-
1
-
-
84859474722
-
Deaths: Final data for 2008
-
Minino AM, Murphy SL, Xu J, Kochanek KD (2011) Deaths: final data for 2008. National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System 59: 1-126.
-
(2011)
National Vital Statistics Reports : From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System
, vol.59
, pp. 1-126
-
-
Minino, A.M.1
Murphy, S.L.2
Xu, J.3
Kochanek, K.D.4
-
2
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes & Development 13: 2570-2580.
-
(1999)
Genes & Development
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
3
-
-
0034703217
-
Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
4
-
-
0033600176
-
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
-
Frye RA (1999) Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochemical and Biophysical Research Communications 260: 273-279.
-
(1999)
Biochemical and Biophysical Research Communications
, vol.260
, pp. 273-279
-
-
Frye, R.A.1
-
5
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye RA (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochemical and Biophysical Research Communications 273: 793-798.
-
(2000)
Biochemical and Biophysical Research Communications
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
6
-
-
0037108799
-
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
-
Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP (2002) SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proceedings of the National Academy of Sciences of the United States of America 99: 13653-13658.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 13653-13658
-
-
Onyango, P.1
Celic, I.2
McCaffery, J.M.3
Boeke, J.D.4
Feinberg, A.P.5
-
7
-
-
37549002891
-
Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, et al. (2007) Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology 27: 8807-8814.
-
(2007)
Molecular and Cellular Biology
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
Alt, F.W.2
Cheng, H.L.3
Bunkenborg, J.4
Streeper, R.S.5
-
9
-
-
33745889628
-
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
-
Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E (2006) Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proceedings of the National Academy of Sciences of the United States of America 103: 10224-10229.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 10224-10229
-
-
Schwer, B.1
Bunkenborg, J.2
Verdin, R.O.3
Andersen, J.S.4
Verdin, E.5
-
10
-
-
78651468707
-
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
-
Hallows WC, Yu W, Smith BC, Devires MK, Ellinger JJ, et al. (2011) Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction. Molecular Cell 41: 139-149.
-
(2011)
Molecular Cell
, vol.41
, pp. 139-149
-
-
Hallows, W.C.1
Yu, W.2
Smith, B.C.3
Devires, M.K.4
Ellinger, J.J.5
-
11
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, et al. (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464: 121-137.
-
(2010)
Nature
, vol.464
, pp. 121-137
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
-
12
-
-
79961032436
-
SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
-
Lu ZP, Bourdi M, Li JH, Aponte AM, Chen Y, et al. (2011) SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity. Embo Reports 12: 840-846.
-
(2011)
Embo Reports
, vol.12
, pp. 840-846
-
-
Lu, Z.P.1
Bourdi, M.2
Li, J.H.3
Aponte, A.M.4
Chen, Y.5
-
13
-
-
84891867434
-
Sirtuins and the Warburg effect
-
Guarente L (2014) Sirtuins and the Warburg effect. Nature Medicine 20: 24-25.
-
(2014)
Nature Medicine
, vol.20
, pp. 24-25
-
-
Guarente, L.1
-
14
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1 alpha destabilization
-
Finley LWS, Carracedo A, Lee J, Souza A, Egia A, et al. (2011) SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1 alpha Destabilization. Cancer Cell 19: 416-428.
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.S.1
Carracedo, A.2
Lee, J.3
Souza, A.4
Egia, A.5
-
16
-
-
84893442805
-
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes AP, Price NL, Ling AJY, Moslehi JJ, Montgomery MK, et al. (2013) Declining NAD(+) Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell 155: 1624-1638.
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
Price, N.L.2
Ling, A.J.Y.3
Moslehi, J.J.4
Montgomery, M.K.5
-
17
-
-
84864401965
-
Age-associated changes in oxidative stress and NAD(+) metabolism in human tissue
-
Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, et al. (2012) Age-Associated Changes In Oxidative Stress and NAD(+) Metabolism In Human Tissue. Plos One 7: e42357.
-
(2012)
Plos One
, vol.7
, pp. e42357
-
-
Massudi, H.1
Grant, R.2
Braidy, N.3
Guest, J.4
Farnsworth, B.5
-
20
-
-
0036467928
-
Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry
-
Smythe GA, Braga O, Brew BJ, Grant RS, Guillemin GJ, et al. (2002) Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry. Analytical Biochemistry 301: 21-26.
