-
1
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson R.M., Bitterman K.J., Wood J.G., Medvedik O., Sinclair D.A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 423:2003;181-185.
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
2
-
-
0036229718
-
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity
-
Armstrong C.M., Kaeberlein M., Imai S.I., Guarente L. Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol. Biol. Cell. 13:2002;1427-1438.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 1427-1438
-
-
Armstrong, C.M.1
Kaeberlein, M.2
Imai, S.I.3
Guarente, L.4
-
3
-
-
0036753953
-
Structure of a Sir2 enzyme bound to an acetylated p53 peptide
-
Avalos J.L., Celic I., Muhammad S., Cosgrove M.S., Boeke J.D., Wolberger C. Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol. Cell. 10:2002;523-535.
-
(2002)
Mol. Cell
, vol.10
, pp. 523-535
-
-
Avalos, J.L.1
Celic, I.2
Muhammad, S.3
Cosgrove, M.S.4
Boeke, J.D.5
Wolberger, C.6
-
4
-
-
0030807274
-
Unusual conformation of nicotinamide adenine dinucleotide (NAD) bound to diphtheria toxin: A comparison with NAD bound to the oxidoreductase enzymes
-
Bell C.E., Yeates T.O., Eisenberg D. Unusual conformation of nicotinamide adenine dinucleotide (NAD) bound to diphtheria toxin. a comparison with NAD bound to the oxidoreductase enzymes Protein Sci. 6:1997;2084-2096.
-
(1997)
Protein Sci.
, vol.6
, pp. 2084-2096
-
-
Bell, C.E.1
Yeates, T.O.2
Eisenberg, D.3
-
5
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
-
Bitterman K.J., Anderson R.M., Cohen H.Y., Latorre-Esteves M., Sinclair D.A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277:2002;45099-45107.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
6
-
-
0027192267
-
Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
-
Braunstein M., Rose A.B., Holmes S.G., Allis C.D., Broach J.R. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7:1993;592-604.
-
(1993)
Genes Dev.
, vol.7
, pp. 592-604
-
-
Braunstein, M.1
Rose, A.B.2
Holmes, S.G.3
Allis, C.D.4
Broach, J.R.5
-
7
-
-
3543012707
-
Crystallography & NMR system: A new software suite for macromolecular structure determination
-
Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S.et al. Crystallography & NMR system. a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54:1998;905-921.
-
(1998)
Acta Crystallogr. D Biol. Crystallogr.
, vol.54
, pp. 905-921
-
-
Brunger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
-
8
-
-
0037072885
-
Structural basis for the NAD-dependent deacetylase mechanism of Sir2
-
Chang J.H., Kim H.C., Hwang K.Y., Lee J.W., Jackson S.P., Bell S.D., Cho Y. Structural basis for the NAD-dependent deacetylase mechanism of Sir2. J. Biol. Chem. 277:2002;34489-34498.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 34489-34498
-
-
Chang, J.H.1
Kim, H.C.2
Hwang, K.Y.3
Lee, J.W.4
Jackson, S.P.5
Bell, S.D.6
Cho, Y.7
-
10
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M., Schiltz R.L., Iezzi S., King M.T., Zhao P., Kashiwaya Y., Hoffman E., Veech R.L., Sartorelli V. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell. 12:2003;51-62.
-
(2003)
Mol. Cell
, vol.12
, pp. 51-62
-
-
Fulco, M.1
Schiltz, R.L.2
Iezzi, S.3
King, M.T.4
Zhao, P.5
Kashiwaya, Y.6
Hoffman, E.7
Veech, R.L.8
Sartorelli, V.9
-
11
-
-
0024536650
-
A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
-
Gottlieb S., Esposito R.E. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell. 56:1989;771-776.
