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Volumn 1, Issue 1, 2000, Pages 21-30

Neuronal KCNQ potassium channels: Physislogy and role in disease

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; KCNQ2 PROTEIN, HUMAN; KCNQ3 PROTEIN, HUMAN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; VOLTAGE GATED POTASSIUM CHANNEL;

EID: 0034303612     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/35036198     Document Type: Article
Times cited : (736)

References (84)
  • 1
    • 0032509484 scopus 로고    scopus 로고
    • Neurobiology of the Caenorhabditis elegans genome
    • Bargmann, C. I. Neurobiology of the Caenorhabditis elegans genome. Science 282, 2028-2033 (1998).
    • (1998) Science , vol.282 , pp. 2028-2033
    • Bargmann, C.I.1
  • 2
    • 0032823307 scopus 로고    scopus 로고
    • Voltage-gated ion channels and hereditary disease
    • Lehmann-Horn, F. & Jurkat-Rott, K. Voltage-gated ion channels and hereditary disease. Physiol. Rev. 79, 1317-1372 (1999).
    • (1999) Physiol. Rev. , vol.79 , pp. 1317-1372
    • Lehmann-Horn, F.1    Jurkat-Rott, K.2
  • 3
    • 9044240040 scopus 로고    scopus 로고
    • Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
    • Wang, Q. et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nature Genei. 12, 17-23 (1996).
    • (1996) Nature Genei , vol.12 , pp. 17-23
    • Wang, Q.1
  • 4
    • 0032536030 scopus 로고    scopus 로고
    • A potassium channel mutation in neonatal human epilepsy
    • Biervert, C. et al. A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406 (1998).
    • (1998) Science , vol.279 , pp. 403-406
    • Biervert, C.1
  • 5
    • 17344372328 scopus 로고    scopus 로고
    • A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns
    • Singh, N. A. et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nature Genet. 18, 25-29 (1998).
    • (1998) Nature Genet , vol.18 , pp. 25-29
    • Singh, N.A.1
  • 6
    • 0031974209 scopus 로고    scopus 로고
    • A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family
    • Charlier, C. et al. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nature Genei. 18, 53-55 (1998).
    • (1998) Nature Genei , vol.18 , pp. 53-55
    • Charlier, C.1
  • 7
    • 0031054075 scopus 로고    scopus 로고
    • A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
    • Neyroud, N. et al. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nature Genel 15, 186-189 (1997).
    • (1997) Nature Genel , vol.15 , pp. 186-189
    • Neyroud, N.1
  • 8
    • 0033524936 scopus 로고    scopus 로고
    • KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
    • Kubisch, C. et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96, 437-446 (1999).
    • (1999) Cell , vol.96 , pp. 437-446
    • Kubisch, C.1
  • 9
    • 0029952101 scopus 로고
    • KvLQT1 and IsK (MinK) proteins associate to form the /Kscardiac potassium current
    • Kscardiac potassium current. Nature 384, 78-80 (1995).
    • (1995) Nature , vol.384 , pp. 78-80
    • Barhanin, J.1
  • 10
    • 0029854263 scopus 로고    scopus 로고
    • Coassembly of KvLQT1 and minK (IsK) proteins to form cardiac /fe potassium channel
    • fe potassium channel. Nature 384, 80-83 (1996).
    • (1996) Nature , vol.384 , pp. 80-83
    • Sanguinetti, M.C.1
  • 11
    • 0030461289 scopus 로고    scopus 로고
    • Inner ear defects induced by null mutation of the isk gene
    • Vetter, D. E. et al. Inner ear defects induced by null mutation of the isk gene. Neuron 17, 1251-1264 (1996).
    • (1996) Neuron , vol.17 , pp. 1251-1264
    • Vetter, D.E.1
  • 12
    • 0034642569 scopus 로고    scopus 로고
    • A constitutively open potassium channel formed by KCNQ1 and KCNE3
    • Schroeder, B. C. et al. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403, 196-199 (2000).
