-
1
-
-
67949102053
-
Recent Progress in the Biology and Physiology of Sirtuins
-
Finkel, T.; Deng, C. X.; Mostoslavsky, R. Recent Progress in the Biology and Physiology of Sirtuins Nature 2009, 460, 587-591
-
(2009)
Nature
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
2
-
-
77949887506
-
Mammalian Sirtuins: Biological Insights and Disease Relevance
-
Haigis, M. C.; Sinclair, D. A. Mammalian Sirtuins: Biological Insights and Disease Relevance Annu. Rev. Pathol. Mech. Dis. 2010, 5, 253-295
-
(2010)
Annu. Rev. Pathol. Mech. Dis.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
3
-
-
84861852370
-
Are Sirtuins Viable Targets for Improving Healthspan and Lifespan?
-
Baur, J. A.; Ungvari, Z.; Minor, R. K.; Le Couteur, D. G.; de Cabo, R. Are Sirtuins Viable Targets for Improving Healthspan and Lifespan? Nat. Rev. Drug Discovery 2012, 11, 443-461
-
(2012)
Nat. Rev. Drug Discovery
, vol.11
, pp. 443-461
-
-
Baur, J.A.1
Ungvari, Z.2
Minor, R.K.3
Le Couteur, D.G.4
De Cabo, R.5
-
4
-
-
33745203038
-
The biochemistry of sirtuins
-
DOI 10.1146/annurev.biochem.74.082803.133500
-
Sauve, A. A.; Wolberger, C.; Schramm, V. L.; Boeke, J. D. The Biochemistry of Sirtuins Annu. Rev. Biochem. 2006, 75, 435-465 (Pubitemid 44118039)
-
(2006)
Annual Review of Biochemistry
, vol.75
, pp. 435-465
-
-
Sauve, A.A.1
Wolberger, C.2
Schramm, V.L.3
Boeke, J.D.4
-
5
-
-
79957944140
-
Advances in Characterization of Human Sirtuin Isoforms: Chemistries, Targets and Therapeutic Applications
-
Cen, Y.; Youn, D. Y.; Sauve, A. A. Advances in Characterization of Human Sirtuin Isoforms: Chemistries, Targets and Therapeutic Applications Curr. Med. Chem. 2011, 18, 1919-1935
-
(2011)
Curr. Med. Chem.
, vol.18
, pp. 1919-1935
-
-
Cen, Y.1
Youn, D.Y.2
Sauve, A.A.3
-
6
-
-
77958523925
-
NAD(+)-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets
-
Uciechowska, U.; Sippl, W.; Jung, M. NAD(+)-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets Med. Res. Rev. 2010, 30, 861-889
-
(2010)
Med. Res. Rev.
, vol.30
, pp. 861-889
-
-
Uciechowska, U.1
Sippl, W.2
Jung, M.3
-
7
-
-
77954415435
-
Metabolic Networks of Longevity
-
Houtkooper, R. H.; Williams, R. W.; Auwerx, J. Metabolic Networks of Longevity Cell 2010, 142, 9-14
-
(2010)
Cell
, vol.142
, pp. 9-14
-
-
Houtkooper, R.H.1
Williams, R.W.2
Auwerx, J.3
-
8
-
-
81055155738
-
Sirtuins: Multifaceted Drug Targets
-
Chakrabarty, S. P.; Balaram, H.; Chandrasekaran, S. Sirtuins: Multifaceted Drug Targets Curr. Mol. Med. 2011, 11, 709-718
-
(2011)
Curr. Mol. Med.
, vol.11
, pp. 709-718
-
-
Chakrabarty, S.P.1
Balaram, H.2
Chandrasekaran, S.3
-
9
-
-
78650132019
-
Sirtuin Mechanism and Inhibition: Explored with N (ε)-acetyl-lysine Analogs
-
Hirsch, B. M.; Zheng, W. Sirtuin Mechanism and Inhibition: Explored with N (ε)-acetyl-lysine Analogs Mol. BioSyst. 2011, 7, 16-28
-
(2011)
Mol. BioSyst.
