메뉴 건너뛰기




Volumn 41, Issue 10, 2006, Pages 910-921

The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries

Author keywords

Aging; C. elegans; daf 16; daf 2; Dauer; Fat; FOXO; Longevity

Indexed keywords

TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO;

EID: 33751430460     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.06.040     Document Type: Article
Times cited : (154)

References (66)
  • 1
    • 0037448528 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    • Ashrafi K., et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421 6920 (2003) 268-272
    • (2003) Nature , vol.421 , Issue.6920 , pp. 268-272
    • Ashrafi, K.1
  • 2
    • 0035082093 scopus 로고    scopus 로고
    • Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
    • Barsyte D., Lovejoy D.A., and Lithgow G.J. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 15 3 (2001) 627-634
    • (2001) FASEB J. , vol.15 , Issue.3 , pp. 627-634
    • Barsyte, D.1    Lovejoy, D.A.2    Lithgow, G.J.3
  • 3
    • 33646024345 scopus 로고    scopus 로고
    • DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest
    • Baugh L.R., and Sternberg P.W. DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. Curr. Biol. 16 8 (2006) 780-785
    • (2006) Curr. Biol. , vol.16 , Issue.8 , pp. 780-785
    • Baugh, L.R.1    Sternberg, P.W.2
  • 4
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M., Kahn B.B., and Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 5606 (2003) 572-574
    • (2003) Science , vol.299 , Issue.5606 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 5
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 5666 (2004) 2011-2015
    • (2004) Science , vol.303 , Issue.5666 , pp. 2011-2015
    • Brunet, A.1
  • 6
    • 0034730161 scopus 로고    scopus 로고
    • Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysis
    • Bussemaker H.J., Li H., and Siggia E.D. Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysis. Proc. Natl. Acad. Sci. USA 97 18 (2000) 10096-10100
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.18 , pp. 10096-10100
    • Bussemaker, H.J.1    Li, H.2    Siggia, E.D.3
  • 7
    • 0032509302 scopus 로고    scopus 로고
    • Genome sequence of the nematode C. elegans: a platform for investigating biology
    • Consortium C.e.S. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282 5396 (1998) 2012-2018
    • (1998) Science , vol.282 , Issue.5396 , pp. 2012-2018
    • Consortium, C.e.S.1
  • 8
    • 0037174629 scopus 로고    scopus 로고
    • Timing requirements for insulin/IGF-1 signaling in C. elegans
    • Dillin A., Crawford D.K., and Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298 5594 (2002) 830-834
    • (2002) Science , vol.298 , Issue.5594 , pp. 830-834
    • Dillin, A.1    Crawford, D.K.2    Kenyon, C.3
  • 9
    • 0032441150 scopus 로고    scopus 로고
    • Cluster analysis and display of genome-wide expression patterns
    • Eisen M.B., et al. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95 25 (1998) 14863-14868
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , Issue.25 , pp. 14863-14868
    • Eisen, M.B.1
  • 10
    • 18844382368 scopus 로고    scopus 로고
    • Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    • Essers M.A., et al. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 5725 (2005) 1181-1184
    • (2005) Science , vol.308 , Issue.5725 , pp. 1181-1184
    • Essers, M.A.1
  • 11
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • Fraser A.G., et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408 6810 (2000) 325-330
    • (2000) Nature , vol.408 , Issue.6810 , pp. 325-330
    • Fraser, A.G.1
  • 12
    • 0034661826 scopus 로고    scopus 로고
    • Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    • Furuyama T., et al. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349 Pt 2 (2000) 629-634
    • (2000) Biochem. J. , vol.349 , Issue.PART 2 , pp. 629-634
    • Furuyama, T.1
  • 13
    • 13844303637 scopus 로고    scopus 로고
    • Microarray analysis of gene expression with age in individual nematodes
    • Golden T.R., and Melov S. Microarray analysis of gene expression with age in individual nematodes. Aging Cell 3 111-114 (2004)
    • (2004) Aging Cell , vol.3 , Issue.111-114
    • Golden, T.R.1    Melov, S.2
  • 14
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer E.L., and Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24 50 (2005) 7410-7425
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 15
    • 21144460742 scopus 로고    scopus 로고
    • Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression
    • Halaschek-Wiener J., et al. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Genome. Res. 15 5 (2005) 603-615
    • (2005) Genome. Res. , vol.15 , Issue.5 , pp. 603-615
    • Halaschek-Wiener, J.1
  • 16
    • 22344443522 scopus 로고    scopus 로고