    • (2000) Nature , vol.403 , pp. 196-199
    • Schroeder, B.C.1
  • 13
    • 0032483972 scopus 로고    scopus 로고
    • KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel
    • Wang, H. S. et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890-1893 (1998).
    • (1998) Science , vol.282 , pp. 1890-1893
    • Wang, H.S.1
  • 14
    • 0018886033 scopus 로고
    • Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone
    • Brown, D. A. & Adams, P R. Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone. Nature 283, 673-676 (1980).
    • (1980) Nature , vol.283 , pp. 673-676
    • Brown, D.A.1    Adams, P.R.2
  • 15
    • 0032542232 scopus 로고    scopus 로고
    • Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy
    • Schroeder, B. C., Kubisch, C., Stein, V. & Jentsch, T. J. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 396, 687-690 (1998).
    • (1998) Nature , vol.396 , pp. 687-690
    • Schroeder, B.C.1    Kubisch, C.2    Stein, V.3    Jentsch, T.J.4
  • 16
    • 0034126582 scopus 로고    scopus 로고
    • Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    • Watanabe, H. et al. Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J. Neurochem. 75, 28-33 (2000).
    • (2000) J. Neurochem. , vol.75 , pp. 28-33
    • Watanabe, H.1
  • 17
    • 0034604631 scopus 로고    scopus 로고
    • KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
    • Schroeder, B. C., Hechenberger, M., Weinreich, F., Kubisch, C. & Jentsch, T. J. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J. Biol. Chem. 275, 24089-24095 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 24089-24095
    • Schroeder, B.C.1    Hechenberger, M.2    Weinreich, F.3    Kubisch, C.4    Jentsch, T.J.5
  • 18
    • 0034698079 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity
    • Lerche, C. et al. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J. Biol. Chem. 275, 22395-22400 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 22395-22400
    • Lerche, C.1
  • 19
    • 0034636056 scopus 로고    scopus 로고
    • KCNQ4, a K+-channel mutated in a form of dominant deafness, is expressed in the inner ear and in the central auditory pathway
    • Kharkovets, T. et al. KCNQ4, a K+-channel mutated in a form of dominant deafness, is expressed in the inner ear and in the central auditory pathway. Proc. Nail Acad. Sci. USA 97, 4333-4338 (2000).
    • (2000) Proc. Nail Acad. Sci. USA , vol.97 , pp. 4333-4338
    • Kharkovets, T.1
  • 20
    • 0032838656 scopus 로고    scopus 로고
    • Ion channel defects in cardiac arrhythmia
    • Kirsch, G. E. Ion channel defects in cardiac arrhythmia. J. Membr. Biol. 170, 181-190 (1999).
    • (1999) J. Membr. Biol. , vol.170 , pp. 181-190
    • Kirsch, G.E.1
  • 21
    • 0033530381 scopus 로고    scopus 로고
    • Long QT syndromes and torsade de pointes
    • Viskin, S. Long QT syndromes and torsade de pointes. Lancel 354, 1625-1633 (1999).
    • (1999) Lancel , vol.354 , pp. 1625-1633
    • Viskin, S.1
  • 22
    • 0032900445 scopus 로고    scopus 로고
    • The LQT syndromes—current status of molecular mechanisms
    • Schulze-Bahr, E. et al. The LQT syndromes—current status of molecular mechanisms. Z. Kardiol. 88, 245-254 (1999).
