Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle

British Journal of Pharmacology

Volumn 117, Issue 1, 1996, Pages 119-129

  Holland, Michael ^a   Langton, Philip D ^a   Standen, Nicholas B ^a   Boyle, John P ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b Dept Cell Physiol and Pharmacol ^*

Author keywords

Basilar artery; Channel; Delayed rectifier K+; Iberiotoxin; L type calcium channel; Large conductance, calcium activated K+ channel; NS1619; Vasorelaxation

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; APAMIN; BENZIMIDAZOLE DERIVATIVE; CALCIUM; GLIBENCLAMIDE; IBERIOTOXIN; PEPTIDE; POTASSIUM CHANNEL; SCORPION VENOM; BARIUM ION; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL; ARTICLE; BRAIN ARTERY; CELL MEMBRANE POTENTIAL; COMPARATIVE STUDY; DRUG EFFECT; MALE; METABOLISM; MUSCLE RELAXATION; PATCH CLAMP; RAT; VASCULAR SMOOTH MUSCLE; WISTAR RAT; ANIMAL CELL; ANIMAL TISSUE; ARTERY DILATATION; ARTERY MUSCLE; BASILAR ARTERY; CALCIUM CURRENT; CONTROLLED STUDY; DEPOLARIZATION; HYPERPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROBABILITY; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL;

ANIMALS; APAMIN; BENZIMIDAZOLES; CALCIUM; CEREBRAL ARTERIES; GLYBURIDE; MALE; MEMBRANE POTENTIALS; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SCORPION VENOMS;

EID: 0029671016     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15163.x     Document Type: Article

References (26)

1. BEECH, D.J. & BOLTON, T.B. (1989). Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein. J. Physiol., 418, 293-309.
2. BRAYDEN, J.E. & NELSON, M.T. (1992). Regulation of arterial tone by activation of calcium-dependent potassium channels. Science, 256, 532-535.
3. + channel, Biophys. J., 63, 583-590.
4. DAVIES, N.W.(1993). A suite of programs for acquisition and analysis of voltage- and patch-clamp data using the Axobasic library. J. Physiol., 459, 111P.
5. Ca channel opener in vascular smooth muscle. Br. J. Pharmacol., 113, 1538-1547.
6. GALVEZ, A., GIMENEZ-GALLEGOS, G., REUBEN J.P., ROY-CONTANCIN, L., FEIGENBAUM, P., KACZOROWSKI, G.J. & GARCIA, M.L. (1989). Purification and characterisation of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from the venom of the scorpion Buthus tamalus. J. Biol. Chem., 265, 11083-11090.
7. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch clamp techniques for high-resolution recordings from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
8. HOLLAND, M., LANGTON, P.D., STANDEN, N.B. & BOYLE, J.P. (1995). Effects of an activator of large-conductance calcium activated potassium channels (NS1619) on ion channels in isolated cerebral arterial myocytes. Br. J. Pharmacol., 116, 28p.
9. HUGUES, M., ROMEY, G., DUVAL, D., VINCENT, J.P. & LAZDUNSKI, M. (1982). Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells. Proc. Nat. Acad. Sci. U.S.A., 79, 1308-1312.
10. KAMISHIMA, T. & MCCARRON, J.G. (1995). Calcium signalling in arterial smooth muscle. Biophys, J., 68, A280.
11. LANGTON, P.D. (1993). Calcium channel currents recorded from isolated myocytes of rat basilar artery arc stretch sensitive. J. Physiol., 47, 1-11.
12. LANGTON, P.D., NELSON, M.T., HUANG, Y. & STANDEN, N.B. (1991). Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions. Am. J. Physiol., 260, H927-H934.
13. LANGTON, P.D. & STANDEN, N.B. (1993). Calcium currents elicited by voltage steps and steady voltages in myocytes isolated from the rat basilar artery. J. Physiol., 469, 535-548.
14. LATORRE, R., OBERHAUSER, A. & ALVAREZ, O. (1989). Varieties of calcium-activated potassium channels. Annu. Rev. Physiol., 51, 385-399.
15. MCKAY, M.C. DWORETSKY, S.I., MEANWELL, N.A., OLESEN, S.P., REINHART, P.H., LEVITAN, I.B., ADELMEN, J.P. & GRIBKOFF, V.K. (1994). Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004. J. Neurophys., 71, 1873-1882.
16. MCMANUS, O.B., HARRIS, G.H., GIANGIACOMO, K.M., FEIGENBAUM, P., REUBEN, J.P., ADDY, M.E., BURKA, J.F., KACZOROWSKI, G.J. & GARCIA, M.I., (1993). An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry, 32, 5819-5828.
17. NELSON, M.T. & QUAYLE, J.M. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol., 268, C799-C822.
18. + channels. Exp. Opin. Invest. Drugs, 3, 1181-1188.
19. + channels by novel benimidazole. Eur. J. Pharmacol., 252, 53-59.
20. + channels in cerebral granule cells. Neuroreport, 5, 1001-1004.
21. Ca channels by niflumic, flufenamic and mefenamic acids. Biophys. J., 67, 2272-2279.
22. + currents in rabbit arterial smooth muscle via protein kinase A. J. Physiol., 475, 9-13.
23. ATP channels in vascular smooth muscle. Cardiovasc. Res., 28, 797-804
24. RAE, J., COOPER, K., GATES, P. & WATSKY, M. (1991). Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Meth., 57, 15-26.
25. SARGENT, C.A., GROVER, G.J., ANTONACCIO, M.J. & MCCULLOCH, J.R. (1993). The cardioprotective, vasorelaxam and electrophysiological profile of the large conductance potassium channel opener NS-004. J. Pharmacol. Exp. Ther., 266, 1422-1429.
26. VOLK, K.A., MATSUDA, J.J. & SHIBATA, E.F. (1991). A voltage-dependent potassium current in rabbit coronary artery smooth muscle cells. J. Physiol., 439, 751-768.