Human β-defensin 2 is a novel opener of Ca2+-activated potassium channels and induces vasodilation and hypotension in monkeys

Hypertension

Volumn 62, Issue 2, 2013, Pages 415-425

  Liu, Rui ^a,d   Zhang, Zheng ^b   Liu, Huan ^a,g   Hou, Panpan ^b   Lang, Jun ^c   Wang, Sheng ^b   Yan, Hongli ^d   Li, Pengcheng ^c   Huang, Zhigang ^b   Wu, Hongbing ^e   Rong, Mingqiang ^a   Huang, Jian ^f   Wang, Hong ^a   Lv, Longbao ^a   Qiu, Mingfeng ^e   Ding, Jiuping ^b   Lai, Ren ^a,d  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d NANJING AGRICULTURAL UNIVERSITY   (China)

^e SHANGHAI JIAO TONG UNIVERSITY   (China)

^f SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

^g UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

defensin 2, human; Antimicrobial peptides; Ca2+ activated K+ channels; Hypertension; Regional blood flow

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA DEFENSIN 2; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PAXILLINE; POTASSIUM CHANNEL; RECOMBINANT BETA DEFENSIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; HAPLORHINI; HUMAN; HUMAN CELL; HYPERTENSION; HYPOTENSION; IN VITRO STUDY; INNATE IMMUNITY; MALE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; VASODILATATION;

Β-DEFENSIN 2, HUMAN; ANTIMICROBIAL PEPTIDES; CA2+-ACTIVATED K+ CHANNELS; HYPERTENSION; REGIONAL BLOOD FLOW;

ANIMALS; BETA-DEFENSINS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; FEMALE; HUMANS; HYPOTENSION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MACACA MULATTA; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECOMBINANT PROTEINS; RHOA GTP-BINDING PROTEIN; VASODILATION;

EID: 84880940484     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.01076     Document Type: Article

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