    • (1999) Z. Kardiol. , vol.88 , pp. 245-254
    • Schulze-Bahr, E.1
  • 23
    • 0034213745 scopus 로고    scopus 로고
    • Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium
    • Nerbonne, J. M. Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J. Physiol. (Lond.) 525, 285-298 (2000)
    • (2000) J. Physiol. (Lond.) , vol.525 , pp. 285-298
    • Nerbonne, J.M.1
  • 24
    • 0034607698 scopus 로고    scopus 로고
    • Surface expression and single-channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy
    • Schwake, M., Pusch, M., Kharkovets, T. & Jentsch, T. J. Surface expression and single-channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy. J. Biol. Chem. 275, 13343-13348 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 13343-13348
    • Schwake, M.1    Pusch, M.2    Kharkovets, T.3    Jentsch, T.J.4
  • 25
    • 0034141999 scopus 로고    scopus 로고
    • A recessive C-terminal Jervell and Lange- Nielsen mutation of the KCNQ1 channel impairs subunit assembly
    • Schmitt, N. et al. A recessive C-terminal Jervell and Lange- Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J. 19, 332-340 (2000).
    • (2000) EMBO J , vol.19 , pp. 332-340
    • Schmitt, N.1
  • 26
    • 0031768841 scopus 로고    scopus 로고
    • The KCNQ2 potassium channel: Splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3
    • Tinel, N., Lauritzen, I., Chouabe, C., Lazdunski, M. & Borsotto, M. The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS Lett. 438, 171-176 (1998).
    • (1998) FEBS Lett , vol.438 , pp. 171-176
    • Tinel, N.1    Lauritzen, I.2    Chouabe, C.3    Lazdunski, M.4    Borsotto, M.5
  • 27
    • 0032584595 scopus 로고    scopus 로고
    • Functional expression of two KvLQT1- related potassium channels responsible for an inherited idiopathic epilepsy
    • Yang, W. P et al. Functional expression of two KvLQT1- related potassium channels responsible for an inherited idiopathic epilepsy. J. Biol. Chem. 273, 19419-19423 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 19419-19423
    • Yang, W.P.1
  • 28
    • 0034712923 scopus 로고    scopus 로고
    • Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy
    • Cooper, E. C. et al. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc. Nail Acad. Sci. USA 97, 4914-4919 (2000).
    • (2000) Proc. Nail Acad. Sci. USA , vol.97 , pp. 4914-4919
    • Cooper, E.C.1
  • 29
    • 0031817383 scopus 로고    scopus 로고
    • KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    • Nakamura, M. et al. KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels. Recepiors Channels 5, 255-271 (1998).
    • (1998) Recepiors Channels , vol.5 , pp. 255-271
    • Nakamura, M.1
  • 30
    • 0033964653 scopus 로고    scopus 로고
    • Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels
    • Hadley, J. K. et al. Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br. J. Pharmacol. 129, 413-415 (2000).
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 413-415
    • Hadley, J.K.1
  • 31
    • 0030890712 scopus 로고    scopus 로고
    • KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias
    • Yang, W. P. et al. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc. Nail Acad. Sci. USA 94, 4017-4021 (1997).
    • (1997) Proc. Nail Acad. Sci. USA , vol.94 , pp. 4017-4021
    • Yang, W.P.1
  • 33
  • 34
    • 0027292974 scopus 로고
    • Seizure characteristics in chromosome 20 benign familial neonatal convulsions
    • Ronen, G. M., Rosales, T. O., Connolly, M., Anderson, V. E. & Leppert, M. Seizure characteristics in chromosome 20 benign familial neonatal convulsions. Neurology 43, 1355-1360 (1993).
    • (1993) Neurology , vol.43 , pp. 1355-1360
    • Ronen, G.M.1    Rosales, T.O.2    Connolly, M.3    Erson, V.E.4    Leppert, M.5
  • 35
    • 0024502803 scopus 로고
    • Benign familial neonatal convulsions linked to genetic markers on chromosome 20
    • Leppert, M. et al. Benign familial neonatal convulsions linked to genetic markers on chromosome 20. Nature 337, 647-648 (1989).