-
(2002)
Analytical Biochemistry
, vol.301
, pp. 21-26
-
-
Smythe, G.A.1
Braga, O.2
Brew, B.J.3
Grant, R.S.4
Guillemin, G.J.5
-
21
-
-
0014409901
-
Metabolism of pyridium precursors of pyridine nucleotides in perfused rat liver
-
Hagino Y, Lan SJ, Ng CY, Henderso. Lm (1968) Metabolism of Pyridium Precursors of Pyridine Nucleotides in Perfused Rat Liver. Journal of Biological Chemistry 243: 4980-4986.
-
(1968)
Journal of Biological Chemistry
, vol.243
, pp. 4980-4986
-
-
Hagino, Y.1
Lan, S.J.2
Ng, C.Y.3
Henderso, L.4
-
22
-
-
1642297558
-
Structural basis for the mechanism and regulation of Sir2 enzymes
-
Avalos JL, Boeke JD, Wolberger C (2004) Structural basis for the mechanism and regulation of Sir2 enzymes. Molecular Cell 13: 639-648.
-
(2004)
Molecular Cell
, vol.13
, pp. 639-648
-
-
Avalos, J.L.1
Boeke, J.D.2
Wolberger, C.3
-
23
-
-
13944258164
-
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition
-
Sauve AA, Moir RD, Schramm VL, Willis IM (2005) Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Molecular Cell 17: 595-601.
-
(2005)
Molecular Cell
, vol.17
, pp. 595-601
-
-
Sauve, A.A.1
Moir, R.D.2
Schramm, V.L.3
Willis, I.M.4
-
24
-
-
0041571570
-
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
-
Sauve AA, Schramm VL (2003) Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 42: 9249-9256.
-
(2003)
Biochemistry
, vol.42
, pp. 9249-9256
-
-
Sauve, A.A.1
Schramm, V.L.2
-
25
-
-
61449209922
-
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3
-
Jin L, Galonek H, Israelian K, Choy W, Morrison M, et al. (2009) Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Science 18: 514-525.
-
(2009)
Protein Science
, vol.18
, pp. 514-525
-
-
Jin, L.1
Galonek, H.2
Israelian, K.3
Choy, W.4
Morrison, M.5
-
26
-
-
79951996670
-
Assessing the performance of the molecular mechanics/poisson boltzmann surface area and molecular mechanics/generalized born surface area methods. II. The accuracy of ranking poses generated from docking
-
Hou T, Wang J, Li Y, Wang W (2011) Assessing the performance of the molecular mechanics/Poisson Boltzmann surface area and molecular mechanics/generalized Born surface area methods. II. The accuracy of ranking poses generated from docking. J Comput Chem 32: 866-877.
-
(2011)
J Comput Chem
, vol.32
, pp. 866-877
-
-
Hou, T.1
Wang, J.2
Li, Y.3
Wang, W.4
-
28
-
-
33746872935
-
Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring
-
Lyne PD, Lamb ML, Saeh JC (2006) Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring. J Med Chem 49: 4805-4808.
-
(2006)
J Med Chem
, vol.49
, pp. 4805-4808
-
-
Lyne, P.D.1
Lamb, M.L.2
Saeh, J.C.3
-
32
-
-
74049131893
-
Calorie restriction effects on silencing and recombination at the yeast rDNA
-
Smith DL, Li CH, Matecic M, Maqani N, Bryk M, et al. (2009) Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell 8: 633-642.
-
(2009)
Aging Cell
, vol.8
, pp. 633-642
-
-
Smith, D.L.1
Li, C.H.2
Matecic, M.3
Maqani, N.4
Bryk, M.5
-
33
-
-
0025900189
-
Modifiers of position effect are shared between telomeric and silent mating-type loci in saccharomyces
-
Aparicio OM, Billington BL, Gottschling DE (1991) Modifiers of Position Effect Are Shared Between Telomeric and Silent Mating-Type Loci in Saccharomyces-Cerevisiae Cell 66: 1279-1287.
-
(1991)
Cerevisiae Cell
, vol.66
, pp. 1279-1287
-
-
Aparicio, O.M.1
Billington, B.L.2
Gottschling, D.E.3
-
34
-
-
25444484672
-
Small molecule regulation of Sir2 protein deacetylases
-
Grubisha O, Smith BC, Denu JM (2005) Small molecule regulation of Sir2 protein deacetylases. Febs Journal 272: 4607-4616.
