Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP

Cell Death and Disease

Volumn 3, Issue 6, 2012, Pages

  Zheng, X ^a   Wang, X ^a   Ma, Z ^a   Gupta Sunkari, V ^a   Botusan, I ^a   Takeda, T ^b,c   Bjorklund A ^a   Inoue, M ^b,c   Catrina, S B ^a   Brismar, K ^a   Poellinger, L ^a,d   Pereira, T S ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

apoptosis; CHOP; ER stress; hypoxia; pancreatic cells; UPR

Indexed keywords

CASPASE 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYPOXIA INDUCIBLE FACTOR 1ALPHA; DDIT3 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; HYPOXIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; C57BL MOUSE; CELL HYPOXIA; GENETICS; INSULINOMA; MALE; METABOLISM; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; TUMOR CELL LINE; UPREGULATION;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; INSULIN-SECRETING CELLS; INSULINOMA; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTIONAL ACTIVATION; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

EID: 84863474509     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.66     Document Type: Article

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