    • (1989) Nature , vol.337 , pp. 647-648
    • Leppert, M.1
  • 36
    • 0027359350 scopus 로고
    • Genetic heterogeneity in benign familial neonatal convulsions: Identification of a new locus on chromosome 8q
    • Lewis, T. B., Leach, R. J., Ward, K., O'Connell, P. & Ryan, S. G. Genetic heterogeneity in benign familial neonatal convulsions: identification of a new locus on chromosome 8q. Am. J. Hum. Genei. 53, 670-675 (1993).
    • (1993) Am. J. Hum. Genei. , vol.53 , pp. 670-675
    • Lewis, T.B.1    Leach, R.J.2    Ward, K.3    O'connell, P.4    Ryan, S.G.5
  • 37
    • 0032832304 scopus 로고    scopus 로고
    • A reduced K+current due to a novel mutation in KCNQ2 causes neonatal convulsions
    • +current due to a novel mutation in KCNQ2 causes neonatal convulsions. Ann. Neurol. 46, 305-312 (1999).
    • (1999) Ann. Neurol. , vol.46 , pp. 305-312
    • Lerche, H.1
  • 38
    • 0032911049 scopus 로고    scopus 로고
    • Structural and mutational analysis of KCNQ2, the major gene locus for benign familial neonatal convulsions
    • Biervert, C. & Steinlein, O. K. Structural and mutational analysis of KCNQ2, the major gene locus for benign familial neonatal convulsions. Hum. Genei. 104, 234-240 (1999).
    • (1999) Hum. Genei. , vol.104 , pp. 234-240
    • Biervert, C.1    Steinlein, O.K.2
  • 39
    • 0034100615 scopus 로고    scopus 로고
    • A KCNQ2 splice site mutation causing benign neonatal convulsions in a Scottish family
    • Lee, W. L. et al. A KCNQ2 splice site mutation causing benign neonatal convulsions in a Scottish family. Neuropediairics 31, 9-12 (2000).
    • (2000) Neuropediairics , vol.31 , pp. 9-12
    • Lee, W.L.1
  • 40
    • 18844468798 scopus 로고    scopus 로고
    • A novel mutation of KCNQ3 (C.925T^C) in a Japanese family with benign familial neonatal convulsions
    • Hirose, S. et al. A novel mutation of KCNQ3 (c.925T^C) in a Japanese family with benign familial neonatal convulsions. Ann. Neurol. 47, 822-826 (2000).
    • (2000) Ann. Neurol. , vol.47 , pp. 822-826
    • Hirose, S.1
  • 41
    • 0033606072 scopus 로고    scopus 로고
    • The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy
    • Steinlein, O. K., Stoodt, J., Biervert, C., Janz, D. & Sander, T. The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy. Neuroreport 10, 1163-1166 (1999).
    • (1999) Neuroreport , vol.10 , pp. 1163-1166
    • Steinlein, O.K.1    Stoodt, J.2    Biervert, C.3    Janz, D.4    Sander, T.5
  • 42
    • 0031001337 scopus 로고    scopus 로고
    • Control of M-current
    • Marrion, N. V. Control of M-current. Annu. Rev. Physiol. 59, 483-504 (1997).
    • (1997) Annu. Rev. Physiol. , vol.59 , pp. 483-504
    • Marrion, N.V.1
  • 43
    • 0030959835 scopus 로고    scopus 로고
    • Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents (/kM and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons
    • Lamas, J. A., Selyanko, A. A. & Brown, D. A. Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents kM and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons. Eur. J. Neurosci. 9, 605-616 (1997).
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 605-616
    • Lamas, J.A.1    Selyanko, A.A.2    Brown, D.A.3
  • 44
    • 0034161572 scopus 로고    scopus 로고
    • Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K+channels that underlie the neuronal M current
    • +channels that underlie the neuronal M current. J. Neurosci. 20, 1710-1721 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 1710-1721
    • Shapiro, M.S.1
  • 45
    • 0034142060 scopus 로고    scopus 로고
    • Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic receptors
    • Selyanko, A. A. et al. Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic receptors. J. Physiol. (Lond.) 522, 349-355 (2000).
