Anticonvulsant medications extend worm life-span

Science

Volumn 307, Issue 5707, 2005, Pages 258-262

  Evason, Kimberley ^a   Huang, Cheng ^a   Yamben, Idella ^a   Covey, Douglas F ^a   Kornfeld, Kerry ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; KETONES; NEUROLOGY; PHYSIOLOGY;

ANTICONVULSANT MEDICATIONS; ETHOSUXIMIDE; NEURAL ACTIVITY; TRIMETHADIONE;

GENETIC ENGINEERING;

2 PYRROLIDONE DERIVATIVE; 3,3 DIETHYL 2 PYRROLIDINONE; ANTICONVULSIVE AGENT; ETHOSUXIMIDE; TRIMETHADIONE; UNCLASSIFIED DRUG;

LONGEVITY;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; LIFESPAN; NEMATODE; NERVE CONDUCTION; NEUROMODULATION; NEUROMUSCULAR FUNCTION; NONHUMAN; PRIORITY JOURNAL;

AGING; ALDICARB; ANIMALS; ANTICONVULSANTS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EPILEPSY, ABSENCE; ETHOSUXIMIDE; FEMALE; GENES, HELMINTH; HERMAPHRODITISM; HUMANS; LACTAMS; LONGEVITY; MOVEMENT; MUSCLES; MUTATION; NEURONS; OVIPOSITION; PHARYNX; REPRODUCTION; SYNAPTIC TRANSMISSION; TRANSCRIPTION FACTORS; TRIMETHADIONE; VULVA;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 12244261636     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105299     Document Type: Article

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23. Strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH National Center for Research Resources. We thank M. Nonet for helpful suggestions and aex-3 mutants, S. Hughes for experimental assistance, and D. Redmond for assistance with graphics. Support was provided by the Washington University Alzheimer's Disease Research Center (grant no. P50 AG05681) and the Longer Life Foundation, a Reinsurance Group of America, Inc. (RGA)/Washington University Partnership (grant no. 1999-001). C.H. was supported by a Predoctoral Fellowship from the Howard Hughes Medical Institute. K.K. is a scholar of the Leukemia and Lymphoma Society.