, vol.7
, pp. 16-28
-
-
Hirsch, B.M.1
Zheng, W.2
-
10
-
-
78751506349
-
Catalysis and Mechanistic Insights into Sirtuin Activation
-
Dittenhafer-Reed, K. E.; Feldman, J. L.; Denu, J. M. Catalysis and Mechanistic Insights into Sirtuin Activation ChemBioChem 2011, 12, 281-289
-
(2011)
ChemBioChem
, vol.12
, pp. 281-289
-
-
Dittenhafer-Reed, K.E.1
Feldman, J.L.2
Denu, J.M.3
-
11
-
-
79958244669
-
Computer- and Structure-Based Lead Design for Epigenetic Targets
-
Heinke, R.; Carlino, L.; Kannan, S.; Jung, M.; Sippl, W. Computer- and Structure-Based Lead Design for Epigenetic Targets Bioorg. Med. Chem. 2011, 19, 3605-3615
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 3605-3615
-
-
Heinke, R.1
Carlino, L.2
Kannan, S.3
Jung, M.4
Sippl, W.5
-
12
-
-
70149123204
-
Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate
-
Asaba, T.; Suzuki, T.; Ueda, R.; Tsumoto, H.; Nakagawa, H.; Miyata, N. Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate J. Am. Chem. Soc. 2009, 131, 6989-6996
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 6989-6996
-
-
Asaba, T.1
Suzuki, T.2
Ueda, R.3
Tsumoto, H.4
Nakagawa, H.5
Miyata, N.6
-
13
-
-
77953292895
-
Sirtuins Inhibitors: The Approach to Affinity and Selectivity
-
Cen, Y. Sirtuins Inhibitors: The Approach to Affinity and Selectivity Biochim. Biophys. Acta 2010, 1804, 1635-1644
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1635-1644
-
-
Cen, Y.1
-
14
-
-
82955233648
-
Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent Deacylases
-
Hirschey, M. D. Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent Deacylases Cell Metab. 2011, 14, 718-719
-
(2011)
Cell Metab.
, vol.14
, pp. 718-719
-
-
Hirschey, M.D.1
-
15
-
-
77953291365
-
Sirtuin Chemical Mechanisms
-
Sauve, A. A. Sirtuin Chemical Mechanisms Biochim. Biophys. Acta 2010, 1804, 1591-1603
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1591-1603
-
-
Sauve, A.A.1
-
16
-
-
53649086367
-
Mechanisms and Molecular Probes of Sirtuins
-
Smith, B. C.; Hallows, W. C.; Denu, J. M. Mechanisms and Molecular Probes of Sirtuins Chem. Biol. 2008, 15, 1002-1013
-
(2008)
Chem. Biol.
