Acute activation of Maxi-K channels (hSlo) by estradiol binding to the β subunit

Science

Volumn 285, Issue 5435, 1999, Pages 1929-1931

  Valverde, Miguel A ^a   Rojas, Patricio ^b,c   Amigo, Julio ^b,c   Cosmelli, Diego ^b,c   Orio, Patricio ^b,c   Bahamonde, Maria I ^b,c   Mann, Giovanni E ^e   Vergara, Cecilia ^b,c   Latorre, Ramon ^b,c,d  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b UNIVERSITY OF CHILE   (Chile)

^c CENTRO DE ESTUDIOS CIENTÍFICOS CECS   (Chile)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; ESTRADIOL;

ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CALCIUM TRANSPORT; CELL CULTURE; FEMALE; HORMONE PROTEIN COMPLEX; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE TONE; VASCULAR SMOOTH MUSCLE; XENOPUS LAEVIS;

ANIMALS; CATTLE; CELL LINE; ELECTROPHYSIOLOGY; ESTRADIOL; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN BINDING; RATS; RNA, MESSENGER; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0033578667     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5435.1929     Document Type: Article

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41. Supported by Human Frontiers Science Program (M.A.V. and R.L.), The Royal Society and The Physiological Society (M.A.V.), Wellcome Trust and Tommy's Campaign (G.E.M.), and Chilean grants 198-1053 (C.V.) and 197-0739, Catedra Presidencial and a group of Chilean companies (CODELCO, CMPC, CGE, Minera Escondida, NOVAGAS, Bussiness Design Ass., and XEROX Chile) (R.L.). We thank L. Toro for providing us with the clones for the α and β subunit of hSlo channel and for discussions, S. Hall and M. J. Shipston for providing HEK-293 cells stably expressing α or α and β subunits, and E. Rosemann for technical assistance.