    • (2000) J. Physiol. (Lond.) , vol.522 , pp. 349-355
    • Selyanko, A.A.1
  • 46
    • 0023865684 scopus 로고
    • Jr Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells
    • Sims, S. M., Singer, J. J. & Walsh, J. V. Jr Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells. Science 239, 190-193 (1988).
    • (1988) Science , vol.239 , pp. 190-193
    • Sims, S.M.1    Singer, J.J.2    Walsh, J.V.3
  • 47
    • 0031809240 scopus 로고    scopus 로고
    • Two new potent neurotransmitter release enhancers, 10,10-bis(4- pyridinylmethyl)-9(10H)- anthracenone and 10,10-bis(2-fluoro-4- pyridinylmethyl)- 9(10H)-anthracenone: Comparison to linopirdine
    • Zaczek, R. et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4- pyridinylmethyl)-9(10H)- anthracenone and 10,10-bis(2-fluoro-4- pyridinylmethyl)- 9(10H)-anthracenone: comparison to linopirdine. J. Pharmacol. Exp. Ther. 285, 724-730 (1998).
    • (1998) J. Pharmacol. Exp. Ther , vol.285 , pp. 724-730
    • Zaczek, R.1
  • 48
    • 0034677733 scopus 로고    scopus 로고
    • The novel anticonvulsant retigabine activates M-currents in chinese hamster ovary- cells transfected with human KCNQ2/3 subunits
    • Rundfeldt, C. & Netzer, R. The novel anticonvulsant retigabine activates M-currents in chinese hamster ovary- cells transfected with human KCNQ2/3 subunits. Neurosci. Lett. 282, 73-76 (2000).
    • (2000) Neurosci. Lett. , vol.282 , pp. 73-76
    • Rundfeldt, C.1    Netzer, R.2
  • 49
    • 0033568873 scopus 로고    scopus 로고
    • Two types of K+ channel subunits, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell
    • Selyanko, A. A. et al. Two types of K+ channel subunits, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J. Neurosci. 19, 7742-7756 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 7742-7756
    • Selyanko, A.A.1
  • 50
    • 0032773288 scopus 로고    scopus 로고
    • Separation of M-like current and ERG current in NG108-15 cells
    • Meves, H., Schwarz, J. R. & Wulfsen, I. Separation of M-like current and ERG current in NG108-15 cells. Br. J. Pharmacol. 127, 1213-1223 (1999).
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 1213-1223
    • Meves, H.1    Schwarz, J.R.2    Wulfsen, I.3
  • 52
    • 0028101878 scopus 로고
    • Linkage of autosomal dominant hearing loss to the short arm of chromosome 1 in two families
    • Coucke, P. et al. Linkage of autosomal dominant hearing loss to the short arm of chromosome 1 in two families. N. Engl. J. Med. 331, 425-431 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , pp. 425-431
    • Coucke, P.1
  • 53
    • 0032810047 scopus 로고    scopus 로고
    • Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families
    • Coucke, P. J. et al. Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Hum. Mol. Genei. 8, 1321-1328 (1999).
    • (1999) Hum. Mol. Genei. , vol.8 , pp. 1321-1328
    • Coucke, P.J.1
  • 54
    • 0025954512 scopus 로고
    • Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation
    • Sakagami, M. et al. Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation. Hear. Res. 56, 168-172 (1991).
    • (1991) Hear. Res. , vol.56 , pp. 168-172
    • Sakagami, M.1
  • 55
    • 0031278313 scopus 로고    scopus 로고
    • KCNE1 mutations cause Jervell and Lange-Nielsen syndrome
    • Schulze-Bahr, E. et al. KCNE1 mutations cause Jervell and Lange-Nielsen syndrome. Nature Genet. 17, 267-268 (1997).