    • A systematic RNAi screen for longevity genes in C. elegans
    • Hamilton B., et al. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19 13 (2005) 1544-1555
    • (2005) Genes Dev. , vol.19 , Issue.13 , pp. 1544-1555
    • Hamilton, B.1
  • 17
    • 33645472504 scopus 로고    scopus 로고
    • New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
    • Hansen M., et al. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1 1 (2005) e17
    • (2005) PLoS Genet. , vol.1 , Issue.1
    • Hansen, M.1
  • 18
    • 0035846604 scopus 로고    scopus 로고
    • daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • Henderson S.T., and Johnson T.E. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 24 (2001) 1975-1980
    • (2001) Curr. Biol. , vol.11 , Issue.24 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 19
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Honda Y., and Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13 11 (1999) 1385-1393
    • (1999) FASEB J. , vol.13 , Issue.11 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 20
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu A.L., Murphy C.T., and Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300 5622 (2003) 1142-1145
    • (2003) Science , vol.300 , Issue.5622 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 21
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo D.S., et al. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 6991 (2004) 562-566
    • (2004) Nature , vol.429 , Issue.6991 , pp. 562-566
    • Hwangbo, D.S.1
  • 22
    • 19944367254 scopus 로고    scopus 로고
    • Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions
    • Impey S., et al. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119 7 (2004) 1041-1054
    • (2004) Cell , vol.119 , Issue.7 , pp. 1041-1054
    • Impey, S.1
  • 23
    • 0035945567 scopus 로고    scopus 로고
    • Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
    • Iyer V.R., et al. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature 409 6819 (2001) 533-538
    • (2001) Nature , vol.409 , Issue.6819 , pp. 533-538
    • Iyer, V.R.1
  • 24
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia K., Chen D., and Riddle D.L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 16 (2004) 3897-3906
    • (2004) Development , vol.131 , Issue.16 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 25
    • 0025004091 scopus 로고
    • Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
    • Johnson T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249 4971 (1990) 908-912
    • (1990) Science , vol.249 , Issue.4971 , pp. 908-912
    • Johnson, T.E.1
  • 26
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C., et al. A C. elegans mutant that lives twice as long as wild type. Nature 366 6454 (1993) 461-464
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1
  • 27
    • 33645420945 scopus 로고    scopus 로고
    • Enrichment of regulatory motifs upstream of predicted DAF-16 targets
    • Kenyon C., and Murphy C.T. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat. Genet. 38 4 (2006) 397-398
    • (2006) Nat. Genet. , vol.38 , Issue.4 , pp. 397-398
    • Kenyon, C.1    Murphy, C.T.2
  • 28
    • 0035860551 scopus 로고    scopus 로고
    • A gene expression map for Caenorhabditis elegans
    • Kim S.K., et al. A gene expression map for Caenorhabditis elegans. Science 293 5537 (2001) 2087-2092
    • (2001) Science , vol.293 , Issue.5537 , pp. 2087-2092
    • Kim, S.K.1
  • 29
    • 18744380399 scopus 로고    scopus 로고
    • Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment
    • Kim J., et al. Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. Nat. Methods 2 1 (2005) 47-53
    • (2005) Nat. Methods , vol.2 , Issue.1 , pp. 47-53
    • Kim, J.1
  • 30
    • 27744509099 scopus 로고    scopus 로고
    • The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase
    • Kormish J.D., and McGhee J.D. The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase. Dev. Biol. 287 1 (2005) 35-47
    • (2005) Dev. Biol. , vol.287 , Issue.1 , pp. 35-47
    • Kormish, J.D.1    McGhee, J.D.2
  • 31
    • 12144264839 scopus 로고    scopus 로고
    • Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
    • Lamitina S.T., and Strange K. Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Am. J. Physiol. Cell Physiol. 288 2 (2005) C467-C474
    • (2005) Am. J. Physiol. Cell Physiol. , vol.288 , Issue.2
    • Lamitina, S.T.1    Strange, K.2
  • 32
    • 0037466652 scopus 로고    scopus 로고
    • DAF-16 target genes that control C. elegans life-span and metabolism
    • Lee S.S., et al. DAF-16 target genes that control C. elegans life-span and metabolism. Science 300 5619 (2003) 644-647
    • (2003) Science , vol.300 , Issue.5619 , pp. 644-647
    • Lee, S.S.1
  • 34
    • 0345447590 scopus 로고    scopus 로고
    • Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    • Libina N., Berman J.R., and Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115 4 (2003) 489-502
    • (2003) Cell , vol.115 , Issue.4 , pp. 489-502
    • Libina, N.1    Berman, J.R.2    Kenyon, C.3
  • 35
    • 0034934774 scopus 로고    scopus 로고
    • Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association
    • Lieb J.D., et al. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat. Genet. 28 4 (2001) 327-334
    • (2001) Nat. Genet. , vol.28 , Issue.4 , pp. 327-334
    • Lieb, J.D.1
  • 36
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin K., et al. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28 2 (2001) 139-145
    • (2001) Nat. Genet. , vol.28 , Issue.2 , pp. 139-145
    • Lin, K.1
  • 37
    • 0037162295 scopus 로고    scopus 로고
    • Inducible antibacterial defense system in C. elegans
    • Mallo G., et al. Inducible antibacterial defense system in C. elegans. Curr. Biol. 12 14 (2002) 1209
    • (2002) Curr. Biol. , vol.12 , Issue.14 , pp. 1209
    • Mallo, G.1
  • 38
    • 0842267618 scopus 로고    scopus 로고
    • Comparing genomic expression patterns across species identifies shared transcriptional profile in aging
    • McCarroll S.A., et al. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat. Genet. 36 2 (2004) 197-204
    • (2004) Nat. Genet. , vol.36 , Issue.2 , pp. 197-204
    • McCarroll, S.A.1
  • 39
    • 7244238167 scopus 로고    scopus 로고
    • Shared transcriptional signature in Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    • McElwee J.J., et al. Shared transcriptional signature in Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J. Biol. Chem. 279 43 (2004) 44533-44543
    • (2004) J. Biol. Chem. , vol.279 , Issue.43 , pp. 44533-44543
    • McElwee, J.J.1
  • 40
    • 0042631524 scopus 로고    scopus 로고
    • Outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee J., Bubb K., and Thomas J.H. Outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2 2 (2003) 111-121
    • (2003) Aging Cell , vol.2 , Issue.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 41
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris J.Z., Tissenbaum H.A., and Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382 6591 (1996) 536-539
    • (1996) Nature , vol.382 , Issue.6591 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 42
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy C.T., et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 6946 (2003) 277-283
    • (2003) Nature , vol.424 , Issue.6946 , pp. 277-283
    • Murphy, C.T.1
  • 43
    • 33745880714 scopus 로고    scopus 로고
    • Murphy, C.T., 2006. Using whole-genome transcriptional analyses to identify molecular mechanisms of aging. Drug Disc. Today Dis. Mech., in press.
  • 44
    • 33751406833 scopus 로고    scopus 로고
    • Murphy, C.T., Lee, S.-J., Kenyon, C, Alignment of stress-response pathways by insulin-like peptides in C. elegans, in press.
  • 45
    • 0025160127 scopus 로고
    • Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription
    • O'Brien R.M., et al. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 249 4968 (1990) 533-537
    • (1990) Science , vol.249 , Issue.4968 , pp. 533-537
    • O'Brien, R.M.1
  • 46
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S., et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389 6654 (1997) 994-999
    • (1997) Nature , vol.389 , Issue.6654 , pp. 994-999
    • Ogg, S.1
  • 47
    • 33645395334 scopus 로고    scopus 로고
    • Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    • Oh S.W., et al. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat. Genet (2005)
    • (2005) Nat. Genet
    • Oh, S.W.1
  • 48
    • 15444371989 scopus 로고    scopus 로고
    • JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    • Oh S.W., et al. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 102 12 (2005) 4494-4499
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.12 , pp. 4494-4499
    • Oh, S.W.1
  • 49
    • 0037418579 scopus 로고    scopus 로고
    • Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans
    • Ookuma S., Fukuda M., and Nishida E. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr. Biol. 13 5 (2003) 427-431
    • (2003) Curr. Biol. , vol.13 , Issue.5 , pp. 427-431
    • Ookuma, S.1    Fukuda, M.2    Nishida, E.3
  • 50
    • 2442421023 scopus 로고    scopus 로고
    • Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans
    • Petriv O.I., and Rachubinski R.A. Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. J. Biol. Chem. 279 19 (2004) 19996-20001
    • (2004) J. Biol. Chem. , vol.279 , Issue.19 , pp. 19996-20001
    • Petriv, O.I.1    Rachubinski, R.A.2
  • 51
    • 0035868890 scopus 로고    scopus 로고
    • Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
