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Volumn 8, Issue 7, 2013, Pages

Neurogenic Detrusor Overactivity Is Associated with Decreased Expression and Function of the Large Conductance Voltage- and Ca2+-Activated K+ Channels

Author keywords

[No Author keywords available]

Indexed keywords

IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MESSENGER RNA;

EID: 84879836005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068052     Document Type: Article
Times cited : (49)

References (45)
  • 1
    • 0037253578 scopus 로고    scopus 로고
    • The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society
    • Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, et al. (2003) The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology 61: 37-49.
    • (2003) Urology , vol.61 , pp. 37-49
    • Abrams, P.1    Cardozo, L.2    Fall, M.3    Griffiths, D.4    Rosier, P.5
  • 2
    • 9244234710 scopus 로고    scopus 로고
    • Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence
    • Andersson KE, Wein AJ, (2004) Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56: 581-631.
    • (2004) Pharmacol Rev , vol.56 , pp. 581-631
    • Andersson, K.E.1    Wein, A.J.2
  • 3
    • 84871933736 scopus 로고    scopus 로고
    • Botulinum toxin injection for lower urinary tract dysfunction
    • Kuo YC, Kuo HC, (2013) Botulinum toxin injection for lower urinary tract dysfunction. Int J Urol 20: 40-55.
    • (2013) Int J Urol , vol.20 , pp. 40-55
    • Kuo, Y.C.1    Kuo, H.C.2
  • 5
    • 0028999091 scopus 로고
    • Lower urinary changes over time in suprasacral spinal cord injury
    • Cardenas DD, Mayo ME, Turner LR, (1995) Lower urinary changes over time in suprasacral spinal cord injury. Paraplegia 33: 326-329.
    • (1995) Paraplegia , vol.33 , pp. 326-329
    • Cardenas, D.D.1    Mayo, M.E.2    Turner, L.R.3
  • 6
    • 46549084672 scopus 로고    scopus 로고
    • Refractory idiopathic urge urinary incontinence and botulinum A injection
    • Brubaker L, Richter HE, Visco A, Mahajan S, Nygaard I, et al. (2008) Refractory idiopathic urge urinary incontinence and botulinum A injection. J Urol 180: 217-222.
    • (2008) J Urol , vol.180 , pp. 217-222
    • Brubaker, L.1    Richter, H.E.2    Visco, A.3    Mahajan, S.4    Nygaard, I.5
  • 7
    • 35748930227 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of fesoterodine for overactive bladder syndrome
    • Nitti VW, Dmochowski R, Sand PK, Forst HT, Haag-Molkenteller C, et al. (2007) Efficacy, safety and tolerability of fesoterodine for overactive bladder syndrome. J Urol 178: 2488-2494.
    • (2007) J Urol , vol.178 , pp. 2488-2494
    • Nitti, V.W.1    Dmochowski, R.2    Sand, P.K.3    Forst, H.T.4    Haag-Molkenteller, C.5
  • 8
    • 33646770677 scopus 로고    scopus 로고
    • Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: a pooled analysis
    • Wagg A, Wyndaele JJ, Sieber P, (2006) Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: a pooled analysis. Am J Geriatr Pharmacother 4: 14-24.
    • (2006) Am J Geriatr Pharmacother , vol.4 , pp. 14-24
    • Wagg, A.1    Wyndaele, J.J.2    Sieber, P.3
  • 9
    • 33644846418 scopus 로고    scopus 로고
    • Efficacy, tolerability and safety of darifenacin, an M(3) selective receptor antagonist: an investigation of warning time in patients with OAB
    • Zinner N, Susset J, Gittelman M, Arguinzoniz M, Rekeda L, et al. (2006) Efficacy, tolerability and safety of darifenacin, an M(3) selective receptor antagonist: an investigation of warning time in patients with OAB. Int J Clin Pract 60: 119-126.
