Gating mechanism of BK (Slo1) channels: So near, yet so far

Journal of General Physiology

Volumn 121, Issue 2, 2003, Pages 81-96

  Magleby, Karl L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALCIUM SENSING RECEPTOR; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MAGNESIUM ION; POTASSIUM ION; TRANSMEMBRANE CONDUCTANCE REGULATOR; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; DEPOLARIZATION; FLOW KINETICS; GENE MUTATION; MEMBRANE CHANNEL; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR SENSITIVITY; SENSOR; SEQUENCE ANALYSIS; SHORT SURVEY; SLO1 CHANNEL;

ANIMALS; CALCIUM; HUMANS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 0037324895     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028721     Document Type: Short Survey

References (80)

1. Adelman, J.P., K.Z. Shen, M.P. Kavanaugh, R.A. Warren, Y.N. Wu, A. Lagrutta, C.T. Bond, and R.A. North. 1992. Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron. 9:209-216.
2. + channel. Neuron. 16: 1169-1177.
3. 2+ sensitivity. J. Gen. Physiol. 120:173-189.
4. Barrett, J.N., K.L. Magleby and B.S. Pallotta. 1982. Properties of single calcium-activated potassium channels in cultured rat muscle. J. Physiol. 331:211-230.
5. Bezanilla, F. 2000. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80:555-592.
6. 2+-dependent activation. Proc. Natl. Acad. Sci. USA. 98:4776-4781.
7. + channel. J. Physiol. 533:681-695.
8. Brenner, R., G.J. Perez, A.D. Bonev, D.M. Eckman, J.C. Kosek, S.W. Wiler, A.J. Patterson, M.T. Nelson, and R.W. Aldrich. 2000. Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature. 407:870-876.
9. Butler, A., S. Tsunoda, D.P. McCobb, A. Wei, and L. Salkoff. 1993. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 261:221-224.
10. Butler, A., A. Wei, and L. Salkoff. 1990. Shal, Shab, and Shaw: three genes encoding potassimn channels in Drosophila. Nucleic Acids Res. 18:2173-2174.
11. Colquhoun, D., and A.G. Hawkes. 1981. On the stochastic properties of single ion channels. Proc. R. Soc. Lond. B Biol. Sci. 211: 205-235.
12. Colquhoun, D., and A.G. Hawkes. 1987. A note on correlations in single ion channel records. Proc. R. Soc. Lond. B Biol. Sci. 230:15-52.
13. 2+ sensitivity. J. Gen. Physiol. 116: 411-432.
14. + channel. J. Gen. Physiol. 110: 257-281.
15. + channels. Biochemistry. 39:15612-15619.
16. Diaz, L., P. Meera, J. Amigo, E. Stefani, O. Alvarez, L. Toro, and R. Latorre. 1998. Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J. Biol. Chem. 273: 32430-32436.
17. Eigen, M. 1968. New looks and outlooks on physical enzymology. Q. Rev. Biophys. 1:3-33.
18. Ferguson, W.B., O.B. McManus, and K.L. Magleby. 1993. Opening and closing transitions for BK channels often occur in two steps via sojourns through a brief lifetime subconductance state. Biophys. J. 65:702-714.
19. Fersht, A. 1984. Enzyme Structure and Mechanism. W. H. Freeman and Co., New York.
20. Fredkin, D.R., M. Montal, and J.A. Rice. 1985. Identification of aggregated Markovian models: application to the nicotinic acetylcholine receptor. In Proceedings of the Berkeley Conference in Honor of Jerzy Neyman and Jack Kiefer. L.M. LeCam and R.A. Olshen, editors. Wadsworth Press, Belmont. 269-289.
21. Fu, J., H.L. Ji, A.P. Naren, and K.L. Kirk. 2001. A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gating. J. Physiol. 536:459-470.
22. + channel gating kinetics by deletions in the S3-S4 linker. Proc. Natl. Acad. Sci. USA. 98: 9617-9623.
23. Horn, R. 2002. Coupled movements in voltage-gated channels. J. Gen. Physiol. 120:449-453.
24. 2+. J. Gen. Physiol. 114:305-336.
25. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120:267-305.
26. 2+. J. Gen. Physiol. 114:277-304.
27. Isacoff, E., D. Papazian, L. Timpe, Y.N. Jan, and L.Y. Jan. 1990. Molecular studies of voltage-gated potassium channels. Cold Spring Harb. Symp. Quant. Biol. 55:9-17.
28. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002a. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417:515-522.
29. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002b. The open pore conformation of potassium channels. Nature. 417:523-526.
30. + channel and demonstration of its presence in the human BK channel. Neuron. 29:593-601.
31. Jones, S.W. 1999. Commentary: a plausible model. J. Gen. Physiol. 114:271-275.
32. Kaczorowski, G.J., H.G. Knaus, R.J. Leonard, O.B. McManus, and M.L. Garcia. 1996. High-conductance calcium-activated potassium channels; structure, pharmacology, and function. J. Bioenerg. Biomembr. 28:255-267.
33. + channel from transverse tubule membranes isolated from rabbit skeletal muscle. Proc. Natl. Acad. Sci. USA. 79:805-809.
34. Lingle, C.J. 2002. Setting the stage for molecular dissection of the regulatory components of BK channels. J. Gen. Physiol. 120:261-265.
35. Magleby, K.L. 2001. Kinetic gating mechanisms for BK channels: when complexity leads to simplicity. J. Gen. Physiol. 118:583-587.
36. + (BK) channels. Biophys. J. 80:222a.
37. Marks, T.N., and S.W. Jones. 1992. Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action. J. Gen. Physiol. 99:367-390.
