal Physiol 302(2):F251-263
2. Andersson KE, Wein AJ (2004) Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56(4):581-631
3. + channel. Am J Physiol Renal Physiol 295(4):F1149-F1157
4. Carvacho I, Gonzalez W, Torres YP, Brauchi S, Alvarez O, Gonzalez-Nilo FD, Latorre R (2008) Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block. J Gen Physiol 131(2):147-161
5. Chang S, Gomes CM, Hypolite JA, Marx J, Alanzi J, Zderic SA, Malkowicz B, Wein AJ, Chacko S (2010) Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. Am J Physiol Renal Physiol 298(6):F1416-F1423
6. Chen M, Petkov GV (2009) Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle. J Urol 182(1):374-381
7. 2+ sensitivity. J Gen Physiol 116(3):411-432
8. + channel in rat skeletal muscle. J Gen Physiol 98:163-181
9. Ganitkevich VY, Isenberg G (1991) Depolarization-mediated intracellular calcium transients in isolated smooth muscle cells of guinea-pig urinary bladder. J Physiol 435:187-205
10. Gessner G, Cui YM, Otani Y, Ohwada T, Soom M, Hoshi T, Heinemann SH (2012) Molecular mechanism of pharmacological activation of BK channels. Proc Nat Acad Sci USA 109(9):3552-3557
11. Gopalakrishnan M, Shieh CC (2004) Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders. Expert Opin Ther Targets 8(5):437-458
12. Gribkoff VK, Lum-Ragan JT, Boissard CG, Post-Munson DJ, Meanwell NA, Starrett JE Jr, Kozlowski ES, Romine JL, Trojnacki JT, McKay MC, Zhong J, Dworetzky SI (1996) Effects of channel modulators on cloned large-conductance calcium-activated potassium channels. Mol Pharmacol 50(1):206-217
13. Hashitani H, Brading AF (2003) Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br J Pharmacol 140(1):146-158
14. Hashitani H, Brading AF (2003) Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder. Br J Pharmacol 140(1):159-169
15. + channels regulate action potential repolarization in urinary bladder smooth muscle. Am J Physiol 273(1 Pt 1):C110-C117
16. Ca channels in urinary bladder smooth muscle. Am J Physiol Cell Physiol 280(3):C481-C490
17. Ca channel activator, NS1619, on rat cerebral artery smooth muscle. Br J Pharmacol 117(1):119-129
18. 2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol 120(3):267-305
19. + channels regulate human detrusor smooth muscle function. Am J Physiol Cell Physiol 301(4):C903-C912
20. + channels. Am J Physiol Cell Physiol 295(5):C1344-C1353
21. + channels. Am J Physiol Cell Physiol 302(11):C1632-1641
22. Hu S, Kim HS (1996) On the mechanism of the differential effects of NS004 and NS1608 in smooth muscle cells from guinea pig bladder. Eur J Pharmacol 318(2-3):461-468
23. + channels in human myometrium during pregnancy and labour. Proc Biol Sci Royal Soc 251(1330):9-15
24. + channels in rat bladder. Am J Physiol Regul Integr Comp Physiol 298(5):R1310-1319
25. 2+ and voltage. Biol Res 39(3):385-401
26. 2+-activated (BK) channel. J Physiol 588(Pt 17):3141-3148
27. Latorre R, Oberhauser A, Labarca P, Alvarez O (1989) Varieties of calcium-activated potassium channels. Ann Rev Physiol 51:385-399
28. Layne JJ, Nausch B, Olesen SP, Nelson MT (2010) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol 298(2):R378-R384
29. + channels in rat mesenteric arterial cells. Eur J Pharmacol 372(1):103-107
30. Ca channels formed by bicistronic expression of hSloalpha and beta1-4 subunits in HEK293 cells. J Memb Biol 192(2):141-148
31. Lu R, Alioua A, Kumar Y, Eghbali M, Stefani E, Toro L (2006) MaxiK channel partners: physiological impact. J Physiol 570(Pt 1):65-72
32. + channel openers in bladder and vascular smooth muscle. Naunyn Schmied Arch Pharmacol 369(5):481-489
33. Meera P, Wallner M, Jiang Z, Toro L (1996) A calcium switch for the functional coupling between alpha (hslo) and beta subunits (Kv, Ca beta) of maxi K channels. FEBS Lett 385(1-2):127-128
34. + channel resistant to charybdotoxin and iberiotoxin. Proc Nat Acad Sci USA 97(10):5562-5567
35. + channel. J Biol Chem 279(35):36746-36752
36. 2+-activated potassium channels by retaining the gating in the bursting states. J Gen Physiol 113(3):425-440
37. Orio P, Latorre R (2005) Differential effects of beta1 and beta2 subunits on BK channel activity. J Gen Physiol 125(4):395-411
38. Petkov GV (2012) Role of potassium ion channels in detrusor smooth muscle function and dysfunction. Nat Rev Urol 9(1):30-40
39. + channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol 537(Pt 2):443-452
40. Sanchez M, McManus OB (1996) Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacol 35(7):963-968
41. Ca and inhibition of calcium currents. J Pharmacol Exp Ther 283(3):1193-1200
42. Siemer C, Bushfield M, Newgreen D, Grissmer S (2000) Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder. J Memb Biol 173(1):57-66
43. + channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle. Eur J Pharmacol 670(1):252-259
44. + channel (hslo). Proc Nat Acad Sci USA 94(10):5427-5431
45. Sun XP, Schlichter LC, Stanley EF (1999) Single-channel properties of BK-type calcium-activated potassium channels at a cholinergic presynaptic nerve terminal. J Physiol 518:639-651
46. Tanaka M, Sasaki Y, Kimura Y, Fukui T, Hamada K, Ukai Y (2003) A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int 92(9):1031-1036
47. Tanaka Y, Koike K, Alioua A, Shigenobu K, Stefani E, Toro L (2004) Beta1-subunit of MaxiK channel in smooth muscle: a key molecule which tunes muscle mechanical activity. J Pharmacol Sci 94(4):339-347
48. Thorneloe KS, Meredith AL, Knorn AM, Aldrich RW, Nelson MT (2005) Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. Am J Physiol Renal Physiol 289(3):F604-610
49. + channel from colonic smooth muscle. Am J Physiol Gastrointest Liver 271(4 Pt 1):G629-639
50. Ca) channel in freshly isolated myocytes of human and rat corpora. Int J Impot Res 12(1):9-18
51. + channel. Am J Physiol Cell Physiol 302(9):C1361-1370
52. Zhou Y, Tang QY, Xia XM, Lingle CJ (2010) Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J Gen Physiol 135(5):481-494