    • (2006) Int J Clin Pract , vol.60 , pp. 119-126
    • Zinner, N.1    Susset, J.2    Gittelman, M.3    Arguinzoniz, M.4    Rekeda, L.5
  • 10
    • 62049083475 scopus 로고    scopus 로고
    • Efficacy and safety of oxybutynin chloride topical gel for overactive bladder: a randomized, double-blind, placebo controlled, multicenter study
    • Staskin DR, Dmochowski RR, Sand PK, Macdiarmid SA, Caramelli KE, et al. (2009) Efficacy and safety of oxybutynin chloride topical gel for overactive bladder: a randomized, double-blind, placebo controlled, multicenter study. J Urol 181: 1764-1772.
    • (2009) J Urol , vol.181 , pp. 1764-1772
    • Staskin, D.R.1    Dmochowski, R.R.2    Sand, P.K.3    Macdiarmid, S.A.4    Caramelli, K.E.5
  • 11
    • 36649018085 scopus 로고    scopus 로고
    • Safety and tolerability of extended-release oxybutynin once daily in urinary incontinence: combined results from two phase 4 controlled clinical trials
    • Armstrong RB, Dmochowski RR, Sand PK, Macdiarmid S, (2007) Safety and tolerability of extended-release oxybutynin once daily in urinary incontinence: combined results from two phase 4 controlled clinical trials. Int Urol Nephrol 39: 1069-1077.
    • (2007) Int Urol Nephrol , vol.39 , pp. 1069-1077
    • Armstrong, R.B.1    Dmochowski, R.R.2    Sand, P.K.3    Macdiarmid, S.4
  • 12
    • 80051577809 scopus 로고    scopus 로고
    • Safety and tolerability profiles of anticholinergic agents used for the treatment of overactive bladder
    • Oefelein MG, (2011) Safety and tolerability profiles of anticholinergic agents used for the treatment of overactive bladder. Drug Saf 34: 733-754.
    • (2011) Drug Saf , vol.34 , pp. 733-754
    • Oefelein, M.G.1
  • 13
    • 84857672160 scopus 로고    scopus 로고
    • Mirabegron for the treatment of overactive bladder
    • Gras J, (2012) Mirabegron for the treatment of overactive bladder. Drugs Today (Barc) 48: 25-32.
    • (2012) Drugs Today (Barc) , vol.48 , pp. 25-32
    • Gras, J.1
  • 14
    • 77957729784 scopus 로고    scopus 로고
    • Mirabegron, a beta(3)-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder
    • Tyagi P, Tyagi V, (2010) Mirabegron, a beta(3)-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder. IDrugs 13: 713-722.
    • (2010) IDrugs , vol.13 , pp. 713-722
    • Tyagi, P.1    Tyagi, V.2
  • 15
    • 84859873402 scopus 로고    scopus 로고
    • Botulinum toxin A modulates afferent fibers in neurogenic detrusor overactivity
    • Conte A, Giannantoni A, Proietti S, Giovannozzi S, Fabbrini G, et al. (2012) Botulinum toxin A modulates afferent fibers in neurogenic detrusor overactivity. Eur J Neurol 19: 725-732.
    • (2012) Eur J Neurol , vol.19 , pp. 725-732
    • Conte, A.1    Giannantoni, A.2    Proietti, S.3    Giovannozzi, S.4    Fabbrini, G.5
  • 16
    • 78049454598 scopus 로고    scopus 로고
    • Adverse events of intravesical botulinum toxin a injections for idiopathic detrusor overactivity: risk factors and influence on treatment outcome
    • Kuo HC, Liao CH, Chung SD, (2010) Adverse events of intravesical botulinum toxin a injections for idiopathic detrusor overactivity: risk factors and influence on treatment outcome. Eur Urol 58: 919-926.