, vol.15
, pp. 1002-1013
-
-
Smith, B.C.1
Hallows, W.C.2
Denu, J.M.3
-
17
-
-
34248595983
-
+ cleavage
-
DOI 10.1021/ja070162w
-
Smith, B. C.; Denu, J. M. Sir2 Deacetylases Exhibit Nucleophilic Participation of Acetyl Lysine in NAD+ Cleavage J. Am. Chem. Soc. 2007, 129, 5802-5803 (Pubitemid 46748469)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.18
, pp. 5802-5803
-
-
Smith, B.C.1
Denu, J.M.2
-
18
-
-
33745534953
-
+ and Acetylated Peptide
-
DOI 10.1016/j.str.2006.06.006, PII S0969212606002899
-
Hoff, K. G.; Avalos, J. L.; Sens, K.; Wolberger, C. Insights into the Sirtuin Mechanism From Ternary Complexes Containing NAD(+) and Acetylated Peptide Structure 2006, 14, 1231-1240 (Pubitemid 44176368)
-
(2006)
Structure
, vol.14
, Issue.8
, pp. 1231-1240
-
-
Hoff, K.G.1
Avalos, J.L.2
Sens, K.3
Wolberger, C.4
-
19
-
-
33745119442
-
The structural basis of sirtuin substrate affinity
-
DOI 10.1021/bi0526332
-
Cosgrove, M. S.; Bever, K.; Avalos, J. L.; Muhammad, S.; Zhang, X.; Wolberger, C. The Structural Basis of Sirtuin Substrate Affinity Biochemistry 2006, 45, 7511-7521 (Pubitemid 43894945)
-
(2006)
Biochemistry
, vol.45
, Issue.24
, pp. 7511-7521
-
-
Cosgrove, M.S.1
Bever, K.2
Avalos, J.L.3
Muhammad, S.4
Zhang, X.5
Wolberger, C.6
-
20
-
-
50849135494
-
Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction
-
Hawse, W. F.; Hoff, K. G.; Fatkins, D. G.; Daines, A.; Zubkova, O. V.; Schramm, V. L.; Zheng, W.; Wolberger, C. Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction Structure 2008, 16, 1368-1377
-
(2008)
Structure
, vol.16
, pp. 1368-1377
-
-
Hawse, W.F.1
Hoff, K.G.2
Fatkins, D.G.3
Daines, A.4
Zubkova, O.V.5
Schramm, V.L.6
Zheng, W.7
Wolberger, C.8
-
21
-
-
78650786849
-
Structure of Sir2Tm Bound to a Propionylated Peptide
-
Bheda, P.; Wang, J. T.; Escalante-Semerena, J. C.; Wolberger, C. Structure of Sir2Tm Bound to a Propionylated Peptide Protein Sci. 2011, 20, 131-139
-
(2011)
Protein Sci.
, vol.20
, pp. 131-139
-
-
Bheda, P.1
Wang, J.T.2
Escalante-Semerena, J.C.3
Wolberger, C.4
-
22
-
-
57549110245
-
Highly Dissociative and Concerted Mechanism for the Nicotinamide Cleavage Reaction in Sir2Tm Enzyme Suggested by Ab Initio QM/MM Molecular Dynamics Simulations
-
Hu, P.; Wang, S.; Zhang, Y. Highly Dissociative and Concerted Mechanism for the Nicotinamide Cleavage Reaction in Sir2Tm Enzyme Suggested By Ab Initio QM/MM Molecular Dynamics Simulations J. Am. Chem. Soc. 2008, 130, 16721-16728
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 16721-16728
-
-
Hu, P.1
Wang, S.2
Zhang, Y.3
-
23
-
-
77956246695
-
A Transition State of ADP-Ribosylation of Acetyllysine Catalyzed by Archaeoglobus Fulgidus Sir2 Determined by Kinetic Isotope Effects and Computational Approaches
-
Cen, Y.; Sauve, A. A Transition State of ADP-Ribosylation of Acetyllysine Catalyzed by Archaeoglobus Fulgidus Sir2 Determined by Kinetic Isotope Effects and Computational Approaches J. Am. Chem. Soc. 2010, 132, 12286-12298
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 12286-12298
-
-
Cen, Y.1
Sauve, A.2
-
24
-
-
77956509704
-
Investigation of the Catalytic Mechanism of Sir2 Enzyme with QM/MM Approach: SN1 vs SN2?
