Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane

Science

Volumn 298, Issue 5595, 2002, Pages 1029-1033

  Xu, Wenhong ^a   Liu, Yongge ^a   Wang, Sheng ^a   McDonald, Todd ^a   Van Eyk, Jennifer E ^a   Sidor, Agnieszka ^a   O'Rourke, Brian ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARDIOVASCULAR SYSTEM; CELLS;

INFACTION;

BIOLOGICAL MEMBRANES;

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHARYBDOTOXIN; MITOCHONDRIAL PROTEIN; PAXILLINE; POTASSIUM ION; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; BENZIMIDAZOLE DERIVATIVE; CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM;

ION; MITOCHONDRIAL DNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; GUINEA PIG; HEART INFARCTION; HEART MITOCHONDRION; HEART PROTECTION; HEART VENTRICLE WALL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; ANIMAL; HEART; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; INTRACELLULAR MEMBRANE; ION TRANSPORT; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZIMIDAZOLES; CALCIUM; CHARYBDOTOXIN; CYTOPROTECTION; GUINEA PIGS; HEART; HEMODYNAMIC PROCESSES; INTRACELLULAR MEMBRANES; ION TRANSPORT; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS, CALCIUM-ACTIVATED;

EID: 0036826892     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074360     Document Type: Article

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31. Supported by NIHRO1HLS4598 (B.O'R.) and CIHR 49843 (J.V.E.). We thank P. L. Pedersen and Y. H. Ko for the liver submitochondrial particles and M. Aon and E. Marbán for helpful comments.