-
(1989)
Cell
, vol.56
, pp. 771-776
-
-
Gottlieb, S.1
Esposito, R.E.2
-
12
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S., Armstrong C.M., Kaeberlein M., Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403:2000;795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
13
-
-
0346435109
-
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases
-
Jackson M.D., Schmidt M.T., Oppenheimer N.J., Denu J.M. Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J. Biol. Chem. 278:2003;50985-50998.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50985-50998
-
-
Jackson, M.D.1
Schmidt, M.T.2
Oppenheimer, N.J.3
Denu, J.M.4
-
14
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A. 47:1991;110-119.
-
(1991)
Acta Crystallogr. a
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.Y.2
Cowan, S.W.3
Kjeldgaard4
-
15
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13:1999;2570-2580.
-
(1999)
Genes Dev.
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
16
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
Landry J., Sutton A., Tafrov S.T., Heller R.C., Stebbins J., Pillus L., Sternglanz R. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA. 97:2000;5807-5811.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
Sutton, A.2
Tafrov, S.T.3
Heller, R.C.4
Stebbins, J.5
Pillus, L.6
Sternglanz, R.7
-
17
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin S.J., Defossez P.A., Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 289:2000;2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
18
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107:2001;137-148.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
19
-
-
0032790081
-
XtalView/Xfit - A versatile program for manipulating atomic coordinates and electron density
-
McRee D.E. XtalView/Xfit - a versatile program for manipulating atomic coordinates and electron density. J. Struct. Biol. 125:1999;156-165.
-
(1999)
J. Struct. Biol.
, vol.125
, pp. 156-165
-
-
McRee, D.E.1
-
20
-
-
0035917536
-
Crystal structure of a SIR2 homolog-NAD complex
-
Min J., Landry J., Sternglanz R., Xu R.M. Crystal structure of a SIR2 homolog-NAD complex. Cell. 105:2001;269-279.
-
(2001)
Cell
, vol.105
, pp. 269-279
-
-
Min, J.1
Landry, J.2
Sternglanz, R.3
Xu, R.M.4
-
21
-
-
0035868764
-
Acetylation of TAF (I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
-
Muth V., Nadaud S., Grummt I., Voit R. Acetylation of TAF (I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 20:2001;1353-1362.
-
(2001)
EMBO J.
, vol.20
, pp. 1353-1362
-
-
Muth, V.1
Nadaud, S.2
Grummt, I.3
Voit, R.4
-
22
-
-
0037291214
-
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
-
North B.J., Marshall B.L., Borra M.T., Denu J.M., Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell. 11:2003;437-444.
-
(2003)
Mol. Cell
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
23
-
-
0041519401
-
The amide rotational barriers in picolinamide and nicotinamide: NMR and ab initio studies
-
Olsen R.A., Liu L., Ghaderi N., Johns A., Hatcher M.E., Mueller L.J. The amide rotational barriers in picolinamide and nicotinamide. NMR and ab initio studies J. Am. Chem. Soc. 125:2003;10125-10132.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 10125-10132
-
-
Olsen, R.A.1
Liu, L.2
Ghaderi, N.3
Johns, A.4
Hatcher, M.E.5
Mueller, L.J.6
-
24
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski Z., Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:1997;307-326.
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
25
-
-
0034625082
-
Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects
-
Parikh S.S., Walcher G., Jones G.D., Slupphaug G., Krokan H.E., Blackburn G.M., Tainer J.A. Uracil-DNA glycosylase-DNA substrate and product structures. conformational strain promotes catalytic efficiency by coupled stereoelectronic effects Proc. Natl. Acad. Sci. USA. 97:2000;5083-5088.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5083-5088
-
-
Parikh, S.S.1
Walcher, G.2
Jones, G.D.3
Slupphaug, G.4
Krokan, H.E.5
Blackburn, G.M.6
Tainer, J.A.7
-
26
-
-
0041571570
-
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
-
Sauve A.A., Schramm V.L. Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry. 42:2003;9249-9256.
-
(2003)
Biochemistry
, vol.42
, pp. 9249-9256
-
-
Sauve, A.A.1
Schramm, V.L.2
-
27
-
-
0035951072
-
Chemistry of gene silencing: The mechanism of NAD+-dependent deacetylation reactions
-
Sauve A.A., Celic I., Avalos J., Deng H., Boeke J.D., Schramm V.L. Chemistry of gene silencing. the mechanism of NAD+-dependent deacetylation reactions Biochemistry. 40:2001;15456-15463.