    • (1997) Nature Genet , vol.17 , pp. 267-268
    • Schulze-Bahr, E.1
  • 56
    • 0033037730 scopus 로고    scopus 로고
    • Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter
    • Delpire, E., Lu, J., England, R., Dull, C. & Thorne, T. Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter. Nature Genet. 22, 192-195 (1999).
    • (1999) Nature Genet , vol.22 , pp. 192-195
    • Delpire, E.1    Lu, J.2    England, R.3    Dull, C.4    Thorne, T.5
  • 57
    • 0016654458 scopus 로고
    • Effect of absence of cochlear outer hair cells on behavioural auditory threshold
    • Ryan, A. & Dallos, P. Effect of absence of cochlear outer hair cells on behavioural auditory threshold. Nature 253, 44-46 (1975).
    • (1975) Nature , vol.253 , pp. 44-46
    • Ryan, A.1    Dallos, P.2
  • 58
    • 0031007349 scopus 로고    scopus 로고
    • Connexin 26 mutations in hereditary non- syndromic sensorineural deafness
    • Kelsell, D. P. et al. Connexin 26 mutations in hereditary non- syndromic sensorineural deafness. Nature 387, 80-83 (1997).
    • (1997) Nature , vol.387 , pp. 80-83
    • Kelsell, D.P.1
  • 59
    • 85069240579 scopus 로고    scopus 로고
    • Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus
    • Grifa, A. et al. Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus. Nature Genet. 23, 16-18 (1999).
    • (1999) Nature Genet , vol.23 , pp. 16-18
    • Grifa, A.1
  • 60
    • 17344373747 scopus 로고    scopus 로고
    • Mutations in the gene encoding gap junction protein p-3 associated with autosomal dominant hearing impairment
    • Xia, J. H. et al. Mutations in the gene encoding gap junction protein p-3 associated with autosomal dominant hearing impairment. Nature Genet. 20, 370-373 (1998).
    • (1998) Nature Genet , vol.20 , pp. 370-373
    • Xia, J.H.1
  • 61
    • 0033596845 scopus 로고    scopus 로고
    • Sensorineural deafness in X-linked Charcot- Marie-Tooth disease with connexin 32 mutation (R142Q)
    • Stojkovic, T, Latour, P, Vandenberghe, A., Hurtevent, J. F. & Vermersch, P. Sensorineural deafness in X-linked Charcot- Marie-Tooth disease with connexin 32 mutation (R142Q). Neurology 52, 1010-1014 (1999).
    • (1999) Neurology , vol.52 , pp. 1010-1014
    • Stojkovic, T.1    Latour, P.2    Vandenberghe, A.3    Hurtevent, J.F.4    Vermersch, P.5
  • 62
    • 0028843286 scopus 로고
    • Gap junctions in the rat cochlea: Immunohistochemical and ultrastructural analysis
    • Kikuchi, T., Kimura, R. S., Paul, D. L. & Adams, J. C. Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis. Anai. Embryol. (Berl.) 191, 101-118 (1995).
    • (1995) Anai. Embryol. (Berl.) , vol.191 , pp. 101-118
    • Kikuchi, T.1    Kimura, R.S.2    Paul, D.L.3    Adams, J.C.4
  • 63
    • 0031795109 scopus 로고    scopus 로고
    • Expression of the gap-junction connexins 26 and 30 in the rat cochlea
    • Lautermann, J. et al. Expression of the gap-junction connexins 26 and 30 in the rat cochlea. Cell Tissue Res. 294, 415-420 (1998).
    • (1998) Cell Tissue Res , vol.294 , pp. 415-420
    • Lautermann, J.1
  • 64
    • 0028171563 scopus 로고
    • Ionic properties of IK, nin outer hair cells of guinea pig cochlea
    • K, nin outer hair cells of guinea pig cochlea. Brain Res. 661, 293-297 (1994).
    • (1994) Brain Res , vol.661 , pp. 293-297
    • Nakagawa, T.1
  • 65
    • 0030833819 scopus 로고    scopus 로고
    • Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation
    • Santos-Sacchi, J., Huang, G. J. & Wu, M. Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation. Biophys. J. 73, 1424-1429 (1997).