-
Liang, Z.; Shi, T.; Ouyang, S.; Li, H.; Yu, K.; Zhu, W.; Luo, C.; Jiang, H. Investigation of the Catalytic Mechanism of Sir2 Enzyme with QM/MM Approach: SN1 vs SN2? J. Phys. Chem. B 2010, 114, 11927-11933
-
(2010)
J. Phys. Chem. B
, vol.114
, pp. 11927-11933
-
-
Liang, Z.1
Shi, T.2
Ouyang, S.3
Li, H.4
Yu, K.5
Zhu, W.6
Luo, C.7
Jiang, H.8
-
25
-
-
1642297558
-
Structural basis for the mechanism and regulation of Sir2 enzymes
-
DOI 10.1016/S1097-2765(04)00082-6, PII S1097276504000826
-
Avalos, J. L.; Boeke, J. D.; Wolberger, C. Structural Basis for the Mechanism and Regulation of Sir2 Enzymes Mol. Cell 2004, 13, 639-648 (Pubitemid 38368122)
-
(2004)
Molecular Cell
, vol.13
, Issue.5
, pp. 639-648
-
-
Avalos, J.L.1
Boeke, J.D.2
Wolberger, C.3
-
26
-
-
33744956371
-
Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases
-
DOI 10.1074/jbc.M511482200
-
Khan, A. N.; Lewis, P. N. Use of Substrate Analogs and Mutagenesis to Study Substrate Binding and Catalysis in the Sir2 Family of NAD-dependent Protein Deacetylases J. Biol. Chem. 2006, 281, 11702-11711 (Pubitemid 43855428)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.17
, pp. 11702-11711
-
-
Khan, A.N.1
Lewis, P.N.2
-
27
-
-
0035951072
-
+-dependent deacetylation reactions
-
DOI 10.1021/bi011858j
-
Sauve, A. A.; Celic, I.; Avalos, J.; Deng, H. T.; Boeke, J. D.; Schramm, V. L. Chemistry of Gene Silencing: The Mechanism of NAD(+)-Dependent Deacetylation Reactions Biochemistry 2001, 40, 15456-15463 (Pubitemid 34015172)
-
(2001)
Biochemistry
, vol.40
, Issue.51
, pp. 15456-15463
-
-
Sauve, A.A.1
Celic, I.2
Avalos, J.3
Deng, H.4
Boeke, J.D.5
Schramm, V.L.6
-
28
-
-
0041571570
-
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
-
DOI 10.1021/bi034959l
-
Sauve, A. A.; Schramm, V. L. Sir2 Regulation by Nicotinamide Results from Switching Between Base Exchange and Deacetylation Chemistry Biochemistry 2003, 42, 9249-9256 (Pubitemid 36959231)
-
(2003)
Biochemistry
, vol.42
, Issue.31
, pp. 9249-9256
-
-
Sauve, A.A.1
Schramm, V.L.2
-
29
-
-
30144431571
-
Sir2 protein deacetylases: Evidence for chemical intermediates and functions of a conserved histidine
-
DOI 10.1021/bi052014t
-
Smith, B. C.; Denu, J. M. Sir2 Protein Deacetylases: Evidence for Chemical Intermediates and Functions of a Conserved Histidine Biochemistry 2006, 45, 272-282 (Pubitemid 43054104)
-
(2006)
Biochemistry
, vol.45
, Issue.1
, pp. 272-282
-
-
Smith, B.C.1
Denu, J.M.2
-
30
-
-
84865225339
-
The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
-
Zhou, Y.; Zhang, H.; He, B.; Du, J.; Lin, H.; Cerione, R. A.; Hao, Q. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) J. Biol. Chem. 2012, 287, 28307-28314
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 28307-28314
-
-
Zhou, Y.1
Zhang, H.2
He, B.3
Du, J.4
Lin, H.5
Cerione, R.A.6
Hao, Q.7
-
31
-
-
84871171710
-
Structural Basis for Sirtuin Activity and Inhibition
-
Yuan, H.; Marmorstein, R. Structural Basis for Sirtuin Activity and Inhibition J. Biol. Chem. 2012, 287, 42428-42435
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 42428-42435
-
-
Yuan, H.1
Marmorstein, R.2
-
32
-
-
0001582558
-
A pseudobond approach to combining quantum mechanical and molecular mechanical methods
-
DOI 10.1063/1.478083, PII S0021960699302014
-
Zhang, Y.; Lee, T. S.; Yang, W. A Pseudobond Approach to Combining Quantum Mechanical and Molecular Mechanical Methods J. Chem. Phys. 1999, 110, 46-54 (Pubitemid 129708024)
-
(1999)
Journal of Chemical Physics
, vol.110
, Issue.1
, pp. 46-54
-
-
Zhang, Y.1
Lee, T.-S.2
Yang, W.3
-
33
-
-
22944472113
-
Improved Pseudobonds for Combined Ab Initio Quantum Mechanical/Molecular Mechanical Methods
-
Zhang, Y. Improved Pseudobonds for Combined Ab Initio Quantum Mechanical/Molecular Mechanical Methods J. Chem. Phys. 2005, 122, 024114
-
(2005)
