Crystal structures of human SIRT3 displaying substrate-induced conformational changes

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24394-24405

  Jin, Lei ^a   Wei, Wentao ^b,c   Jiang, Yaobin ^b   Peng, Hao ^c   Cai, Jianhua ^b,c   Mao, Chen ^b,c   Dai, Han ^a   Choy, Wendy ^a   Bemis, Jean E ^a   Jirousek, Michael R ^a   Milne, Jill C ^a   Westphal, Christoph H ^a   Perni, Robert B ^a  

^a GLAXOSMITHKLINE   (United States)

^b Viva Biotech   (China)

^c Shanghai Medicilon Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; BENEFICIAL EFFECTS; BINDING STUDIES; BIOPHYSICAL STUDIES; CALORIC RESTRICTION; CONFORMATIONAL CHANGE; DEACETYLATION; ENERGY PRODUCTIONS; FUNCTIONAL RELATIONSHIP; ISOTHERMAL TITRATION CALORIMETRY; MITOCHONDRIAL METABOLISM; NATURAL SUBSTRATES; NEUROLOGICAL DISEASE; PROTEIN DEACETYLASE; REACTION INTERMEDIATE; SUBSTRATE PEPTIDES; SYNTHETASES; THERAPEUTIC TARGETS;

AMINES; AMINO ACIDS; CRYSTAL STRUCTURE; METABOLISM; PEPTIDES;

SUBSTRATES;

NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 3;

ACETYLATION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DEACETYLATION; ENZYME SUBSTRATE COMPLEX; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACETATE-COA LIGASE; ACETYLATION; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NAD; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; SIRTUINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949151709     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014928     Document Type: Article

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