-
(2001)
Biochemistry
, vol.40
, pp. 15456-15463
-
-
Sauve, A.A.1
Celic, I.2
Avalos, J.3
Deng, H.4
Boeke, J.D.5
Schramm, V.L.6
-
28
-
-
12944283150
-
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
-
Smith J.S., Brachmann C.B., Celic I., Kenna M.A., Muhammad S., Starai V.J., Avalos J.L., Escalante-Semerena J.C., Grubmeyer C., Wolberger C.et al. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA. 97:2000;6658-6663.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6658-6663
-
-
Smith, J.S.1
Brachmann, C.B.2
Celic, I.3
Kenna, M.A.4
Muhammad, S.5
Starai, V.J.6
Avalos, J.L.7
Escalante-Semerena, J.C.8
Grubmeyer, C.9
Wolberger, C.10
-
29
-
-
0036279988
-
SIR2 family of NAD (+)-dependent protein deacetylases
-
Smith J.S., Avalos J., Celic I., Muhammad S., Wolberger C., Boeke J.D. SIR2 family of NAD (+)-dependent protein deacetylases. Methods Enzymol. 353:2002;282-300.
-
(2002)
Methods Enzymol.
, vol.353
, pp. 282-300
-
-
Smith, J.S.1
Avalos, J.2
Celic, I.3
Muhammad, S.4
Wolberger, C.5
Boeke, J.D.6
-
30
-
-
0347457075
-
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine
-
Starai V.J., Celic I., Cole R.N., Boeke J.D., Escalante-Semerena J.C. Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science. 298:2002;2390-2392.
-
(2002)
Science
, vol.298
, pp. 2390-2392
-
-
Starai, V.J.1
Celic, I.2
Cole, R.N.3
Boeke, J.D.4
Escalante-Semerena, J.C.5
-
31
-
-
0034687694
-
Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
-
Tanner K.G., Landry J., Sternglanz R., Denu J.M. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc. Natl. Acad. Sci. USA. 97:2000;14178-14182.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 14178-14182
-
-
Tanner, K.G.1
Landry, J.2
Sternglanz, R.3
Denu, J.M.4
-
32
-
-
0035895275
-
Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
-
Tanny J.C., Moazed D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2. evidence for acetyl transfer from substrate to an NAD breakdown product Proc. Natl. Acad. Sci. USA. 98:2001;415-420.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 415-420
-
-
Tanny, J.C.1
Moazed, D.2
-
33
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 410:2001;227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
34
-
-
0037020199
-
Structure and catalytic mechanism of a SET domain protein methyltransferase
-
Trievel R.C., Beach B.M., Dirk L.M., Houtz R.L., Hurley J.H. Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell. 111:2002;91-103.
-
(2002)
Cell
, vol.111
, pp. 91-103
-
-
Trievel, R.C.1
Beach, B.M.2
Dirk, L.M.3
Houtz, R.L.4
Hurley, J.H.5
-
35
-
-
0000560808
-
Molrep: An automated program for molecular replacement
-
Vagin A., Teplyakov A. Molrep. an automated program for molecular replacement J. Appl. Crystallogr. 30:1997;1022-1025.
-
(1997)
J. Appl. Crystallogr.
, vol.30
, pp. 1022-1025
-
-
Vagin, A.1
Teplyakov, A.2
-
36
-
-
0035913903
-
HSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:2001;149-159.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
38
-
-
0242626891
-
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2′-O-acetyl ADP ribose and histone peptide
-
b
-
Zhao K., Chai X., Marmorstein R. Structure of the yeast Hst2 protein deacetylase in ternary complex with 2′-O-acetyl ADP ribose and histone peptide. Structure. 11:2003;1403-1411. b.
-
(2003)
Structure
, vol.11
, pp. 1403-1411
-
-
Zhao, K.1
Chai, X.2
Marmorstein, R.3
|