J. Chem. Phys.
, vol.122
, pp. 024114
-
-
Zhang, Y.1
-
34
-
-
33746563448
-
Advances in Methods and Algorithms in a Modern Quantum Chemistry Program Package
-
Shao, Y.; Fusti-Molnar, L.; Jung, Y.; Kussmann, J.; Ochsenfeld, C.; Brown, S. T.; Gilbert, A. T. B.; Slipchenko, L. V.; Levchenko, S. V.; O'Neill, D. P. Advances in Methods and Algorithms in a Modern Quantum Chemistry Program Package Phys. Chem. Chem. Phys. 2006, 8, 3172-3191
-
(2006)
Phys. Chem. Chem. Phys.
, vol.8
, pp. 3172-3191
-
-
Shao, Y.1
Fusti-Molnar, L.2
Jung, Y.3
Kussmann, J.4
Ochsenfeld, C.5
Brown, S.T.6
Gilbert, A.T.B.7
Slipchenko, L.V.8
Levchenko, S.V.9
O'Neill, D.P.10
-
36
-
-
41149125431
-
How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations
-
DOI 10.1021/ja075896n
-
Hu, P.; Wang, S.; Zhang, Y. How Do SET-Domain Protein Lysine Methyltransferases Achieve the Methylation State Specificity? Revisited by Ab Initio QM/MM Molecular Dynamics Simulations J. Am. Chem. Soc. 2008, 130, 3806-3813 (Pubitemid 351429846)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.12
, pp. 3806-3813
-
-
Hu, P.1
Wang, S.2
Zhang, Y.3
-
37
-
-
73349112879
-
Born-Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations of the Hydrolysis Reaction Catalyzed by Protein Arginine Deiminase 4
-
Ke, Z.; Wang, S.; Xie, D.; Zhang, Y. Born-Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations of the Hydrolysis Reaction Catalyzed by Protein Arginine Deiminase 4 J. Phys.Chem. B 2009, 113, 16705-16710
-
(2009)
J. Phys.Chem. B
, vol.113
, pp. 16705-16710
-
-
Ke, Z.1
Wang, S.2
Xie, D.3
Zhang, Y.4
-
38
-
-
70349266325
-
Active Site Cysteine Is Protonated in the PAD4Michaelis Complex: Evidence from Born-Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations
-
Ke, Z.; Zhou, Y.; Hu, P.; Wang, S.; Xie, D.; Zhang, Y. Active Site Cysteine Is Protonated in the PAD4Michaelis Complex: Evidence from Born-Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations J. Phys. Chem. B 2009, 113, 12750-12758
-
(2009)
J. Phys. Chem. B
, vol.113
, pp. 12750-12758
-
-
Ke, Z.1
Zhou, Y.2
Hu, P.3
Wang, S.4
Xie, D.5
Zhang, Y.6
-
39
-
-
34248219463
-
Ab Initio Quantum Mechanical/Molecular Mechanical Moleculardynamics Simulation of Enzyme Catalysis: The Case of Histone Lysine Methyltransferase SET7/9
-
Wang, S.; Hu, P.; Zhang, Y. Ab Initio Quantum Mechanical/Molecular Mechanical Moleculardynamics Simulation of Enzyme Catalysis: The Case of Histone Lysine Methyltransferase SET7/9 J. Phys.Chem. B 2007, 111, 3758-37564
-
(2007)
J. Phys.Chem. B
, vol.111
, pp. 3758-37564
-
-
Wang, S.1
Hu, P.2
Zhang, Y.3
-
40
-
-
77955808765
-
A Proton-Shuttle Reaction Mechanism for Histone Deacetylase 8 and the Catalytic Role of Metal Ions
-