38. Marty, A. 1981. Ca-dependent K channels with large unitary conductance in chromaffin cell membranes. Nature. 291:497-500.
39. + channels. Neuron. 12:301-315.
40. McManus, O.B. 1991. Calcium-activated potassium channels: regulation by calcium. J. Bioenerg. Biomembr. 23:537-560.
41. McManus, O.B., A.L. Blatz, and K.L. Magleby. 1985. Inverse relationship of the durations of adjacent open and shut intervals for C1 and K channels. Nature. 317:625-627.
42. McManus, O.B., and K.L. Magleby. 1988. Kinetic states and modes of single large-conductance calcium-activated potassium channels in cultured rat skeletal muscle. J. Physiol. 402:79-120.
43. McManus, O.B., and K.L. Magleby. 1989. Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channel. J. Gen. Physiol. 94:1037-1070.
44. + channels in rat skeletal muscle. J. Physiol. 443:739-777.
45. + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc. Natl. Acad. Sci. USA. 94:14066-14071.
46. Monod, J., J. Wyman, and J.P. Changeux. 1965. On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12:88-118.
47. Moss, B.L., and K.L. Magleby. 2001. Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels. J. Gen. Physiol. 118:711-734.
48. Moss, G.W., J. Marshall, and E. Moczydlowski. 1996. Hypothesis for a serine proteinase-like domain at the COOH terminus of Slowpoke calcium-activated potassium channels. J. Gen. Physiol. 108: 473-484.
49. 2+-independent mechanism. J. Gen. Physiol. 115:719-736.
50. Niu, X., and K.L. Magleby. 2001. Single-channel data obtained at the extremes of voltage and calcium place restrictions on the gating mechanism for BK channels. Biophys. J. 80:222a.
51. 2+. Proc. Natl. Acad. Sci. USA. 99:11441-11446
52. + currents in rat muscle cell culture. Nature. 293:471-474.
53. Papazian, D.M., T.L. Schwarz, B.L. Tempel, YN. Jan, and L.Y. Jan. 1987. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science. 237:749-753.
54. Perozo, E., L. Santacruz-Toloza, E. Stefani, F. Bezanilla, and D.M. Papazian. 1994. S4 mutations alter gating currents of Shaker K channels. Biophys. J. 66:345-354.
55. ca potassium channels lacking calcium bowl and RCK domains. Nature. 420:499-502.
56. Ramanathan, K., T.H. Michael, G.J. Jiang, H. Hiel, and P.A. Fuchs. 1999. A molecular mechanism for electrical tuning of cochlear hair cells. Science. 283:215-217.
57. Rios, E., M. Karhanek, J. Ma, and A. Gonzalez. 1993. An allosteric model of the molecular interactions of excitation-contraction coupling in skeletal muscle. J. Gen. Physiol. 102:449-481.
58. Robitaille, R., M.L. Garcia, G.J. Kaczorowski, and M.P. Charlton. 1993. Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron. 11: 645-655.
59. + channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers. J. Gen. Physiol. 111:751-780.
60. 2+ suggest a two-tiered allosteric gating mechanism. J. Gen. Physiol. 114: 93-124.
61. + channels described by a two-tiered allosteric gating mechanism. J. Gen. Physiol. 116:75-99.
62. Schreiber, M., and L. Salkoff. 1997. A novel calcium-sensing domain in the BK channel. Biophys. J. 73:1355-1363.
63. + channel from mammalian spermatocytes. J. Biol. Chem. 273:3509-3516.
64. Schreiber, M., A. Yuan, and L. Salkoff. 1999. Transplantable sites confer calcium sensitivity to BK channels. Nat. Neurosci. 2:416-421.
65. + channel. Neuron. 16:1159-1167.
66. Shen, K.Z., A. Lagrutta, N.W. Davies, N.B. Standen, J.P. Adelman, and R.A. North. 1994. Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation. Pflugers Arch. 426:440-445.
67. + channels. J. Gen. Physiol. 118:589-606.
68. Shi, J., G. Krishnamoorthy, Y. Yang, L. Hu, N. Chaturvedi, D. Harilal, J. Qin, and J. Cui. 2002. Mechanism of magnesium activation of calcium-activated potassium channels. Nature. 418:876-880.
69. + channel (hslo). Proc. Natl. Acad. Sci. USA. 94:5427-5431.
70. Talukder, G., and R.W. Aldrich. 2000. Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels. Biophys. J. 78:761-772.
71. Wang, Z.W., O. Saifee, M.L. Nonet, and L. Salkoff. 2001. SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction. Neuron. 32:867-881.
72. + current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 248:599-603.
73. Wei, A., C. Solaro, C. Lingle, and L. Salkoff. 1994. Calcium sensitivity of BK-type KCa channels determined by a separable domain. Neuron. 13:671-681.
74. Wu, Y.C., J.J. Art, M.B. Goodman, and R. Fettiplace. 1995. A kinetic description of the calcium-activated potassium channel and its application to electrical tuning of hair cells. Prog. Biophys. Mol. Biol. 63:131-158.
75. Xia, X.M., X. Zeng, and C.J. Lingle. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 418:880-884.
76. Yellen, G. 1998. The moving parts of voltage-gated ion channels. Q. Rev. Biophys. 31:239-295.
77. Yellen, G. 2002. The voltage-gated potassium channels and their relatives. Nature. 419:35-42.
78. - dependence. Nat. Neurosci. 3:771-779.
79. Zeng, X.H., J.P. Ding, X.M. Xia, and C.J. Lingle. 2001. Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. J. Gen. Physiol. 117:607-628.
80. 2+ through a nonselective, low affinity, divalent cation site. J. Gen. Physiol. 118:607-636.