    • (2010) Eur Urol , vol.58 , pp. 919-926
    • Kuo, H.C.1    Liao, C.H.2    Chung, S.D.3
  • 17
    • 0031466747 scopus 로고    scopus 로고
    • A myogenic basis for the overactive bladder
    • discussion 68-73
    • Brading AF (1997) A myogenic basis for the overactive bladder. Urology 50: 57-67; discussion 68-73.
    • (1997) Urology , vol.50 , pp. 57-67
    • Brading, A.F.1
  • 18
    • 79961090110 scopus 로고    scopus 로고
    • Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients
    • Oger S, Behr-Roussel D, Gorny D, Bernabe J, Comperat E, et al. (2011) Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients. BJU Int 108: 604-611.
    • (2011) BJU Int , vol.108 , pp. 604-611
    • Oger, S.1    Behr-Roussel, D.2    Gorny, D.3    Bernabe, J.4    Comperat, E.5
  • 19
    • 1242273728 scopus 로고    scopus 로고
    • Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder
    • Hashitani H, Brading AF, Suzuki H, (2004) Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 141: 183-193.
    • (2004) Br J Pharmacol , vol.141 , pp. 183-193
    • Hashitani, H.1    Brading, A.F.2    Suzuki, H.3
  • 20
    • 84855219569 scopus 로고    scopus 로고
    • Role of potassium ion channels in detrusor smooth muscle function and dysfunction
    • Petkov GV, (2012) Role of potassium ion channels in detrusor smooth muscle function and dysfunction. Nat Rev Urol 9: 30-40.
    • (2012) Nat Rev Urol , vol.9 , pp. 30-40
    • Petkov, G.V.1
  • 21
    • 84861866235 scopus 로고    scopus 로고
    • Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+-activated K+ channels
    • Hristov KL, Parajuli SP, Soder RP, Cheng Q, Rovner ES, et al. (2012) Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+-activated K+ channels. Am J Physiol Cell Physiol: C1632-1641.
    • (2012) Am J Physiol Cell Physiol , pp. 1632-1641
    • Hristov, K.L.1    Parajuli, S.P.2    Soder, R.P.3    Cheng, Q.4    Rovner, E.S.5
  • 22
    • 64049085358 scopus 로고    scopus 로고
    • Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder
    • Hayase M, Hashitani H, Kohri K, Suzuki H, (2009) Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder. J Urol 181: 2355-2365.
    • (2009) J Urol , vol.181 , pp. 2355-2365
    • Hayase, M.1    Hashitani, H.2    Kohri, K.3    Suzuki, H.4
  • 23
    • 0030860425 scopus 로고    scopus 로고
    • Ca2+-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle
    • Heppner TJ, Bonev AD, Nelson MT, (1997) Ca2+-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle. Am J Physiol 273: C110-117.
    • (1997) Am J Physiol , vol.273
    • Heppner, T.J.1    Bonev, A.D.2    Nelson, M.T.3
  • 24
    • 57049119669 scopus 로고    scopus 로고
    • Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel
    • Brown SM, Bentcheva-Petkova LM, Liu L, Hristov KL, Chen M, et al. (2008) Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. Am J Physiol Renal Physiol 295: F1149-1157.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Brown, S.M.1    Bentcheva-Petkova, L.M.2    Liu, L.3    Hristov, K.L.4    Chen, M.5
  • 25
    • 0036623894 scopus 로고    scopus 로고
    • Differential regulation of SK and BK channels by Ca2+ signals from Ca2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes
    • Herrera GM, Nelson MT, (2002) Differential regulation of SK and BK channels by Ca2+ signals from Ca2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes. J Physiol 541: 483-492.
    • (2002) J Physiol , vol.541 , pp. 483-492
    • Herrera, G.M.1    Nelson, M.T.2
  • 26
    • 0035529041 scopus 로고    scopus 로고
    • Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle
    • Petkov GV, Bonev AD, Heppner TJ, Brenner R, Aldrich RW, et al. (2001) Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol 537: 443-452.