Wu, R.; Wang, S.; Zhou, N.; Cao, Z.; Zhang, Y. A Proton-Shuttle Reaction Mechanism for Histone Deacetylase 8 and the Catalytic Role of Metal Ions J. Am. Chem. Soc. 2010, 132, 9471-9479
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 9471-9479
-
-
Wu, R.1
Wang, S.2
Zhou, N.3
Cao, Z.4
Zhang, Y.5
-
41
-
-
77954339384
-
Catalytic Reaction Mechanism of Acetylcholinesterase Determined by Born-Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations
-
Zhou, Y.; Wang, S.; Zhang, Y. Catalytic Reaction Mechanism of Acetylcholinesterase Determined by Born-Oppenheimer Ab Initio QM/MM Molecular Dynamics Simulations J. Phys. Chem. B 2010, 114, 8817-8825
-
(2010)
J. Phys. Chem. B
, vol.114
, pp. 8817-8825
-
-
Zhou, Y.1
Wang, S.2
Zhang, Y.3
-
42
-
-
79960593151
-
Molecular Mechanism for Eliminylation, a Newly Discovered Post-Translational Modification
-
Ke, Z.; Smith, G. K.; Zhang, Y.; Guo, H. Molecular Mechanism for Eliminylation, a Newly Discovered Post-Translational Modification J. Am. Chem. Soc. 2011, 133, 11103-11305
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 11103-11305
-
-
Ke, Z.1
Smith, G.K.2
Zhang, Y.3
Guo, H.4
-
43
-
-
78751489563
-
Serine Protease Acylation Proceeds with a Subtle Re-Orientation of the Histidine Ring at the Tetrahedral Intermediate
-
Zhou, Y.; Zhang, Y. Serine Protease Acylation Proceeds with a Subtle Re-Orientation of the Histidine Ring at the Tetrahedral Intermediate Chem. Commun. 2011, 47, 1577-1579
-
(2011)
Chem. Commun.
, vol.47
, pp. 1577-1579
-
-
Zhou, Y.1
Zhang, Y.2
-
44
-
-
84867519412
-
Preferred WMSA Catalytic Mechanism of the Nucleotidyl Transfer Reaction in Human DNA Polymerase Kappa Elucidates Error-Free Bypass of a Bulky DNA Lesion
-
Lior-Hoffmann, L.; Wang, L.; Wang, S.; Geacintov, N. E.; Broyde, S.; Zhang, Y. Preferred WMSA Catalytic Mechanism of the Nucleotidyl Transfer Reaction in Human DNA Polymerase Kappa Elucidates Error-Free Bypass of a Bulky DNA Lesion Nucleic Acids Res. 2012, 40, 9193-9205
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 9193-9205
-
-
Lior-Hoffmann, L.1
Wang, L.2
Wang, S.3
Geacintov, N.E.4
Broyde, S.5
Zhang, Y.6
-
45
-
-
15244355745
-
+ cosubstrate specificity of a Sir2 enzyme
-
DOI 10.1016/j.molcel.2005.02.022
-
Avalos, J. L.; Bever, K. M.; Wolberger, C. Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD(+) Cosubstrate Specificity of a Sir2 Enzyme Mol. Cell 2005, 17, 855-868 (Pubitemid 40386946)
-
(2005)
Molecular Cell
, vol.17
, Issue.6
, pp. 855-868
-
-
Avalos, J.L.1
Bever, K.M.2
Wolberger, C.3
-
46
-
-
3343024449
-
+-dependent histone/protein deacetylases
-
DOI 10.1021/bi049592e
-
Borra, M. T.; Langer, M. R.; Slama, J. T.; Denu, J. M. Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD(+)-Dependent Histone/Protein Deacetylases Biochemistry 2004, 43, 9877-9887 (Pubitemid 38993837)
-
(2004)
