Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+ (BK) Channel Modulators: The GoSlo-SR Family

ChemMedChem

Volumn 7, Issue 10, 2012, Pages 1763-1769

  Roy, Subhrangsu ^a   MorayoAkande, Adebola ^a   Large, Roddy J ^a   Webb, Tim I ^a   Camarasu, Costin ^a   Sergeant, Gerard P ^a   Mchale, Noel G ^a   Thornbury, Keith D ^a   Hollywood, Mark A ^a  

^a DUNDALK INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Bladder smooth muscle; Ion channels; Microwave chemistry; Potassium channels; Structure activity relationships

Indexed keywords

ANTHRAQUINONE DERIVATIVE; GOSLO SR 5 44; GOSLO SR 5 6; GOSLO SR FAMILY; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BLADDER MUSCLE; CELL MEMBRANE POTENTIAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYDROPHOBICITY; LIPOPHILICITY; MEMBRANE POTENTIAL; OVERACTIVE BLADDER; PATCH CLAMP; PHARMACOPHORE; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTHRAQUINONES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MUSCLE, SMOOTH; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY BLADDER;

EID: 84866755794     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200321     Document Type: Article

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