    • Pierce S.B., et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 15 6 (2001) 672-686
    • (2001) Genes Dev. , vol.15 , Issue.6 , pp. 672-686
    • Pierce, S.B.1
  • 52
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
    • Puig O., et al. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 16 (2003) 2006-2020
    • (2003) Genes Dev. , vol.17 , Issue.16 , pp. 2006-2020
    • Puig, O.1
  • 53
    • 26944461217 scopus 로고    scopus 로고
    • Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    • Puig O., and Tjian R. Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19 20 (2005) 2435-2446
    • (2005) Genes Dev. , vol.19 , Issue.20 , pp. 2435-2446
    • Puig, O.1    Tjian, R.2
  • 54
    • 33644779774 scopus 로고    scopus 로고
    • Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1
    • Puig O., and Tjian R. Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1. Cell Cycle 5 5 (2006)
    • (2006) Cell Cycle , vol.5 , Issue.5
    • Puig, O.1    Tjian, R.2
  • 55
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy S., et al. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2 1 (2002) 81-91
    • (2002) Cancer Cell , vol.2 , Issue.1 , pp. 81-91
    • Ramaswamy, S.1
  • 56
    • 0041440219 scopus 로고    scopus 로고
    • A metabolic model for life span determination in Caenorhabditis elegans
    • Rea S., and Johnson T.E. A metabolic model for life span determination in Caenorhabditis elegans. Dev. Cell 5 2 (2003) 197-203
    • (2003) Dev. Cell , vol.5 , Issue.2 , pp. 197-203
    • Rea, S.1    Johnson, T.E.2
  • 57
    • 0001104583 scopus 로고    scopus 로고
    • Genetic and environmental regulation of dauer larva development
    • Riddle D.L. (Ed), Cold Spring Harbor Laboratory Press, New York
    • Riddle D.L., and Albert P.S. Genetic and environmental regulation of dauer larva development. In: Riddle D.L. (Ed). C. elegans II (1997), Cold Spring Harbor Laboratory Press, New York 739-768
    • (1997) C. elegans II , pp. 739-768
    • Riddle, D.L.1    Albert, P.S.2
  • 58
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 6825 (2001) 227-230
    • (2001) Nature , vol.410 , Issue.6825 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 59
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98 9 (2001) 5116-5121
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.9 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 60
    • 0032483307 scopus 로고    scopus 로고
    • Extracting regulatory sites from the upstream region of yeast genes by computational analysis of oligonucleotide frequencies
    • van Helden J., Andre B., and Collado-Vides J. Extracting regulatory sites from the upstream region of yeast genes by computational analysis of oligonucleotide frequencies. J. Mol. Biol. 281 5 (1998) 827-842
    • (1998) J. Mol. Biol. , vol.281 , Issue.5 , pp. 827-842
    • van Helden, J.1    Andre, B.2    Collado-Vides, J.3
  • 61
    • 0034953956 scopus 로고    scopus 로고
    • Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans
    • Walker G.A., et al. Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 56 7 (2001) B281-B287
    • (2001) J. Gerontol. A Biol. Sci. Med. Sci. , vol.56 , Issue.7
    • Walker, G.A.1
  • 62
    • 0038406208 scopus 로고    scopus 로고
    • Global analysis of dauer gene expression in Caenorhabditis elegans
    • Wang J., and Kim S.K. Global analysis of dauer gene expression in Caenorhabditis elegans. Development 130 8 (2003) 1621-1634
    • (2003) Development , vol.130 , Issue.8 , pp. 1621-1634
    • Wang, J.1    Kim, S.K.2
  • 63
    • 9644278037 scopus 로고    scopus 로고
    • Insulin regulation of heart function in aging fruit flies
    • Wessells R.J., et al. Insulin regulation of heart function in aging fruit flies. Nat. Genet. 36 12 (2004) 1275-1281
    • (2004) Nat. Genet. , vol.36 , Issue.12 , pp. 1275-1281
    • Wessells, R.J.1
  • 64
    • 33644750381 scopus 로고    scopus 로고
    • SMK-1, an essential regulator of DAF-16-mediated longevity
    • Wolff S., et al. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124 5 (2006) 1039-1053
    • (2006) Cell , vol.124 , Issue.5 , pp. 1039-1053
    • Wolff, S.1
  • 65
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C. elegans life-span by insulinlike signaling in the nervous system
    • Wolkow C.A., et al. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290 5489 (2000) 147-150
    • (2000) Science , vol.290 , Issue.5489 , pp. 147-150
    • Wolkow, C.A.1
  • 66
    • 0035861993 scopus 로고    scopus 로고
    • DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs
    • Yu H., and Larsen P.L. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. J. Mol. Biol. 314 5 (2001) 1017-1028
    • (2001) J. Mol. Biol. , vol.314 , Issue.5 , pp. 1017-1028
    • Yu, H.1    Larsen, P.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.