    • (2001) J Physiol , vol.537 , pp. 443-452
    • Petkov, G.V.1    Bonev, A.D.2    Heppner, T.J.3    Brenner, R.4    Aldrich, R.W.5
  • 27
    • 22244447729 scopus 로고    scopus 로고
    • Differential regulation of Ca2+-activated K+ channels by beta-adrenoceptors in guinea pig urinary bladder smooth muscle
    • Petkov GV, Nelson MT, (2005) Differential regulation of Ca2+-activated K+ channels by beta-adrenoceptors in guinea pig urinary bladder smooth muscle. Am J Physiol Cell Physiol 288: C1255-1263.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Petkov, G.V.1    Nelson, M.T.2
  • 28
    • 61349179466 scopus 로고    scopus 로고
    • Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder
    • Sprossmann F, Pankert P, Sausbier U, Wirth A, Zhou XB, et al. (2009) Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J 276: 1680-1697.
    • (2009) FEBS J , vol.276 , pp. 1680-1697
    • Sprossmann, F.1    Pankert, P.2    Sausbier, U.3    Wirth, A.4    Zhou, X.B.5
  • 29
    • 80053205792 scopus 로고    scopus 로고
    • Large-conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function
    • Hristov KL, Chen M, Kellett WF, Rovner ES, Petkov GV, (2011) Large-conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function. Am J Physiol Cell Physiol 301: C903-912.
    • (2011) Am J Physiol Cell Physiol , vol.301
    • Hristov, K.L.1    Chen, M.2    Kellett, W.F.3    Rovner, E.S.4    Petkov, G.V.5
  • 30
    • 4344596359 scopus 로고    scopus 로고
    • Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel
    • Meredith AL, Thorneloe KS, Werner ME, Nelson MT, Aldrich RW, (2004) Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. J Biol Chem 279: 36746-36752.
    • (2004) J Biol Chem , vol.279 , pp. 36746-36752
    • Meredith, A.L.1    Thorneloe, K.S.2    Werner, M.E.3    Nelson, M.T.4    Aldrich, R.W.5
  • 31
    • 80054754765 scopus 로고    scopus 로고
    • Large conductance Ca2+ -activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle
    • Soder RP, Petkov GV, (2011) Large conductance Ca2+-activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle. Eur J Pharmacol 670: 252-259.
    • (2011) Eur J Pharmacol , vol.670 , pp. 252-259
    • Soder, R.P.1    Petkov, G.V.2
  • 32
    • 84860539089 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large-conductance voltage- and Ca2+-activated K+ channel
    • Xin W, Cheng Q, Soder RP, Petkov GV, (2012) Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large-conductance voltage- and Ca2+-activated K+ channel. Am J Physiol Cell Physiol 302: C1361-1370.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Xin, W.1    Cheng, Q.2    Soder, R.P.3    Petkov, G.V.4
  • 33
    • 77952682768 scopus 로고    scopus 로고
    • Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein
    • Chang S, Gomes CM, Hypolite JA, Marx J, Alanzi J, et al. (2010) Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. Am J Physiol Renal Physiol 298: F1416-1423.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Chang, S.1    Gomes, C.M.2    Hypolite, J.A.3    Marx, J.4    Alanzi, J.5
  • 34
    • 75449085109 scopus 로고    scopus 로고
    • BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle
    • Layne JJ, Nausch B, Olesen SP, Nelson MT, (2010) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol 298: R378-384.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298
    • Layne, J.J.1    Nausch, B.2    Olesen, S.P.3    Nelson, M.T.4
  • 35
    • 0035199133 scopus 로고    scopus 로고
    • Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo
    • Christ GJ, Day NS, Day M, Santizo C, Zhao W, et al. (2001) Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo. Am J Physiol Regul Integr Comp Physiol 281: R1699-1709.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Christ, G.J.1    Day, N.S.2    Day, M.3    Santizo, C.4    Zhao, W.5
  • 36
    • 33947515906 scopus 로고    scopus 로고
    • Plasmid-based gene transfer for treatment of erectile dysfunction and overactive bladder: results of a phase I trial
    • Melman A, Bar-Chama N, McCullough A, Davies K, Christ G, (2007) Plasmid-based gene transfer for treatment of erectile dysfunction and overactive bladder: results of a phase I trial. Isr Med Assoc J 9: 143-146.