-
(2005)
Febs Journal
, vol.272
, pp. 4607-4616
-
-
Grubisha, O.1
Smith, B.C.2
Denu, J.M.3
-
36
-
-
33745119442
-
The structural basis of sirtuin substrate affinity
-
Cosgrove MS, Bever K, Avalos JL, Muhammad S, Zhang XB, et al. (2006) The structural basis of sirtuin substrate affinity. Biochemistry 45: 7511-7521.
-
(2006)
Biochemistry
, vol.45
, pp. 7511-7521
-
-
Cosgrove, M.S.1
Bever, K.2
Avalos, J.L.3
Muhammad, S.4
Zhang, X.B.5
-
37
-
-
69949151709
-
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
-
Jin L, Wei WT, Jiang YB, Peng H, Cai JH, et al. (2009) Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. Journal of Biological Chemistry 284: 24394-24405.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 24394-24405
-
-
Jin, L.1
Wei, W.T.2
Jiang, Y.B.3
Peng, H.4
Cai, J.H.5
-
38
-
-
84873929641
-
The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD(+)) and an indole (EX527 Analogue) reveals a novel mechanism of histone deacetylase inhibition
-
Zhao X, Allison D, Condon B, Zhang FY, Gheyi T, et al. (2013) The 2.5 angstrom Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition. Journal of Medicinal Chemistry 56: 963-969.
-
(2013)
Journal of Medicinal Chemistry
, vol.56
, pp. 963-969
-
-
Zhao, X.1
Allison, D.2
Condon, B.3
Zhang, F.Y.4
Gheyi, T.5
-
39
-
-
84892495970
-
Structural and functional analysis of human SIRT1
-
Davenport AM, Huber FM, Hoelz A (2014) Structural and functional analysis of human SIRT1. J Mol Biol 426: 526-541.
-
(2014)
J Mol Biol
, vol.426
, pp. 526-541
-
-
Davenport, A.M.1
Huber, F.M.2
Hoelz, A.3
-
40
-
-
15244355745
-
Mechanism of sirtuin inhibition by nicotinamide: Altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
-
Avalos JL, Bever KM, Wolberger C (2005) Mechanism of sirtuin inhibition by nicotinamide: Altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Molecular Cell 17: 855-868.
-
(2005)
Molecular Cell
, vol.17
, pp. 855-868
-
-
Avalos, J.L.1
Bever, K.M.2
Wolberger, C.3
-
41
-
-
2942564591
-
Sirtuins: Sir2-related NAD-dependent protein deacetylases
-
North BJV, E. (2004) Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biology 5: 224.
-
(2004)
Genome Biology
, vol.5
, pp. 224
-
-
North, B.J.V.1
-
42
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
-
Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1. Journal of Biological Chemistry 277: 45099-45107.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
43
-
-
84860809347
-
SIRT3, a pivotal actor in mitochondrial functions: Metabolism, cell death and aging
-
Giralt A, Villarroya F (2012) SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. Biochemical Journal 444: 1-10.
-
(2012)
Biochemical Journal
, vol.444
, pp. 1-10
-
-
Giralt, A.1
Villarroya, F.2
-
44
-
-
84883491871
-
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
-
Imai S, Yoshino J (2013) The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes Obesity & Metabolism 15: 26-33.
-
(2013)
Diabetes Obesity & Metabolism
, vol.15
, pp. 26-33
-
-
Imai, S.1
Yoshino, J.2
-
45
-
-
34548627517
-
Nutrient-sensitive mitochondrial NAD(+) levels dictate cell survival
-
Yang HY, Yang T, Baur JA, Perez E, Matsui T, et al. (2007) Nutrient-sensitive mitochondrial NAD(+) levels dictate cell survival. Cell 130: 1095-1107.
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.Y.1
Yang, T.2
Baur, J.A.3
Perez, E.4
Matsui, T.5
-
46
-
-
4544243684
-
Coenzyme specificity of Sir2 protein deacetylases - Implications for physiological regulation
-
Schmidt MT, Smith BC, Jackson MD, Denu JM (2004) Coenzyme specificity of Sir2 protein deacetylases - Implications for physiological regulation. Journal of Biological Chemistry 279: 40122-40129.