    • (1997) Biophys. J. , vol.73 , pp. 1424-1429
    • Santos-Sacchi, J.1    Huang, G.J.2    Wu, M.3
  • 66
    • 0033230252 scopus 로고    scopus 로고
    • Developmental expression of the potassium current /K, n contributes to maturation of mouse outer hair cells
    • K, n contributes to maturation of mouse outer hair cells. J. Physiol. (Lond.) 520, 653-660 (1999).
    • (1999) J. Physiol. (Lond.) , vol.520 , pp. 653-660
    • Marcotti, W.1    Kros, C.J.2
  • 67
    • 0033928810 scopus 로고    scopus 로고
    • Major potassium conductance in type I hair cells from rat semicircular canals: Characterization and modulation by nitric oxide
    • Chen, J. W. & Eatock, R. A. Major potassium conductance in type I hair cells from rat semicircular canals: characterization and modulation by nitric oxide. J. Neurophysiol. 84, 139-151 (2000).
    • (2000) J. Neurophysiol. , vol.84 , pp. 139-151
    • Chen, J.W.1    Eatock, R.A.2
  • 68
    • 0033038107 scopus 로고    scopus 로고
    • Synaptic mechanisms for coding timing in auditory neurons
    • Trussell, L. O. Synaptic mechanisms for coding timing in auditory neurons. Annu. Rev. Physiol. 61, 477-496 (1999).
    • (1999) Annu. Rev. Physiol. , vol.61 , pp. 477-496
    • Trussell, L.O.1
  • 69
    • 0032560610 scopus 로고    scopus 로고
    • A recessive variant of the Romano-Ward long-QT syndrome?
    • Priori, S. G. et al. A recessive variant of the Romano-Ward long-QT syndrome? Circulaiion 97, 2420-2425 (1998).
    • (1998) Circulaiion , vol.97 , pp. 2420-2425
    • Priori, S.G.1
  • 70
    • 0032833719 scopus 로고    scopus 로고
    • Recessive Romano-Ward syndrome associated with compound heterozygosity for two mutations in the KVLQT1 gene
    • Larsen, L. A. et al. Recessive Romano-Ward syndrome associated with compound heterozygosity for two mutations in the KVLQT1 gene. Eur. J. Hum. Genei. 7, 724-728 (1999).
    • (1999) Eur. J. Hum. Genei. , vol.7 , pp. 724-728
    • Larsen, L.A.1
  • 71
    • 0033969369 scopus 로고    scopus 로고
    • Novel mutations in KvLQT1 that affect Ife activation through interactions with Isk
    • feactivation through interactions with Isk. Cardiovasc. Res. 45, 971-980 (2000).
    • (2000) Cardiovasc. Res. , vol.45 , pp. 971-980
    • Chouabe, C.1
  • 72
    • 0032810047 scopus 로고    scopus 로고
    • Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families
    • Coucke, P. J. et al. Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Hum. Mol. Genet. 8, 1321-1328 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1321-1328
    • Coucke, P.J.1
  • 73
    • 0032794410 scopus 로고    scopus 로고
    • Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss
    • Talebizadeh, Z., Kelley, P M., Askew, J. W., Beisel, K. W. & Smith, S. D. Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss. Hum. Muiat. 14, 493-501 (1999).
    • (1999) Hum. Muiat. , vol.14 , pp. 493-501
    • Talebizadeh, Z.1    Kelley, P.M.2    Askew, J.W.3    Beisel, K.W.4    Smith, S.D.5
  • 74
    • 0030799943 scopus 로고    scopus 로고
    • Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
    • + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J. 16, 5472-5479 (1997).