Biochemistry
, vol.43
, Issue.30
, pp. 9877-9887
-
-
Borra, M.T.1
Langer, M.R.2
Slama, J.T.3
Denu, J.M.4
-
47
-
-
0035917536
-
Crystal structure of a SIR2 homolog-NAD complex
-
DOI 10.1016/S0092-8674(01)00317-8
-
Min, J.; Landry, J.; Sternglanz, R.; Xu, R. M. Crystal Structure of a SIR2 Homolog-NAD Complex Cell 2001, 105, 269-279 (Pubitemid 32429516)
-
(2001)
Cell
, vol.105
, Issue.2
, pp. 269-279
-
-
Min, J.1
Landry, J.2
Sternglanz, R.3
Xu, R.-M.4
-
48
-
-
77953289094
-
Structural Basis for Sirtuin Function: What We Know and What We Don't
-
Sanders, B. D.; Jackson, B.; Marmorstein, R. Structural Basis for Sirtuin Function: What We Know and What We Don't Biochim. Biophys. Acta 2010, 1804, 1604-1616
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1604-1616
-
-
Sanders, B.D.1
Jackson, B.2
Marmorstein, R.3
-
49
-
-
0034956304
-
Structure of the histone deacetylase SIRT2
-
DOI 10.1038/89668
-
Finnin, M. S.; Donigian, J. R.; Pavletich, N. P. Structure of the Histone Deacetylase SIRT2 Nat. Struct. Biol. 2001, 8, 621-625 (Pubitemid 32613012)
-
(2001)
Nature Structural Biology
, vol.8
, Issue.7
, pp. 621-625
-
-
Finnin, M.S.1
Donigian, J.R.2
Pavletich, N.P.3
-
50
-
-
33847635635
-
+-Dependent Deacetylase SIRT5 by Suramin
-
DOI 10.1016/j.str.2007.02.002, PII S0969212607000755
-
Schuetz, A.; Min, J.; Antoshenko, T.; Wang, C. L.; Allali-Hassani, A.; Dong, A.; Loppnau, P.; Vedadi, M.; Bochkarev, A.; Sternglanz, R. Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin Structure 2007, 15, 377-389 (Pubitemid 46366726)
-
(2007)
Structure
, vol.15
, Issue.3
, pp. 377-389
-
-
Schuetz, A.1
Min, J.2
Antoshenko, T.3
Wang, C.-L.4
Allali-Hassani, A.5
Dong, A.6
Loppnau, P.7
Vedadi, M.8
Bochkarev, A.9
Sternglanz, R.10
Plotnikov, A.N.11
-
51
-
-
69949151709
-
Crystal Structures of Human SIRT3 Displaying Substrate-Induced Conformational Changes
-
Jin, L.; Wei, W. T.; Jiang, Y. B.; Peng, H.; Cai, J. H.; Mao, C.; Dai, H.; Choy, W.; Bemis, J. E.; Jirousek, M. R. Crystal Structures of Human SIRT3 Displaying Substrate-Induced Conformational Changes J. Biol. Chem. 2009, 284, 24394-24405
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 24394-24405
-
-
Jin, L.1
Wei, W.T.2
Jiang, Y.B.3
Peng, H.4
Cai, J.H.5
Mao, C.6
Dai, H.7
Choy, W.8
Bemis, J.E.9
Jirousek, M.R.10
-
52
-
-
2942534101
-
+-dependent Sir2 histone/protein deacetylases
-
DOI 10.1073/pnas.0401057101
-
Zhao, K. H.; Harshaw, R.; Chai, X. M.; Marmorstein, R. Structural Basis for Nicotinamide Cleavage and ADP-Ribose Transfer by NAD(+)-Dependent Sir2 Histone/Protein Deacetylases Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 8563-8568 (Pubitemid 38745810)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.23
, pp. 8563-8568
-
-
Zhao, K.1
Harshaw, R.2
Chai, X.3
Marmorstein, R.4
|