    • (2007) Isr Med Assoc J , vol.9 , pp. 143-146
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4    Christ, G.5
  • 37
    • 39449121888 scopus 로고    scopus 로고
    • Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat
    • Melman A, Biggs G, Davies K, Zhao W, Tar MT, et al. (2008) Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat. Gene Ther 15: 364-370.
    • (2008) Gene Ther , vol.15 , pp. 364-370
    • Melman, A.1    Biggs, G.2    Davies, K.3    Zhao, W.4    Tar, M.T.5
  • 38
    • 23944468730 scopus 로고    scopus 로고
    • Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder
    • Thorneloe KS, Meredith AL, Knorn AM, Aldrich RW, Nelson MT, (2005) Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. Am J Physiol Renal Physiol 289: F604-610.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Thorneloe, K.S.1    Meredith, A.L.2    Knorn, A.M.3    Aldrich, R.W.4    Nelson, M.T.5
  • 39
    • 85027951013 scopus 로고    scopus 로고
    • Large-conductance calcium-activated potassium channel activity, as determined by whole-cell patch clamp recording, is decreased in urinary bladder smooth muscle cells from male rats with partial urethral obstruction
    • Aydin M, Wang HZ, Zhang X, Chua R, Downing K, et al. (2012) Large-conductance calcium-activated potassium channel activity, as determined by whole-cell patch clamp recording, is decreased in urinary bladder smooth muscle cells from male rats with partial urethral obstruction. BJU Int 110: E402-408.
    • (2012) BJU Int , vol.110
    • Aydin, M.1    Wang, H.Z.2    Zhang, X.3    Chua, R.4    Downing, K.5
  • 40
    • 84865146659 scopus 로고    scopus 로고
    • SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions
    • Afeli SA, Rovner ES, Petkov GV, (2012) SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions. Am J Physiol Renal Physiol 303: F559-568.
    • (2012) Am J Physiol Renal Physiol , vol.303
    • Afeli, S.A.1    Rovner, E.S.2    Petkov, G.V.3
  • 41
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ, (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391: 85-100.
    • (1981) Pflugers Arch , vol.391 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3    Sakmann, B.4    Sigworth, F.J.5
  • 42
    • 0023795593 scopus 로고
    • Muscarinic activation of ionic currents measured by a new whole-cell recording method
    • Horn R, Marty A, (1988) Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol 92: 145-159.
    • (1988) J Gen Physiol , vol.92 , pp. 145-159
    • Horn, R.1    Marty, A.2
  • 43
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 44
    • 43949128087 scopus 로고    scopus 로고
    • Altered expression of calcium-activated K and Cl channels in detrusor overactivity of rats with partial bladder outlet obstruction
    • Li L, Jiang C, Song B, Yan J, Pan J, (2008) Altered expression of calcium-activated K and Cl channels in detrusor overactivity of rats with partial bladder outlet obstruction. BJU Int 101: 1588-1594.
    • (2008) BJU Int , vol.101 , pp. 1588-1594
    • Li, L.1    Jiang, C.2    Song, B.3    Yan, J.4    Pan, J.5
  • 45
    • 48949117594 scopus 로고    scopus 로고
    • BK channel modulators: a comprehensive overview
    • Nardi A, Olesen SP, (2008) BK channel modulators: a comprehensive overview. Curr Med Chem 15: 1126-1146.
    • (2008) Curr Med Chem , vol.15 , pp. 1126-1146
    • Nardi, A.1    Olesen, S.P.2


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