Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways

Expert Opinion on Drug Discovery

Volumn 9, Issue 9, 2014, Pages 1021-1032

  O'Reilly, Linda P ^a   Benson, Joshua A ^a   Cummings, Erin E ^a   Perlmutter, David H ^a   Silverman, Gary A ^a   Pak, Stephen C ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Caenorhabditis elegans; Conformational disease; Drug discovery; Insulin signaling; Proteostasis network

Indexed keywords

HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; INSULIN; SMALL MOLECULE TRANSPORT AGENT; SOMATOMEDIN;

CAENORHABDITIS ELEGANS; CELLULAR STRESS RESPONSE; HEAT SHOCK RESPONSE; HIGH THROUGHPUT SCREENING; LONGEVITY; NONHUMAN; PERSONALIZED MEDICINE; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; REVIEW; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; DRUG DEVELOPMENT; HUMAN; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROCEDURES; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CAENORHABDITIS ELEGANS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INSULIN; LONGEVITY; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SOMATOMEDINS; STRESS, PHYSIOLOGICAL;

EID: 84906354624     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2014.930125     Document Type: Review

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