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 40122-40129
-
-
Schmidt, M.T.1
Smith, B.C.2
Jackson, M.D.3
Denu, J.M.4
-
47
-
-
9744284968
-
An in silico approach to discovering novel inhibitors of human sirtuin type 2
-
Tervo AJ, Kyrylenko S, Niskanen P, Salminen A, Leppanen J, et al. (2004) An in silico approach to discovering novel inhibitors of human sirtuin type 2. Journal of Medicinal Chemistry 47: 6292-6298.
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, pp. 6292-6298
-
-
Tervo, A.J.1
Kyrylenko, S.2
Niskanen, P.3
Salminen, A.4
Leppanen, J.5
-
48
-
-
84866552404
-
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition
-
Fischer F, Gertz M, Suenkel B, Lakshminarasimhan M, Schutkowski M, et al. (2012) Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition. Plos One 7: e45098.
-
(2012)
Plos One
, vol.7
, pp. e45098
-
-
Fischer, F.1
Gertz, M.2
Suenkel, B.3
Lakshminarasimhan, M.4
Schutkowski, M.5
-
49
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185.
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
51
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
-
Qin WP, Yang TL, Ho L, Zhao Z, Wang J, et al. (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. Journal of Biological Chemistry 281: 21745-21754.
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 21745-21754
-
-
Qin, W.P.1
Yang, T.L.2
Ho, L.3
Zhao, Z.4
Wang, J.5
-
52
-
-
84862022077
-
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, et al. (2012) The NAD(+) Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity. Cell Metabolism 15: 838-847.
-
(2012)
Cell Metabolism
, vol.15
, pp. 838-847
-
-
Canto, C.1
Houtkooper, R.H.2
Pirinen, E.3
Youn, D.Y.4
Oosterveer, M.H.5
-
54
-
-
84880681461
-
Ex-527 inhibits Sirtuins by exploiting their unique NAD(+)- dependent deacetylation mechanism
-
Gertz M, Fischer F, Nguyen GTT, Lakshminarasimhan M, Schutkowski M, et al. (2013) Ex-527 inhibits Sirtuins by exploiting their unique NAD(+)- dependent deacetylation mechanism. Proceedings of the National Academy of Sciences of the United States of America 110: E2772-E2781.
-
(2013)
Proceedings of the National Academy of Sciences of the United States of America
, vol.110
, pp. E2772-E2781
-
-
Gertz, M.1
Fischer, F.2
Nguyen, G.T.T.3
Lakshminarasimhan, M.4
Schutkowski, M.5
-
55
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, et al. (2005) Substrate-specific activation of sirtuins by resveratrol. Journal of Biological Chemistry 280: 17038-17045.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
McDonagh, T.2
Heltweg, B.3
Hixon, J.4
Westman, E.A.5
-
57
-
-
57549110245
-
Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations
-
Hu P, Wang SL, Zhang YK (2008) Highly Dissociative and Concerted Mechanism for the Nicotinamide Cleavage Reaction in Sir2Tm Enzyme Suggested by Ab Initio QM/MM Molecular Dynamics Simulations. Journal of the American Chemical Society 130: 16721-16728.
-
(2008)
Journal of the American Chemical Society
, vol.130
, pp. 16721-16728
-
-
Hu, P.1
Wang, S.L.2
Zhang, Y.K.3
-
58
-
-
77956509704
-
Investigation of the catalytic mechanism of Sir2 enzyme with QM/MM approach: SN1 vs SN2?
-
Liang ZJ, Shi T, Ouyang SS, Li HL, Yu KQ, et al. (2010) Investigation of the Catalytic Mechanism of Sir2 Enzyme with QM/MM Approach: SN1 vs SN2? Journal of Physical Chemistry B 114: 11927-11933.
-
(2010)
Journal of Physical Chemistry B
, vol.114
, pp. 11927-11933
-
-
Liang, Z.J.1
Shi, T.2
Ouyang, S.S.3
Li, H.L.4
Yu, K.Q.5
-
59
-
-
67849103759
-
IC50-to-K-i: A web-based tool for converting IC50 to K-i values for inhibitors of enzyme activity and ligand binding
-
Cer RZ, Mudunuri U, Stephens R, Lebeda FJ (2009) IC50-to-K-i: a web-based tool for converting IC50 to K-i values for inhibitors of enzyme activity and ligand binding. Nucleic Acids Research 37: W441-W445.
-
(2009)
Nucleic Acids Research
, vol.37
, pp. W441-W445
-
-
Cer, R.Z.1
Mudunuri, U.2
Stephens, R.3
Lebeda, F.J.4
-
62
-
-
84886686038
-
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins
-
Feldman JL, Baeza J, Denu JM (2013) Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins. Journal of Biological Chemistry 288: 31350-31356.