    • (1997) EMBO J , vol.16 , pp. 5472-5479
    • Chouabe, C.1
  • 75
    • 0029840732 scopus 로고    scopus 로고
    • KVLQT1 mutations in three families with familial or sporadic long QT syndrome
    • Russell, M. W., Dick, M., Collins, F. S. & Brody, L. C. KVLQT1 mutations in three families with familial or sporadic long QT syndrome. Hum. Mol. Genet. 5, 1319-1324 (1996).
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1319-1324
    • Russell, M.W.1    Dick, M.2    Collins, F.S.3    Brody, L.C.4
  • 76
    • 0030782276 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of dominant and recessive KvLQT1 K+ channel mutations found in inherited cardiac arrhythmias
    • + channel mutations found in inherited cardiac arrhythmias. Hum. Mol. Genet. 6, 1943-1949 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1943-1949
    • Wollnik, B.1
  • 77
    • 0027324240 scopus 로고
    • On the mechanism of M-current inhibition by muscarinic m1 receptors in DNA- transfected rodent neuroblastoma x glioma cells
    • Robbins, J., Marsh, S. J. & Brown, D. A. On the mechanism of M-current inhibition by muscarinic m1 receptors in DNA- transfected rodent neuroblastoma x glioma cells. J. Physiol. (Lond.) 469, 153-178 (1993).
    • (1993) J. Physiol. (Lond.) , vol.469 , pp. 153-178
    • Robbins, J.1    Marsh, S.J.2    Brown, D.A.3
  • 78
    • 0023073007 scopus 로고
    • Positive endocochlear potential: Mechanism of production by marginal cells of stria vascularis
    • Offner, F. F., Dallos, P. & Cheatham, M. A. Positive endocochlear potential: mechanism of production by marginal cells of stria vascularis. Hear. Res. 29, 117-124 (1987).
    • (1987) Hear. Res. , vol.29 , pp. 117-124
    • Offner, F.F.1    Dallos, P.2    Cheatham, M.A.3
  • 79
    • 0028955296 scopus 로고
    • Ion transport mechanisms responsible for K+ secretion and the transepithelial voltage across marginal cells of stria vascularis in viro
    • + secretion and the transepithelial voltage across marginal cells of stria vascularis in viro. Hear. Res. 84, 19-29 (1995).
    • (1995) Hear. Res. , vol.84 , pp. 19-29
    • Wangemann, P.1    Liu, J.2    Marcus, D.C.3
  • 80
    • 9844261701 scopus 로고    scopus 로고
    • IsK and KvLQT1: Mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome
    • Tyson, J. et al. IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome. Hum. Mol. Genet. 6, 2179-2185 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 2179-2185
    • Tyson, J.1
  • 81
    • 0032837542 scopus 로고    scopus 로고
    • Mutation of the Na-K-Cl co-transporter gene Slc12a2 results in deafness in mice
    • Dixon, M. J. et al. Mutation of the Na-K-Cl co-transporter gene Slc12a2 results in deafness in mice. Hum. Mol. Genet. 8, 1579-1584 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1579-1584
    • Dixon, M.J.1
  • 82
    • 0033578605 scopus 로고    scopus 로고
    • Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf
    • Flagella, M. et al. Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J. Biol. Chem. 274, 26946-28955 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 26946-28955
    • Flagella, M.1
  • 83
    • 0026530109 scopus 로고
    • Mechanoelectrical transduction by hair cells
    • Pickles, J. O. & Corey, D. P. Mechanoelectrical transduction by hair cells. Trends Neurosci. 15, 254-259 (1992).
    • (1992) Trends Neurosci , vol.15 , pp. 254-259
    • Pickles, J.O.1    Corey, D.P.2
  • 84
    • 0034636553 scopus 로고    scopus 로고
    • Prestin is the motor protein of cochlear outer hair cells
    • Zheng, J. et al. Prestin is the motor protein of cochlear outer hair cells. Nature 405, 149-155 (2000).
    • (2000) Nature , vol.405 , pp. 149-155
    • Zheng, J.1


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