Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition

Molecular Cell

Volumn 17, Issue 4, 2005, Pages 595-601

  Sauve, Anthony A ^a   Moir, Robyn D ^a   Schramm, Vern L ^a   Willis, Ian M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISONICOTINAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SILENT INFORMATION REGULATOR PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 2 AGONIST; UNCLASSIFIED DRUG;

ARTICLE; DEACETYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE LOCUS; GENE SILENCING; LONGEVITY; NONHUMAN;

EID: 13944258164     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.12.032     Document Type: Article

References (36)

1. + levels. J. Biol. Chem. 277:2002;18888-18890
2. Anderson R.M., Bitterman K.J., Wood J.G., Medvedik O., Sinclair D.A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 423:2003;181-185
3. Bitterman K.J., Anderson R.M., Cohen H.Y., Latorre-Esteves M., Sinclair D.A. Inhibition of silencing and accelerated aging by nicotinamide, a putative regulator of yeast Sir2 and human SIRT1. J. Biol. Chem. 277:2002;45099-45107
4. Fritze C.E., Verschueren K., Strich R., Easton Esposito R. Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J. 16:1997;6495-6509
5. Gallo C.M., Smith D.L. Jr., Smith J.S. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol. Cell. Biol. 24:2004;1301-1312
6. Ghaemmaghami S., Huh W.K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Global analysis of protein expression in yeast. Nature. 425:2003;737-741
7. Goldstein A.L., McCusker J.H. Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast. 15:1999;1541-1553
8. Hekimi S., Guarente L. Genetics and the specificity of the aging process. Science. 299:2003;1351-1354
9. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425:2003;191-196
10. Huh W.K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Global analysis of protein localization in budding yeast. Nature. 425:2003;686-691
11. Imai S., Armstrong C.M., Kaeberlain M., Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403:2000;795-800
12. Jackson M.D., Schmidt M.T., Oppenheimer N.J., Denu J.M. Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J. Biol. Chem. 278:2003;50985-50998
13. Jorgensen P., Nishikawa J.L., Breitkreutz B.J., Tyers M. Systematic identification of pathways that couple cell growth and division in yeast. Science. 297:2002;395-400
14. Kaeberlein M., McVey M., Guarente L. The Sir2/3/4 complex and Sir2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13:1999;2570-2580
15. Kaeberlein M., Andalis A.A., Fink G.R., Guarente L. High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell. Biol. 22:2002;8056-8066
16. 18O-labelled nicotinamide. J. Labelled Comp. Radiopharm. 45:2002;1-6
17. Landry J., Sutton A., Tafrov S.T., Heller R.C., Stebbins J., Pillus L., Sternglanz R. The silencing protein Sir2 and its homologs are NAD-dependent deacetylases. Proc. Natl. Acad. Sci. USA. 97:2000;5807-5811
18. Lin S.J., Deffossez P.A., Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 289:2000;2126-2128
19. Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 418:2003;344-348
20. Lin S.J., Ford E., Haigis M., Liszt G., Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 18:2004;12-16
21. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2a promotes cell survival under stress. Cell. 107:2001;137-148
22. Roy N., Runge K.W. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr. Biol. 10:2000;111-114
23. Rusche L.N., Kirchmaier A.L., Rine J. The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae. Annu. Rev. Biochem. 72:2003;481-516
24. + salvage pathway. Genetics. 160:2002;877-889
25. Sauve A.A., Schramm V.L. Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry. 42:2003;9249-9256
26. +-dependent deacetylation reactions Biochemistry. 40:2001;15456-15463
27. Singer M.S., Kahana A., Wolf A.J., Meisinger L.L., Peterson S.E., Goggin C., Mahowald M., Gottschling D.E. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics. 150:1998;613-632
28. Smith J.S., Boeke J.D. An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev. 11:1997;241-254
29. Smith J.S., Brachmann C.B., Pillus L., Boeke J.D. Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics. 149:1998;1205-1219
30. +-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA. 97:2000;6658-6663
31. Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 410:2001;227-230
32. Tong A.H., Lesage G., Bader G.D., Ding H., Xu H., Xin X., Young J., Berriz G.F., Brost R.L., Chang M., et al. Global mapping of the yeast genetic interaction network. Science. 303:2004;808-813
33. van Leeuwen F., Gottschling D.E. Assays for gene silencing in yeast. Methods Enzymol. 350:2002;165-186
34. van Leeuwen F., Gafken P.R., Gottschling D.E. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell. 109:2002;745-756
35. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:2001;149-159
36. Winey M., Yarar D., Giddings T.H. Jr., Mastronarde D.N. Nuclear pore complex number and distribution throughout the Saccharomyces cerevisiae cell cycle by three-dimensional reconstruction from electron micrographs of nuclear envelopes. Mol. Biol. Cell. 8:1997;2117-2132