-
(2013)
Journal of Biological Chemistry
, vol.288
, pp. 31350-31356
-
-
Feldman, J.L.1
Baeza, J.2
Denu, J.M.3
-
63
-
-
84874721105
-
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
-
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, et al. (2013) Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators. Science 339: 1216-1219.
-
(2013)
Science
, vol.339
, pp. 1216-1219
-
-
Hubbard, B.P.1
Gomes, A.P.2
Dai, H.3
Li, J.4
Case, A.W.5
-
64
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
-
65
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
-
66
-
-
79957944140
-
Advances in characterization of human sirtuin isoforms: Chemistries, targets and therapeutic applications
-
Cen Y, Youn DY, Sauve AA (2011) Advances in Characterization of Human Sirtuin Isoforms: Chemistries, Targets and Therapeutic Applications. Current Medicinal Chemistry 18: 1919-1935.
-
(2011)
Current Medicinal Chemistry
, vol.18
, pp. 1919-1935
-
-
Cen, Y.1
Youn, D.Y.2
Sauve, A.A.3
-
69
-
-
0017184389
-
Rapid and sensitive method for quantitation of microgram quantities of protein utilizing principle of protein-dye binding
-
Bradford MM (1976) Rapid and Sensitive Method for Quantitation of Microgram Quantities of Protein Utilizing Principle of Protein-Dye Binding. Analytical Biochemistry 72: 248-254.
-
(1976)
Analytical Biochemistry
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
70
-
-
29144501185
-
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
-
Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, et al. (2005) Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. Journal of Medicinal Chemistry 48: 8045-8054.
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, pp. 8045-8054
-
-
Napper, A.D.1
Hixon, J.2
McDonagh, T.3
Keavey, K.4
Pons, J.F.5
-
71
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, et al. (2010) SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1. Journal of Biological Chemistry 285: 8340-8351.
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
Bleasdale, J.E.2
Chrunyk, B.3
Cunningham, D.4
Flynn, D.5
-
72
-
-
84874721105
-
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
-
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, et al. (2013) Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators. Science 339: 1216-1219.
-
(2013)
Science
, vol.339
, pp. 1216-1219
-
-
Hubbard, B.P.1
Gomes, A.P.2
Dai, H.3
Li, J.4
Case, A.W.5
-
73
-
-
33748518255
-
Comparison of multiple amber force fields and development of improved protein backbone parameters
-
Hornak V, Abel R, Okur A, Strockbine B, Roitberg A, et al. (2006) Comparison of multiple amber force fields and development of improved protein backbone parameters. Proteins-Structure Function and Bioinformatics 65: 712-725.
-
(2006)
Proteins-Structure Function and Bioinformatics
, vol.65
, pp. 712-725
-
-
Hornak, V.1
Abel, R.2
Okur, A.3
Strockbine, B.4
Roitberg, A.5
-
74
-
-
0001398008
-
How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules?
-
Wang JM, Cieplak P, Kollman PA (2000) How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules? Journal of Computational Chemistry 21: 1049-1074.
-
(2000)
Journal of Computational Chemistry
, vol.21
, pp. 1049-1074
-
-
Wang, J.M.1
Cieplak, P.2
Kollman, P.A.3
-
75
-
-
35348950535
-
Molecular dynamics simulations of p53 DNAbinding domain
-
Lu Q, Tan YH, Luo R (2007) Molecular dynamics simulations of p53 DNAbinding domain. Journal of Physical Chemistry B 111: 11538-11545.
-
(2007)
Journal of Physical Chemistry B
, vol.111
, pp. 11538-11545
-
-
Lu, Q.1
Tan, Y.H.2
Luo, R.3
-
76
-
-
0037038533
-
Large and fast relaxations inside a protein: Calculation and measurement of reorganization energies in alcohol dehydrogenase
-
Walker RC, de Souza MM, Mercer IP, Gould IR, Klug DR (2002) Large and fast relaxations inside a protein: Calculation and measurement of reorganization energies in alcohol dehydrogenase. Journal of Physical Chemistry B 106: 11658-11665.
-
(2002)
Journal of Physical Chemistry B
, vol.106
, pp. 11658-11665
-
-
Walker, R.C.1
De Souza, M.M.2
Mercer, I.P.3
Gould, I.R.4
Klug, D.R.5
-
77
-
-
0001015978
-
A molecular mechanics force field for NAD(+), NADH, and the pyrophosphate groups of nucleotides
-
Pavelites JJ, Gao JL, Bash PA, Mackerell AD (1997) A molecular mechanics force field for NAD(+), NADH, and the pyrophosphate groups of nucleotides. Journal of Computational Chemistry 18: 221-239.
-
(1997)
Journal of Computational Chemistry
, vol.18
, pp. 221-239
-
-
Pavelites, J.J.1
Gao, J.L.2
Bash, P.A.3
MacKerell, A.D.4
-
78
-
-
84859882285
-
Structural role of RKS Motifs in chromatin interactions: A molecular dynamics study of HP1 bound to a variably modified histone tail
-
Papamokos GV, Tziatzos G, Papageorgiou DG, Georgatos SD, Politou AS, et al. (2012) Structural Role of RKS Motifs in Chromatin Interactions: A Molecular Dynamics Study of HP1 Bound to a Variably Modified Histone Tail. Biophysical Journal 102: 1926-1933.
-
(2012)
Biophysical Journal
, vol.102
, pp. 1926-1933
-
-
Papamokos, G.V.1
Tziatzos, G.2
Papageorgiou, D.G.3
Georgatos, S.D.4
Politou, A.S.5
-
79
-
-
27344436659
-
Scalable molecular dynamics with NAMD
-
Phillips JC, Braun R, Wang W, Gumbart J, Tajkhorshid E, et al. (2005) Scalable molecular dynamics with NAMD. Journal of Computational Chemistry 26: 1781-1802.
-
(2005)
Journal of Computational Chemistry
, vol.26
, pp. 1781-1802
-
-
Phillips, J.C.1
Braun, R.2
Wang, W.3
Gumbart, J.4
Tajkhorshid, E.5
-
80
-
-
33846823909
-
Particle mesh Ewald - An N.log(N) method for Ewald sums in large systems
-
Darden T, York D, Pedersen L (1993) Particle mesh Ewald - An N.log(N) method for Ewald sums in large systems. Journal of Chemical Physics 98: 10089-10092.
-
(1993)
Journal of Chemical Physics
, vol.98
, pp. 10089-10092
-
-
Darden, T.1
York, D.2
Pedersen, L.3
-
81
-
-
33646940952
-
Numerical integration of the cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes
-
Ryckaert JP, Ciccotti G, Berendsen HJC (1977) Numerical integration of the Cartesian Equations of Motion of a System with Constraints: Molecular Dynamics of n-Alkanes. Journal of Computational Physics 23: 327-341.
-
(1977)
Journal of Computational Physics
, vol.23
, pp. 327-341
-
-
Ryckaert, J.P.1
Ciccotti, G.2
Berendsen, H.J.C.3
-
82
-
-
84866167816
-
MMPBSA.py: An efficient program for end-state free energy calculations
-
Miller BR, McGee TD, Swails JM, Homeyer N, Gohlke H, et al. (2012) MMPBSA.py: An Efficient Program for End-State Free Energy Calculations. Journal of Chemical Theory and Computation 8: 3314-3321.
-
(2012)
Journal of Chemical Theory and Computation
, vol.8
, pp. 3314-3321
-
-
Miller, B.R.1
McGee, T.D.2
Swails, J.M.3
Homeyer, N.4
Gohlke, H.5
-
83
-
-
1842479952
-
Exploring protein native states and large-scale conformational changes with a modified generalized born model
-
Onufriev A, Bashford D, Case DA (2004) Exploring protein native states and large-scale conformational changes with a modified generalized born model. Proteins-Structure Function and Bioinformatics 55: 383-394.
-
(2004)
Proteins-Structure Function and Bioinformatics
, vol.55
, pp. 383-394
-
-
Onufriev, A.1
Bashford, D.2
Case, D.A.3
-
84
-
-
0000408363
-
Approximate atomic surfaces from linear combinations of pairwise overlaps (LCPO)
-
Weiser J, Shenkin PS, Still WC (1999) Approximate atomic surfaces from linear combinations of pairwise overlaps (LCPO). Journal of Computational Chemistry 20: 217-230.
-
(1999)
Journal of Computational Chemistry
, vol.20
, pp. 217-230
-
-
Weiser, J.1
Shenkin, P.S.2
Still, W.C.3
|